iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021548

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02040788

Gene Name

HERC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000011101.3	ENSCPOT00000011204.2	ENSCPOP00000009982.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.10e-94	315.4	726	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+ +g+a++++ ++dl
   Q: 726  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV-----EHNWFHLIGITCGLAIYNSTVVDL 807
           899******************************************9999999776554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k  ledl+e+ p+  +sl+e++++  +d+ee+ ++l+f++  e++g +++++L+pgG+++ V  +N++e+v+++
   Q: 808  HFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEET-FCLNFTICRESYGIIEQKKLIPGGDKVTVCRDNRQEFVDAY 893
           *************************************99999997.******99********************************* PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++ +++e ++af +Gf +v+  ++l+lF+++el+ ++ G++++++e+l++++ ykg+y++++p+++ Fwe+++ef  e++k+f
   Q: 894  VNYVFQISVHEWYTAFASGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEATAIYKGDYSASHPTVKLFWETFHEFPLEKKKKF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+a+l+   +vi+  ++ ++ lP ++TC+n+L+LP+Ysskeil  +L  A ++ +gF+l
   Q: 981  LLFLTGSDRIPIYGMASLQ---IVIQStASGEEYLPVAHTCYNLLDLPKYSSKEILSARLSQALDNYEGFSL 1049
           *******************...8888867788**************************************97 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MLCWGYWSLG QPGIGTHLRG IVAEPQACGF VSDRSVKEVA CGGDHCVFLL EDGEVYTCGL 60
NTKGQLGHER EGNQPEQIGA LADQHIIHVA CGESHSLALS DQGQLFSWGA GSDGQLGLMT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTATGCT GGGGATATTG GTCTCTGGGC CAGCCGGGTA TTGGCACCCA CCTGCGAGGG 60
ATTGTGGCCG AGCCACAGGC GTGTGGATTT GTGTCGGACA GAAGCGTCAA GGAGGTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	96.95	0.00e+00	2066.00
IUUC-Apl-003535	Anas platyrhynchos	87.24	0.00e+00	1869.00
IUUC-Aca-005223	Anolis carolinensis	84.76	0.00e+00	1820.00
IUUC-Ame-010816	Astyanax mexicanus	65.92	0.00e+00	1159.00
IUUC-Bta-013373	Bos taurus	96.67	0.00e+00	2068.00
IUUC-Cel-018150	Caenorhabditis elegans	33.30	1.00e-153	537.00
IUUC-Cja-019609	Callithrix jacchus	97.43	0.00e+00	2071.00
IUUC-Cfa-021071	Canis familiaris	96.76	0.00e+00	2062.00
IUUC-Csa-023987	Chlorocebus sabaeus	97.81	0.00e+00	2077.00
IUUC-Cho-024325	Choloepus hoffmanni	97.61	0.00e+00	1200.00
IUUC-Dre-027472	Danio rerio	66.16	0.00e+00	1390.00
IUUC-Dno-029241	Dasypus novemcinctus	95.63	0.00e+00	2036.00
IUUC-Dor-030672	Dipodomys ordii	91.36	0.00e+00	1124.00
IUUC-Ete-032642	Echinops telfairi	91.14	0.00e+00	1881.00
IUUC-Eca-033646	Equus caballus	96.95	0.00e+00	2066.00
IUUC-Eeu-035098	Erinaceus europaeus	84.29	0.00e+00	1373.00
IUUC-Fal-036952	Ficedula albicollis	87.14	0.00e+00	1865.00
IUUC-Gmo-039297	Gadus morhua	63.90	0.00e+00	1313.00
IUUC-Gga-040591	Gallus gallus	86.39	0.00e+00	1848.00
IUUC-Gac-041741	Gasterosteus aculeatus	65.09	0.00e+00	1378.00
IUUC-Gma-043616	Glycine max	37.46	9.00e-51	194.00
IUUC-Ggo-044769	Gorilla gorilla	97.53	0.00e+00	2070.00
IUUC-Hsa-046066	Homo sapiens	97.62	0.00e+00	2074.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	97.34	0.00e+00	2066.00
IUUC-Lch-050301	Latimeria chalumnae	72.76	0.00e+00	1606.00
IUUC-Loc-052803	Lepisosteus oculatus	67.16	0.00e+00	1451.00
IUUC-Laf-053364	Loxodonta africana	96.76	0.00e+00	2062.00
IUUC-Mcc-054930	Macaca mulatta	97.71	0.00e+00	2077.00
IUUC-Meu-056274	Macropus eugenii	77.25	0.00e+00	851.00
IUUC-Mtr-058277	Medicago truncatula	37.25	6.00e-52	197.00
IUUC-Mga-059563	Meleagris gallopavo	86.86	0.00e+00	1863.00
IUUC-Mmr-060792	Microcebus murinus	95.33	0.00e+00	2014.00
IUUC-Mdo-062195	Monodelphis domestica	90.77	0.00e+00	1941.00
IUUC-Mmu-063855	Mus musculus	94.19	0.00e+00	2023.00
IUUC-Mpu-066308	Mustela putorius furo	97.24	0.00e+00	2073.00
IUUC-Mlu-066927	Myotis lucifugus	96.57	0.00e+00	2055.00
IUUC-Nle-070090	Nomascus leucogenys	97.62	0.00e+00	2074.00
IUUC-Opr-070891	Ochotona princeps	85.33	0.00e+00	1761.00
IUUC-Ont-072201	Oreochromis niloticus	63.99	0.00e+00	1340.00
IUUC-Ocu-074770	Oryctolagus cuniculus	96.67	0.00e+00	2064.00
IUUC-Ola-086550	Oryzias latipes	64.99	0.00e+00	1383.00
IUUC-Olu-087836	Ostreococcus lucimarinus	34.14	1.00e-40	160.00
IUUC-Oga-088831	Otolemur garnettii	96.86	0.00e+00	2059.00
IUUC-Oar-090449	Ovis aries	96.57	0.00e+00	2059.00
IUUC-Pan-092135	Papio anubis	97.72	0.00e+00	2073.00
IUUC-Psi-093832	Pelodiscus sinensis	85.06	0.00e+00	1867.00
IUUC-Ppa-095354	Physcomitrella patens	32.78	5.00e-142	498.00
IUUC-Pfo-097268	Poecilia formosa	65.62	0.00e+00	1386.00
IUUC-Pab-098249	Pongo abelii	97.62	0.00e+00	2071.00
IUUC-Pca-100855	Procavia capensis	91.94	0.00e+00	1404.00
IUUC-Pva-102506	Pteropus vampyrus	88.96	0.00e+00	1829.00
IUUC-Rno-105242	Rattus norvegicus	94.48	0.00e+00	2068.00
IUUC-Sha-107186	Sarcophilus harrisii	88.44	0.00e+00	1184.00
IUUC-Sar-113612	Sorex araneus	95.40	0.00e+00	745.00
IUUC-Ssc-115473	Sus scrofa	96.10	0.00e+00	2053.00
IUUC-Tgu-116974	Taeniopygia guttata	87.35	0.00e+00	1844.00
IUUC-Tru-118077	Takifugu rubripes	63.74	0.00e+00	1318.00
IUUC-Tsy-119619	Tarsius syrichta	85.81	0.00e+00	1835.00
IUUC-Tni-120807	Tetraodon nigroviridis	63.55	0.00e+00	1334.00
IUUC-Tbe-127640	Tupaia belangeri	92.95	0.00e+00	1928.00
IUUC-Ttr-129172	Tursiops truncatus	96.19	0.00e+00	2047.00
IUUC-Vpa-130442	Vicugna pacos	80.98	0.00e+00	1667.00
IUUC-Xtr-132194	Xenopus tropicalis	71.32	0.00e+00	1437.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence