iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-097760

Ensembl Protein ID

ENSPPYP00000024707.1

UniProt Accession

K7EVW9; K7EVW9_PONAB

Genbank Protein ID

ENSPPYP00000024707

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01297844

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000029751.1	ENSPPYT00000033971.1	ENSPPYP00000024707.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-93	313.5	2394	2728
E3 adaptor/Cullin RING/DCX/DWD	3.10e-17	62.1	1314	1344

Active Site

Position(s)	Description	Evidence
2697	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 2394 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 2480
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+ ++l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 2481 PLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 2567
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 2568 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 2652
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 2653 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDM 2728
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 1314 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 1344
           55416677.*9778****************97 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MWLYRAYSGN LYHNGEQTLT LSSFTQGDFI TCVLDMEART ISFGKNGEEP KLAFEDVDAA 60
ELYPCVMFYS SNPGEKVKIC DMQMRGTPRD LLPGDPICSP VAAVLAEATI QLIRILHRTD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGCTCT ATAGGGCCTA CAGTGGTAAC CTCTATCACA ATGGAGAACA GACTCTCACA 60
TTGTCCAGCT TTACTCAAGG AGATTTCATT ACCTGTGTGT TAGACATGGA AGCCAGGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	97.50	0.00e+00	4991.00
IUUC-Atr-003065	Amborella trichopoda	32.66	3.00e-48	187.00
IUUC-Apl-003461	Anas platyrhynchos	91.81	0.00e+00	4718.00
IUUC-Aca-004452	Anolis carolinensis	83.27	0.00e+00	4053.00
IUUC-Aly-006545	Arabidopsis lyrata	36.36	9.00e-49	189.00
IUUC-Ame-011268	Astyanax mexicanus	60.63	0.00e+00	2227.00
IUUC-Bta-013213	Bos taurus	97.82	0.00e+00	4977.00
IUUC-Bdi-014791	Brachypodium distachyon	34.69	1.00e-52	200.00
IUUC-Bol-015203	Brassica oleracea	35.07	2.00e-50	194.00
IUUC-Bra-017584	Brassica rapa	34.46	2.00e-49	191.00
IUUC-Cja-019298	Callithrix jacchus	98.91	0.00e+00	5095.00
IUUC-Cfa-021213	Canis familiaris	97.97	0.00e+00	5038.00
IUUC-Cpo-021674	Cavia porcellus	96.70	0.00e+00	4948.00
IUUC-Csa-023341	Chlorocebus sabaeus	99.20	0.00e+00	5083.00
IUUC-Cho-024567	Choloepus hoffmanni	96.05	0.00e+00	1718.00
IUUC-Cin-025709	Ciona intestinalis	36.52	2.00e-175	610.00
IUUC-Csv-026336	Ciona savignyi	37.62	2.00e-179	625.00
IUUC-Dre-028289	Danio rerio	78.59	0.00e+00	4032.00
IUUC-Dno-029988	Dasypus novemcinctus	96.95	0.00e+00	4982.00
IUUC-Dor-030636	Dipodomys ordii	94.62	0.00e+00	2142.00
IUUC-Dme-032171	Drosophila melanogaster	40.11	5.00e-162	567.00
IUUC-Ete-032598	Echinops telfairi	84.80	0.00e+00	1364.00
IUUC-Eca-033754	Equus caballus	97.79	0.00e+00	5023.00
IUUC-Eeu-034702	Erinaceus europaeus	85.84	0.00e+00	1127.00
IUUC-Fca-035900	Felis catus	98.26	0.00e+00	5048.00
IUUC-Fal-037034	Ficedula albicollis	88.82	0.00e+00	3624.00
IUUC-Gmo-038634	Gadus morhua	90.87	0.00e+00	1219.00
IUUC-Gga-040321	Gallus gallus	92.06	0.00e+00	4793.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.08	0.00e+00	2219.00
IUUC-Gma-043808	Glycine max	33.68	2.00e-46	181.00
IUUC-Ggo-045134	Gorilla gorilla	99.27	0.00e+00	3494.00
IUUC-Hsa-046516	Homo sapiens	99.35	0.00e+00	5111.00
IUUC-Hvu-047529	Hordeum vulgare	35.38	1.00e-48	188.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	97.83	0.00e+00	2567.00
IUUC-Lch-049903	Latimeria chalumnae	86.57	0.00e+00	4491.00
IUUC-Lpe-051165	Leersia perrieri	33.58	2.00e-50	192.00
IUUC-Loc-052149	Lepisosteus oculatus	82.91	0.00e+00	4212.00
IUUC-Laf-053426	Loxodonta africana	97.49	0.00e+00	4962.00
IUUC-Mcc-055826	Macaca mulatta	99.31	0.00e+00	5107.00
IUUC-Meu-056521	Macropus eugenii	87.95	0.00e+00	1550.00
IUUC-Mga-059964	Meleagris gallopavo	82.34	0.00e+00	849.00
IUUC-Mmr-061512	Microcebus murinus	98.22	0.00e+00	5061.00
IUUC-Mdo-062177	Monodelphis domestica	93.62	0.00e+00	4789.00
IUUC-Mmu-064373	Mus musculus	97.10	0.00e+00	4994.00
IUUC-Mpu-066148	Mustela putorius furo	97.85	0.00e+00	5011.00
IUUC-Mlu-067680	Myotis lucifugus	97.35	0.00e+00	5000.00
IUUC-Nle-069633	Nomascus leucogenys	98.80	0.00e+00	5036.00
IUUC-Opr-070609	Ochotona princeps	95.97	0.00e+00	1448.00
IUUC-Ont-071249	Oreochromis niloticus	79.51	0.00e+00	4175.00
IUUC-Oan-073157	Ornithorhynchus anatinus	92.87	0.00e+00	4759.00
IUUC-Ocu-074841	Oryctolagus cuniculus	97.74	0.00e+00	5027.00
IUUC-Oba-075262	Oryza barthii	33.75	6.00e-49	187.00
IUUC-Obr-076115	Oryza brachyantha	34.10	2.00e-48	186.00
IUUC-Ogl-077586	Oryza glaberrima	33.75	7.00e-49	187.00
IUUC-Ogu-078796	Oryza glumaepatula	33.50	3.00e-48	186.00
IUUC-Oin-079298	Oryza indica	33.50	2.00e-48	186.00
IUUC-Olo-080768	Oryza longistaminata	35.07	8.00e-54	204.00
IUUC-Oni-082049	Oryza nivara	33.50	3.00e-48	186.00
IUUC-Opu-083608	Oryza punctata	33.42	1.00e-49	190.00
IUUC-Oru-084712	Oryza rufipogon	33.50	3.00e-48	186.00
IUUC-Osa-086078	Oryza sativa	33.50	3.00e-48	186.00
IUUC-Ola-086889	Oryzias latipes	79.09	0.00e+00	4136.00
IUUC-Oga-088459	Otolemur garnettii	98.18	0.00e+00	5039.00
IUUC-Oar-089888	Ovis aries	97.86	0.00e+00	4979.00
IUUC-Ptr-091114	Pan troglodytes	99.27	0.00e+00	5086.00
IUUC-Pan-092442	Papio anubis	99.56	0.00e+00	5114.00
IUUC-Psi-093833	Pelodiscus sinensis	91.82	0.00e+00	4746.00
IUUC-Pma-094275	Petromyzon marinus	48.24	2.00e-86	314.00
IUUC-Ppa-095790	Physcomitrella patens	36.47	7.00e-56	211.00
IUUC-Pfo-097262	Poecilia formosa	79.18	0.00e+00	4100.00
IUUC-Pop-099121	Populus trichocarpa	36.63	6.00e-52	199.00
IUUC-Pca-100465	Procavia capensis	96.36	0.00e+00	4581.00
IUUC-Ppe-101345	Prunus persica	34.02	5.00e-52	199.00
IUUC-Pva-102950	Pteropus vampyrus	97.20	0.00e+00	3086.00
IUUC-Rno-104892	Rattus norvegicus	97.20	0.00e+00	4956.00
IUUC-Sha-106633	Sarcophilus harrisii	92.71	0.00e+00	4689.00
IUUC-Smo-108827	Selaginella moellendorffii	35.40	5.00e-52	199.00
IUUC-Sit-110415	Setaria italica	36.15	3.00e-53	202.00
IUUC-Sly-111155	Solanum lycopersicum	37.39	7.00e-54	205.00
IUUC-Stu-112166	Solanum tuberosum	32.23	3.00e-49	191.00
IUUC-Sar-113251	Sorex araneus	86.15	0.00e+00	1465.00
IUUC-Sbi-114352	Sorghum bicolor	32.26	5.00e-46	179.00
IUUC-Ssc-116391	Sus scrofa	97.89	0.00e+00	5029.00
IUUC-Tgu-116554	Taeniopygia guttata	91.52	0.00e+00	4754.00
IUUC-Tru-118695	Takifugu rubripes	79.16	0.00e+00	4165.00
IUUC-Tsy-119647	Tarsius syrichta	92.37	0.00e+00	3651.00
IUUC-Tni-120707	Tetraodon nigroviridis	79.23	0.00e+00	4135.00
IUUC-Tca-121094	Theobroma cacao	35.07	5.00e-51	196.00
IUUC-Tae-124157	Triticum aestivum	31.82	1.00e-45	178.00
IUUC-Tur-126300	Triticum urartu	35.38	3.00e-49	191.00
IUUC-Tbe-127346	Tupaia belangeri	90.15	0.00e+00	2594.00
IUUC-Ttr-128542	Tursiops truncatus	94.91	0.00e+00	3919.00
IUUC-Vpa-130611	Vicugna pacos	96.60	0.00e+00	2784.00
IUUC-Xtr-131933	Xenopus tropicalis	84.35	0.00e+00	4211.00
IUUC-Xma-134216	Xiphophorus maculatus	75.84	0.00e+00	3919.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence