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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046805
UUCD1 version UUC-HoS-01219
Ensembl Protein ID ENSP00000219689.7
UniProt Accession Q70CQ4; Q6AW97; Q6ZTC0; Q6ZTN2; Q9ULL7; UBP31_HUMAN
Genbank Protein ID CAE51935.2; BAC86554.1; BAA86517.1; CAH10383.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 31; Deubiquitinating enzyme 31; Ubiquitin thioesterase 31; Ubiquitin-specific-processing protease 31
Genbank Nucleotide ID AJ586135; AK126447; AK126752; BX648357
Gene Name USP31; KIAA1203
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000103404.14 ENST00000219689.11 ENSP00000219689.7
ENSG00000103404.14 ENST00000567975.1 ENSP00000461621.1
ENSG00000103404.14 ENST00000563525.2 ENSP00000481339.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
iRefIndexMentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELM
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.50e-93 315.4 129 765
Active Site
Position(s) Description Evidence
137 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
723 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp.........kepkgellkslqklfeelwkskkkavsprell 74
           Gl+N+gNtC+mN++LQcLsn++ ++e+l            +         p          + +ge++++l++l+++lw+ + +    r+++
   Q: 129  GLRNHGNTCFMNATLQCLSNTELFAEYLALgqyragrpepS---------PdpeqpagrgAQGQGEVTEQLAHLVRALWTLEYTPQHSRDFK 211
           9***************************9954444333330.........133334444456666*************************** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssre 166
           ++++k a +++g++q+DaqEfl +lld+++e+l++ + k+  +   +  se++++ e       ++++++lFq q++s+++c++c+++s+++
   Q: 212  TIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNH-SVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTF 302
           *********************************65.33333333334445566667777778888*************************** PP
   S: 167  epfldlslpvpgkeetkke......................................................................... 185
           +pfl +slp+p  +++ ++                                                                         
   Q: 303  DPFLCISLPIPLPHTR-PLyvtvvyqgkcshcmrigvavplsgtvarlreavsmetkiptdqivltemyydgfhrsfcdtddletvhesdci 393
           ***********87755.34689********************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 394  fafetpeifrpegilsqrgihlnnnlnhlkfgldyhrlssptqtaakqgkmdsptsragsdkivllvcnractgqqgkrfglpfvlhlekti 485
           ******************************************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 486  awdllqkeilekmkyflrptvciqvcpfslrvvsvvgityllpqeeqplchpiveralkscgpggtahvklvvewdketrdflfvntedeyi 577
           ******************************************************************************************** PP
   S: 186  ...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple 258
                              +l++c++ +tkee+l  ++++ c++ck++q+ + +l+l++lP+vLi+hLkRf  ++e+++r k+++ v+fpl+
   Q: 578  pdaesvrlqrerhhqpqtcTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRF--RQEGDRRMKLQNMVKFPLT 667
           ***********************************************************************..99***************** PP
   S: 259  .Ldlspfctspeekqke...................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgst 329
            Ld++p+++++++++ +                   +++Y+L+av++H+G++++GHY+ay+kn+ ++ W++fdDs V++++e+ev++   +t
   Q: 668  gLDMTPHVVKRSQSSWSlpshwspwrrpyglgrdpeDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGlWYCFDDSDVQQLSEDEVCT---QT 756
           *********977666559999999999999999999***************************87777*******************...** PP
   S: 330  aYvlfYkrr 338
           aY+lfY+rr
   Q: 757  AYILFYQRR 765
           *******96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
 May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
Protein Sequence
(Fasta)
MSKVTAPGSG PPAAASGKEK RSFSKRLFRS GRAGGGGAGG PGASGPAAPS SPSSPSSARS 60
VGSFMSRVLK TLSTLSHLSS EGAAPDRGGL RSCFPPGPAA APTPPPCPPP PASPAPPACA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046805|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCCAAGG TAACGGCGCC TGGGTCCGGG CCGCCGGCGG CGGCGAGCGG GAAGGAGAAG 60
CGCTCCTTCA GCAAGCGGCT GTTTCGGAGC GGCCGCGCTG GCGGCGGCGG CGCGGGGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046805|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:57478
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001207 Ailuropoda melanoleuca 92.99 0.00e+00 1976.00
IUUC-Apl-003186 Anas platyrhynchos 77.45 0.00e+00 1442.00
IUUC-Aca-004949 Anolis carolinensis 67.59 0.00e+00 1400.00
IUUC-Ame-010968 Astyanax mexicanus 66.80 0.00e+00 1112.00
IUUC-Bta-013271 Bos taurus 93.89 0.00e+00 1619.00
IUUC-Cja-019663 Callithrix jacchus 96.24 0.00e+00 1799.00
IUUC-Cfa-021258 Canis familiaris 93.00 0.00e+00 1984.00
IUUC-Csa-024188 Chlorocebus sabaeus 98.45 0.00e+00 1644.00
IUUC-Cho-024813 Choloepus hoffmanni 86.85 0.00e+00 1580.00
IUUC-Csv-026086 Ciona savignyi 38.65 2.00e-133 469.00
IUUC-Dre-027372 Danio rerio 70.50 0.00e+00 1024.00
IUUC-Dno-029964 Dasypus novemcinctus 90.38 0.00e+00 1807.00
IUUC-Dor-030448 Dipodomys ordii 84.20 0.00e+00 1174.00
IUUC-Ete-032975 Echinops telfairi 77.04 0.00e+00 1461.00
IUUC-Eca-034030 Equus caballus 93.62 0.00e+00 1924.00
IUUC-Eeu-034629 Erinaceus europaeus 75.94 0.00e+00 1179.00
IUUC-Fca-035788 Felis catus 92.96 0.00e+00 1869.00
IUUC-Fal-036874 Ficedula albicollis 84.10 0.00e+00 1283.00
IUUC-Gmo-039479 Gadus morhua 59.12 0.00e+00 1192.00
IUUC-Gga-041092 Gallus gallus 73.26 0.00e+00 1563.00
IUUC-Gac-041609 Gasterosteus aculeatus 70.96 0.00e+00 1132.00
IUUC-Ggo-044782 Gorilla gorilla 97.35 0.00e+00 825.00
IUUC-Itr-048158 Ictidomys tridecemlineatus 92.99 0.00e+00 1773.00
IUUC-Lch-050332 Latimeria chalumnae 65.20 0.00e+00 1312.00
IUUC-Loc-051953 Lepisosteus oculatus 60.81 0.00e+00 1263.00
IUUC-Mcc-055398 Macaca mulatta 97.91 0.00e+00 2070.00
IUUC-Meu-056822 Macropus eugenii 77.74 0.00e+00 1459.00
IUUC-Mga-060115 Meleagris gallopavo 74.93 0.00e+00 1416.00
IUUC-Mmr-061150 Microcebus murinus 95.53 0.00e+00 1937.00
IUUC-Mdo-062700 Monodelphis domestica 80.41 0.00e+00 1813.00
IUUC-Mmu-063512 Mus musculus 89.66 0.00e+00 1850.00
IUUC-Mpu-066059 Mustela putorius furo 91.00 0.00e+00 1722.00
IUUC-Mlu-067870 Myotis lucifugus 86.40 0.00e+00 1724.00
IUUC-Nle-069898 Nomascus leucogenys 98.77 0.00e+00 2016.00
IUUC-Opr-070338 Ochotona princeps 81.23 0.00e+00 889.00
IUUC-Ont-072469 Oreochromis niloticus 68.49 0.00e+00 1107.00
IUUC-Oan-073175 Ornithorhynchus anatinus 86.26 0.00e+00 1357.00
IUUC-Ola-087303 Oryzias latipes 70.53 0.00e+00 1098.00
IUUC-Oga-089021 Otolemur garnettii 94.78 0.00e+00 1924.00
IUUC-Oar-090016 Ovis aries 95.67 0.00e+00 1627.00
IUUC-Ptr-090864 Pan troglodytes 99.33 0.00e+00 2095.00
IUUC-Pan-092370 Papio anubis 97.94 0.00e+00 1957.00
IUUC-Psi-093881 Pelodiscus sinensis 75.77 0.00e+00 1441.00
IUUC-Pfo-097427 Poecilia formosa 69.80 0.00e+00 1113.00
IUUC-Pab-098104 Pongo abelii 95.71 0.00e+00 2006.00
IUUC-Pca-100640 Procavia capensis 97.73 2.00e-130 460.00
IUUC-Pva-102287 Pteropus vampyrus 82.91 0.00e+00 1528.00
IUUC-Rno-106033 Rattus norvegicus 91.28 0.00e+00 1811.00
IUUC-Sha-107041 Sarcophilus harrisii 84.51 0.00e+00 1648.00
IUUC-Ssc-116412 Sus scrofa 85.12 0.00e+00 749.00
IUUC-Tgu-116889 Taeniopygia guttata 76.68 0.00e+00 1442.00
IUUC-Tru-118340 Takifugu rubripes 70.40 0.00e+00 1113.00
IUUC-Tsy-118887 Tarsius syrichta 90.09 0.00e+00 1742.00
IUUC-Tni-120463 Tetraodon nigroviridis 70.52 0.00e+00 1116.00
IUUC-Tbe-127491 Tupaia belangeri 94.08 4.00e-134 473.00
IUUC-Ttr-128210 Tursiops truncatus 89.26 0.00e+00 1547.00
IUUC-Vpa-130222 Vicugna pacos 82.62 0.00e+00 813.00
IUUC-Xtr-132509 Xenopus tropicalis 63.69 0.00e+00 1335.00
Created Date 25-Jun-2017

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