iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062963

Ensembl Protein ID

ENSMODP00000026834.2

UniProt Accession

F7G374; F7G374_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

YES1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000021477.3	ENSMODT00000027315.3	ENSMODP00000026834.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.50e-13	48.2	94	149

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++++L++kk +  ++i  ++++++W+++ + ++gk G +P+n+v+ ++
   Q: 94   FVALYDYEARTTEDLSFKKSERFQII--NNTEGDWWEARSIATGKTGYIPSNYVAPAD 149
           789***********************..8999**********************9875 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MGCVKSKEDK DPAMKYGTES SSEPISINVG HFGSELTLGC QSSSIKGSTV NFSSHSMAPF 60
GGSAGMTPFG GATSSFSSMP SPHSTGLTGG VTIFVALYDY EARTTEDLSF KKSERFQIIN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTGCG TTAAAAGTAA GGAAGACAAA GATCCAGCTA TGAAATATGG AACCGAAAGC 60
AGTTCAGAGC CCATTAGCAT AAATGTCGGT CATTTTGGTT CAGAACTTAC CCTAGGGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	91.51	0.00e+00	1016.00
IUUC-Apl-004032	Anas platyrhynchos	91.50	0.00e+00	1032.00
IUUC-Aca-004255	Anolis carolinensis	90.39	0.00e+00	1034.00
IUUC-Ame-010954	Astyanax mexicanus	85.19	0.00e+00	971.00
IUUC-Bta-013503	Bos taurus	90.94	0.00e+00	990.00
IUUC-Cel-018682	Caenorhabditis elegans	58.39	2.00e-151	528.00
IUUC-Cja-019694	Callithrix jacchus	90.42	0.00e+00	998.00
IUUC-Cfa-020402	Canis familiaris	91.87	0.00e+00	1023.00
IUUC-Cpo-022506	Cavia porcellus	91.50	0.00e+00	1013.00
IUUC-Csa-023713	Chlorocebus sabaeus	91.16	0.00e+00	1007.00
IUUC-Cin-025390	Ciona intestinalis	71.00	0.00e+00	660.00
IUUC-Csv-026029	Ciona savignyi	64.75	0.00e+00	635.00
IUUC-Dre-027978	Danio rerio	83.70	0.00e+00	942.00
IUUC-Dno-029897	Dasypus novemcinctus	89.92	0.00e+00	895.00
IUUC-Dor-030202	Dipodomys ordii	96.24	0.00e+00	918.00
IUUC-Eca-034157	Equus caballus	91.50	0.00e+00	1017.00
IUUC-Eeu-034950	Erinaceus europaeus	86.69	6.00e-171	593.00
IUUC-Fca-036233	Felis catus	91.68	0.00e+00	1046.00
IUUC-Fal-037461	Ficedula albicollis	91.31	0.00e+00	1044.00
IUUC-Gmo-038929	Gadus morhua	81.59	0.00e+00	904.00
IUUC-Gga-041107	Gallus gallus	91.68	0.00e+00	1034.00
IUUC-Gac-042321	Gasterosteus aculeatus	83.24	0.00e+00	932.00
IUUC-Hsa-047010	Homo sapiens	91.90	0.00e+00	1017.00
IUUC-Lch-050239	Latimeria chalumnae	88.91	0.00e+00	1008.00
IUUC-Loc-052314	Lepisosteus oculatus	86.97	0.00e+00	939.00
IUUC-Laf-053517	Loxodonta africana	91.31	0.00e+00	990.00
IUUC-Mcc-055626	Macaca mulatta	91.16	0.00e+00	1006.00
IUUC-Meu-056155	Macropus eugenii	75.17	0.00e+00	717.00
IUUC-Mga-059310	Meleagris gallopavo	91.68	0.00e+00	1034.00
IUUC-Mmr-061652	Microcebus murinus	91.13	0.00e+00	1007.00
IUUC-Mmu-064128	Mus musculus	90.76	0.00e+00	1023.00
IUUC-Mpu-065906	Mustela putorius furo	91.87	0.00e+00	1020.00
IUUC-Mlu-067035	Myotis lucifugus	90.99	0.00e+00	1012.00
IUUC-Nle-069041	Nomascus leucogenys	87.48	0.00e+00	956.00
IUUC-Opr-070299	Ochotona princeps	81.52	0.00e+00	886.00
IUUC-Ont-072337	Oreochromis niloticus	84.28	0.00e+00	951.00
IUUC-Oan-072997	Ornithorhynchus anatinus	97.14	0.00e+00	931.00
IUUC-Ocu-074171	Oryctolagus cuniculus	91.68	0.00e+00	1017.00
IUUC-Ola-086619	Oryzias latipes	82.94	0.00e+00	946.00
IUUC-Oga-087957	Otolemur garnettii	90.39	0.00e+00	997.00
IUUC-Oar-089670	Ovis aries	90.20	0.00e+00	1000.00
IUUC-Ptr-091352	Pan troglodytes	91.90	0.00e+00	1017.00
IUUC-Pan-092202	Papio anubis	91.16	0.00e+00	1006.00
IUUC-Psi-093310	Pelodiscus sinensis	90.76	0.00e+00	1041.00
IUUC-Pma-094232	Petromyzon marinus	86.02	0.00e+00	862.00
IUUC-Pfo-096137	Poecilia formosa	83.36	0.00e+00	940.00
IUUC-Pab-098301	Pongo abelii	95.88	0.00e+00	952.00
IUUC-Pva-102592	Pteropus vampyrus	87.43	0.00e+00	958.00
IUUC-Rno-105544	Rattus norvegicus	91.13	0.00e+00	999.00
IUUC-Sar-113364	Sorex araneus	88.91	0.00e+00	947.00
IUUC-Tgu-117380	Taeniopygia guttata	91.31	0.00e+00	1044.00
IUUC-Tru-117594	Takifugu rubripes	83.12	0.00e+00	941.00
IUUC-Tni-120433	Tetraodon nigroviridis	83.00	0.00e+00	930.00
IUUC-Ttr-128893	Tursiops truncatus	90.94	0.00e+00	1012.00
IUUC-Vpa-130060	Vicugna pacos	91.68	0.00e+00	1004.00
IUUC-Xtr-132322	Xenopus tropicalis	88.91	0.00e+00	1009.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence