iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020869

Ensembl Protein ID

ENSCAFP00000011661.2

UniProt Accession

E2QX70; E2QX70_CANLF

Genbank Protein ID

ENSCAFP00000011661

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AAEX03010511

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000007884.2	ENSCAFT00000012594.2	ENSCAFP00000011661.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.80e-09	36.6	215	261

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 215  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 261
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

GRMLGQQQQQ LYSSAALLTG ERSRLLTCYV QDYLECVESL PHDMQRNVSV LRELDNKYQE 60
TLKEIDDVYE KYKKEDDSNQ KKRLQQHLQR ALINSQELGD EKIQIVTQML ELVENRARQM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAGGATGT TAGGGCAGCA GCAGCAGCAA CTCTACTCGT CGGCCGCGCT CCTGACCGGG 60
GAGCGGAGCC GGCTGCTCAC CTGCTACGTG CAGGACTACC TCGAGTGCGT GGAGTCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	99.64	1.00e-123	435.00
IUUC-Apl-003705	Anas platyrhynchos	88.79	1.00e-91	328.00
IUUC-Aca-004990	Anolis carolinensis	81.47	4.00e-98	350.00
IUUC-Ame-011426	Astyanax mexicanus	70.44	3.00e-83	301.00
IUUC-Bta-012721	Bos taurus	97.79	6.00e-120	423.00
IUUC-Cja-018960	Callithrix jacchus	97.35	1.00e-105	375.00
IUUC-Cpo-021414	Cavia porcellus	96.43	2.00e-119	421.00
IUUC-Csa-023304	Chlorocebus sabaeus	97.50	7.00e-112	396.00
IUUC-Dre-028562	Danio rerio	69.37	2.00e-89	322.00
IUUC-Dno-029945	Dasypus novemcinctus	97.35	7.00e-115	406.00
IUUC-Dor-030141	Dipodomys ordii	96.43	7.00e-118	416.00
IUUC-Ete-032709	Echinops telfairi	95.59	8.00e-127	446.00
IUUC-Eca-033432	Equus caballus	98.16	2.00e-119	421.00
IUUC-Eeu-035285	Erinaceus europaeus	97.56	3.00e-90	324.00
IUUC-Fca-036467	Felis catus	99.24	7.00e-117	413.00
IUUC-Fal-036700	Ficedula albicollis	87.56	7.00e-91	326.00
IUUC-Gmo-038748	Gadus morhua	63.04	3.00e-85	308.00
IUUC-Gga-040175	Gallus gallus	88.34	2.00e-91	327.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.60	3.00e-90	324.00
IUUC-Hsa-045837	Homo sapiens	97.50	7.00e-112	396.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	97.86	6.00e-121	426.00
IUUC-Lch-049965	Latimeria chalumnae	79.77	5.00e-99	353.00
IUUC-Laf-053353	Loxodonta africana	95.56	2.00e-99	354.00
IUUC-Mcc-055155	Macaca mulatta	97.13	6.00e-72	262.00
IUUC-Meu-056470	Macropus eugenii	92.52	3.00e-110	390.00
IUUC-Mga-059570	Meleagris gallopavo	88.34	7.00e-91	326.00
IUUC-Mmr-061385	Microcebus murinus	97.86	2.00e-112	398.00
IUUC-Mdo-062144	Monodelphis domestica	92.58	1.00e-111	395.00
IUUC-Mmu-063215	Mus musculus	96.44	7.00e-119	419.00
IUUC-Mpu-065749	Mustela putorius furo	99.16	2.00e-101	361.00
IUUC-Mlu-067245	Myotis lucifugus	75.56	2.00e-81	294.00
IUUC-Nle-069968	Nomascus leucogenys	96.84	2.00e-80	291.00
IUUC-Ont-071524	Oreochromis niloticus	66.30	5.00e-87	313.00
IUUC-Ocu-074870	Oryctolagus cuniculus	98.53	2.00e-120	424.00
IUUC-Ola-087400	Oryzias latipes	90.24	1.00e-44	172.00
IUUC-Oga-088336	Otolemur garnettii	96.49	1.00e-111	395.00
IUUC-Oar-090136	Ovis aries	97.41	5.00e-118	416.00
IUUC-Ptr-091348	Pan troglodytes	97.37	3.00e-81	294.00
IUUC-Pan-092819	Papio anubis	97.50	7.00e-112	396.00
IUUC-Pfo-096633	Poecilia formosa	64.14	5.00e-81	293.00
IUUC-Pab-098346	Pongo abelii	97.50	8.00e-112	396.00
IUUC-Pca-100278	Procavia capensis	94.88	7.00e-116	409.00
IUUC-Pva-103190	Pteropus vampyrus	98.48	8.00e-116	409.00
IUUC-Rno-104940	Rattus norvegicus	96.59	1.00e-113	402.00
IUUC-Sha-107533	Sarcophilus harrisii	90.81	1.00e-112	398.00
IUUC-Sar-113630	Sorex araneus	96.59	2.00e-90	324.00
IUUC-Ssc-115734	Sus scrofa	98.48	9.00e-116	409.00
IUUC-Tgu-117034	Taeniopygia guttata	88.00	2.00e-91	328.00
IUUC-Tru-118168	Takifugu rubripes	60.34	5.00e-81	293.00
IUUC-Tsy-119494	Tarsius syrichta	97.89	8.00e-82	296.00
IUUC-Tni-120100	Tetraodon nigroviridis	60.52	5.00e-77	280.00
IUUC-Ttr-128442	Tursiops truncatus	97.56	3.00e-90	324.00
IUUC-Vpa-130063	Vicugna pacos	97.86	3.00e-121	427.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence