iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021394

Ensembl Protein ID

ENSCPOP00000006531.2

UniProt Accession

H0V9N1; H0V9N1_CAVPO

Genbank Protein ID

ENSCPOP00000006531

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAKN02013476

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000007250.3	ENSCPOT00000007322.2	ENSCPOP00000006531.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	88.69	2.00e-155	546.00	IUUC-Hsa-046179
E3 activity/RING/RING	90.49	1.00e-155	546.00	IUUC-Mmu-063206
E3 activity/RING/RING	90.80	8.00e-156	546.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Cavia porcellus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSTGPS ANKPCSKQPP PPQTQHAQSP AVPPAAATIS ASGPGSSAVP AAAAVISGPG 60
GGGGGGAGNV SRQPHELTSL FECPVCFDYV LPPILQCQAG HLVCNQCRQK LSCCPTCRGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCGCC CGTCCTCCAC CGGCCCCAGC GCTAACAAGC CCTGCAGCAA GCAGCCGCCG 60
CCGCCGCAGA CCCAGCACGC TCAGTCCCCG GCTGTGCCCC CGGCCGCCGC CACCATCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	99.22	2.00e-154	538.00
IUUC-Ame-011678	Astyanax mexicanus	92.09	4.00e-142	497.00
IUUC-Bta-012750	Bos taurus	99.22	3.00e-153	534.00
IUUC-Cja-019800	Callithrix jacchus	88.69	1.00e-156	545.00
IUUC-Cfa-020505	Canis familiaris	99.22	2.00e-153	534.00
IUUC-Csa-023374	Chlorocebus sabaeus	88.69	1.00e-156	545.00
IUUC-Cho-024933	Choloepus hoffmanni	99.61	5.00e-154	536.00
IUUC-Dre-027711	Danio rerio	91.70	1.00e-141	495.00
IUUC-Dno-029260	Dasypus novemcinctus	96.88	9.00e-149	519.00
IUUC-Dor-030489	Dipodomys ordii	96.22	2.00e-108	384.00
IUUC-Ete-032946	Echinops telfairi	87.16	3.00e-157	547.00
IUUC-Eca-033546	Equus caballus	98.84	2.00e-154	537.00
IUUC-Eeu-034861	Erinaceus europaeus	95.35	7.00e-147	513.00
IUUC-Fal-037160	Ficedula albicollis	88.05	3.00e-133	467.00
IUUC-Gmo-039091	Gadus morhua	88.72	4.00e-140	490.00
IUUC-Gga-040252	Gallus gallus	83.79	6.00e-152	529.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.72	7.00e-140	489.00
IUUC-Ggo-044618	Gorilla gorilla	88.69	1.00e-156	545.00
IUUC-Hsa-046179	Homo sapiens	88.69	1.00e-156	545.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	97.67	7.00e-152	529.00
IUUC-Lch-049496	Latimeria chalumnae	80.97	6.00e-155	539.00
IUUC-Loc-052107	Lepisosteus oculatus	92.80	5.00e-142	496.00
IUUC-Laf-054257	Loxodonta africana	98.84	3.00e-152	530.00
IUUC-Mcc-055023	Macaca mulatta	88.69	1.00e-156	545.00
IUUC-Meu-055922	Macropus eugenii	96.86	5.00e-149	520.00
IUUC-Mga-060070	Meleagris gallopavo	95.70	7.00e-147	513.00
IUUC-Mmr-061494	Microcebus murinus	88.69	1.00e-156	545.00
IUUC-Mdo-061971	Monodelphis domestica	98.43	1.00e-152	531.00
IUUC-Mmu-063206	Mus musculus	92.64	5.00e-156	543.00
IUUC-Mpu-066597	Mustela putorius furo	88.69	1.00e-156	545.00
IUUC-Mlu-067199	Myotis lucifugus	99.22	2.00e-153	534.00
IUUC-Nle-069342	Nomascus leucogenys	88.69	1.00e-156	545.00
IUUC-Opr-070341	Ochotona princeps	56.86	3.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	88.72	6.00e-141	493.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	6.00e-50	190.00
IUUC-Ocu-073950	Oryctolagus cuniculus	98.46	1.00e-153	535.00
IUUC-Oga-089154	Otolemur garnettii	88.69	1.00e-156	545.00
IUUC-Oar-089446	Ovis aries	99.22	3.00e-153	533.00
IUUC-Ptr-091088	Pan troglodytes	88.69	1.00e-156	545.00
IUUC-Psi-093079	Pelodiscus sinensis	98.11	4.00e-156	543.00
IUUC-Pfo-097007	Poecilia formosa	85.38	2.00e-133	468.00
IUUC-Pab-098092	Pongo abelii	88.69	1.00e-156	545.00
IUUC-Pca-100328	Procavia capensis	87.16	3.00e-152	530.00
IUUC-Pva-102368	Pteropus vampyrus	100.00	1.00e-64	239.00
IUUC-Rno-105477	Rattus norvegicus	92.94	5.00e-156	543.00
IUUC-Sha-107630	Sarcophilus harrisii	98.45	5.00e-153	533.00
IUUC-Ssc-116441	Sus scrofa	88.07	7.00e-156	542.00
IUUC-Tru-118004	Takifugu rubripes	87.35	2.00e-135	474.00
IUUC-Tsy-119548	Tarsius syrichta	89.47	3.00e-68	251.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.93	7.00e-138	482.00
IUUC-Vpa-130799	Vicugna pacos	99.42	3.00e-104	370.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence