iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.30e-06	29.3	282	351

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp..sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawce 70
            p+e++Cp+ +e+Mrd   ++  +  +y  ++I+ ++  +   c    +++  +dl Pn+tlr++i++ +e
   Q: 282  FPPELKCPLCKEVMRDAALASkcCLKSYCDKCIRDHIIAKSM-CVCGATHVLADDLLPNKTLRDTINRILE 351
           699***************99977889***********77776.7777777899*************98766 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin ligase acting as a negative regulator of oxidative stress tolerance, probably by mediating 26S proteasome-mediated degradation of PRMT13/PRMT4B, thus preventing APX1 and GPX1 accumulation via the reduction of histone H3 methylation (H3R17me2a). Confers sensitivity to cadmium CdCl(2) and salt NaCl stresses.

Protein Sequence
(Fasta)

MAIYYKFKSA RDYDTISMDG PFITVGLLKE KIYETKHLGS GKDLDIVISN AQTNEEYLDE 60
AMLIPKNTSV LIRRVPGRPR IRIITREEPR VEDKVENVQA DMNNVITADA SPVEDEFDEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAGAATTA GGTGAAGAGT CTTTTGGATT CGGTTACGAT AGTTCTCTAT TCCTCTTCAA 60
ACCCTAGAGT TCGTGTTTCT GCGATATCCA TCGGTTTCTC CTTCATATAT CCATCAAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0346--Stress response
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014891--DWNN_domain
IPR025829--Zn_knuckle_CX2CX3GHX4C
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51282--DWNN

Pfam

PF08783--DWNN
PF13696--zf-CCHC_2

SMART

SM01180--DWNN

Gene Ontology

GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0072756--P:cellular response to paraquat
GO:0034971--P:histone H3-R17 methylation
GO:1902883--P:negative regulation of response to oxidative stress
GO:0016567--P:protein ubiquitination
GO:0046686--P:response to cadmium ion
GO:0042542--P:response to hydrogen peroxide
GO:0010555--P:response to mannitol
GO:0006979--P:response to oxidative stress
GO:1901562--P:response to paraquat
GO:0009651--P:response to salt stress
GO:0009414--P:response to water deprivation

KEGG

ath:AT4G17410

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002768	Amborella trichopoda	52.28	2.00e-139	488.00
IUUC-Apl-004100	Anas platyrhynchos	29.81	9.00e-25	109.00
IUUC-Aly-006036	Arabidopsis lyrata	88.37	0.00e+00	1137.00
IUUC-Bgr-012229	Blumeria graminis	25.33	9.00e-24	104.00
IUUC-Bol-016223	Brassica oleracea	75.34	0.00e+00	802.00
IUUC-Bra-016649	Brassica rapa	76.23	0.00e+00	832.00
IUUC-Cho-024327	Choloepus hoffmanni	30.58	2.00e-35	145.00
IUUC-Cin-025439	Ciona intestinalis	27.76	1.00e-15	75.90
IUUC-Dre-028023	Danio rerio	30.73	2.00e-36	147.00
IUUC-Dse-031312	Dothistroma septosporum	25.78	6.00e-19	88.60
IUUC-Eeu-034677	Erinaceus europaeus	28.48	3.00e-23	104.00
IUUC-Fso-038202	Fusarium solani	24.87	4.00e-25	108.00
IUUC-Lch-050524	Latimeria chalumnae	30.75	1.00e-38	155.00
IUUC-Loc-052709	Lepisosteus oculatus	30.49	6.00e-33	136.00
IUUC-Meu-056399	Macropus eugenii	47.30	6.00e-15	77.00
IUUC-Mor-057073	Magnaporthe oryzae	31.40	6.00e-18	85.50
IUUC-Mga-060129	Meleagris gallopavo	29.68	1.00e-24	108.00
IUUC-Mmu-064009	Mus musculus	30.49	7.00e-36	146.00
IUUC-Ncr-068886	Neurospora crassa	26.00	2.00e-28	120.00
IUUC-Pca-100875	Procavia capensis	38.04	3.00e-13	71.20
IUUC-Rno-105264	Rattus norvegicus	30.49	9.00e-36	145.00
IUUC-Tgu-117215	Taeniopygia guttata	29.68	1.00e-24	108.00
IUUC-Tbe-127263	Tupaia belangeri	48.61	2.00e-14	74.70
IUUC-Ttr-128498	Tursiops truncatus	29.20	5.00e-34	140.00
IUUC-Vpa-130795	Vicugna pacos	28.21	5.00e-18	87.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence