iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034349

Ensembl Protein ID

ENSECAP00000020111.1

UniProt Accession

F6U2B9; F6U2B9_HORSE

Protein Name

Uncharacterized protein

Gene Name

BRWD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000022262.1	ENSECAT00000024216.1	ENSECAP00000020111.1
ENSECAG00000022262.1	ENSECAT00000024237.1	ENSECAP00000020130.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-35	119.2	118	155
UBD/Beta-Prp	5.20e-55	186.9	220	477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH + v+c+af  + +++ +GsdD+ +k+W+++ g+ll
   Q: 118  GHLSAVYCVAFdRTgHRIFTGSDDCLVKIWSTHNGRLL 155
           8**********955599***************999987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlsl 100
           +++++++++dgt+  w+++ ++l      l+  ++  ++v+ ++  fs  g +l+tgs+D++i+ +   +++++ +  l+ h+d+v s+
   Q: 220  QRYMVSTGADGTVCFWQWDLESLkfsprpLKFTEKPRPGVQMLCssFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSI 308
           689*****************99999988777778888888755522888888**************99999****************** PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
           +f+ +gd+++sGs+d t+r+w  e+ ++ +                 ++  +  v++++++++++++v++ +D ++++W++ tg+ll+ 
   Q: 309  QFCNNGDRFLSGSRDGTARIWRFEQLEWRSIlldmatrisgdlsseEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHN 397
           **************************99998999********998877777888*********************************** PP
   S: 175  ltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l g h d v  l+   fds  + ++s+++dg++ +wd+ +g+ ++ + +         v + +fs+++++++++ s+g + i+
   Q: 398  LLG-HADEVFVLEthpFDS--RIMLSAGHDGSIFIWDITKGTKMKHYFNMIegqghGAVFDCKFSQDGQHFACTDSHGHLLIF 477
           **9.*********555555..99****************999977766544444456677789999*****999999998886 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

VLSNKHVAPD HLLQICQRIG PMLDKEIPPS ISRVTSLLGA GRQSLLRTAK DCRHTVWKGS 60
AFAALHRGRP PEMPVNYGSP PNLVEIHRGK QLTGCSTFST AFPGTMYQHI KMHRRILGHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCTTGTCC AATAAGCATG TGGCTCCTGA TCATCTGTTG CAAATCTGCC AGCGCATCGG 60
TCCCATGTTG GATAAGGAAA TTCCACCCAG TATTTCAAGA GTCACTTCTT TACTTGGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002332	Ailuropoda melanoleuca	87.10	0.00e+00	3362.00
IUUC-Apl-004083	Anas platyrhynchos	57.80	0.00e+00	2072.00
IUUC-Aly-006517	Arabidopsis lyrata	30.27	7.00e-65	243.00
IUUC-Ath-006577	Arabidopsis thaliana	30.10	3.00e-64	240.00
IUUC-Ame-010718	Astyanax mexicanus	69.74	0.00e+00	1095.00
IUUC-Bta-013217	Bos taurus	90.46	0.00e+00	3669.00
IUUC-Bol-015737	Brassica oleracea	31.50	4.00e-69	257.00
IUUC-Bra-017961	Brassica rapa	31.63	5.00e-69	256.00
IUUC-Cja-019966	Callithrix jacchus	88.48	0.00e+00	3585.00
IUUC-Cfa-021037	Canis familiaris	90.43	0.00e+00	3609.00
IUUC-Cpo-021934	Cavia porcellus	91.10	0.00e+00	2605.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	46.56	3.00e-26	114.00
IUUC-Csa-023352	Chlorocebus sabaeus	89.37	0.00e+00	3446.00
IUUC-Cho-024690	Choloepus hoffmanni	82.34	0.00e+00	1413.00
IUUC-Dre-028205	Danio rerio	69.09	0.00e+00	1070.00
IUUC-Dno-028938	Dasypus novemcinctus	88.35	0.00e+00	3620.00
IUUC-Dme-031752	Drosophila melanogaster	49.55	3.00e-173	603.00
IUUC-Fca-035485	Felis catus	83.64	0.00e+00	3110.00
IUUC-Ggo-045500	Gorilla gorilla	90.15	0.00e+00	3620.00
IUUC-Hsa-046350	Homo sapiens	89.97	0.00e+00	3630.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	93.72	0.00e+00	1079.00
IUUC-Lch-049662	Latimeria chalumnae	64.91	0.00e+00	1981.00
IUUC-Laf-053848	Loxodonta africana	88.83	0.00e+00	3535.00
IUUC-Mcc-054638	Macaca mulatta	89.70	0.00e+00	3598.00
IUUC-Meu-056739	Macropus eugenii	79.91	0.00e+00	1121.00
IUUC-Mtr-058094	Medicago truncatula	30.91	3.00e-65	244.00
IUUC-Mga-060165	Meleagris gallopavo	76.25	0.00e+00	2180.00
IUUC-Mmr-061227	Microcebus murinus	90.76	0.00e+00	3659.00
IUUC-Mdo-062074	Monodelphis domestica	69.77	0.00e+00	2707.00
IUUC-Mmu-064075	Mus musculus	82.06	0.00e+00	2840.00
IUUC-Mpu-066643	Mustela putorius furo	92.63	0.00e+00	3016.00
IUUC-Mlu-067735	Myotis lucifugus	89.18	0.00e+00	3630.00
IUUC-Nle-069402	Nomascus leucogenys	91.81	0.00e+00	2882.00
IUUC-Oan-072954	Ornithorhynchus anatinus	69.82	0.00e+00	2717.00
IUUC-Ocu-074456	Oryctolagus cuniculus	87.77	0.00e+00	3635.00
IUUC-Olu-087745	Ostreococcus lucimarinus	28.57	2.00e-56	214.00
IUUC-Oga-087938	Otolemur garnettii	82.76	0.00e+00	3089.00
IUUC-Oar-090214	Ovis aries	89.75	0.00e+00	3620.00
IUUC-Ptr-091213	Pan troglodytes	90.15	0.00e+00	3582.00
IUUC-Pan-092444	Papio anubis	89.22	0.00e+00	3575.00
IUUC-Pma-094427	Petromyzon marinus	67.66	7.00e-109	386.00
IUUC-Ppa-095793	Physcomitrella patens	30.42	1.00e-64	243.00
IUUC-Pfo-097318	Poecilia formosa	62.19	0.00e+00	1672.00
IUUC-Pab-097573	Pongo abelii	88.73	0.00e+00	3513.00
IUUC-Pop-099672	Populus trichocarpa	31.43	5.00e-65	243.00
IUUC-Pca-100759	Procavia capensis	72.75	0.00e+00	1104.00
IUUC-Pva-102782	Pteropus vampyrus	90.17	0.00e+00	3693.00
IUUC-Rno-105687	Rattus norvegicus	78.62	0.00e+00	3190.00
IUUC-Sar-113519	Sorex araneus	81.49	0.00e+00	1755.00
IUUC-Tsy-118921	Tarsius syrichta	88.77	0.00e+00	1927.00
IUUC-Tca-121098	Theobroma cacao	31.25	3.00e-69	257.00
IUUC-Tbe-127663	Tupaia belangeri	81.52	0.00e+00	1375.00
IUUC-Ttr-128561	Tursiops truncatus	89.22	0.00e+00	3470.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence