iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aor-009947

Ensembl Protein ID

BAE57099

UniProt Accession

Q2UMW6; ATG12_ASPOR

Genbank Protein ID

BAE57099.1

Protein Name

Ubiquitin-like protein ATG12; Autophagy-related protein 12

Genbank Nucleotide ID

AP007154

Gene Name

atg12; AO090001000593

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AO090001000593	BAE57099	BAE57099

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG12	30.34	1.00e-10	63.50	IUUC-Hsa-046903

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Aspergillus oryzae

Functional Description
(View)

Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MDPSSPQHPS QDSPRPTQNL SAGSRASLSH RPASRKQSSD STSNNKNAPI PDDEHGADMP 60
LTMSASVVLT SLPRDAHQAL ADAEAVDKGK VTVRFQPLAS APILKNKVFK ISASQKFETV 120

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Nucleotide Sequence
(Fasta)

ATGGACCCCT CATCTCCGCA ACACCCCTCT CAGGACTCCC CGAGACCGAC CCAGAATTTG 60
TCCGCCGGTT CGCGGGCGAG TCTGAGCCAT CGACCCGCCA GTCGGAAGCA AAGCTCAGAC 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom

Pfam

PF04110--APG12

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0000045--P:autophagosome assembly
GO:0015031--P:protein transport

KEGG

aor:AOR_1_1064164

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001177	Aegilops tauschii	42.53	4.00e-16	73.60
IUUC-Aml-002116	Ailuropoda melanoleuca	31.46	7.00e-13	64.70
IUUC-Atr-002615	Amborella trichopoda	41.38	1.00e-14	68.90
IUUC-Apl-003753	Anas platyrhynchos	47.50	3.00e-07	44.30
IUUC-Aca-005231	Anolis carolinensis	31.03	4.00e-09	52.00
IUUC-Aly-006172	Arabidopsis lyrata	43.68	1.00e-15	72.40
IUUC-Ath-006953	Arabidopsis thaliana	43.68	1.00e-16	75.50
IUUC-Ago-007970	Ashbya gossypii	45.98	1.00e-14	70.90
IUUC-Acl-008072	Aspergillus clavatus	94.74	1.00e-61	225.00
IUUC-Afl-008725	Aspergillus flavus	100.00	4.00e-94	334.00
IUUC-Afu-008967	Aspergillus fumigatus	79.66	2.00e-78	282.00
IUUC-Ani-009248	Aspergillus nidulans	85.71	4.00e-74	268.00
IUUC-Ang-009684	Aspergillus niger	78.14	7.00e-79	283.00
IUUC-Ame-011656	Astyanax mexicanus	30.43	1.00e-11	60.10
IUUC-Bgr-012174	Blumeria graminis	58.89	2.00e-26	108.00
IUUC-Bta-012483	Bos taurus	30.34	2.00e-12	62.40
IUUC-Bci-013755	Botrytis cinerea	58.20	3.00e-32	128.00
IUUC-Bdi-014156	Brachypodium distachyon	42.71	2.00e-17	78.20
IUUC-Bol-015683	Brassica oleracea	43.68	1.00e-16	75.50
IUUC-Bra-016802	Brassica rapa	42.53	8.00e-16	72.80
IUUC-Cel-018242	Caenorhabditis elegans	38.46	2.00e-13	66.20
IUUC-Cja-019514	Callithrix jacchus	30.34	3.00e-12	62.80
IUUC-Cfa-020748	Canis familiaris	31.46	6.00e-13	64.70
IUUC-Cpo-021965	Cavia porcellus	31.46	1.00e-12	63.50
IUUC-Cre-023009	Chlamydomonas reinhardtii	39.13	3.00e-14	67.80
IUUC-Csa-023494	Chlorocebus sabaeus	30.34	2.00e-12	63.20
IUUC-Cho-024631	Choloepus hoffmanni	30.34	2.00e-12	63.50
IUUC-Cin-025609	Ciona intestinalis	44.83	7.00e-20	86.70
IUUC-Cgl-026722	Colletotrichum gloeosporioides	50.77	6.00e-34	134.00
IUUC-Dre-027479	Danio rerio	31.25	3.00e-13	65.10
IUUC-Dno-029693	Dasypus novemcinctus	26.97	3.00e-06	42.40
IUUC-Dse-031440	Dothistroma septosporum	55.94	1.00e-45	172.00
IUUC-Dme-031892	Drosophila melanogaster	24.44	9.00e-10	53.10
IUUC-Ete-032550	Echinops telfairi	29.76	1.00e-11	59.70
IUUC-Eca-033553	Equus caballus	30.34	1.00e-12	63.20
IUUC-Fca-036524	Felis catus	31.46	2.00e-11	59.70
IUUC-Fal-036942	Ficedula albicollis	32.56	3.00e-12	60.80
IUUC-Fox-037753	Fusarium oxysporum	65.00	1.00e-39	153.00
IUUC-Gmo-039498	Gadus morhua	30.34	4.00e-11	58.20
IUUC-Ggr-039852	Gaeumannomyces graminis	60.33	7.00e-31	124.00
IUUC-Gga-041263	Gallus gallus	31.46	1.00e-12	63.90
IUUC-Gac-042346	Gasterosteus aculeatus	32.14	5.00e-11	57.80
IUUC-Gma-042896	Glycine max	41.38	3.00e-14	67.80
IUUC-Ggo-045601	Gorilla gorilla	30.34	2.00e-12	63.50
IUUC-Hsa-046903	Homo sapiens	30.34	2.00e-12	62.80
IUUC-Hvu-047239	Hordeum vulgare	42.27	3.00e-16	74.30
IUUC-Itr-048445	Ictidomys tridecemlineatus	30.34	1.00e-12	63.50
IUUC-Kpa-049355	Komagataella pastoris	33.33	3.00e-15	72.00
IUUC-Lch-050619	Latimeria chalumnae	31.46	6.00e-13	64.70
IUUC-Loc-052102	Lepisosteus oculatus	29.09	4.00e-04	33.50
IUUC-Lma-053299	Leptosphaeria maculans	55.65	7.00e-33	130.00
IUUC-Laf-054205	Loxodonta africana	30.34	9.00e-13	63.90
IUUC-Meu-056804	Macropus eugenii	31.46	1.00e-12	63.20
IUUC-Mor-057052	Magnaporthe oryzae	59.83	4.00e-31	125.00
IUUC-Mtr-057961	Medicago truncatula	42.53	7.00e-15	69.70
IUUC-Mla-059045	Melampsora laricipopulina	49.02	5.00e-25	103.00
IUUC-Mvi-060360	Microbotryum violaceum	49.00	2.00e-24	102.00
IUUC-Mmr-061654	Microcebus murinus	30.34	1.00e-12	62.80
IUUC-Mdo-062649	Monodelphis domestica	30.34	9.00e-13	63.90
IUUC-Mmu-064105	Mus musculus	30.34	2.00e-12	63.20
IUUC-Mac-065532	Musa acuminata	43.68	6.00e-16	73.60
IUUC-Mpu-066269	Mustela putorius furo	31.46	4.00e-13	65.10
IUUC-Mlu-067631	Myotis lucifugus	30.34	7.00e-13	64.70
IUUC-Nfi-068468	Neosartorya fischeri	93.86	4.00e-61	223.00
IUUC-Ncr-068750	Neurospora crassa	55.80	3.00e-40	155.00
IUUC-Nle-069483	Nomascus leucogenys	30.34	8.00e-13	64.70
IUUC-Opr-070936	Ochotona princeps	30.34	1.00e-12	63.90
IUUC-Obr-076322	Oryza brachyantha	40.22	2.00e-16	74.70
IUUC-Ogl-077226	Oryza glaberrima	39.76	3.00e-14	67.80
IUUC-Oin-079220	Oryza indica	38.81	9.00e-11	56.60
IUUC-Olo-080688	Oryza longistaminata	39.76	3.00e-14	67.80
IUUC-Ome-081265	Oryza meridionalis	39.76	3.00e-14	67.80
IUUC-Oru-084342	Oryza rufipogon	40.00	2.00e-15	73.90
IUUC-Osa-086212	Oryza sativa	39.76	3.00e-14	67.80
IUUC-Ola-087277	Oryzias latipes	31.11	2.00e-12	62.40
IUUC-Olu-087780	Ostreococcus lucimarinus	32.97	5.00e-09	50.40
IUUC-Oga-088175	Otolemur garnettii	30.34	2.00e-12	62.80
IUUC-Oar-089477	Ovis aries	30.34	2.00e-12	63.20
IUUC-Ptr-091129	Pan troglodytes	30.34	2.00e-12	63.50
IUUC-Psi-093351	Pelodiscus sinensis	30.34	3.00e-12	62.40
IUUC-Pno-094948	Phaeosphaeria nodorum	59.81	8.00e-35	137.00
IUUC-Ppa-095788	Physcomitrella patens	41.38	6.00e-16	73.60
IUUC-Pfo-096993	Poecilia formosa	28.72	2.00e-11	59.30
IUUC-Pab-098502	Pongo abelii	30.34	1.00e-12	63.90
IUUC-Pop-098819	Populus trichocarpa	41.38	6.00e-15	70.10
IUUC-Ppe-101560	Prunus persica	41.18	1.00e-13	65.90
IUUC-Pva-102810	Pteropus vampyrus	28.99	2.00e-08	49.70
IUUC-Pgr-103531	Puccinia graminis	46.49	2.00e-25	105.00
IUUC-Ptt-103753	Puccinia triticina	49.02	1.00e-24	102.00
IUUC-Pyt-104733	Pyrenophora triticirepentis	54.55	9.00e-42	160.00
IUUC-Rno-106072	Rattus norvegicus	31.46	5.00e-13	64.70
IUUC-Sce-106275	Saccharomyces cerevisiae	45.98	2.00e-19	86.70
IUUC-Sha-107554	Sarcophilus harrisii	31.46	4.00e-13	65.10
IUUC-Sja-107682	Schizosaccharomyces japonicus	37.90	3.00e-25	105.00
IUUC-Spo-108275	Schizosaccharomyces pombe	43.68	3.00e-19	85.10
IUUC-Smo-109151	Selaginella moellendorffii	43.02	8.00e-15	69.30
IUUC-Sit-110270	Setaria italica	42.55	3.00e-16	73.90
IUUC-Sly-111862	Solanum lycopersicum	41.30	7.00e-15	69.70
IUUC-Stu-112663	Solanum tuberosum	42.22	4.00e-05	38.10
IUUC-Sbi-114148	Sorghum bicolor	42.55	3.00e-16	73.90
IUUC-Sre-115216	Sporisorium reilianum	48.48	5.00e-25	104.00
IUUC-Ssc-116051	Sus scrofa	30.34	1.00e-12	63.50
IUUC-Tru-118466	Takifugu rubripes	29.07	1.00e-09	52.40
IUUC-Tsy-119334	Tarsius syrichta	28.09	2.00e-09	53.50
IUUC-Tni-119792	Tetraodon nigroviridis	29.07	2.00e-10	54.70
IUUC-Tca-121861	Theobroma cacao	40.57	1.00e-14	69.70
IUUC-Tvi-122499	Trichoderma virens	59.50	2.00e-35	138.00
IUUC-Tae-123431	Triticum aestivum	42.53	4.00e-16	73.60
IUUC-Tme-126934	Tuber melanosporum	53.40	1.00e-28	117.00
IUUC-Ttr-129001	Tursiops truncatus	28.09	2.00e-08	49.70
IUUC-Uma-129324	Ustilago maydis	47.47	1.00e-24	103.00
IUUC-Vda-129846	Verticillium dahliae	63.33	1.00e-38	149.00
IUUC-Vpa-130202	Vicugna pacos	45.00	1.00e-06	44.30
IUUC-Vvi-131474	Vitis vinifera	44.29	1.00e-10	56.60
IUUC-Xtr-132782	Xenopus tropicalis	32.58	3.00e-13	65.50
IUUC-Xma-134140	Xiphophorus maculatus	28.72	7.00e-11	57.80
IUUC-Yli-134517	Yarrowia lipolytica	46.67	2.00e-19	87.00
IUUC-Zma-134764	Zea mays	42.53	4.00e-16	73.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence