iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017580

Ensembl Protein ID

Bra018606.1-P

UniProt Accession

M4DQ15; M4DQ15_BRARP

Protein Name

Presenilin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra018606	Bra018606.1	Bra018606.1-P

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	48.00	5.00e-24	108.00	IUUC-Cel-018553
UBD/Alpha-Helix/CUE	33.12	2.00e-26	117.00	IUUC-Dre-028689

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Brassica rapa

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MAPVSICMFL VVLLTYSLSV TSDPQIRTAA NLIYIENPSD SATVKLEGSL ENAIVFVVLV 60
AAVTFVLVLL FYFNFTNFLK HYMRFSAFFV LGTMGGAIFL SIIQHFSIPV DSITCFILLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCCCG TCTCCATCTG CATGTTCCTC GTCGTCCTCC TCACCTACTC CCTCTCCGTC 60
ACCTCCGACC CCCAGATCCG CACCGCCGCC AACCTCATCT ACATCGAGAA CCCCTCCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005798--C:Golgi-associated vesicle
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	50.34	3.00e-74	273.00
IUUC-Aml-001648	Ailuropoda melanoleuca	35.94	1.00e-33	136.00
IUUC-Atr-003039	Amborella trichopoda	58.26	9.00e-126	443.00
IUUC-Apl-003959	Anas platyrhynchos	29.81	4.00e-19	89.00
IUUC-Aca-004582	Anolis carolinensis	33.57	2.00e-34	140.00
IUUC-Aly-005455	Arabidopsis lyrata	81.92	2.00e-164	572.00
IUUC-Ath-006730	Arabidopsis thaliana	79.45	7.00e-166	576.00
IUUC-Ame-010686	Astyanax mexicanus	30.77	7.00e-23	101.00
IUUC-Bta-013097	Bos taurus	30.77	2.00e-23	103.00
IUUC-Bdi-014196	Brachypodium distachyon	52.78	4.00e-90	325.00
IUUC-Bol-015841	Brassica oleracea	92.81	0.00e+00	636.00
IUUC-Cel-018553	Caenorhabditis elegans	32.07	4.00e-45	175.00
IUUC-Cja-019994	Callithrix jacchus	33.25	9.00e-35	140.00
IUUC-Cfa-020074	Canis familiaris	32.86	2.00e-35	142.00
IUUC-Cpo-022237	Cavia porcellus	33.25	7.00e-35	141.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	44.14	1.00e-45	177.00
IUUC-Csa-023537	Chlorocebus sabaeus	32.86	1.00e-35	143.00
IUUC-Cho-024735	Choloepus hoffmanni	30.75	1.00e-30	127.00
IUUC-Cin-025780	Ciona intestinalis	30.47	2.00e-41	162.00
IUUC-Csv-025967	Ciona savignyi	31.58	3.00e-24	105.00
IUUC-Dre-028689	Danio rerio	31.80	2.00e-29	122.00
IUUC-Dno-029758	Dasypus novemcinctus	33.01	7.00e-34	137.00
IUUC-Dor-030609	Dipodomys ordii	41.35	4.00e-20	92.40
IUUC-Dme-031929	Drosophila melanogaster	31.07	1.00e-25	110.00
IUUC-Ete-032487	Echinops telfairi	37.13	4.00e-16	79.00
IUUC-Eca-033391	Equus caballus	32.67	1.00e-18	87.00
IUUC-Eeu-035134	Erinaceus europaeus	35.37	5.00e-33	134.00
IUUC-Fca-035396	Felis catus	32.78	2.00e-33	136.00
IUUC-Fal-037457	Ficedula albicollis	31.73	9.00e-22	97.80
IUUC-Gmo-038550	Gadus morhua	32.21	1.00e-23	103.00
IUUC-Gga-040993	Gallus gallus	32.52	5.00e-33	135.00
IUUC-Gac-042511	Gasterosteus aculeatus	31.15	2.00e-32	133.00
IUUC-Gma-043822	Glycine max	68.47	8.00e-48	183.00
IUUC-Ggo-045338	Gorilla gorilla	30.29	1.00e-22	100.00
IUUC-Hsa-046822	Homo sapiens	32.86	1.00e-35	143.00
IUUC-Hvu-047141	Hordeum vulgare	50.56	2.00e-84	305.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	35.90	9.00e-34	137.00
IUUC-Lch-049946	Latimeria chalumnae	31.25	1.00e-19	90.90
IUUC-Lpe-051132	Leersia perrieri	51.06	4.00e-86	311.00
IUUC-Loc-052427	Lepisosteus oculatus	29.45	3.00e-33	135.00
IUUC-Laf-053979	Loxodonta africana	32.20	5.00e-30	125.00
IUUC-Mcc-055682	Macaca mulatta	32.86	1.00e-35	143.00
IUUC-Meu-056004	Macropus eugenii	30.77	2.00e-20	93.20
IUUC-Mtr-058392	Medicago truncatula	63.06	1.00e-108	386.00
IUUC-Mga-059466	Meleagris gallopavo	32.52	2.00e-33	136.00
IUUC-Mmr-060890	Microcebus murinus	29.81	3.00e-22	99.40
IUUC-Mdo-062122	Monodelphis domestica	32.85	5.00e-34	138.00
IUUC-Mmu-063176	Mus musculus	32.21	1.00e-21	97.10
IUUC-Mac-064858	Musa acuminata	73.55	3.00e-41	161.00
IUUC-Mpu-065927	Mustela putorius furo	32.86	3.00e-35	142.00
IUUC-Mlu-067079	Myotis lucifugus	32.93	1.00e-37	150.00
IUUC-Nle-070180	Nomascus leucogenys	32.86	1.00e-35	143.00
IUUC-Opr-070847	Ochotona princeps	33.01	3.00e-21	96.30
IUUC-Ont-071867	Oreochromis niloticus	30.77	1.00e-20	94.40
IUUC-Oan-072783	Ornithorhynchus anatinus	35.69	2.00e-31	129.00
IUUC-Ocu-074527	Oryctolagus cuniculus	32.77	1.00e-34	140.00
IUUC-Oba-075256	Oryza barthii	52.19	5.00e-81	294.00
IUUC-Obr-076302	Oryza brachyantha	62.50	2.00e-44	173.00
IUUC-Ogl-077097	Oryza glaberrima	52.78	9.00e-86	310.00
IUUC-Ogu-078570	Oryza glumaepatula	52.78	6.00e-86	310.00
IUUC-Oin-079244	Oryza indica	52.67	1.00e-85	310.00
IUUC-Olo-080484	Oryza longistaminata	51.80	2.00e-60	225.00
IUUC-Ome-081814	Oryza meridionalis	51.20	7.00e-86	310.00
IUUC-Oni-082057	Oryza nivara	52.67	1.00e-85	310.00
IUUC-Opu-084176	Oryza punctata	51.94	1.00e-86	313.00
IUUC-Oru-084618	Oryza rufipogon	52.78	8.00e-86	310.00
IUUC-Osa-085602	Oryza sativa	52.40	6.00e-87	314.00
IUUC-Ola-086707	Oryzias latipes	31.96	1.00e-24	106.00
IUUC-Olu-087811	Ostreococcus lucimarinus	42.65	1.00e-46	179.00
IUUC-Oga-088560	Otolemur garnettii	30.29	1.00e-22	100.00
IUUC-Oar-090348	Ovis aries	32.28	3.00e-36	145.00
IUUC-Ptr-091060	Pan troglodytes	32.86	1.00e-35	143.00
IUUC-Pan-091742	Papio anubis	30.29	9.00e-23	100.00
IUUC-Psi-093505	Pelodiscus sinensis	32.28	1.00e-34	140.00
IUUC-Pma-094612	Petromyzon marinus	30.29	3.00e-18	85.90
IUUC-Ppa-095431	Physcomitrella patens	56.19	4.00e-52	198.00
IUUC-Pfo-097396	Poecilia formosa	31.88	3.00e-36	145.00
IUUC-Pab-098591	Pongo abelii	33.65	1.00e-35	143.00
IUUC-Pop-099661	Populus trichocarpa	48.57	7.00e-84	303.00
IUUC-Pca-101029	Procavia capensis	34.29	7.00e-32	131.00
IUUC-Ppe-101495	Prunus persica	63.19	1.00e-139	489.00
IUUC-Pva-102244	Pteropus vampyrus	31.22	7.00e-23	101.00
IUUC-Rno-105861	Rattus norvegicus	32.69	2.00e-21	97.10
IUUC-Sha-106876	Sarcophilus harrisii	30.29	3.00e-23	102.00
IUUC-Smo-109325	Selaginella moellendorffii	53.33	1.00e-40	160.00
IUUC-Sit-110624	Setaria italica	49.89	7.00e-80	290.00
IUUC-Sly-110865	Solanum lycopersicum	87.14	2.00e-30	123.00
IUUC-Stu-112433	Solanum tuberosum	61.00	7.00e-112	397.00
IUUC-Sar-113169	Sorex araneus	35.67	2.00e-31	129.00
IUUC-Sbi-114305	Sorghum bicolor	50.66	4.00e-81	295.00
IUUC-Ssc-115766	Sus scrofa	33.74	3.00e-36	145.00
IUUC-Tgu-117280	Taeniopygia guttata	31.73	9.00e-22	97.80
IUUC-Tru-117732	Takifugu rubripes	31.65	3.00e-33	135.00
IUUC-Tsy-119303	Tarsius syrichta	53.09	3.00e-05	43.10
IUUC-Tni-119852	Tetraodon nigroviridis	32.30	5.00e-32	131.00
IUUC-Tca-121865	Theobroma cacao	69.80	2.00e-138	485.00
IUUC-Tae-125925	Triticum aestivum	51.11	3.00e-84	305.00
IUUC-Tur-126237	Triticum urartu	50.27	2.00e-78	285.00
IUUC-Tbe-128148	Tupaia belangeri	29.55	1.00e-21	97.10
IUUC-Ttr-128793	Tursiops truncatus	32.85	9.00e-33	134.00
IUUC-Vpa-130625	Vicugna pacos	40.95	2.00e-19	90.10
IUUC-Vvi-131312	Vitis vinifera	81.67	4.00e-78	285.00
IUUC-Xtr-132756	Xenopus tropicalis	30.64	1.00e-31	130.00
IUUC-Xma-133377	Xiphophorus maculatus	32.04	2.00e-37	149.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence