iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073497

UUCD1 version

UUC-OrA-00431

Ensembl Protein ID

ENSOANP00000003233.1

UniProt Accession

F7BGK2; F7BGK2_ORNAN

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000002038.1	ENSOANT00000003234.1	ENSOANP00000003233.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-134	448.7	590	922

Active Site

Position(s)	Description	Evidence
891	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 590  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 677
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNkeeY+ l++e
   Q: 678  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKEEYIGLMAE 763
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r +++qFv
   Q: 764  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLMQFV 851
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 852  TGTCRLPLGGFAELMgsngPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 922
           *********************************************************************96 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MATASPRSDR SNNLNGRSPL QVTVSSAKLK RKKNWFGTAI YAELLVDGEI KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATVD LQQALEVHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACAG CTTCACCCAG ATCTGATAGA AGTAATAACC TTAATGGAAG ATCACCACTA 60
CAGGTGACTG GTAAGTTACC TTACTGATCT CTCCTAATCC TTCCTCTCTT TTCTTCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001739--Methyl_CpG_DNA-bd
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS50982--MBD
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

oaa:100075459

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	86.46	0.00e+00	1593.00
IUUC-Apl-003310	Anas platyrhynchos	86.21	0.00e+00	1568.00
IUUC-Aca-005388	Anolis carolinensis	83.46	0.00e+00	1505.00
IUUC-Ago-007742	Ashbya gossypii	46.94	1.00e-157	549.00
IUUC-Ame-010601	Astyanax mexicanus	75.93	0.00e+00	969.00
IUUC-Bta-012857	Bos taurus	85.70	0.00e+00	1548.00
IUUC-Cel-018299	Caenorhabditis elegans	67.42	0.00e+00	841.00
IUUC-Cja-019448	Callithrix jacchus	86.24	0.00e+00	1595.00
IUUC-Cfa-020728	Canis familiaris	86.89	0.00e+00	1580.00
IUUC-Cpo-021635	Cavia porcellus	82.42	0.00e+00	1533.00
IUUC-Csa-023805	Chlorocebus sabaeus	88.03	0.00e+00	1219.00
IUUC-Cho-024943	Choloepus hoffmanni	77.07	0.00e+00	1069.00
IUUC-Cin-025212	Ciona intestinalis	74.27	0.00e+00	917.00
IUUC-Csv-026256	Ciona savignyi	73.36	0.00e+00	911.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	46.58	3.00e-152	531.00
IUUC-Cne-026849	Cryptococcus neoformans	47.12	2.00e-155	542.00
IUUC-Dre-028245	Danio rerio	73.03	0.00e+00	1233.00
IUUC-Dno-029618	Dasypus novemcinctus	86.24	0.00e+00	1576.00
IUUC-Dor-030665	Dipodomys ordii	70.84	0.00e+00	1019.00
IUUC-Dme-032041	Drosophila melanogaster	70.02	0.00e+00	897.00
IUUC-Ete-032779	Echinops telfairi	92.43	0.00e+00	1092.00
IUUC-Eca-033313	Equus caballus	86.02	0.00e+00	1556.00
IUUC-Eeu-035259	Erinaceus europaeus	78.55	0.00e+00	1409.00
IUUC-Fca-035420	Felis catus	85.59	0.00e+00	1575.00
IUUC-Fal-037335	Ficedula albicollis	85.34	0.00e+00	1568.00
IUUC-Fso-038393	Fusarium solani	46.27	1.00e-151	529.00
IUUC-Gmo-039172	Gadus morhua	87.68	0.00e+00	1059.00
IUUC-Ggr-040107	Gaeumannomyces graminis	46.49	2.00e-151	528.00
IUUC-Gga-040246	Gallus gallus	85.45	0.00e+00	1556.00
IUUC-Gac-042211	Gasterosteus aculeatus	93.17	0.00e+00	1183.00
IUUC-Ggo-045001	Gorilla gorilla	85.22	0.00e+00	1396.00
IUUC-Hsa-046544	Homo sapiens	85.48	0.00e+00	1583.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	85.16	0.00e+00	1540.00
IUUC-Kpa-049273	Komagataella pastoris	47.42	9.00e-159	553.00
IUUC-Lch-050398	Latimeria chalumnae	79.01	0.00e+00	1404.00
IUUC-Loc-052116	Lepisosteus oculatus	78.58	0.00e+00	1419.00
IUUC-Laf-053551	Loxodonta africana	85.06	0.00e+00	1546.00
IUUC-Meu-056455	Macropus eugenii	69.94	0.00e+00	863.00
IUUC-Mor-057097	Magnaporthe oryzae	46.51	2.00e-151	529.00
IUUC-Mga-059986	Meleagris gallopavo	85.42	0.00e+00	1564.00
IUUC-Mmr-060945	Microcebus murinus	83.01	0.00e+00	1513.00
IUUC-Mdo-063024	Monodelphis domestica	87.38	0.00e+00	1549.00
IUUC-Mmu-063202	Mus musculus	85.05	0.00e+00	1512.00
IUUC-Mpu-065773	Mustela putorius furo	86.49	0.00e+00	1573.00
IUUC-Mlu-067373	Myotis lucifugus	95.50	0.00e+00	644.00
IUUC-Nle-069188	Nomascus leucogenys	86.02	0.00e+00	1590.00
IUUC-Opr-070965	Ochotona princeps	83.10	0.00e+00	1490.00
IUUC-Ont-072226	Oreochromis niloticus	92.01	0.00e+00	1190.00
IUUC-Ocu-073891	Oryctolagus cuniculus	82.58	0.00e+00	1463.00
IUUC-Ola-087438	Oryzias latipes	92.59	0.00e+00	1179.00
IUUC-Oga-087922	Otolemur garnettii	85.73	0.00e+00	1559.00
IUUC-Oar-089317	Ovis aries	84.76	0.00e+00	1524.00
IUUC-Ptr-090484	Pan troglodytes	85.48	0.00e+00	1582.00
IUUC-Pan-092117	Papio anubis	85.81	0.00e+00	1587.00
IUUC-Psi-093338	Pelodiscus sinensis	86.67	0.00e+00	1592.00
IUUC-Pma-094279	Petromyzon marinus	74.09	0.00e+00	842.00
IUUC-Pfo-096171	Poecilia formosa	94.52	0.00e+00	1188.00
IUUC-Pab-098654	Pongo abelii	85.90	0.00e+00	1180.00
IUUC-Pva-102811	Pteropus vampyrus	76.27	0.00e+00	1335.00
IUUC-Rno-106125	Rattus norvegicus	83.86	0.00e+00	1523.00
IUUC-Sha-107243	Sarcophilus harrisii	88.37	0.00e+00	1595.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	46.09	1.00e-157	549.00
IUUC-Sar-113761	Sorex araneus	77.87	0.00e+00	972.00
IUUC-Ssc-115368	Sus scrofa	85.75	0.00e+00	1546.00
IUUC-Tgu-117079	Taeniopygia guttata	85.01	0.00e+00	1556.00
IUUC-Tru-118062	Takifugu rubripes	72.62	0.00e+00	1370.00
IUUC-Tsy-119507	Tarsius syrichta	80.72	0.00e+00	1461.00
IUUC-Tni-120151	Tetraodon nigroviridis	71.46	0.00e+00	1335.00
IUUC-Tre-122203	Trichoderma reesei	46.21	1.00e-148	520.00
IUUC-Ttr-129260	Tursiops truncatus	76.38	0.00e+00	1333.00
IUUC-Vpa-130103	Vicugna pacos	68.11	0.00e+00	828.00
IUUC-Xtr-132877	Xenopus tropicalis	71.58	0.00e+00	1221.00
IUUC-Xma-133778	Xiphophorus maculatus	94.52	0.00e+00	1187.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence