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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045741
Ensembl Protein ID ENSP00000225298.7
UniProt Accession Q9Y5J1; Q9H4N6; UTP18_HUMAN
Genbank Protein ID AAD34043.1; AAH25276.2; AAG01999.1
Protein Name U3 small nucleolar RNA-associated protein 18 homolog; WD repeat-containing protein 50
Genbank Nucleotide ID AF151806; BC025276; AY007138
Gene Name UTP18; WDR50; CDABP0061; CGI-48
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000011260.13 ENST00000225298.11 ENSP00000225298.7
ENSG00000011260.13 ENST00000508506.3 ENSP00000441335.2
ENSG00000011260.13 ENST00000583725.5 ENSP00000462614.1
ENSG00000011260.13 ENST00000583205.5 ENSP00000464095.1
ENSG00000011260.13 ENST00000579261.6 ENSP00000464194.2
ENSG00000011260.13 ENST00000582832.1 ENSP00000463499.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-08 36.6 389 417
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 10   af.sd.tllvsGsdDgtikvWDlrtgvll 36
            f sd + + ++s+Dg ++vWD+ + ++l
   Q: 389  TFsSDsKKVYASSGDGEVYVWDVNSRKCL 417
           477788999*************9887775 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in nucleolar processing of pre-18S ribosomal RNA.
 Involved in nucleolar processing of pre-18S ribosomal RNA.
Protein Sequence
(Fasta)
MPPERRRRMK LDRRTGAKPK RKPGMRPDWK AGAGPGGPPQ KPAPSSQRKP PARPSAAAAA 60
IAVAAAEEER RLRQRNRLRL EEDKPAVERC LEELVFGDVE NDEDALLRRL RGPRVQEHED 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045741|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCGCATGC GCAGCGAGGT TCCACGTGAG CGCCTGCGTT TCTCCTCAAA CCTAACGATG 60
CCGCCGGAGC GGAGGAGACG AATGAAACTG GACCGGAGAA CCGGAGCGAA GCCGAAGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045741|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0698--rRNA processing
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
SMART

SM00320--WD40
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0034388--C:Pwp2p-containing subcomplex of 90S preribosome
GO:0032040--C:small-subunit processome
GO:0003723--F:RNA binding
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364--P:rRNA processing
KEGG hsa:51096
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000184 Aegilops tauschii 38.60 6.00e-78 285.00
IUUC-Aml-002252 Ailuropoda melanoleuca 92.21 0.00e+00 852.00
IUUC-Atr-002575 Amborella trichopoda 41.95 2.00e-74 273.00
IUUC-Aly-006512 Arabidopsis lyrata 43.94 1.00e-74 273.00
IUUC-Ath-007244 Arabidopsis thaliana 44.24 1.00e-73 270.00
IUUC-Ago-007895 Ashbya gossypii 25.00 3.00e-31 130.00
IUUC-Acl-008343 Aspergillus clavatus 27.33 1.00e-30 128.00
IUUC-Afl-008445 Aspergillus flavus 25.00 2.00e-37 150.00
IUUC-Aor-009986 Aspergillus oryzae 25.00 6.00e-36 145.00
IUUC-Ame-011338 Astyanax mexicanus 53.14 3.00e-143 501.00
IUUC-Bgr-012201 Blumeria graminis 27.79 4.00e-37 149.00
IUUC-Bta-013058 Bos taurus 87.55 0.00e+00 842.00
IUUC-Bci-013619 Botrytis cinerea 23.27 1.00e-29 124.00
IUUC-Bdi-014771 Brachypodium distachyon 38.50 2.00e-77 283.00
IUUC-Bol-015230 Brassica oleracea 44.82 3.00e-74 272.00
IUUC-Bra-017041 Brassica rapa 44.21 4.00e-71 262.00
IUUC-Cel-018293 Caenorhabditis elegans 28.27 2.00e-49 190.00
IUUC-Cja-019503 Callithrix jacchus 96.84 0.00e+00 846.00
IUUC-Cfa-020743 Canis familiaris 91.56 0.00e+00 847.00
IUUC-Cpo-021488 Cavia porcellus 89.47 0.00e+00 806.00
IUUC-Cre-022926 Chlamydomonas reinhardtii 33.61 6.00e-60 225.00
IUUC-Csa-023110 Chlorocebus sabaeus 97.12 0.00e+00 936.00
IUUC-Cin-025208 Ciona intestinalis 41.93 5.00e-73 268.00
IUUC-Cme-027351 Cyanidioschyzon merolae 27.27 3.00e-41 163.00
IUUC-Dre-027524 Danio rerio 47.88 2.00e-112 399.00
IUUC-Dno-029243 Dasypus novemcinctus 85.25 0.00e+00 839.00
IUUC-Dor-030110 Dipodomys ordii 72.22 0.00e+00 738.00
IUUC-Dse-031217 Dothistroma septosporum 25.58 1.00e-25 111.00
IUUC-Dme-031999 Drosophila melanogaster 33.51 4.00e-54 205.00
IUUC-Eca-034350 Equus caballus 92.63 0.00e+00 855.00
IUUC-Eeu-034991 Erinaceus europaeus 81.93 0.00e+00 772.00
IUUC-Fal-036614 Ficedula albicollis 61.88 5.00e-156 544.00
IUUC-Gmo-039183 Gadus morhua 50.98 7.00e-123 434.00
IUUC-Gga-040922 Gallus gallus 61.57 1.00e-166 579.00
IUUC-Gac-041475 Gasterosteus aculeatus 55.86 2.00e-129 456.00
IUUC-Gma-043598 Glycine max 37.82 2.00e-75 276.00
IUUC-Ggo-044517 Gorilla gorilla 99.46 0.00e+00 939.00
IUUC-Hvu-047463 Hordeum vulgare 40.57 1.00e-32 132.00
IUUC-Itr-048128 Ictidomys tridecemlineatus 90.30 0.00e+00 833.00
IUUC-Kpa-049335 Komagataella pastoris 30.12 3.00e-44 173.00
IUUC-Lch-049816 Latimeria chalumnae 66.06 6.00e-165 573.00
IUUC-Lpe-051140 Leersia perrieri 36.70 3.00e-75 276.00
IUUC-Loc-051942 Lepisosteus oculatus 58.10 6.00e-148 517.00
IUUC-Laf-054245 Loxodonta africana 87.95 0.00e+00 883.00
IUUC-Meu-056300 Macropus eugenii 70.35 9.00e-151 526.00
IUUC-Mor-057184 Magnaporthe oryzae 26.78 8.00e-32 132.00
IUUC-Mtr-058019 Medicago truncatula 37.41 5.00e-68 252.00
IUUC-Mga-060179 Meleagris gallopavo 64.75 3.00e-154 538.00
IUUC-Mvi-060435 Microbotryum violaceum 33.04 4.00e-50 192.00
IUUC-Mdo-062187 Monodelphis domestica 67.29 3.00e-176 611.00
IUUC-Mmu-063386 Mus musculus 79.46 0.00e+00 778.00
IUUC-Mpu-066084 Mustela putorius furo 91.58 0.00e+00 847.00
IUUC-Mlu-068130 Myotis lucifugus 91.98 0.00e+00 855.00
IUUC-Nle-069743 Nomascus leucogenys 92.28 0.00e+00 846.00
IUUC-Opr-071111 Ochotona princeps 92.65 0.00e+00 659.00
IUUC-Ont-071979 Oreochromis niloticus 57.38 2.00e-141 496.00
IUUC-Ocu-073754 Oryctolagus cuniculus 88.72 0.00e+00 829.00
IUUC-Oba-075007 Oryza barthii 37.32 2.00e-73 270.00
IUUC-Obr-076447 Oryza brachyantha 37.33 7.00e-75 275.00
IUUC-Ogl-077733 Oryza glaberrima 37.32 2.00e-73 270.00
IUUC-Ogu-078828 Oryza glumaepatula 37.32 2.00e-73 270.00
IUUC-Oin-080152 Oryza indica 37.09 4.00e-73 269.00
IUUC-Olo-080983 Oryza longistaminata 41.74 2.00e-73 270.00
IUUC-Oni-082443 Oryza nivara 41.12 6.00e-73 268.00
IUUC-Opu-083771 Oryza punctata 38.03 5.00e-74 271.00
IUUC-Oru-084272 Oryza rufipogon 37.09 3.00e-73 269.00
IUUC-Osa-085885 Oryza sativa 36.70 2.00e-73 270.00
IUUC-Olu-087644 Ostreococcus lucimarinus 25.08 8.00e-18 85.10
IUUC-Oga-088834 Otolemur garnettii 94.75 0.00e+00 887.00
IUUC-Oar-089712 Ovis aries 92.24 0.00e+00 788.00
IUUC-Pan-092561 Papio anubis 98.02 0.00e+00 945.00
IUUC-Ppa-095397 Physcomitrella patens 43.65 5.00e-75 275.00
IUUC-Pfo-097068 Poecilia formosa 55.06 2.00e-136 479.00
IUUC-Pop-099471 Populus trichocarpa 37.34 4.00e-66 246.00
IUUC-Ppe-101446 Prunus persica 38.84 1.00e-72 267.00
IUUC-Pva-102851 Pteropus vampyrus 90.53 0.00e+00 838.00
IUUC-Pgr-103370 Puccinia graminis 26.71 8.00e-41 162.00
IUUC-Ptt-103838 Puccinia triticina 27.40 2.00e-38 154.00
IUUC-Rno-104910 Rattus norvegicus 80.43 0.00e+00 757.00
IUUC-Sce-106258 Saccharomyces cerevisiae 27.60 2.00e-38 154.00
IUUC-Sja-107746 Schizosaccharomyces japonicus 24.57 2.00e-40 160.00
IUUC-Spo-108268 Schizosaccharomyces pombe 26.52 3.00e-44 173.00
IUUC-Smo-108815 Selaginella moellendorffii 41.69 2.00e-76 280.00
IUUC-Sit-109706 Setaria italica 38.07 2.00e-76 280.00
IUUC-Sly-111533 Solanum lycopersicum 39.51 3.00e-79 288.00
IUUC-Stu-112853 Solanum tuberosum 39.96 8.00e-82 297.00
IUUC-Sbi-114747 Sorghum bicolor 38.06 2.00e-75 276.00
IUUC-Ssc-115916 Sus scrofa 93.25 0.00e+00 835.00
IUUC-Tgu-117291 Taeniopygia guttata 61.95 2.00e-143 502.00
IUUC-Tru-118724 Takifugu rubripes 50.00 8.00e-127 447.00
IUUC-Tsy-118928 Tarsius syrichta 82.10 0.00e+00 713.00
IUUC-Tca-121229 Theobroma cacao 44.24 2.00e-78 286.00
IUUC-Tae-125218 Triticum aestivum 38.60 5.00e-78 285.00
IUUC-Tur-126082 Triticum urartu 34.04 1.00e-49 190.00
IUUC-Ttr-128904 Tursiops truncatus 81.68 0.00e+00 783.00
IUUC-Vpa-130817 Vicugna pacos 93.04 0.00e+00 867.00
IUUC-Vvi-131395 Vitis vinifera 38.44 9.00e-76 278.00
IUUC-Xtr-132971 Xenopus tropicalis 59.06 3.00e-145 508.00
IUUC-Xma-133391 Xiphophorus maculatus 54.30 2.00e-135 476.00
IUUC-Yli-134613 Yarrowia lipolytica 30.86 9.00e-50 191.00
Created Date 25-Jun-2017

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