iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046085

UUCD1 version

UUC-HoS-00473

Ensembl Protein ID

ENSP00000355658.2

UniProt Accession

Q9Y577; B4DVJ2; Q5VST8; TRI17_HUMAN

Genbank Protein ID

AAD40286.1; BAG62704.1; CAH71674.1; CAH71674.1; CAI23334.1; CAI23334.1; AAH33788.1

Protein Name

E3 ubiquitin-protein ligase TRIM17; RING finger protein 16; RING-type E3 ubiquitin transferase TRIM17; Testis RING finger protein; Tripartite motif-containing protein 17

Genbank Nucleotide ID

AF156271; AK301105; AL670729; AL139288; AL139288; AL670729; BC033788

Gene Name

TRIM17; RBCC; RNF16; TERF

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000162931.11	ENST00000366697.6	ENSP00000355658.2
ENSG00000162931.11	ENST00000456946.6	ENSP00000403312.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
Mentha
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19358823; 20559321; 20352094

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	4.50e-05	25.1	12	82
E3 activity/RING/RING	2.60e-09	39.1	16	66

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIe.kwlasggk..........tcPvtrqplteedlvPnltlrr 63
           ee  C+I l+ ++dPv++ +G+ + r++I+  w +  gk           cP +r+   +++l Pn  l +
   Q: 12   EEATCSICLDYFTDPVMTTCGHNFCRACIQlSWEKARGKkgrrkrkgsfPCPECREMSPQRNLLPNRLLTK 82
           7889*************************95576444445888999********************98865 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw.....pglknssskefrCPlCr 46
           C+iCl+ f d p+ + CgH f++ C+   w     +   ++ +++f CP Cr
   Q: 16   CSICLDYFTD-PVMTTCGHNFCRACIqLSWekargKKGRRKRKGSFPCPECR 66
           **********.999************8888999**888888**********8 PP

Organism

Homo sapiens

Functional Description
(View)

May function as a ubiquitin E3 ligase.

Protein Sequence
(Fasta)

MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK KGRRKRKGSF 60
PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ EHHEPLKLFC QKDQSPICVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCAGCACC CGCTGCGCCT GTCCCCGGCT CGTCCAGAGC CTTCCACCCC CTGCCGCCTT 60
CCTTCCCCAA GCCACCCCCA ACCTCTCCTA AGAGGCGCCG CCCCAGTCCC GGCCGCCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR032918--TRIM17
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0030674--F:protein binding, bridging
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051865--P:protein autoubiquitination
GO:0032880--P:regulation of protein localization

KEGG

hsa:51127

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013369	Bos taurus	73.43	0.00e+00	677.00
IUUC-Cja-019509	Callithrix jacchus	87.66	0.00e+00	784.00
IUUC-Cfa-020311	Canis familiaris	75.26	0.00e+00	674.00
IUUC-Cpo-021862	Cavia porcellus	75.89	0.00e+00	671.00
IUUC-Csa-023705	Chlorocebus sabaeus	96.15	2.00e-115	408.00
IUUC-Cho-024594	Choloepus hoffmanni	71.09	3.00e-108	384.00
IUUC-Dno-029337	Dasypus novemcinctus	75.31	0.00e+00	701.00
IUUC-Dor-030385	Dipodomys ordii	65.08	4.00e-67	248.00
IUUC-Ete-032497	Echinops telfairi	69.73	5.00e-155	540.00
IUUC-Eeu-034725	Erinaceus europaeus	65.13	5.00e-141	494.00
IUUC-Fca-036296	Felis catus	76.52	0.00e+00	685.00
IUUC-Ggo-044516	Gorilla gorilla	98.11	0.00e+00	879.00
IUUC-Itr-048579	Ictidomys tridecemlineatus	81.13	0.00e+00	743.00
IUUC-Mcc-055376	Macaca mulatta	96.02	0.00e+00	815.00
IUUC-Mmr-061341	Microcebus murinus	78.24	0.00e+00	701.00
IUUC-Mmu-064039	Mus musculus	76.52	0.00e+00	700.00
IUUC-Nle-069350	Nomascus leucogenys	95.18	0.00e+00	815.00
IUUC-Opr-071165	Ochotona princeps	73.17	1.00e-178	619.00
IUUC-Oga-088905	Otolemur garnettii	79.33	0.00e+00	688.00
IUUC-Ptr-090539	Pan troglodytes	97.90	0.00e+00	830.00
IUUC-Pan-091818	Papio anubis	96.65	0.00e+00	822.00
IUUC-Pab-097880	Pongo abelii	97.71	5.00e-92	330.00
IUUC-Pca-101074	Procavia capensis	75.56	2.00e-100	359.00
IUUC-Pva-102309	Pteropus vampyrus	74.38	8.00e-121	426.00
IUUC-Rno-104939	Rattus norvegicus	74.84	0.00e+00	667.00
IUUC-Ssc-115951	Sus scrofa	76.36	0.00e+00	719.00
IUUC-Tsy-119187	Tarsius syrichta	86.08	1.00e-98	353.00
IUUC-Tbe-127586	Tupaia belangeri	81.76	0.00e+00	757.00
IUUC-Ttr-129241	Tursiops truncatus	72.06	0.00e+00	650.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence