iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044637

UUCD1 version

UUC-GoG-00019

Ensembl Protein ID

ENSGGOP00000000361.2

UniProt Accession

G3QDN7; G3QDN7_GORGO

Protein Name

Uncharacterized protein

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000000368.2	ENSGGOT00000000370.2	ENSGGOP00000000361.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-66	217.6	197	240
UBD/Beta-Prp	4.20e-80	269.5	106	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg++++WD++ g++++
   Q: 197  GHSKWITGLSWeplhvnPEsRYVASSSKDGSVRIWDTTAGRCER 240
           8***************9888**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+s+sp+g+kl+sG +   i +wd +tg+ +  t
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRT 194
           5799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv+sl +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LAGHSKWITGLSWeplhvNPESRYVASSSKDGSVRIWDTTAGRCERILTG-HTQSVTSLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           *********9865222227899***************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnde 235
           tl+gh  +v+ +++s  d 
   Q: 282  TLQGHGHWVNTMALS-TDY 299
           *************99.333 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MAAAVADEAV ARDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL 60
AFFVHDAEIV SSLGKTLESQ AVETEKVLDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTTCTCC TCCACGTGGG GACGCAGGAT GGCGGCGGCA GTGGCGGTGG GTGTGCGTGG 60
ATGGGGGCGG GGGGCGTCGC CGCGGGGCGC TAGGGCCCGG GTCGCTGAGG CCTGAGAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

KEGG

ggo:101126517

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.37	6.00e-169	587.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.41	0.00e+00	937.00
IUUC-Atr-002507	Amborella trichopoda	58.42	1.00e-165	576.00
IUUC-Apl-003964	Anas platyrhynchos	84.80	0.00e+00	813.00
IUUC-Aly-006396	Arabidopsis lyrata	54.47	7.00e-160	556.00
IUUC-Ath-007278	Arabidopsis thaliana	54.68	6.00e-160	556.00
IUUC-Ago-007951	Ashbya gossypii	48.36	3.00e-129	455.00
IUUC-Acl-008298	Aspergillus clavatus	47.08	1.00e-119	422.00
IUUC-Afl-008581	Aspergillus flavus	52.38	2.00e-107	382.00
IUUC-Afu-008906	Aspergillus fumigatus	46.36	5.00e-119	421.00
IUUC-Ani-009189	Aspergillus nidulans	44.83	4.00e-115	408.00
IUUC-Ang-009630	Aspergillus niger	50.00	1.00e-121	429.00
IUUC-Aor-010038	Aspergillus oryzae	47.40	3.00e-125	442.00
IUUC-Ate-010278	Aspergillus terreus	46.60	3.00e-121	428.00
IUUC-Ame-011890	Astyanax mexicanus	80.55	0.00e+00	818.00
IUUC-Bgr-012011	Blumeria graminis	48.24	2.00e-130	459.00
IUUC-Bta-012964	Bos taurus	95.57	0.00e+00	934.00
IUUC-Bci-013592	Botrytis cinerea	44.81	3.00e-119	422.00
IUUC-Bdi-015035	Brachypodium distachyon	58.46	3.00e-170	591.00
IUUC-Bol-015501	Brassica oleracea	55.56	3.00e-160	557.00
IUUC-Bra-017642	Brassica rapa	55.34	1.00e-159	555.00
IUUC-Cel-018430	Caenorhabditis elegans	58.67	3.00e-167	581.00
IUUC-Cja-019125	Callithrix jacchus	98.31	0.00e+00	955.00
IUUC-Cfa-021013	Canis familiaris	95.15	0.00e+00	851.00
IUUC-Cpo-021743	Cavia porcellus	95.56	0.00e+00	934.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	46.92	7.00e-122	430.00
IUUC-Csa-024270	Chlorocebus sabaeus	98.33	0.00e+00	963.00
IUUC-Cin-025795	Ciona intestinalis	65.67	0.00e+00	679.00
IUUC-Csv-025953	Ciona savignyi	66.52	0.00e+00	677.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	50.66	9.00e-107	380.00
IUUC-Cne-026901	Cryptococcus neoformans	48.91	9.00e-138	483.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.45	2.00e-113	403.00
IUUC-Dre-028515	Danio rerio	77.80	0.00e+00	799.00
IUUC-Dno-029596	Dasypus novemcinctus	96.41	0.00e+00	938.00
IUUC-Dor-030494	Dipodomys ordii	96.19	0.00e+00	933.00
IUUC-Dse-031538	Dothistroma septosporum	47.83	4.00e-128	451.00
IUUC-Dme-031974	Drosophila melanogaster	59.61	5.00e-168	583.00
IUUC-Ete-032948	Echinops telfairi	96.65	2.00e-117	415.00
IUUC-Eca-033399	Equus caballus	97.45	0.00e+00	943.00
IUUC-Eeu-035013	Erinaceus europaeus	94.26	1.00e-115	409.00
IUUC-Fca-035860	Felis catus	96.62	0.00e+00	939.00
IUUC-Fal-037069	Ficedula albicollis	87.60	7.00e-132	462.00
IUUC-Fox-038059	Fusarium oxysporum	45.93	2.00e-123	435.00
IUUC-Fso-038445	Fusarium solani	47.18	2.00e-124	439.00
IUUC-Gmo-039319	Gadus morhua	75.32	0.00e+00	729.00
IUUC-Ggr-040095	Gaeumannomyces graminis	46.96	4.00e-121	427.00
IUUC-Gga-040303	Gallus gallus	85.60	3.00e-130	457.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.27	0.00e+00	762.00
IUUC-Gma-043974	Glycine max	57.45	7.00e-169	586.00
IUUC-Hsa-046128	Homo sapiens	98.97	0.00e+00	980.00
IUUC-Hvu-047373	Hordeum vulgare	57.82	3.00e-168	584.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	96.23	0.00e+00	939.00
IUUC-Kpa-049274	Komagataella pastoris	44.56	7.00e-126	444.00
IUUC-Lch-049907	Latimeria chalumnae	82.18	0.00e+00	818.00
IUUC-Lpe-050778	Leersia perrieri	53.24	9.00e-150	523.00
IUUC-Loc-051889	Lepisosteus oculatus	80.55	0.00e+00	823.00
IUUC-Lma-053041	Leptosphaeria maculans	49.88	4.00e-117	415.00
IUUC-Laf-053598	Loxodonta africana	96.62	0.00e+00	944.00
IUUC-Mcc-055660	Macaca mulatta	98.12	0.00e+00	961.00
IUUC-Meu-056197	Macropus eugenii	80.17	0.00e+00	774.00
IUUC-Mor-056949	Magnaporthe oryzae	45.96	2.00e-118	419.00
IUUC-Mpo-057571	Magnaporthe poae	52.78	2.00e-62	233.00
IUUC-Mtr-058530	Medicago truncatula	57.87	8.00e-165	573.00
IUUC-Mla-059133	Melampsora laricipopulina	46.75	8.00e-125	440.00
IUUC-Mga-059252	Meleagris gallopavo	84.38	0.00e+00	659.00
IUUC-Mvi-060522	Microbotryum violaceum	49.29	2.00e-135	476.00
IUUC-Mmr-061117	Microcebus murinus	96.21	0.00e+00	934.00
IUUC-Mdo-062892	Monodelphis domestica	89.43	0.00e+00	886.00
IUUC-Mmu-064108	Mus musculus	95.77	0.00e+00	909.00
IUUC-Mac-064430	Musa acuminata	58.89	9.00e-171	593.00
IUUC-Mpu-065882	Mustela putorius furo	95.77	0.00e+00	929.00
IUUC-Mlu-068123	Myotis lucifugus	96.62	0.00e+00	947.00
IUUC-Nfi-068484	Neosartorya fischeri	46.76	9.00e-119	420.00
IUUC-Ncr-068649	Neurospora crassa	43.96	5.00e-115	407.00
IUUC-Nle-069140	Nomascus leucogenys	98.73	0.00e+00	951.00
IUUC-Opr-070220	Ochotona princeps	88.96	0.00e+00	817.00
IUUC-Ont-072643	Oreochromis niloticus	80.42	0.00e+00	819.00
IUUC-Ocu-074007	Oryctolagus cuniculus	96.41	0.00e+00	910.00
IUUC-Oba-075904	Oryza barthii	58.46	1.00e-169	589.00
IUUC-Obr-076280	Oryza brachyantha	58.03	9.00e-169	586.00
IUUC-Ogl-077425	Oryza glaberrima	58.46	5.00e-170	590.00
IUUC-Ogu-078586	Oryza glumaepatula	58.46	1.00e-169	589.00
IUUC-Oin-079489	Oryza indica	56.32	5.00e-161	560.00
IUUC-Olo-080766	Oryza longistaminata	58.33	2.00e-169	588.00
IUUC-Ome-081905	Oryza meridionalis	58.46	9.00e-170	589.00
IUUC-Oni-083022	Oryza nivara	58.46	5.00e-170	590.00
IUUC-Opu-083615	Oryza punctata	58.46	9.00e-170	589.00
IUUC-Oru-085076	Oryza rufipogon	58.46	5.00e-170	590.00
IUUC-Osa-085744	Oryza sativa	58.67	2.00e-170	592.00
IUUC-Ola-087290	Oryzias latipes	78.11	0.00e+00	801.00
IUUC-Olu-087898	Ostreococcus lucimarinus	52.83	1.00e-144	506.00
IUUC-Oga-088980	Otolemur garnettii	95.75	0.00e+00	928.00
IUUC-Oar-089580	Ovis aries	95.61	0.00e+00	813.00
IUUC-Ptr-090845	Pan troglodytes	98.30	0.00e+00	946.00
IUUC-Pan-092836	Papio anubis	98.35	0.00e+00	974.00
IUUC-Psi-093965	Pelodiscus sinensis	82.46	4.00e-56	209.00
IUUC-Pno-095052	Phaeosphaeria nodorum	47.02	6.00e-122	431.00
IUUC-Ppa-095432	Physcomitrella patens	58.64	9.00e-170	589.00
IUUC-Pfo-096963	Poecilia formosa	72.00	0.00e+00	703.00
IUUC-Pab-097716	Pongo abelii	95.12	0.00e+00	907.00
IUUC-Pop-099224	Populus trichocarpa	58.72	2.00e-170	591.00
IUUC-Pca-100682	Procavia capensis	92.68	0.00e+00	676.00
IUUC-Ppe-101819	Prunus persica	58.42	6.00e-168	583.00
IUUC-Pva-102338	Pteropus vampyrus	96.37	0.00e+00	715.00
IUUC-Pgr-103583	Puccinia graminis	54.99	8.00e-133	467.00
IUUC-Ptt-103737	Puccinia triticina	44.80	8.00e-101	360.00
IUUC-Pte-104150	Pyrenophora teres	50.11	3.00e-121	428.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	50.11	3.00e-121	428.00
IUUC-Rno-105987	Rattus norvegicus	95.55	0.00e+00	931.00
IUUC-Sce-106315	Saccharomyces cerevisiae	47.45	2.00e-129	455.00
IUUC-Sha-107273	Sarcophilus harrisii	90.49	0.00e+00	900.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	46.75	2.00e-118	419.00
IUUC-Spo-108092	Schizosaccharomyces pombe	49.20	7.00e-124	437.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	43.78	9.00e-114	403.00
IUUC-Smo-108855	Selaginella moellendorffii	55.44	2.00e-162	565.00
IUUC-Sit-110329	Setaria italica	58.89	4.00e-170	591.00
IUUC-Sly-111830	Solanum lycopersicum	59.53	9.00e-173	599.00
IUUC-Stu-112603	Solanum tuberosum	59.53	1.00e-172	598.00
IUUC-Sar-113504	Sorex araneus	91.55	8.00e-74	270.00
IUUC-Sbi-114560	Sorghum bicolor	58.03	2.00e-167	582.00
IUUC-Sre-115133	Sporisorium reilianum	41.29	9.00e-123	434.00
IUUC-Ssc-115903	Sus scrofa	96.20	0.00e+00	937.00
IUUC-Tgu-116798	Taeniopygia guttata	85.20	0.00e+00	855.00
IUUC-Tru-118361	Takifugu rubripes	78.11	0.00e+00	801.00
IUUC-Tsy-118849	Tarsius syrichta	97.02	0.00e+00	936.00
IUUC-Tni-120094	Tetraodon nigroviridis	78.69	0.00e+00	802.00
IUUC-Tca-121634	Theobroma cacao	57.87	3.00e-166	578.00
IUUC-Tre-122051	Trichoderma reesei	45.30	7.00e-118	417.00
IUUC-Tvi-122322	Trichoderma virens	46.56	1.00e-121	429.00
IUUC-Tae-125822	Triticum aestivum	58.24	5.00e-169	587.00
IUUC-Tur-126766	Triticum urartu	52.00	1.00e-160	559.00
IUUC-Tme-127175	Tuber melanosporum	50.95	3.00e-130	458.00
IUUC-Tbe-127779	Tupaia belangeri	95.32	0.00e+00	828.00
IUUC-Ttr-128224	Tursiops truncatus	91.12	0.00e+00	802.00
IUUC-Uma-129537	Ustilago maydis	41.48	2.00e-123	436.00
IUUC-Vda-129927	Verticillium dahliae	44.98	6.00e-110	390.00
IUUC-Vpa-130658	Vicugna pacos	83.65	0.00e+00	788.00
IUUC-Vvi-131659	Vitis vinifera	58.42	9.00e-170	589.00
IUUC-Xtr-132918	Xenopus tropicalis	77.47	0.00e+00	791.00
IUUC-Xma-133700	Xiphophorus maculatus	80.21	0.00e+00	813.00
IUUC-Yli-134478	Yarrowia lipolytica	50.10	1.00e-137	483.00
IUUC-Zma-135835	Zea mays	55.58	2.00e-164	572.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence