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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105311
Ensembl Protein ID ENSRNOP00000005349.3
UniProt Accession Q5XIL2; P4K2B_RAT
Genbank Protein ID AAH83668.1
Protein Name Phosphatidylinositol 4-kinase type 2-beta; Phosphatidylinositol 4-kinase type II-beta
Genbank Nucleotide ID BC083668
Gene Name Pi4k2b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000003924.6 ENSRNOT00000005349.5 ENSRNOP00000005349.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UFD/MUB 28.82 5.00e-18 89.40 IUUC-Ath-007357
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity).
 Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity).
Protein Sequence
(Fasta)
MPEPPRDIMA EACEATRPSE DEDEEREPLL PRVAWAQPRR GAPGSAVRLQ ADQGAAVLRE 60
PATEEPPVVS EDRSISASLS TELDRTRNAV SETNTFLEDP EFADVVLKAE QAIEIGVFPE 120
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Protein Fasta Sequence


>IUUC-Rno-105311|ULD,MUB|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CTGGTGAGGT GGCGTCGGTG GGAGCGGTCC GCCGCGGTTC GGCGTGATGC TCGGGCCCCA 60
GTCCGGAGCC CGGCGGCTCT GAATGCCCGA GCCGCCCCGG GACATCATGG CGGAGGCCTG 120
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Nucleotide Fasta Sequence


>IUUC-Rno-105311|ULD,MUB|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR000403--PI3/4_kinase_cat_dom
Pfam

PF00454--PI3_PI4_kinase
Gene Ontology

GO:0005768--C:endosome
GO:0005886--C:plasma membrane
GO:0005802--C:trans-Golgi network
GO:0004430--F:1-phosphatidylinositol 4-kinase activity
GO:0005524--F:ATP binding
GO:0007032--P:endosome organization
GO:0007030--P:Golgi organization
GO:0046854--P:phosphatidylinositol phosphorylation
KEGG rno:305419
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000880 Aegilops tauschii 27.18 2.00e-14 74.30
IUUC-Aml-002168 Ailuropoda melanoleuca 78.88 0.00e+00 762.00
IUUC-Atr-002849 Amborella trichopoda 25.27 7.00e-14 72.40
IUUC-Apl-003641 Anas platyrhynchos 78.88 0.00e+00 666.00
IUUC-Aca-004310 Anolis carolinensis 71.05 0.00e+00 667.00
IUUC-Aly-006197 Arabidopsis lyrata 27.56 2.00e-17 84.30
IUUC-Ath-007357 Arabidopsis thaliana 29.37 5.00e-19 89.40
IUUC-Ago-007834 Ashbya gossypii 38.07 4.00e-61 229.00
IUUC-Acl-008056 Aspergillus clavatus 40.15 7.00e-48 185.00
IUUC-Afl-008443 Aspergillus flavus 39.62 7.00e-50 192.00
IUUC-Afu-008894 Aspergillus fumigatus 32.11 7.00e-53 202.00
IUUC-Ani-009242 Aspergillus nidulans 33.41 3.00e-65 243.00
IUUC-Ang-009698 Aspergillus niger 36.41 2.00e-72 267.00
IUUC-Aor-010129 Aspergillus oryzae 39.62 7.00e-50 192.00
IUUC-Ate-010366 Aspergillus terreus 39.53 4.00e-45 176.00
IUUC-Ame-011505 Astyanax mexicanus 56.11 3.00e-138 484.00
IUUC-Bgr-012207 Blumeria graminis 33.80 8.00e-65 241.00
IUUC-Bta-013130 Bos taurus 76.97 0.00e+00 721.00
IUUC-Bci-013857 Botrytis cinerea 33.04 7.00e-62 232.00
IUUC-Bdi-014227 Brachypodium distachyon 27.53 1.00e-14 75.10
IUUC-Bol-015769 Brassica oleracea 29.76 5.00e-19 89.40
IUUC-Bra-017779 Brassica rapa 29.27 3.00e-18 86.70
IUUC-Cel-018333 Caenorhabditis elegans 40.51 3.00e-64 238.00
IUUC-Cja-019512 Callithrix jacchus 80.22 0.00e+00 776.00
IUUC-Cfa-020046 Canis familiaris 87.24 0.00e+00 710.00
IUUC-Cpo-022524 Cavia porcellus 86.49 0.00e+00 684.00
IUUC-Cre-022842 Chlamydomonas reinhardtii 22.30 2.00e-04 39.30
IUUC-Csa-024215 Chlorocebus sabaeus 79.87 0.00e+00 751.00
IUUC-Cho-024651 Choloepus hoffmanni 74.63 4.00e-168 583.00
IUUC-Cin-025197 Ciona intestinalis 58.88 3.00e-145 508.00
IUUC-Csv-026330 Ciona savignyi 63.19 5.00e-148 517.00
IUUC-Cgl-026422 Colletotrichum gloeosporioides 34.43 1.00e-65 244.00
IUUC-Dre-028161 Danio rerio 76.05 0.00e+00 655.00
IUUC-Dno-029087 Dasypus novemcinctus 76.55 0.00e+00 724.00
IUUC-Dor-031108 Dipodomys ordii 74.07 0.00e+00 671.00
IUUC-Dse-031283 Dothistroma septosporum 33.56 8.00e-65 241.00
IUUC-Dme-032030 Drosophila melanogaster 65.92 3.00e-86 312.00
IUUC-Ete-032358 Echinops telfairi 70.83 3.00e-110 392.00
IUUC-Eca-034170 Equus caballus 84.75 0.00e+00 692.00
IUUC-Eeu-034549 Erinaceus europaeus 82.97 3.00e-92 332.00
IUUC-Fca-035541 Felis catus 79.30 0.00e+00 733.00
IUUC-Fal-037138 Ficedula albicollis 79.64 0.00e+00 663.00
IUUC-Fox-037982 Fusarium oxysporum 33.78 9.00e-62 231.00
IUUC-Fso-038407 Fusarium solani 43.68 7.00e-41 162.00
IUUC-Gmo-039406 Gadus morhua 61.47 2.00e-159 555.00
IUUC-Ggr-040017 Gaeumannomyces graminis 46.20 1.00e-39 158.00
IUUC-Gga-040594 Gallus gallus 78.76 0.00e+00 660.00
IUUC-Gac-041355 Gasterosteus aculeatus 77.60 0.00e+00 638.00
IUUC-Gma-044334 Glycine max 27.88 6.00e-16 79.30
IUUC-Ggo-044615 Gorilla gorilla 80.49 0.00e+00 748.00
IUUC-Hsa-046453 Homo sapiens 80.93 0.00e+00 756.00
IUUC-Hvu-047413 Hordeum vulgare 27.53 8.00e-15 75.50
IUUC-Itr-048839 Ictidomys tridecemlineatus 86.41 0.00e+00 726.00
IUUC-Kpa-049368 Komagataella pastoris 37.08 6.00e-69 255.00
IUUC-Lch-049861 Latimeria chalumnae 77.78 0.00e+00 655.00
IUUC-Lpe-051162 Leersia perrieri 26.30 3.00e-13 70.90
IUUC-Loc-052304 Lepisosteus oculatus 77.69 0.00e+00 653.00
IUUC-Lma-053303 Leptosphaeria maculans 34.64 2.00e-66 246.00
IUUC-Laf-053826 Loxodonta africana 79.78 0.00e+00 739.00
IUUC-Mcc-055372 Macaca mulatta 87.24 0.00e+00 721.00
IUUC-Meu-056312 Macropus eugenii 74.62 9.00e-173 599.00
IUUC-Mor-056958 Magnaporthe oryzae 45.41 2.00e-39 157.00
IUUC-Mpo-057554 Magnaporthe poae 45.41 1.00e-40 162.00
IUUC-Mtr-058162 Medicago truncatula 27.62 2.00e-16 80.90
IUUC-Mla-059000 Melampsora laricipopulina 38.12 1.00e-51 197.00
IUUC-Mga-059856 Meleagris gallopavo 78.61 0.00e+00 660.00
IUUC-Mvi-060280 Microbotryum violaceum 44.20 7.00e-34 139.00
IUUC-Mmr-061773 Microcebus murinus 85.38 0.00e+00 716.00
IUUC-Mdo-061817 Monodelphis domestica 82.82 0.00e+00 674.00
IUUC-Mmu-064384 Mus musculus 94.88 0.00e+00 900.00
IUUC-Mpu-066590 Mustela putorius furo 77.30 0.00e+00 754.00
IUUC-Mlu-067287 Myotis lucifugus 74.41 0.00e+00 697.00
IUUC-Nfi-068333 Neosartorya fischeri 34.44 2.00e-64 240.00
IUUC-Ncr-068800 Neurospora crassa 38.52 1.00e-48 188.00
IUUC-Nle-069534 Nomascus leucogenys 80.71 0.00e+00 753.00
IUUC-Opr-071136 Ochotona princeps 67.11 2.00e-172 598.00
IUUC-Ont-071667 Oreochromis niloticus 79.22 0.00e+00 656.00
IUUC-Oan-073489 Ornithorhynchus anatinus 81.61 0.00e+00 665.00
IUUC-Ocu-074482 Oryctolagus cuniculus 87.95 0.00e+00 733.00
IUUC-Oba-075382 Oryza barthii 26.64 1.00e-14 74.70
IUUC-Obr-076060 Oryza brachyantha 27.18 3.00e-16 80.50
IUUC-Ogl-077532 Oryza glaberrima 27.86 1.00e-15 77.80
IUUC-Ogu-078353 Oryza glumaepatula 26.64 1.00e-14 75.50
IUUC-Oin-079936 Oryza indica 26.64 1.00e-14 75.10
IUUC-Olo-080229 Oryza longistaminata 28.01 5.00e-17 82.80
IUUC-Ome-081667 Oryza meridionalis 26.64 9.00e-15 75.50
IUUC-Oni-082917 Oryza nivara 26.64 1.00e-14 75.10
IUUC-Opu-084094 Oryza punctata 28.06 1.00e-16 81.60
IUUC-Oru-084647 Oryza rufipogon 26.64 1.00e-14 74.70
IUUC-Osa-086157 Oryza sativa 26.64 1.00e-14 75.10
IUUC-Ola-086957 Oryzias latipes 78.44 0.00e+00 642.00
IUUC-Olu-087862 Ostreococcus lucimarinus 24.34 2.00e-10 58.90
IUUC-Oga-088698 Otolemur garnettii 78.35 0.00e+00 751.00
IUUC-Oar-090389 Ovis aries 76.97 0.00e+00 720.00
IUUC-Ptr-090638 Pan troglodytes 79.96 0.00e+00 766.00
IUUC-Pan-092030 Papio anubis 71.65 0.00e+00 651.00
IUUC-Psi-093599 Pelodiscus sinensis 75.61 0.00e+00 672.00
IUUC-Pma-094719 Petromyzon marinus 65.40 2.00e-135 475.00
IUUC-Pno-094843 Phaeosphaeria nodorum 31.50 6.00e-55 209.00
IUUC-Pfo-096221 Poecilia formosa 80.83 0.00e+00 660.00
IUUC-Pab-097653 Pongo abelii 80.49 0.00e+00 754.00
IUUC-Pop-099957 Populus trichocarpa 27.15 1.00e-16 81.60
IUUC-Pca-100747 Procavia capensis 51.56 3.00e-70 259.00
IUUC-Ppe-101716 Prunus persica 27.21 3.00e-15 77.00
IUUC-Pva-102926 Pteropus vampyrus 76.99 0.00e+00 728.00
IUUC-Pte-104342 Pyrenophora teres 44.31 8.00e-38 152.00
IUUC-Sce-106456 Saccharomyces cerevisiae 34.15 3.00e-59 223.00
IUUC-Sha-106794 Sarcophilus harrisii 82.78 0.00e+00 689.00
IUUC-Sja-107883 Schizosaccharomyces japonicus 38.32 9.00e-61 228.00
IUUC-Spo-108111 Schizosaccharomyces pombe 35.20 2.00e-59 223.00
IUUC-Ssl-108516 Sclerotinia sclerotiorum 32.82 4.00e-61 229.00
IUUC-Smo-109156 Selaginella moellendorffii 31.23 4.00e-16 79.30
IUUC-Sit-110535 Setaria italica 28.57 4.00e-15 76.60
IUUC-Sly-111242 Solanum lycopersicum 27.56 3.00e-17 83.60
IUUC-Stu-111951 Solanum tuberosum 27.56 1.00e-16 82.00
IUUC-Sar-113055 Sorex araneus 82.90 0.00e+00 682.00
IUUC-Sbi-114147 Sorghum bicolor 28.47 8.00e-16 79.00
IUUC-Sre-114896 Sporisorium reilianum 46.05 2.00e-32 134.00
IUUC-Ssc-115853 Sus scrofa 68.91 4.00e-158 550.00
IUUC-Tgu-116711 Taeniopygia guttata 79.64 0.00e+00 665.00
IUUC-Tru-118416 Takifugu rubripes 74.45 0.00e+00 636.00
IUUC-Tsy-119014 Tarsius syrichta 84.86 0.00e+00 725.00
IUUC-Tni-120317 Tetraodon nigroviridis 78.44 0.00e+00 644.00
IUUC-Tca-121419 Theobroma cacao 27.21 1.00e-15 78.20
IUUC-Tre-122021 Trichoderma reesei 44.74 5.00e-40 159.00
IUUC-Tvi-122384 Trichoderma virens 42.93 2.00e-36 147.00
IUUC-Tae-122680 Triticum aestivum 27.53 5.00e-15 76.30
IUUC-Tur-126000 Triticum urartu 26.77 5.00e-13 69.30
IUUC-Tme-127049 Tuber melanosporum 37.69 3.00e-70 259.00
IUUC-Tbe-127365 Tupaia belangeri 76.92 3.00e-179 620.00
IUUC-Ttr-129032 Tursiops truncatus 78.19 0.00e+00 738.00
IUUC-Uma-129477 Ustilago maydis 44.74 2.00e-31 131.00
IUUC-Vda-129801 Verticillium dahliae 32.75 4.00e-65 243.00
IUUC-Vpa-130255 Vicugna pacos 80.10 0.00e+00 642.00
IUUC-Vvi-131314 Vitis vinifera 25.83 2.00e-17 84.30
IUUC-Xtr-132347 Xenopus tropicalis 72.11 0.00e+00 676.00
IUUC-Xma-133726 Xiphophorus maculatus 80.05 0.00e+00 657.00
IUUC-Yli-134389 Yarrowia lipolytica 38.77 1.00e-74 274.00
IUUC-Zma-134858 Zea mays 28.47 2.00e-14 74.30
Created Date 25-Jun-2017

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