• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063402
UUCD1 version UUC-MuM-00372
Ensembl Protein ID ENSMUSP00000016680.7
UniProt Accession Q3TCH7; Q3THM3; Q91Z44; CUL4A_MOUSE
Genbank Protein ID BAE40173.1; BAE41979.1; AAH10211.2
Protein Name Cullin-4A
Genbank Nucleotide ID AK168215; AK170722; BC010211
Gene Name Cul4a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031446.14 ENSMUST00000016680.13 ENSMUSP00000016680.7
ENSMUSG00000031446.14 ENSMUST00000121426.1 ENSMUSP00000112525.1
ENSMUSG00000031446.14 ENSMUST00000125514.7 ENSMUSP00000123074.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 6.30e-220 733.1 65 660
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eavk+i++++s+++++eely+av+nlc++kv+  lYk+l++v+e+++ +q+   +e+s d+  +Lk++n++W+++++q+ ++r+if
   Q: 65   KLHEAVKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVqAQILPFREDSLDSVlFLKKINTCWQDHCRQMIMIRSIF 153
           5899**********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r++i++d  +++++++ +l li +eR+geavdr+ll+++ ++l++L     ++yk+sFE kfle
   Q: 154  LFLDRTYVLQNSMLPSIWDMGLELFRNHIISDrmVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSDL-----QVYKDSFELKFLE 237
           *******************************************************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+ +y+ae ++++q +ev eYl++v +rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++my+L+
   Q: 238  ETNCLYAAEGQRLMQDREVPEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILqKGLEHLLDENRVPDLTQMYQLF 326
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g + ll++++++ik+ g+++++++ek+kd   +V++ll++k+k++++v+ +F+ +++F++ ++++fetf+nk+     +++p E
   Q: 327  SRVKGGQHALLQHWSEYIKTFGTTIVINPEKDKD---MVQDLLDFKDKVDHVVEVCFQRNERFINLMKESFETFINKR-----PNKPaE 407
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+++D++Lr+++k++t+eele++ldk++++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 408  LIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 496
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkk 528
           d+++S+d++ +Fk++++n+++   ++l+v++L++g+Wpt++ +e v+LP+e+ +++e f++fYl khsgRkLqWq+tlg+a lka +k+
   Q: 497  DMELSKDIMVHFKQHMQNQSAPGPIDLTVNILTMGYWPTYTPME-VHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKE 584
           ****************************************9999.******************************************** PP
   S: 529  gkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           gk+e+qVs fQ++vLL+fn+ + +s+ee+k+at+++++eLrrtlqsL+++k++vl k+p++ke+e++d+f++N +f
   Q: 585  GKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNADF 660
           *************************************************************************998 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL (By similarity).
 Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL (By similarity).
Protein Sequence
(Fasta)
MADEGPRKGS VSALMGRTNG LTKPAALAGG PAKPGGTGGS RKLVIKNFRD RPRLPDNYTQ 60
DTWRKLHEAV KAIQSSTSIR YNLEELYQAV ENLCSHKVSP TLYKQLRQVC EDHVQAQILP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063402|E3,Cullin|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGAAAGAG GAGGAGCCGA GCGCTCACGG GCGGAGCCCG ACAGCAGCAG GAGGAGGAGC 60
CGGGCGCGCA CGGAGCGGGC GCAGGGCAGG AGGAGGAGCC GGGCGGCGCG GGGCGGGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063402|E3,Cullin|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0045732--P:positive regulation of protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process
KEGG mmu:99375
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001592 Ailuropoda melanoleuca 93.36 0.00e+00 1367.00
IUUC-Apl-003269 Anas platyrhynchos 91.97 0.00e+00 1327.00
IUUC-Afu-008833 Aspergillus fumigatus 38.29 1.00e-131 464.00
IUUC-Ani-009373 Aspergillus nidulans 40.05 3.00e-137 483.00
IUUC-Ate-010251 Aspergillus terreus 39.63 1.00e-138 487.00
IUUC-Bta-012355 Bos taurus 93.19 0.00e+00 1370.00
IUUC-Cja-019861 Callithrix jacchus 95.11 0.00e+00 1394.00
IUUC-Cfa-021009 Canis familiaris 92.90 0.00e+00 1419.00
IUUC-Cpo-021867 Cavia porcellus 96.44 0.00e+00 1464.00
IUUC-Csa-024139 Chlorocebus sabaeus 95.13 0.00e+00 1424.00
IUUC-Cho-024899 Choloepus hoffmanni 95.83 0.00e+00 1003.00
IUUC-Cin-025727 Ciona intestinalis 62.54 0.00e+00 768.00
IUUC-Cme-027355 Cyanidioschyzon merolae 33.38 3.00e-114 406.00
IUUC-Dno-028879 Dasypus novemcinctus 86.72 0.00e+00 1319.00
IUUC-Dor-030698 Dipodomys ordii 97.23 0.00e+00 1439.00
IUUC-Ete-033101 Echinops telfairi 89.33 0.00e+00 1268.00
IUUC-Eca-033696 Equus caballus 94.05 0.00e+00 1370.00
IUUC-Fca-036333 Felis catus 94.09 0.00e+00 1362.00
IUUC-Fal-036995 Ficedula albicollis 91.66 0.00e+00 1339.00
IUUC-Gga-040358 Gallus gallus 88.92 0.00e+00 1370.00
IUUC-Hsa-045679 Homo sapiens 95.13 0.00e+00 1425.00
IUUC-Itr-048182 Ictidomys tridecemlineatus 95.85 0.00e+00 1318.00
IUUC-Lch-050417 Latimeria chalumnae 87.24 0.00e+00 1337.00
IUUC-Loc-051804 Lepisosteus oculatus 83.91 0.00e+00 1278.00
IUUC-Laf-054100 Loxodonta africana 93.47 0.00e+00 1362.00
IUUC-Mcc-055168 Macaca mulatta 95.74 0.00e+00 1276.00
IUUC-Meu-056492 Macropus eugenii 74.38 1.00e-172 600.00
IUUC-Mga-059866 Meleagris gallopavo 92.28 0.00e+00 1335.00
IUUC-Mmr-061551 Microcebus murinus 93.94 0.00e+00 1407.00
IUUC-Mdo-062215 Monodelphis domestica 91.37 0.00e+00 1408.00
IUUC-Mpu-066383 Mustela putorius furo 94.25 0.00e+00 1363.00
IUUC-Mlu-067450 Myotis lucifugus 88.74 0.00e+00 1347.00
IUUC-Nle-069606 Nomascus leucogenys 94.99 0.00e+00 1425.00
IUUC-Opr-070671 Ochotona princeps 84.82 8.00e-117 414.00
IUUC-Oan-073299 Ornithorhynchus anatinus 87.48 0.00e+00 1343.00
IUUC-Ocu-074731 Oryctolagus cuniculus 95.65 0.00e+00 1447.00
IUUC-Oar-089346 Ovis aries 92.90 0.00e+00 1362.00
IUUC-Ptr-091177 Pan troglodytes 95.13 0.00e+00 1425.00
IUUC-Pan-092191 Papio anubis 94.49 0.00e+00 1413.00
IUUC-Pab-097622 Pongo abelii 94.60 0.00e+00 1418.00
IUUC-Pca-100391 Procavia capensis 85.29 0.00e+00 1009.00
IUUC-Pgr-103334 Puccinia graminis 34.55 3.00e-106 380.00
IUUC-Ptt-103903 Puccinia triticina 41.85 2.00e-97 350.00
IUUC-Rno-105829 Rattus norvegicus 99.74 0.00e+00 1536.00
IUUC-Sha-106762 Sarcophilus harrisii 93.61 0.00e+00 1326.00
IUUC-Sre-114943 Sporisorium reilianum 38.19 1.00e-129 457.00
IUUC-Ssc-116133 Sus scrofa 92.51 0.00e+00 1392.00
IUUC-Tgu-116961 Taeniopygia guttata 91.26 0.00e+00 1336.00
IUUC-Tre-121907 Trichoderma reesei 39.82 4.00e-129 455.00
IUUC-Tvi-122568 Trichoderma virens 39.41 2.00e-129 456.00
IUUC-Ttr-128326 Tursiops truncatus 88.20 0.00e+00 1176.00
IUUC-Uma-129531 Ustilago maydis 38.08 7.00e-110 391.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved