iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051847

Ensembl Protein ID

ENSLOCP00000011985.1

UniProt Accession

W5MUC6; W5MUC6_LEPOC

Genbank Protein ID

ENSLOCP00000011985

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Genbank Nucleotide ID

AHAT01012875

Gene Name

rnf168; RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000009810.1	ENSLOCT00000012006.1	ENSLOCP00000011985.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.00e-07	30.6	18	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle f + p++lpCgH+f+++C+ q +       + +  CPlCr
   Q: 18   CSVCLEIFLE-PVTLPCGHTFCKTCFqQTV------YKASMCCPLCR 57
           ********99.9**************5555......888999****8 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MPEVPKEEEQ LSHADCICSV CLEIFLEPVT LPCGHTFCKT CFQQTVYKAS MCCPLCRKRV 60
STWCRLHSRN KTLVNAELWR KVQAAFPLQC QRKLSGQDAD DSCRTLVPLR TISKPGELRE 120

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Nucleotide Sequence
(Fasta)

CGCAGGCGCA GTATCACTCC TCCAGCTCAG ATTCCCGGGT TGGTTGATTT ACAAAGGGTG 60
AAAAAAGCAT TTATTTTTTA CGTTGTGAAT TAGGAAACGG GTTTGTTTTC TTTAGAATGT 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	36.78	3.00e-11	63.20
IUUC-Aml-001573	Ailuropoda melanoleuca	38.97	4.00e-47	182.00
IUUC-Atr-002992	Amborella trichopoda	40.00	6.00e-11	61.60
IUUC-Apl-003963	Anas platyrhynchos	43.17	2.00e-48	186.00
IUUC-Aca-004420	Anolis carolinensis	59.12	1.00e-41	164.00
IUUC-Ath-007019	Arabidopsis thaliana	36.36	3.00e-10	60.80
IUUC-Ame-011521	Astyanax mexicanus	55.82	6.00e-54	204.00
IUUC-Bta-013002	Bos taurus	35.95	3.00e-43	169.00
IUUC-Bol-016180	Brassica oleracea	35.96	1.00e-10	60.80
IUUC-Bra-017905	Brassica rapa	35.96	1.00e-10	60.50
IUUC-Cja-019945	Callithrix jacchus	36.12	8.00e-48	184.00
IUUC-Cfa-020533	Canis familiaris	36.36	2.00e-48	186.00
IUUC-Cpo-021643	Cavia porcellus	45.21	7.00e-36	145.00
IUUC-Csa-023638	Chlorocebus sabaeus	34.94	1.00e-48	187.00
IUUC-Cho-024319	Choloepus hoffmanni	34.75	5.00e-39	155.00
IUUC-Cin-025679	Ciona intestinalis	32.39	3.00e-21	95.50
IUUC-Csv-026052	Ciona savignyi	30.56	1.00e-21	96.30
IUUC-Dre-028519	Danio rerio	43.76	2.00e-53	202.00
IUUC-Dno-029294	Dasypus novemcinctus	36.16	5.00e-45	175.00
IUUC-Ete-032714	Echinops telfairi	50.93	3.00e-31	129.00
IUUC-Eca-033343	Equus caballus	36.06	4.00e-50	192.00
IUUC-Fca-036251	Felis catus	36.73	2.00e-51	197.00
IUUC-Fal-037048	Ficedula albicollis	44.60	7.00e-48	184.00
IUUC-Gmo-039400	Gadus morhua	59.17	6.00e-39	152.00
IUUC-Gga-040444	Gallus gallus	36.38	1.00e-51	197.00
IUUC-Gac-041735	Gasterosteus aculeatus	55.61	4.00e-45	174.00
IUUC-Gma-044332	Glycine max	33.64	3.00e-12	66.20
IUUC-Hsa-046424	Homo sapiens	35.64	5.00e-44	172.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	36.14	6.00e-35	142.00
IUUC-Lch-050649	Latimeria chalumnae	35.27	1.00e-45	177.00
IUUC-Laf-053938	Loxodonta africana	32.15	9.00e-50	191.00
IUUC-Mcc-055360	Macaca mulatta	35.23	3.00e-44	173.00
IUUC-Meu-056684	Macropus eugenii	47.34	1.00e-36	147.00
IUUC-Mga-059699	Meleagris gallopavo	37.94	4.00e-53	202.00
IUUC-Mmr-060779	Microcebus murinus	36.02	1.00e-49	191.00
IUUC-Mdo-062225	Monodelphis domestica	33.74	1.00e-45	177.00
IUUC-Mmu-064239	Mus musculus	35.14	2.00e-39	157.00
IUUC-Mpu-066141	Mustela putorius furo	36.76	5.00e-53	202.00
IUUC-Mlu-067945	Myotis lucifugus	36.95	6.00e-48	185.00
IUUC-Nle-069769	Nomascus leucogenys	35.16	8.00e-43	168.00
IUUC-Opr-070905	Ochotona princeps	33.47	6.00e-36	145.00
IUUC-Ont-071477	Oreochromis niloticus	55.45	1.00e-47	183.00
IUUC-Oan-073587	Ornithorhynchus anatinus	53.78	2.00e-37	147.00
IUUC-Ocu-073832	Oryctolagus cuniculus	36.97	7.00e-44	171.00
IUUC-Obr-076219	Oryza brachyantha	39.08	1.00e-11	64.30
IUUC-Ogl-077658	Oryza glaberrima	40.23	5.00e-12	65.50
IUUC-Ogu-078203	Oryza glumaepatula	39.08	1.00e-11	64.30
IUUC-Oin-079383	Oryza indica	40.23	5.00e-12	65.10
IUUC-Ome-081482	Oryza meridionalis	40.23	5.00e-12	65.50
IUUC-Oni-083025	Oryza nivara	40.23	5.00e-12	65.10
IUUC-Opu-083547	Oryza punctata	40.23	4.00e-12	65.50
IUUC-Oru-084946	Oryza rufipogon	33.66	5.00e-08	52.00
IUUC-Osa-085978	Oryza sativa	40.23	5.00e-12	65.10
IUUC-Ola-086478	Oryzias latipes	66.67	4.00e-46	176.00
IUUC-Oga-088318	Otolemur garnettii	36.08	5.00e-42	165.00
IUUC-Oar-089647	Ovis aries	35.79	2.00e-45	177.00
IUUC-Ptr-090516	Pan troglodytes	41.20	3.00e-42	166.00
IUUC-Pan-092302	Papio anubis	34.85	7.00e-45	175.00
IUUC-Psi-093604	Pelodiscus sinensis	52.52	1.00e-42	167.00
IUUC-Pfo-096441	Poecilia formosa	42.22	1.00e-43	170.00
IUUC-Pab-097729	Pongo abelii	39.46	2.00e-39	157.00
IUUC-Pop-099737	Populus trichocarpa	38.78	7.00e-11	62.80
IUUC-Pca-100552	Procavia capensis	50.00	3.00e-28	119.00
IUUC-Ppe-102024	Prunus persica	41.24	1.00e-12	68.60
IUUC-Pva-102780	Pteropus vampyrus	35.76	6.00e-46	178.00
IUUC-Rno-105461	Rattus norvegicus	34.66	7.00e-46	178.00
IUUC-Sha-106809	Sarcophilus harrisii	36.34	5.00e-52	198.00
IUUC-Sly-111317	Solanum lycopersicum	35.09	2.00e-13	70.50
IUUC-Stu-112446	Solanum tuberosum	36.73	3.00e-13	69.70
IUUC-Sar-113579	Sorex araneus	36.38	7.00e-41	161.00
IUUC-Sbi-113834	Sorghum bicolor	35.92	4.00e-13	68.90
IUUC-Tgu-117187	Taeniopygia guttata	54.48	1.00e-43	169.00
IUUC-Tru-118182	Takifugu rubripes	47.18	6.00e-40	158.00
IUUC-Tni-120205	Tetraodon nigroviridis	67.14	3.00e-49	189.00
IUUC-Tca-121416	Theobroma cacao	42.50	2.00e-12	66.60
IUUC-Tvi-122557	Trichoderma virens	43.48	3.00e-05	43.10
IUUC-Tae-123092	Triticum aestivum	36.78	3.00e-11	63.20
IUUC-Tur-126688	Triticum urartu	35.63	2.00e-11	63.20
IUUC-Tbe-127622	Tupaia belangeri	35.00	6.00e-49	188.00
IUUC-Ttr-128988	Tursiops truncatus	36.76	2.00e-48	187.00
IUUC-Vpa-130302	Vicugna pacos	52.14	8.00e-37	148.00
IUUC-Vvi-131424	Vitis vinifera	38.14	6.00e-11	61.60
IUUC-Xtr-132196	Xenopus tropicalis	38.72	1.00e-52	200.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence