iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000006119.3	ENSMMUT00000061492.1	ENSMMUP00000041630.1
ENSMMUG00000006119.3	ENSMMUT00000008556.3	ENSMMUP00000008043.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-11	45.4	172	204

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           H+  ++++++  d t++v++s D+t k++D +t
   Q: 172  HSRQINDIQLsRDmTMFVTASKDNTAKLFDSTT 204
           999********888****************877 PP

Organism

Macaca mulatta

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

MGIKPILLQG HERSITQIKY NREGDLLFTV AKDPVSVALG TYMGPYRAVW CVDAERVCLF 60
CPDSCLFPGK QLALLKTNSA VRTCGFDFGG NIIMFSTDKQ MGYQCFVSFF DLRDPSQIDN 120

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Nucleotide Sequence
(Fasta)

ATGGGTATTG CAGTGGGCGT CCTGGGCTGA GGCCGGGGCC CAATTCCGAG CACTGACGTT 60
ACCATCTTGT CCCCACAGAA GCCGATCCTA CTGCAGGGCC ATGAGCGGTC CATTACGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR027525--eIF3i
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000115	Aegilops tauschii	57.52	2.00e-34	140.00
IUUC-Aml-001321	Ailuropoda melanoleuca	88.27	1.00e-165	575.00
IUUC-Atr-002468	Amborella trichopoda	51.05	9.00e-53	199.00
IUUC-Apl-003841	Anas platyrhynchos	83.95	4.00e-156	543.00
IUUC-Aca-005123	Anolis carolinensis	81.54	5.00e-153	533.00
IUUC-Aly-005473	Arabidopsis lyrata	40.55	5.00e-65	241.00
IUUC-Ath-007094	Arabidopsis thaliana	41.77	4.00e-67	248.00
IUUC-Ago-008000	Ashbya gossypii	40.18	5.00e-63	234.00
IUUC-Acl-008098	Aspergillus clavatus	47.89	1.00e-83	302.00
IUUC-Afl-008494	Aspergillus flavus	47.09	4.00e-82	298.00
IUUC-Afu-009080	Aspergillus fumigatus	47.89	1.00e-83	302.00
IUUC-Ani-009230	Aspergillus nidulans	47.87	2.00e-83	302.00
IUUC-Aor-010114	Aspergillus oryzae	47.09	4.00e-82	298.00
IUUC-Ate-010285	Aspergillus terreus	49.09	5.00e-86	310.00
IUUC-Ame-011534	Astyanax mexicanus	70.95	2.00e-138	484.00
IUUC-Bgr-012121	Blumeria graminis	43.77	2.00e-73	269.00
IUUC-Bta-013143	Bos taurus	87.69	2.00e-165	575.00
IUUC-Bci-013950	Botrytis cinerea	46.79	1.00e-80	293.00
IUUC-Bdi-015019	Brachypodium distachyon	41.10	6.00e-68	251.00
IUUC-Bol-015709	Brassica oleracea	40.61	7.00e-63	235.00
IUUC-Bra-017760	Brassica rapa	40.61	4.00e-63	235.00
IUUC-Cel-018226	Caenorhabditis elegans	38.11	2.00e-63	235.00
IUUC-Cja-019741	Callithrix jacchus	88.62	5.00e-167	579.00
IUUC-Cfa-021204	Canis familiaris	88.58	3.00e-166	577.00
IUUC-Cpo-021661	Cavia porcellus	88.27	6.00e-166	576.00
IUUC-Cre-022952	Chlamydomonas reinhardtii	39.63	1.00e-63	236.00
IUUC-Csa-024038	Chlorocebus sabaeus	88.62	5.00e-167	579.00
IUUC-Cin-025597	Ciona intestinalis	52.74	9.00e-93	333.00
IUUC-Cgl-026583	Colletotrichum gloeosporioides	45.57	7.00e-77	280.00
IUUC-Cne-026838	Cryptococcus neoformans	44.04	3.00e-74	271.00
IUUC-Cme-027304	Cyanidioschyzon merolae	38.63	1.00e-57	216.00
IUUC-Dre-028567	Danio rerio	72.92	1.00e-140	492.00
IUUC-Dno-029171	Dasypus novemcinctus	87.96	5.00e-164	570.00
IUUC-Dor-030257	Dipodomys ordii	77.27	1.00e-72	266.00
IUUC-Dse-031191	Dothistroma septosporum	45.29	3.00e-74	271.00
IUUC-Dme-031879	Drosophila melanogaster	54.91	1.00e-97	349.00
IUUC-Ete-032336	Echinops telfairi	97.66	2.00e-125	441.00
IUUC-Eca-033259	Equus caballus	88.58	3.00e-166	577.00
IUUC-Eeu-035153	Erinaceus europaeus	77.85	7.00e-61	227.00
IUUC-Fca-036489	Felis catus	88.58	3.00e-166	577.00
IUUC-Fal-037485	Ficedula albicollis	83.33	3.00e-155	540.00
IUUC-Fox-037860	Fusarium oxysporum	45.87	5.00e-77	281.00
IUUC-Fso-038188	Fusarium solani	46.48	2.00e-76	278.00
IUUC-Gmo-039311	Gadus morhua	74.69	9.00e-142	496.00
IUUC-Ggr-040045	Gaeumannomyces graminis	45.87	3.00e-78	285.00
IUUC-Gga-040645	Gallus gallus	82.28	4.00e-156	543.00
IUUC-Gac-042086	Gasterosteus aculeatus	73.85	2.00e-140	491.00
IUUC-Gma-043246	Glycine max	41.10	3.00e-67	248.00
IUUC-Ggo-045578	Gorilla gorilla	88.62	5.00e-167	579.00
IUUC-Hsa-046734	Homo sapiens	88.62	5.00e-167	579.00
IUUC-Hvu-047553	Hordeum vulgare	41.41	4.00e-69	254.00
IUUC-Itr-048467	Ictidomys tridecemlineatus	88.58	2.00e-166	577.00
IUUC-Kpa-049325	Komagataella pastoris	38.65	3.00e-63	235.00
IUUC-Lch-049620	Latimeria chalumnae	76.17	1.00e-129	455.00
IUUC-Lpe-051338	Leersia perrieri	40.71	4.00e-61	228.00
IUUC-Loc-052094	Lepisosteus oculatus	69.66	4.00e-126	444.00
IUUC-Lma-053047	Leptosphaeria maculans	44.21	4.00e-75	274.00
IUUC-Laf-053801	Loxodonta africana	88.36	1.00e-162	565.00
IUUC-Meu-056729	Macropus eugenii	85.28	4.00e-160	556.00
IUUC-Mor-057025	Magnaporthe oryzae	46.79	6.00e-77	280.00
IUUC-Mpo-057511	Magnaporthe poae	46.79	2.00e-78	285.00
IUUC-Mtr-058051	Medicago truncatula	42.51	6.00e-68	250.00
IUUC-Mla-059061	Melampsora laricipopulina	41.74	2.00e-63	236.00
IUUC-Mga-059229	Meleagris gallopavo	83.13	6.00e-155	540.00
IUUC-Mvi-060399	Microbotryum violaceum	41.27	3.00e-64	238.00
IUUC-Mmr-060764	Microcebus murinus	88.00	6.00e-166	576.00
IUUC-Mdo-062088	Monodelphis domestica	87.08	1.00e-161	561.00
IUUC-Mmu-064304	Mus musculus	88.00	2.00e-166	577.00
IUUC-Mac-065520	Musa acuminata	42.55	7.00e-69	253.00
IUUC-Mpu-066340	Mustela putorius furo	88.58	3.00e-166	577.00
IUUC-Mlu-067111	Myotis lucifugus	88.27	1.00e-165	575.00
IUUC-Nfi-068478	Neosartorya fischeri	47.29	3.00e-83	301.00
IUUC-Ncr-068820	Neurospora crassa	47.71	9.00e-79	286.00
IUUC-Nle-069903	Nomascus leucogenys	88.58	2.00e-166	577.00
IUUC-Opr-070221	Ochotona princeps	85.54	7.00e-160	556.00
IUUC-Ont-071765	Oreochromis niloticus	74.46	8.00e-143	499.00
IUUC-Oan-073660	Ornithorhynchus anatinus	86.88	7.00e-142	496.00
IUUC-Ocu-074039	Oryctolagus cuniculus	88.89	7.00e-167	579.00
IUUC-Oba-075856	Oryza barthii	38.96	3.00e-60	224.00
IUUC-Obr-076334	Oryza brachyantha	38.96	8.00e-63	233.00
IUUC-Ogl-077060	Oryza glaberrima	40.98	1.00e-64	239.00
IUUC-Ogu-078207	Oryza glumaepatula	41.23	4.00e-67	248.00
IUUC-Oin-079878	Oryza indica	40.80	3.00e-66	244.00
IUUC-Olo-080677	Oryza longistaminata	34.47	1.00e-56	213.00
IUUC-Oni-082411	Oryza nivara	34.55	4.00e-49	187.00
IUUC-Opu-083136	Oryza punctata	39.88	5.00e-65	241.00
IUUC-Oru-084916	Oryza rufipogon	39.70	2.00e-64	239.00
IUUC-Osa-085454	Oryza sativa	40.80	3.00e-66	244.00
IUUC-Ola-087053	Oryzias latipes	74.77	3.00e-142	498.00
IUUC-Olu-087602	Ostreococcus lucimarinus	43.17	3.00e-70	258.00
IUUC-Oga-088154	Otolemur garnettii	88.58	3.00e-166	577.00
IUUC-Oar-089915	Ovis aries	88.58	3.00e-165	574.00
IUUC-Ptr-091124	Pan troglodytes	72.87	2.00e-129	454.00
IUUC-Pan-092035	Papio anubis	88.62	5.00e-167	579.00
IUUC-Psi-094096	Pelodiscus sinensis	89.40	7.00e-118	416.00
IUUC-Pno-094988	Phaeosphaeria nodorum	41.52	5.00e-68	251.00
IUUC-Ppa-095536	Physcomitrella patens	43.69	8.00e-72	263.00
IUUC-Pfo-096101	Poecilia formosa	73.85	3.00e-141	494.00
IUUC-Pab-097726	Pongo abelii	88.62	5.00e-167	579.00
IUUC-Pop-099617	Populus trichocarpa	42.64	6.00e-70	257.00
IUUC-Pca-101014	Procavia capensis	88.31	2.00e-166	578.00
IUUC-Ppe-101320	Prunus persica	42.99	3.00e-66	244.00
IUUC-Pva-102789	Pteropus vampyrus	76.31	1.00e-133	468.00
IUUC-Pgr-103479	Puccinia graminis	41.43	1.00e-63	237.00
IUUC-Ptt-103981	Puccinia triticina	41.74	2.00e-65	242.00
IUUC-Pte-104278	Pyrenophora teres	44.82	5.00e-74	271.00
IUUC-Pyt-104492	Pyrenophora triticirepentis	44.82	5.00e-74	271.00
IUUC-Rno-105867	Rattus norvegicus	65.95	2.00e-108	385.00
IUUC-Sce-106251	Saccharomyces cerevisiae	38.14	2.00e-62	233.00
IUUC-Sha-107039	Sarcophilus harrisii	86.15	2.00e-161	561.00
IUUC-Sja-107758	Schizosaccharomyces japonicus	45.40	9.00e-75	273.00
IUUC-Spo-108314	Schizosaccharomyces pombe	43.25	1.00e-70	259.00
IUUC-Ssl-108478	Sclerotinia sclerotiorum	46.18	6.00e-80	290.00
IUUC-Smo-108728	Selaginella moellendorffii	42.46	1.00e-67	249.00
IUUC-Sit-110801	Setaria italica	40.49	4.00e-67	248.00
IUUC-Sly-111326	Solanum lycopersicum	41.90	1.00e-67	249.00
IUUC-Stu-112458	Solanum tuberosum	42.99	1.00e-67	249.00
IUUC-Sbi-114063	Sorghum bicolor	40.49	8.00e-67	246.00
IUUC-Sre-115096	Sporisorium reilianum	41.69	4.00e-65	241.00
IUUC-Ssc-116080	Sus scrofa	88.00	8.00e-166	575.00
IUUC-Tgu-116988	Taeniopygia guttata	83.02	9.00e-155	539.00
IUUC-Tru-118766	Takifugu rubripes	74.46	3.00e-142	497.00
IUUC-Tni-120197	Tetraodon nigroviridis	73.85	8.00e-142	496.00
IUUC-Tca-121316	Theobroma cacao	41.72	4.00e-67	248.00
IUUC-Tre-122097	Trichoderma reesei	45.26	3.00e-76	278.00
IUUC-Tvi-122442	Trichoderma virens	45.26	1.00e-76	280.00
IUUC-Tae-125800	Triticum aestivum	41.41	6.00e-69	254.00
IUUC-Tur-126334	Triticum urartu	40.13	2.00e-64	239.00
IUUC-Tme-127038	Tuber melanosporum	47.58	2.00e-82	298.00
IUUC-Ttr-128659	Tursiops truncatus	84.92	4.00e-146	510.00
IUUC-Uma-129464	Ustilago maydis	41.69	1.00e-64	239.00
IUUC-Vda-129841	Verticillium dahliae	47.09	2.00e-78	285.00
IUUC-Vvi-131076	Vitis vinifera	42.20	6.00e-68	250.00
IUUC-Xtr-132395	Xenopus tropicalis	80.62	3.00e-152	530.00
IUUC-Xma-133383	Xiphophorus maculatus	73.54	1.00e-140	492.00
IUUC-Yli-134586	Yarrowia lipolytica	43.16	5.00e-63	234.00
IUUC-Zma-135904	Zea mays	40.49	7.00e-67	247.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence