iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/ULP	ULP	20855607

Classification

Family	E-value	Score	Start	End
DUB/ULP	5.20e-51	174.1	288	459

Active Site

Position(s)	Description	Evidence
380	N/A	{ECO:0000250}
397		{ECO:0000250}
448		{ECO:0000250}

Domain Profile

DUB/ULP

   S: 1    isvtnedlkcLeegeflnDviidfylkylvlekl..kkekverihifssffykklkq.kerr..rvktwtr....kvdlfekdlifvpineaaHWsla 89
           i++t e l+cL+++ +lnD++i++yl+ l++e+   + +k+ ++h+f++ffykkl + ++++  +v++wt+     + l+++d+ifvpi++++HW+la
   Q: 288  IDITGEVLQCLTPSAWLNDEVINVYLE-LLKEREtrEPKKYLKCHYFNTFFYKKLVSdSGYNfkAVRRWTTqrklGYALIDCDMIFVPIHRGVHWTLA 384
           5799***********************.77766657889****************998888888******966666889******************* PP
   S: 90   vvcfkkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk.vpqQkNssDCGvyvlqyvesl 164
           v++++++++l+lDSl + ++ +++++l++y+ +e+++ks ++++ +++++++++ +pqQkN++DCG+++l+y++ +
   Q: 385  VINNRESKLLYLDSL-NGVDPMILNALAKYMGDEANEKSGKKIDANSWDMEFVEdLPQQKNGYDCGMFMLKYIDFF 459
           ***************.99**********************************999******************976 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5. Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3. Acts predominantly as an isopeptidase, cleaving SUMO-conjugated proteins better than SUMO peptides. Plays an important role in the control of flowering time.

Protein Sequence
(Fasta)

MGAVAINRKR SDESFNFINQ QSTNPLRNSP YFQASKKRRF SFAMSEDSGK PASSNPTISR 60
ISRYPDAKAP LRREIHAPSR GILRYGKAKS NDYCEKDANF FVRKYDDAKR SALEALRFVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTTTTTC TTTCAAATAT TATTTTTGGA GAAAACCCCC AAATTTAAAA GGAAAGAGAA 60
AAAATCAAAT CATTCATCTT TGAGCTTTCT TTTCTTCTAC AGAACCCTAA TTTCATGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0009911--P:positive regulation of flower development
GO:0016926--P:protein desumoylation
GO:0009909--P:regulation of flower development

KEGG

ath:AT4G15880

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001885	Ailuropoda melanoleuca	39.22	1.00e-42	167.00
IUUC-Atr-003110	Amborella trichopoda	59.86	8.00e-95	340.00
IUUC-Apl-003602	Anas platyrhynchos	41.08	6.00e-43	167.00
IUUC-Aca-005011	Anolis carolinensis	38.19	7.00e-42	164.00
IUUC-Aly-006005	Arabidopsis lyrata	88.82	0.00e+00	796.00
IUUC-Ago-007930	Ashbya gossypii	29.39	5.00e-21	95.10
IUUC-Acl-008277	Aspergillus clavatus	31.60	8.00e-24	105.00
IUUC-Afl-008417	Aspergillus flavus	35.27	5.00e-27	115.00
IUUC-Afu-008940	Aspergillus fumigatus	31.87	2.00e-26	114.00
IUUC-Ani-009245	Aspergillus nidulans	33.33	3.00e-25	110.00
IUUC-Ang-009510	Aspergillus niger	29.51	6.00e-23	102.00
IUUC-Aor-010104	Aspergillus oryzae	34.36	3.00e-25	107.00
IUUC-Ate-010312	Aspergillus terreus	37.59	9.00e-21	95.10
IUUC-Ame-011519	Astyanax mexicanus	36.64	2.00e-36	146.00
IUUC-Bgr-012165	Blumeria graminis	28.14	2.00e-13	69.70
IUUC-Bta-012319	Bos taurus	39.66	4.00e-43	169.00
IUUC-Bci-013594	Botrytis cinerea	26.13	5.00e-14	71.60
IUUC-Bdi-014678	Brachypodium distachyon	58.89	6.00e-89	320.00
IUUC-Bol-015882	Brassica oleracea	85.81	5.00e-156	543.00
IUUC-Bra-017492	Brassica rapa	68.80	0.00e+00	645.00
IUUC-Cel-018426	Caenorhabditis elegans	36.89	2.00e-38	153.00
IUUC-Cja-019463	Callithrix jacchus	39.66	3.00e-43	169.00
IUUC-Cfa-020654	Canis familiaris	39.22	1.00e-42	167.00
IUUC-Cpo-022243	Cavia porcellus	39.22	9.00e-43	167.00
IUUC-Cre-022877	Chlamydomonas reinhardtii	34.21	1.00e-20	91.70
IUUC-Cho-024917	Choloepus hoffmanni	39.39	1.00e-41	164.00
IUUC-Cgl-026530	Colletotrichum gloeosporioides	28.64	5.00e-17	82.80
IUUC-Cne-026848	Cryptococcus neoformans	31.37	1.00e-23	103.00
IUUC-Cme-027184	Cyanidioschyzon merolae	36.20	7.00e-37	147.00
IUUC-Dre-028702	Danio rerio	36.49	2.00e-43	169.00
IUUC-Dno-029507	Dasypus novemcinctus	39.22	2.00e-42	166.00
IUUC-Dor-030693	Dipodomys ordii	40.54	7.00e-29	121.00
IUUC-Dme-031743	Drosophila melanogaster	34.04	4.00e-33	134.00
IUUC-Eca-033511	Equus caballus	39.22	1.00e-42	167.00
IUUC-Eeu-034586	Erinaceus europaeus	39.73	3.00e-41	162.00
IUUC-Fca-036580	Felis catus	38.79	1.00e-41	163.00
IUUC-Fal-037347	Ficedula albicollis	37.71	6.00e-42	163.00
IUUC-Fso-038417	Fusarium solani	27.67	4.00e-15	76.30
IUUC-Gmo-039275	Gadus morhua	34.89	7.00e-37	146.00
IUUC-Ggr-039804	Gaeumannomyces graminis	29.82	9.00e-17	82.00
IUUC-Gga-041045	Gallus gallus	38.30	4.00e-41	162.00
IUUC-Gac-042067	Gasterosteus aculeatus	41.63	2.00e-44	172.00
IUUC-Gma-043245	Glycine max	48.10	4.00e-121	427.00
IUUC-Ggo-044694	Gorilla gorilla	38.26	1.00e-35	144.00
IUUC-Hsa-046229	Homo sapiens	39.22	2.00e-42	166.00
IUUC-Hvu-047684	Hordeum vulgare	60.00	3.00e-89	321.00
IUUC-Itr-048917	Ictidomys tridecemlineatus	39.22	1.00e-42	167.00
IUUC-Lch-049483	Latimeria chalumnae	38.79	1.00e-41	164.00
IUUC-Lpe-051248	Leersia perrieri	61.67	2.00e-86	311.00
IUUC-Loc-052844	Lepisosteus oculatus	40.74	2.00e-44	173.00
IUUC-Laf-053658	Loxodonta africana	38.30	8.00e-42	164.00
IUUC-Mcc-055432	Macaca mulatta	39.22	4.00e-43	168.00
IUUC-Meu-056435	Macropus eugenii	40.35	5.00e-41	161.00
IUUC-Mor-056912	Magnaporthe oryzae	27.14	4.00e-13	70.50
IUUC-Mpo-057341	Magnaporthe poae	26.05	6.00e-16	79.30
IUUC-Mtr-058391	Medicago truncatula	49.39	4.00e-118	417.00
IUUC-Mla-059033	Melampsora laricipopulina	30.88	7.00e-30	124.00
IUUC-Mga-059454	Meleagris gallopavo	39.37	4.00e-40	158.00
IUUC-Mvi-060257	Microbotryum violaceum	30.09	3.00e-23	102.00
IUUC-Mmr-061104	Microcebus murinus	39.22	8.00e-43	167.00
IUUC-Mdo-062256	Monodelphis domestica	36.65	7.00e-41	161.00
IUUC-Mmu-063629	Mus musculus	39.22	7.00e-43	168.00
IUUC-Mac-064839	Musa acuminata	56.88	5.00e-91	327.00
IUUC-Mpu-066790	Mustela putorius furo	39.22	1.00e-42	167.00
IUUC-Mlu-067849	Myotis lucifugus	36.70	1.00e-42	167.00
IUUC-Nfi-068579	Neosartorya fischeri	30.71	1.00e-25	111.00
IUUC-Nle-069931	Nomascus leucogenys	39.22	3.00e-42	166.00
IUUC-Opr-070528	Ochotona princeps	36.60	2.00e-38	153.00
IUUC-Ont-072628	Oreochromis niloticus	37.08	8.00e-41	160.00
IUUC-Ocu-074506	Oryctolagus cuniculus	35.86	1.00e-43	170.00
IUUC-Oba-074983	Oryza barthii	57.99	2.00e-87	315.00
IUUC-Obr-076231	Oryza brachyantha	57.99	5.00e-87	313.00
IUUC-Ogl-076987	Oryza glaberrima	59.18	1.00e-85	309.00
IUUC-Ogu-078658	Oryza glumaepatula	53.67	2.00e-83	302.00
IUUC-Oin-079674	Oryza indica	57.99	2.00e-87	315.00
IUUC-Olo-080443	Oryza longistaminata	58.33	4.00e-88	317.00
IUUC-Ome-081681	Oryza meridionalis	57.99	4.00e-87	314.00
IUUC-Oni-082881	Oryza nivara	60.08	1.00e-84	306.00
IUUC-Opu-083766	Oryza punctata	58.68	1.00e-83	303.00
IUUC-Oru-084743	Oryza rufipogon	57.99	1.00e-87	316.00
IUUC-Osa-085764	Oryza sativa	57.99	1.00e-87	316.00
IUUC-Ola-087348	Oryzias latipes	39.47	5.00e-45	174.00
IUUC-Oga-089135	Otolemur garnettii	39.39	2.00e-38	153.00
IUUC-Oar-090004	Ovis aries	39.22	2.00e-42	166.00
IUUC-Ptr-091310	Pan troglodytes	38.96	9.00e-42	164.00
IUUC-Pan-092232	Papio anubis	39.22	3.00e-42	166.00
IUUC-Psi-093705	Pelodiscus sinensis	39.91	5.00e-41	162.00
IUUC-Pma-094606	Petromyzon marinus	39.66	5.00e-40	156.00
IUUC-Pno-094805	Phaeosphaeria nodorum	29.70	5.00e-14	72.80
IUUC-Pfo-096571	Poecilia formosa	39.47	5.00e-43	168.00
IUUC-Pab-097640	Pongo abelii	39.22	2.00e-42	166.00
IUUC-Pop-098978	Populus trichocarpa	48.76	4.00e-123	434.00
IUUC-Pca-100611	Procavia capensis	39.32	1.00e-41	164.00
IUUC-Ppe-101189	Prunus persica	49.58	1.00e-121	429.00
IUUC-Pva-102437	Pteropus vampyrus	37.93	6.00e-42	164.00
IUUC-Pte-104020	Pyrenophora teres	28.57	2.00e-14	73.90
IUUC-Rno-105520	Rattus norvegicus	39.66	3.00e-43	169.00
IUUC-Sha-106929	Sarcophilus harrisii	38.75	5.00e-42	163.00
IUUC-Ssl-108445	Sclerotinia sclerotiorum	26.10	8.00e-15	74.70
IUUC-Sit-110193	Setaria italica	58.51	3.00e-87	315.00
IUUC-Sly-111206	Solanum lycopersicum	51.63	6.00e-128	450.00
IUUC-Stu-112651	Solanum tuberosum	48.35	9.00e-114	403.00
IUUC-Sar-113372	Sorex araneus	39.00	2.00e-32	133.00
IUUC-Sbi-114067	Sorghum bicolor	58.89	2.00e-89	322.00
IUUC-Ssc-115376	Sus scrofa	39.22	2.00e-42	166.00
IUUC-Tgu-116621	Taeniopygia guttata	39.59	3.00e-44	171.00
IUUC-Tru-118431	Takifugu rubripes	40.86	1.00e-45	176.00
IUUC-Tsy-119028	Tarsius syrichta	36.32	7.00e-33	134.00
IUUC-Tni-120194	Tetraodon nigroviridis	39.46	1.00e-44	173.00
IUUC-Tca-121652	Theobroma cacao	54.87	2.00e-135	475.00
IUUC-Tre-122246	Trichoderma reesei	24.13	7.00e-13	68.20
IUUC-Tvi-122348	Trichoderma virens	29.74	6.00e-17	81.60
IUUC-Tae-125765	Triticum aestivum	59.64	2.00e-90	325.00
IUUC-Tur-126817	Triticum urartu	60.00	3.00e-90	324.00
IUUC-Tbe-127763	Tupaia belangeri	37.50	2.00e-23	103.00
IUUC-Ttr-128910	Tursiops truncatus	37.01	3.00e-38	152.00
IUUC-Vpa-130375	Vicugna pacos	39.39	5.00e-42	165.00
IUUC-Vvi-131660	Vitis vinifera	51.11	2.00e-125	442.00
IUUC-Xtr-132587	Xenopus tropicalis	40.52	5.00e-45	175.00
IUUC-Xma-133896	Xiphophorus maculatus	42.11	8.00e-48	184.00
IUUC-Yli-134367	Yarrowia lipolytica	33.00	4.00e-23	102.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence