iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143409.15	ENST00000361738.10	ENSP00000354669.6
ENSG00000143409.15	ENST00000497067.1	ENSP00000451524.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Information
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/MINDY	MINDY	27292798; 27392144; 28082312
UBD/Alpha-Helix/MIU	MIU	27292798; 27392144; 28082312

Classification

Family	E-value	Score	Start	End
DUB/MINDY	2.50e-64	216.6	192	314
UBD/Alpha-Helix/MIU	1.50e-07	32.8	448	475

Active Site

Position(s)	Description	Evidence
137	Nucleophile	{ECO:0000305\|PubMed:27292798}
319	Proton acceptor	{ECO:0000305\|PubMed:27292798}

Domain Profile

DUB/MINDY

   S: 1    nilllswkvklvpkkevitleelievlgdilldvkdkekseiselnyeqnvddalsllpklaeGldvnvrftGvrsfeytkecsvfdlldid 92
           nil+l+wkvkl+p+kevit++el+++lg++ll++k++ekse+++ln++qnvdda+++lpkla+GldvnvrftGv++feyt+ecsvfdll+i+
   Q: 192  NILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIP 283
           9******************************************************************************************* PP
   S: 93   lyhGWlvdsqideavkavgklsyeqlveril 123
           lyhGWlvd+q++eav+avgklsy+qlveri+
   Q: 284  LYHGWLVDPQSPEAVRAVGKLSYNQLVERII 314
           ******************************8 PP

UBD/Alpha-Helix/MIU

   S: 1    rqkQpr.....tDlELAqqLQqEeyqqf 23
           +q+Qpr     tDlELAqqLQqEeyqq+
   Q: 448  QQQQPRgplglTDLELAQQLQQEEYQQQ 475
           8**************************7 PP

Organism

Homo sapiens

Functional Description
(View)

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

Protein Sequence
(Fasta)

MLLGPPPFNE STKPSPSPCH SFASQAWLRQ VPEVSKHLQC PSAKSLLTME YHQPEDPAPG 60
KAGTAEAVIP ENHEVLAGPD EHPQDTDARD ADGEAREREP ADQALLPSQC GDNLESPLPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCCGGCGA GGCCAAGGGG GCGTGGCGTG GGGCGACGTG GGAAACGTAG TCCCGCAACT 60
CCGCAATGTC CCTAGCAACC GAGGGAAGGA TTGTTTTCTG AGGGATCAGT CGTTCGGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR007518--MINDY
IPR033979--MINDY_domain

Pfam

PF04424--MINDY_DUB

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:0036435--F:K48-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity

KEGG

hsa:55793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-136378	Aegilops tauschii	40.62	1.00e-25	111.00
IUUC-Aml-136381	Ailuropoda melanoleuca	83.44	0.00e+00	683.00
IUUC-Atr-136384	Amborella trichopoda	39.59	5.00e-32	133.00
IUUC-Apl-136388	Anas platyrhynchos	85.96	3.00e-150	524.00
IUUC-Aly-136393	Arabidopsis lyrata	48.72	2.00e-36	147.00
IUUC-Ath-136397	Arabidopsis thaliana	46.78	5.00e-37	149.00
IUUC-Ago-136399	Ashbya gossypii	29.85	1.00e-27	117.00
IUUC-Acl-136400	Aspergillus clavatus	30.38	4.00e-28	120.00
IUUC-Afl-136401	Aspergillus flavus	36.08	4.00e-11	63.90
IUUC-Afu-136402	Aspergillus fumigatus	29.06	1.00e-28	122.00
IUUC-Ani-136403	Aspergillus nidulans	30.90	1.00e-27	119.00
IUUC-Ang-136404	Aspergillus niger	28.40	1.00e-27	118.00
IUUC-Aor-136405	Aspergillus oryzae	30.86	9.00e-26	112.00
IUUC-Ame-136409	Astyanax mexicanus	68.07	4.00e-132	464.00
IUUC-Bgr-136410	Blumeria graminis	29.64	2.00e-24	108.00
IUUC-Bta-136413	Bos taurus	84.50	0.00e+00	682.00
IUUC-Bci-136415	Botrytis cinerea	30.16	1.00e-25	112.00
IUUC-Bdi-136417	Brachypodium distachyon	41.51	7.00e-34	139.00
IUUC-Bol-136420	Brassica oleracea	48.00	4.00e-39	156.00
IUUC-Bra-136422	Brassica rapa	47.74	6.00e-40	159.00
IUUC-Cel-136423	Caenorhabditis elegans	38.58	5.00e-49	188.00
IUUC-Cja-136426	Callithrix jacchus	92.84	0.00e+00	867.00
IUUC-Cfa-136431	Canis familiaris	85.95	0.00e+00	642.00
IUUC-Cpo-136435	Cavia porcellus	81.30	0.00e+00	696.00
IUUC-Cre-136437	Chlamydomonas reinhardtii	35.07	2.00e-29	124.00
IUUC-Csa-136440	Chlorocebus sabaeus	92.32	0.00e+00	753.00
IUUC-Cho-136442	Choloepus hoffmanni	72.48	2.00e-75	276.00
IUUC-Cin-136446	Ciona intestinalis	34.48	1.00e-04	37.70
IUUC-Cme-136451	Cyanidioschyzon merolae	34.90	3.00e-21	96.30
IUUC-Dre-136455	Danio rerio	64.36	2.00e-133	469.00
IUUC-Dno-136458	Dasypus novemcinctus	84.89	0.00e+00	721.00
IUUC-Dor-136460	Dipodomys ordii	59.55	1.00e-105	376.00
IUUC-Dse-136464	Dothistroma septosporum	28.05	3.00e-28	120.00
IUUC-Ete-136470	Echinops telfairi	72.86	4.00e-108	384.00
IUUC-Eca-136474	Equus caballus	86.50	0.00e+00	715.00
IUUC-Eeu-136475	Erinaceus europaeus	86.00	4.00e-133	467.00
IUUC-Fca-136480	Felis catus	85.07	0.00e+00	704.00
IUUC-Fso-136485	Fusarium solani	29.23	9.00e-29	122.00
IUUC-Gga-136494	Gallus gallus	77.20	2.00e-152	532.00
IUUC-Gac-136498	Gasterosteus aculeatus	74.43	4.00e-120	424.00
IUUC-Gma-136500	Glycine max	44.81	7.00e-34	139.00
IUUC-Ggo-136504	Gorilla gorilla	98.07	0.00e+00	934.00
IUUC-Hvu-136509	Hordeum vulgare	43.42	9.00e-36	145.00
IUUC-Itr-136512	Ictidomys tridecemlineatus	85.11	0.00e+00	753.00
IUUC-Kpa-136513	Komagataella pastoris	26.44	7.00e-20	91.70
IUUC-Lch-136516	Latimeria chalumnae	70.55	2.00e-123	435.00
IUUC-Lpe-136519	Leersia perrieri	41.61	2.00e-35	144.00
IUUC-Loc-136523	Lepisosteus oculatus	66.39	7.00e-130	457.00
IUUC-Laf-136529	Loxodonta africana	81.24	0.00e+00	683.00
IUUC-Mcc-136533	Macaca mulatta	91.68	0.00e+00	823.00
IUUC-Meu-136536	Macropus eugenii	75.05	0.00e+00	632.00
IUUC-Mor-136537	Magnaporthe oryzae	29.44	4.00e-25	110.00
IUUC-Mtr-136539	Medicago truncatula	44.65	1.00e-35	145.00
IUUC-Mla-136542	Melampsora laricipopulina	36.84	8.00e-16	77.80
IUUC-Mvi-136546	Microbotryum violaceum	31.49	4.00e-30	126.00
IUUC-Mmr-136550	Microcebus murinus	85.74	0.00e+00	769.00
IUUC-Mdo-136554	Monodelphis domestica	75.80	0.00e+00	642.00
IUUC-Mmu-136557	Mus musculus	83.16	0.00e+00	637.00
IUUC-Mac-136560	Musa acuminata	41.98	4.00e-32	132.00
IUUC-Mpu-136564	Mustela putorius furo	82.09	0.00e+00	706.00
IUUC-Mlu-136567	Myotis lucifugus	86.57	0.00e+00	691.00
IUUC-Nfi-136569	Neosartorya fischeri	28.68	9.00e-29	122.00
IUUC-Nle-136574	Nomascus leucogenys	95.75	0.00e+00	803.00
IUUC-Opr-136578	Ochotona princeps	79.44	0.00e+00	693.00
IUUC-Ont-136581	Oreochromis niloticus	67.12	8.00e-131	460.00
IUUC-Ocu-136587	Oryctolagus cuniculus	79.74	1.00e-175	609.00
IUUC-Oba-136590	Oryza barthii	40.24	2.00e-34	140.00
IUUC-Obr-136591	Oryza brachyantha	40.99	3.00e-34	140.00
IUUC-Ogl-136594	Oryza glaberrima	40.24	2.00e-34	140.00
IUUC-Ogu-136596	Oryza glumaepatula	40.24	2.00e-34	140.00
IUUC-Oin-136598	Oryza indica	40.24	2.00e-34	140.00
IUUC-Olo-136600	Oryza longistaminata	40.88	5.00e-34	139.00
IUUC-Ome-136601	Oryza meridionalis	40.24	2.00e-34	140.00
IUUC-Oni-136603	Oryza nivara	40.24	2.00e-34	140.00
IUUC-Opu-136605	Oryza punctata	40.24	2.00e-34	141.00
IUUC-Oru-136607	Oryza rufipogon	40.24	2.00e-34	140.00
IUUC-Osa-136609	Oryza sativa	40.24	2.00e-34	140.00
IUUC-Ola-136612	Oryzias latipes	63.41	5.00e-119	420.00
IUUC-Oga-136618	Otolemur garnettii	84.89	0.00e+00	723.00
IUUC-Oar-136621	Ovis aries	79.83	0.00e+00	679.00
IUUC-Ptr-136625	Pan troglodytes	98.65	0.00e+00	907.00
IUUC-Pan-136630	Papio anubis	91.90	0.00e+00	753.00
IUUC-Psi-136634	Pelodiscus sinensis	68.40	2.00e-168	585.00
IUUC-Ppa-136639	Physcomitrella patens	44.72	3.00e-38	153.00
IUUC-Pfo-136643	Poecilia formosa	65.65	3.00e-136	478.00
IUUC-Pab-136648	Pongo abelii	96.38	0.00e+00	850.00
IUUC-Pop-136649	Populus trichocarpa	47.01	6.00e-30	123.00
IUUC-Pca-136654	Procavia capensis	76.34	1.00e-154	538.00
IUUC-Ppe-136657	Prunus persica	44.44	8.00e-34	139.00
IUUC-Pva-136661	Pteropus vampyrus	82.20	0.00e+00	729.00
IUUC-Pgr-136662	Puccinia graminis	25.00	2.00e-16	80.50
IUUC-Rno-136668	Rattus norvegicus	81.40	0.00e+00	698.00
IUUC-Sha-136673	Sarcophilus harrisii	75.05	0.00e+00	644.00
IUUC-Sja-136675	Schizosaccharomyces japonicus	28.78	9.00e-19	87.80
IUUC-Spo-136676	Schizosaccharomyces pombe	29.50	1.00e-18	87.40
IUUC-Ssl-136677	Sclerotinia sclerotiorum	30.92	4.00e-27	117.00
IUUC-Smo-136679	Selaginella moellendorffii	48.39	1.00e-37	151.00
IUUC-Sit-136681	Setaria italica	45.27	3.00e-30	127.00
IUUC-Sly-136682	Solanum lycopersicum	45.10	4.00e-34	139.00
IUUC-Stu-136684	Solanum tuberosum	45.10	1.00e-33	138.00
IUUC-Sar-136687	Sorex araneus	71.01	3.00e-129	455.00
IUUC-Sbi-136689	Sorghum bicolor	44.87	2.00e-36	147.00
IUUC-Sre-136690	Sporisorium reilianum	29.72	1.00e-33	138.00
IUUC-Ssc-136693	Sus scrofa	86.41	0.00e+00	769.00
IUUC-Tru-136701	Takifugu rubripes	72.08	7.00e-130	456.00
IUUC-Tsy-136705	Tarsius syrichta	76.15	4.00e-143	501.00
IUUC-Tni-136708	Tetraodon nigroviridis	68.51	1.00e-121	429.00
IUUC-Tca-136710	Theobroma cacao	46.41	4.00e-31	130.00
IUUC-Tae-136715	Triticum aestivum	42.14	2.00e-35	144.00
IUUC-Tur-136717	Triticum urartu	36.25	4.00e-26	113.00
IUUC-Tme-136718	Tuber melanosporum	32.12	8.00e-27	115.00
IUUC-Ttr-136725	Tursiops truncatus	83.94	0.00e+00	735.00
IUUC-Uma-136726	Ustilago maydis	30.25	2.00e-31	131.00
IUUC-Vvi-136733	Vitis vinifera	44.87	2.00e-33	137.00
IUUC-Xtr-136737	Xenopus tropicalis	74.03	8.00e-147	513.00
IUUC-Xma-136740	Xiphophorus maculatus	64.38	3.00e-136	478.00
IUUC-Yli-136742	Yarrowia lipolytica	29.10	2.00e-33	137.00
IUUC-Zma-136744	Zea mays	43.71	3.00e-37	149.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence