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Tag Content
UUCD2 ID IUUC-Pab-097544
UUCD1 version UUC-PoA-00937
Ensembl Protein ID ENSPPYP00000022294.2
UniProt Accession Q5RCF3; CUL2_PONAB
Genbank Protein ID CAH90554.1
Protein Name Cullin-2
Genbank Nucleotide ID CR858317
Gene Name CUL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000019905.2 ENSPPYT00000023224.2 ENSPPYP00000022294.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 2.50e-213 710.3 17 644
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk...vgaklYkklkevleefikqvkkkveesedeqlLktynreWekfreqlkvlrki 86
           l +++k++++ e+v +++++++++++y+lc+++   +g++lY+++k +le+++++++k+v es +eq+L +y+r+We++++++++++++
   Q: 17   LLTTIKAVVMLEYVeRATWNDRFSDIYALCVAYpepLGERLYTETKIFLENHVRHLHKRVLES-EEQVLVMYHRYWEEYSKGADYMDCL 104
           6689***********************************************************.566********************** PP
   S: 87   fayldrtyvkk.................skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLsl 158
           ++yl+++++kk                 ++ ++e+ +Lald+wrk +ve++++ l+++ll+ i+++R ge  ++++++gv++s+v++++
   Q: 105  YRYLNTQFIKKnklteadlqygyggvdmNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQ 193
           ***********999999998888888877778********************************************************9 PP
   S: 159  nk....laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllael 243
           +k    l++y+e FE++fl++t e+yk+e++++lqe+++++Y++kv  rl++ee r+++yl++s++tk++++++++++a+hl++l+ae+
   Q: 194  YKkkfpLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAEC 282
           999************************************************************************************** PP
   S: 244  vallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldka 332
           ++++r++k++d+++my Ll+ v++gl ++++el++hi+++g++a+++ ++e++p+ +Ve++le++ k+ +l+++++n d++F++aldka
   Q: 283  HNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKA 371
           ***************************************************************************************** PP
   S: 333  fetfvnknsvlkaakspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviek 421
           ++++vn ++ ++++k+pEllA+y+D+lL+ks+kg+te+e+e++l+++++vfkyi++kdvF+k+Y+++LakRL++g+s+s+++Ee++i+k
   Q: 372  LTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINK 460
           ***************************************************************************************** PP
   S: 422  LkeecgaeftskLerMfqdlkvSedlnrqFk..eekenteesesvelsvlvLsagaWpta.setekvsLPaelektiekfeefYlekhs 507
           Lk++cg+eftskL+rM++d++vS dln++F+   ++++t ++ +++++++vL+agaWp + +  +++++P+elek++++fe fY++++s
   Q: 461  LKQACGYEFTSKLHRMYTDMSVSADLNNKFNnfIKNQDTVIDLGISFQIYVLQAGAWPLTqAPSSTFAIPQELEKSVQMFELFYSQHFS 549
           *******************************8889***********************99666689*********************** PP
   S: 508  gRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeed 596
           gRkL+W+h+l+++e+k+++  ++y  +V+t+QmavLLafnnse+vs++el+++t+++e+eL++t++sL+++k  ++++++e+++i++e+
   Q: 550  GRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVK--MINHDSEKEDIDAES 636
           *******************999*************************************************9..*************** PP
   S: 597  lfsvNqef 604
           +fs+N++f
   Q: 637  SFSLNMNF 644
           ******99 PP
   
Organism Pongo abelii
Functional Description
(View)

Functional Description


     Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity).
 Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity).
Protein Sequence
(Fasta)
MSLKPRVVDF DETWNKLLTT IKAVVMLEYV ERATWNDRFS DIYALCVAYP EPLGERLYTE 60
TKIFLENHVR HLHKRVLESE EQVLVMYHRY WEEYSKGADY MDCLYRYLNT QFIKKNKLTE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pab-097544|E3,Cullin|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCTTTCCGG GGGGCGGGGG GGGGGGGATT TGGCAGCAGC GGAAGGAGAC CGGAGGGTGT 60
GTGTTGGGAA AAGCCGGAGG CAGAGGAGGA CGATTGTTTT ACGGATCCCG TGATCGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-097544|E3,Cullin|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG pon:100174361
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001969 Ailuropoda melanoleuca 99.73 0.00e+00 1557.00
IUUC-Apl-004067 Anas platyrhynchos 96.79 0.00e+00 1492.00
IUUC-Aca-004534 Anolis carolinensis 92.66 0.00e+00 1452.00
IUUC-Ame-011695 Astyanax mexicanus 93.15 0.00e+00 1452.00
IUUC-Bta-013074 Bos taurus 99.60 0.00e+00 1555.00
IUUC-Cel-018431 Caenorhabditis elegans 43.23 2.00e-177 616.00
IUUC-Cja-019371 Callithrix jacchus 100.00 0.00e+00 1560.00
IUUC-Cfa-020508 Canis familiaris 99.46 0.00e+00 1554.00
IUUC-Cpo-021851 Cavia porcellus 97.99 0.00e+00 1509.00
IUUC-Csa-023583 Chlorocebus sabaeus 100.00 0.00e+00 1553.00
IUUC-Cho-024308 Choloepus hoffmanni 91.71 0.00e+00 677.00
IUUC-Cin-025350 Ciona intestinalis 46.74 0.00e+00 709.00
IUUC-Csv-026096 Ciona savignyi 41.65 0.00e+00 643.00
IUUC-Dre-028828 Danio rerio 92.21 0.00e+00 1432.00
IUUC-Dno-029709 Dasypus novemcinctus 98.79 0.00e+00 1545.00
IUUC-Dor-030319 Dipodomys ordii 84.06 0.00e+00 949.00
IUUC-Dme-031938 Drosophila melanogaster 50.39 0.00e+00 741.00
IUUC-Ete-032756 Echinops telfairi 82.95 0.00e+00 1248.00
IUUC-Eca-034019 Equus caballus 99.33 0.00e+00 1549.00
IUUC-Eeu-034914 Erinaceus europaeus 93.88 0.00e+00 1042.00
IUUC-Fca-035926 Felis catus 99.60 0.00e+00 1555.00
IUUC-Fal-037627 Ficedula albicollis 96.51 0.00e+00 1488.00
IUUC-Gmo-038728 Gadus morhua 92.09 0.00e+00 1431.00
IUUC-Gga-040820 Gallus gallus 93.41 0.00e+00 1482.00
IUUC-Gac-041293 Gasterosteus aculeatus 91.42 0.00e+00 1426.00
IUUC-Ggo-045235 Gorilla gorilla 97.19 0.00e+00 1487.00
IUUC-Hsa-046819 Homo sapiens 100.00 0.00e+00 1560.00
IUUC-Itr-048063 Ictidomys tridecemlineatus 99.50 0.00e+00 843.00
IUUC-Lch-049443 Latimeria chalumnae 94.63 0.00e+00 1465.00
IUUC-Loc-052798 Lepisosteus oculatus 93.57 0.00e+00 1448.00
IUUC-Laf-053379 Loxodonta africana 99.06 0.00e+00 1551.00
IUUC-Mcc-055702 Macaca mulatta 100.00 0.00e+00 1558.00
IUUC-Meu-056223 Macropus eugenii 71.28 0.00e+00 966.00
IUUC-Mga-060034 Meleagris gallopavo 96.39 0.00e+00 1486.00
IUUC-Mmr-061090 Microcebus murinus 98.79 0.00e+00 1549.00
IUUC-Mdo-062530 Monodelphis domestica 96.51 0.00e+00 1489.00
IUUC-Mmu-063857 Mus musculus 97.32 0.00e+00 1476.00
IUUC-Mpu-065915 Mustela putorius furo 99.73 0.00e+00 1558.00
IUUC-Mlu-068049 Myotis lucifugus 99.60 0.00e+00 1557.00
IUUC-Nle-069102 Nomascus leucogenys 97.17 0.00e+00 1133.00
IUUC-Opr-071197 Ochotona princeps 86.86 0.00e+00 1260.00
IUUC-Ont-071902 Oreochromis niloticus 92.21 0.00e+00 1440.00
IUUC-Oan-073307 Ornithorhynchus anatinus 92.39 0.00e+00 1469.00
IUUC-Ocu-074703 Oryctolagus cuniculus 98.66 0.00e+00 1546.00
IUUC-Ola-086789 Oryzias latipes 92.37 0.00e+00 1442.00
IUUC-Oga-088480 Otolemur garnettii 99.06 0.00e+00 1545.00
IUUC-Oar-089899 Ovis aries 99.73 0.00e+00 1557.00
IUUC-Ptr-090965 Pan troglodytes 99.87 0.00e+00 1560.00
IUUC-Pan-092920 Papio anubis 95.72 0.00e+00 1455.00
IUUC-Psi-093122 Pelodiscus sinensis 96.24 0.00e+00 1481.00
IUUC-Pma-094656 Petromyzon marinus 77.88 0.00e+00 1224.00
IUUC-Pfo-096342 Poecilia formosa 92.08 0.00e+00 1440.00
IUUC-Pca-100564 Procavia capensis 98.05 0.00e+00 789.00
IUUC-Pva-102179 Pteropus vampyrus 88.65 0.00e+00 682.00
IUUC-Rno-105439 Rattus norvegicus 97.58 0.00e+00 1477.00
IUUC-Sha-106654 Sarcophilus harrisii 96.51 0.00e+00 1489.00
IUUC-Sar-113138 Sorex araneus 94.09 0.00e+00 1425.00
IUUC-Ssc-115543 Sus scrofa 99.80 0.00e+00 1061.00
IUUC-Tgu-117095 Taeniopygia guttata 96.25 0.00e+00 1485.00
IUUC-Tru-118593 Takifugu rubripes 81.50 0.00e+00 1372.00
IUUC-Tsy-119621 Tarsius syrichta 95.27 0.00e+00 957.00
IUUC-Tni-119697 Tetraodon nigroviridis 91.81 0.00e+00 1429.00
IUUC-Tbe-127831 Tupaia belangeri 90.95 0.00e+00 1224.00
IUUC-Ttr-129108 Tursiops truncatus 99.73 0.00e+00 1558.00
IUUC-Vpa-130414 Vicugna pacos 89.23 0.00e+00 725.00
IUUC-Xtr-132054 Xenopus tropicalis 92.35 0.00e+00 1424.00
Created Date 25-Jun-2017

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