iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046946

UUCD1 version

UUC-HoS-01275

Ensembl Protein ID

ENSP00000351407.5

UniProt Accession

P27540; B2R9H1; C4AMA1; F8WAP6; Q59ED4; Q5QP39; Q8NDC7; ARNT_HUMAN

Genbank Protein ID

AAA51777.1; CAC21446.1; CAC21446.1; CAC21446.1; CAC21446.1; CAC21446.1; CAC21446.1; BAF82866.1; BAF85716.1; BAG36518.1; BAD93114.1; CAD38953.1; AAQ96598.1; EAW53510.1; EAW53513.1

Protein Name

Aryl hydrocarbon receptor nuclear translocator; Class E basic helix-loop-helix protein 2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta

Genbank Nucleotide ID

M69238; Y18859; AJ251863; AJ404851; AJ404852; AJ404853; AJ404854; AK290177; AK293027; AK313780; AB209877; AL834279; AY430083; AL355860; CH471121

Gene Name

ARNT; BHLHE2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143437.20	ENST00000358595.9	ENSP00000351407.5
ENSG00000143437.20	ENST00000471844.6	ENSP00000425899.1
ENSG00000143437.20	ENST00000354396.6	ENSP00000346372.2
ENSG00000143437.20	ENST00000515192.5	ENSP00000423851.1
ENSG00000143437.20	ENST00000505755.5	ENSP00000427571.1
ENSG00000143437.20	ENST00000504358.1	ENSP00000425363.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Drug and target
PDTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/Other	E3 adaptor/Cullin RING/Other	17392787

Organism

Homo sapiens

Functional Description
(View)

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7. Heterodimer with HIF1A.

Protein Sequence
(Fasta)

MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD DDGEGNSKFL 60
RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATAGGCGG GGTCTCCCCG CCGCAGGGGC TGGGATGCTG GGGGCTGCTG AAGCCGCCAT 60
CTTGGATTCC GCGGTAGCGG AGGCGGCGGT CAGGCGCCGC TTCTGGGGAG TGGCCTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR011598--bHLH_dom
IPR001067--Nuc_translocat
IPR001610--PAC
IPR000014--PAS
IPR013767--PAS_fold

PROSITE

PS50888--BHLH
PS50112--PAS

Pfam

PF00010--HLH
PF00989--PAS

PRINTS

PR00785--NCTRNSLOCATR

SMART

SM00353--HLH
SM00086--PAC
SM00091--PAS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0004874--F:aryl hydrocarbon receptor activity
GO:0017162--F:aryl hydrocarbon receptor binding
GO:0035326--F:enhancer binding
GO:0046982--F:protein heterodimerization activity
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0030154--P:cell differentiation
GO:0001892--P:embryonic placenta development
GO:0042789--P:mRNA transcription from RNA polymerase II promoter
GO:0001938--P:positive regulation of endothelial cell proliferation
GO:0045648--P:positive regulation of erythrocyte differentiation
GO:0045821--P:positive regulation of glycolytic process
GO:0046886--P:positive regulation of hormone biosynthetic process
GO:0033235--P:positive regulation of protein sumoylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0030949--P:positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0043619--P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0001666--P:response to hypoxia
GO:0006351--P:transcription, DNA-templated
GO:0006805--P:xenobiotic metabolic process

KEGG

hsa:405

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001940	Ailuropoda melanoleuca	94.68	0.00e+00	1325.00
IUUC-Apl-003615	Anas platyrhynchos	80.41	0.00e+00	1238.00
IUUC-Aca-005047	Anolis carolinensis	77.73	0.00e+00	1170.00
IUUC-Bta-012420	Bos taurus	96.04	0.00e+00	1395.00
IUUC-Cja-019740	Callithrix jacchus	98.23	0.00e+00	1384.00
IUUC-Cfa-020981	Canis familiaris	95.52	0.00e+00	1325.00
IUUC-Cpo-021428	Cavia porcellus	93.89	0.00e+00	1326.00
IUUC-Csa-023451	Chlorocebus sabaeus	99.11	0.00e+00	1420.00
IUUC-Cho-024979	Choloepus hoffmanni	79.55	3.00e-160	559.00
IUUC-Cne-027059	Cryptococcus neoformans	31.76	2.00e-08	55.10
IUUC-Dno-029839	Dasypus novemcinctus	90.61	0.00e+00	1362.00
IUUC-Eca-034359	Equus caballus	91.94	0.00e+00	1317.00
IUUC-Fca-035413	Felis catus	91.61	0.00e+00	1353.00
IUUC-Gga-041165	Gallus gallus	78.11	0.00e+00	1185.00
IUUC-Ggo-045192	Gorilla gorilla	99.74	0.00e+00	1384.00
IUUC-Itr-048123	Ictidomys tridecemlineatus	94.78	0.00e+00	1412.00
IUUC-Lch-050137	Latimeria chalumnae	65.55	0.00e+00	914.00
IUUC-Laf-053433	Loxodonta africana	95.15	0.00e+00	1361.00
IUUC-Mcc-055174	Macaca mulatta	98.73	0.00e+00	1418.00
IUUC-Mga-059606	Meleagris gallopavo	78.68	0.00e+00	1134.00
IUUC-Mmr-060626	Microcebus murinus	92.67	0.00e+00	1341.00
IUUC-Mdo-062779	Monodelphis domestica	87.99	0.00e+00	1313.00
IUUC-Mmu-064192	Mus musculus	91.66	0.00e+00	1375.00
IUUC-Mpu-066471	Mustela putorius furo	95.30	0.00e+00	1256.00
IUUC-Mlu-066968	Myotis lucifugus	95.27	0.00e+00	1438.00
IUUC-Nle-069762	Nomascus leucogenys	98.60	0.00e+00	1373.00
IUUC-Oan-073371	Ornithorhynchus anatinus	73.27	0.00e+00	1038.00
IUUC-Ocu-074390	Oryctolagus cuniculus	86.11	0.00e+00	1218.00
IUUC-Oga-088408	Otolemur garnettii	95.92	0.00e+00	1394.00
IUUC-Oar-089959	Ovis aries	95.82	0.00e+00	1407.00
IUUC-Ptr-091057	Pan troglodytes	99.62	0.00e+00	1399.00
IUUC-Pan-092602	Papio anubis	98.10	0.00e+00	1401.00
IUUC-Psi-093661	Pelodiscus sinensis	77.64	0.00e+00	1216.00
IUUC-Pab-098708	Pongo abelii	99.11	0.00e+00	1383.00
IUUC-Rno-105732	Rattus norvegicus	90.76	0.00e+00	1319.00
IUUC-Sha-107369	Sarcophilus harrisii	87.74	0.00e+00	1298.00
IUUC-Smo-108833	Selaginella moellendorffii	34.78	4.00e-05	43.90
IUUC-Sar-113492	Sorex araneus	89.16	0.00e+00	686.00
IUUC-Ssc-115814	Sus scrofa	96.58	0.00e+00	1391.00
IUUC-Tgu-116662	Taeniopygia guttata	76.09	0.00e+00	1137.00
IUUC-Tni-120034	Tetraodon nigroviridis	54.82	0.00e+00	694.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence