iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106633

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01007699

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000017933.1	ENSSHAT00000021324.1	ENSSHAP00000021154.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-93	313.3	4518	4852
E3 adaptor/Cullin RING/DCX/DWD	6.60e-18	64.3	3435	3465

Active Site

Position(s)	Description	Evidence
4821	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4518 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNATAEVGYNRDRFLFNPsafldEHLMQFKFLGILMGVAIRTKK 4604
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+  +l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4605 PLDLHLAPMVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHIEDSGITEENFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4691
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG++++ip  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4692 EYVERAIEYRLHE-MDRQVAAVREGMSWIIPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 4776
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ i+ e+L+yAi++++++++
   Q: 4777 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLIMAERLRYAINNCRSIDM 4852
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3435 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3465
           55416677.*9778****************97 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MAAMVPPVKL KWLEHLNSSW ITEDSESIAT REGVSVLYSK LVSNKEVVLL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLTSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGCGA TGGTTCCACC GGTGAAGCTC AAATGGCTTG AACATTTAAA CAGCTCCTGG 60
ATCACAGAAG ACAGTGAATC TATTGCTACA AGAGAAGGAG TTTCTGTTCT ATATTCTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	93.83	0.00e+00	8410.00
IUUC-Apl-003461	Anas platyrhynchos	92.74	0.00e+00	8309.00
IUUC-Aca-004452	Anolis carolinensis	84.68	0.00e+00	7341.00
IUUC-Ame-011268	Astyanax mexicanus	59.65	0.00e+00	2191.00
IUUC-Bta-013213	Bos taurus	94.34	0.00e+00	8428.00
IUUC-Bra-017584	Brassica rapa	32.30	2.00e-45	177.00
IUUC-Cja-019298	Callithrix jacchus	93.86	0.00e+00	8414.00
IUUC-Cfa-021213	Canis familiaris	94.11	0.00e+00	8497.00
IUUC-Cpo-021674	Cavia porcellus	92.54	0.00e+00	5680.00
IUUC-Csa-023341	Chlorocebus sabaeus	93.68	0.00e+00	8384.00
IUUC-Cho-024567	Choloepus hoffmanni	93.02	0.00e+00	1754.00
IUUC-Dre-028289	Danio rerio	78.61	0.00e+00	7023.00
IUUC-Dno-029988	Dasypus novemcinctus	93.37	0.00e+00	8353.00
IUUC-Dor-030636	Dipodomys ordii	90.35	0.00e+00	2061.00
IUUC-Ete-032598	Echinops telfairi	83.40	0.00e+00	1318.00
IUUC-Eca-033754	Equus caballus	94.05	0.00e+00	8428.00
IUUC-Eeu-034702	Erinaceus europaeus	89.41	0.00e+00	1467.00
IUUC-Fca-035900	Felis catus	94.46	0.00e+00	8475.00
IUUC-Fal-037034	Ficedula albicollis	90.39	0.00e+00	7116.00
IUUC-Gmo-038634	Gadus morhua	90.87	0.00e+00	1217.00
IUUC-Gga-040321	Gallus gallus	92.68	0.00e+00	8354.00
IUUC-Gac-042444	Gasterosteus aculeatus	56.66	0.00e+00	2196.00
IUUC-Ggo-045134	Gorilla gorilla	92.38	0.00e+00	3244.00
IUUC-Hsa-046516	Homo sapiens	93.86	0.00e+00	8378.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	93.21	0.00e+00	2441.00
IUUC-Lch-049903	Latimeria chalumnae	86.79	0.00e+00	7834.00
IUUC-Lpe-051165	Leersia perrieri	32.83	4.00e-46	178.00
IUUC-Loc-052149	Lepisosteus oculatus	84.05	0.00e+00	7464.00
IUUC-Laf-053426	Loxodonta africana	93.93	0.00e+00	8464.00
IUUC-Mcc-055826	Macaca mulatta	93.97	0.00e+00	8430.00
IUUC-Meu-056521	Macropus eugenii	90.13	0.00e+00	2386.00
IUUC-Mga-059567	Meleagris gallopavo	95.53	0.00e+00	2084.00
IUUC-Mmr-061512	Microcebus murinus	93.64	0.00e+00	8327.00
IUUC-Mdo-062177	Monodelphis domestica	94.27	0.00e+00	8432.00
IUUC-Mmu-064373	Mus musculus	93.68	0.00e+00	8383.00
IUUC-Mpu-066148	Mustela putorius furo	93.80	0.00e+00	8392.00
IUUC-Mlu-067680	Myotis lucifugus	93.70	0.00e+00	8369.00
IUUC-Nle-069633	Nomascus leucogenys	93.58	0.00e+00	8330.00
IUUC-Opr-070609	Ochotona princeps	89.84	0.00e+00	1336.00
IUUC-Ont-071249	Oreochromis niloticus	81.07	0.00e+00	7408.00
IUUC-Oan-073157	Ornithorhynchus anatinus	93.91	0.00e+00	8321.00
IUUC-Ocu-074841	Oryctolagus cuniculus	93.80	0.00e+00	8462.00
IUUC-Ola-086889	Oryzias latipes	79.15	0.00e+00	7193.00
IUUC-Oga-088459	Otolemur garnettii	93.28	0.00e+00	8345.00
IUUC-Oar-089888	Ovis aries	94.36	0.00e+00	8398.00
IUUC-Ptr-091114	Pan troglodytes	93.84	0.00e+00	8405.00
IUUC-Pan-092442	Papio anubis	93.84	0.00e+00	8408.00
IUUC-Psi-093833	Pelodiscus sinensis	92.30	0.00e+00	5445.00
IUUC-Pma-094275	Petromyzon marinus	76.95	0.00e+00	1700.00
IUUC-Pfo-097262	Poecilia formosa	79.58	0.00e+00	7049.00
IUUC-Pab-097760	Pongo abelii	93.00	0.00e+00	4714.00
IUUC-Pca-100465	Procavia capensis	92.50	0.00e+00	4383.00
IUUC-Ppe-101345	Prunus persica	31.89	3.00e-48	187.00
IUUC-Pva-102950	Pteropus vampyrus	93.78	0.00e+00	4007.00
IUUC-Rno-104892	Rattus norvegicus	93.29	0.00e+00	8291.00
IUUC-Sly-111155	Solanum lycopersicum	34.97	9.00e-49	188.00
IUUC-Sar-113251	Sorex araneus	85.72	0.00e+00	2461.00
IUUC-Ssc-116391	Sus scrofa	93.97	0.00e+00	8430.00
IUUC-Tgu-116554	Taeniopygia guttata	92.07	0.00e+00	8272.00
IUUC-Tru-118695	Takifugu rubripes	80.11	0.00e+00	7333.00
IUUC-Tsy-119647	Tarsius syrichta	87.13	0.00e+00	5326.00
IUUC-Tni-120707	Tetraodon nigroviridis	80.29	0.00e+00	7272.00
IUUC-Tbe-127346	Tupaia belangeri	84.81	0.00e+00	2423.00
IUUC-Ttr-128542	Tursiops truncatus	89.57	0.00e+00	5612.00
IUUC-Vpa-130611	Vicugna pacos	94.45	0.00e+00	3888.00
IUUC-Xtr-131933	Xenopus tropicalis	84.48	0.00e+00	7564.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence