iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019714.3	ENSMMUT00000046532.2	ENSMMUP00000039565.1
ENSMMUG00000019714.3	ENSMMUT00000027705.3	ENSMMUP00000025915.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-14	54.3	822	873

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 822  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 873
           688*********************9.999999*****..9*************86 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MEPWKQCAQW LIHCKVLPAN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RAHSINLKEI 60
NLRPQMSQFL CLKNIRTFLT ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCGATCC CGCTCGGGGA AAGGGCAGGC GGCTGCTGGC GTCGGCGGGG CGCGGAGGAA 60
CCGCGGCGGC GGCGGCGGCG GCCGCATCCT CGCCGCCCGC CCCGGCCGGG CCGCGTCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	93.26	0.00e+00	1590.00
IUUC-Apl-003734	Anas platyrhynchos	83.52	0.00e+00	1337.00
IUUC-Aca-004477	Anolis carolinensis	85.60	0.00e+00	1481.00
IUUC-Ame-011279	Astyanax mexicanus	64.77	0.00e+00	1103.00
IUUC-Bta-012722	Bos taurus	92.80	0.00e+00	1582.00
IUUC-Cja-018941	Callithrix jacchus	95.50	0.00e+00	1609.00
IUUC-Cfa-020266	Canis familiaris	92.89	0.00e+00	1412.00
IUUC-Cpo-021966	Cavia porcellus	91.51	0.00e+00	1366.00
IUUC-Csa-023892	Chlorocebus sabaeus	96.17	0.00e+00	1507.00
IUUC-Dre-028199	Danio rerio	67.54	0.00e+00	1152.00
IUUC-Dno-029474	Dasypus novemcinctus	93.26	0.00e+00	1591.00
IUUC-Eca-033961	Equus caballus	92.89	0.00e+00	1442.00
IUUC-Eeu-034719	Erinaceus europaeus	71.83	0.00e+00	770.00
IUUC-Fca-036572	Felis catus	92.93	0.00e+00	1552.00
IUUC-Fal-036802	Ficedula albicollis	87.89	0.00e+00	1561.00
IUUC-Gmo-039409	Gadus morhua	67.12	0.00e+00	1144.00
IUUC-Gga-040884	Gallus gallus	82.97	0.00e+00	1451.00
IUUC-Gac-041395	Gasterosteus aculeatus	69.17	0.00e+00	1232.00
IUUC-Ggo-044460	Gorilla gorilla	93.16	0.00e+00	1413.00
IUUC-Hsa-046099	Homo sapiens	98.86	0.00e+00	1706.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	96.24	0.00e+00	1482.00
IUUC-Lch-049650	Latimeria chalumnae	73.03	9.00e-106	375.00
IUUC-Loc-052487	Lepisosteus oculatus	70.72	0.00e+00	1221.00
IUUC-Laf-054564	Loxodonta africana	92.46	0.00e+00	1584.00
IUUC-Meu-056680	Macropus eugenii	82.51	0.00e+00	1404.00
IUUC-Mga-060013	Meleagris gallopavo	80.09	0.00e+00	1385.00
IUUC-Mmr-061251	Microcebus murinus	95.53	0.00e+00	1701.00
IUUC-Mdo-061875	Monodelphis domestica	90.17	0.00e+00	1560.00
IUUC-Mmu-063735	Mus musculus	91.77	0.00e+00	1591.00
IUUC-Mpu-065856	Mustela putorius furo	93.60	0.00e+00	1594.00
IUUC-Mlu-068108	Myotis lucifugus	93.71	0.00e+00	1542.00
IUUC-Nle-069863	Nomascus leucogenys	97.58	0.00e+00	1670.00
IUUC-Opr-070372	Ochotona princeps	84.80	0.00e+00	1052.00
IUUC-Ont-072286	Oreochromis niloticus	69.45	0.00e+00	1215.00
IUUC-Ocu-074194	Oryctolagus cuniculus	93.94	0.00e+00	1600.00
IUUC-Ola-086336	Oryzias latipes	68.11	0.00e+00	1204.00
IUUC-Oar-089272	Ovis aries	92.91	0.00e+00	1623.00
IUUC-Ptr-090652	Pan troglodytes	93.49	0.00e+00	1610.00
IUUC-Pan-092550	Papio anubis	99.75	0.00e+00	1536.00
IUUC-Psi-093784	Pelodiscus sinensis	84.03	0.00e+00	1344.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	3.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	71.41	0.00e+00	1278.00
IUUC-Pab-098698	Pongo abelii	93.37	0.00e+00	1615.00
IUUC-Pva-102262	Pteropus vampyrus	92.92	0.00e+00	1526.00
IUUC-Rno-105421	Rattus norvegicus	91.66	0.00e+00	1605.00
IUUC-Sha-107325	Sarcophilus harrisii	89.94	0.00e+00	1570.00
IUUC-Sar-113456	Sorex araneus	87.54	0.00e+00	1506.00
IUUC-Tgu-116595	Taeniopygia guttata	80.62	0.00e+00	1382.00
IUUC-Tru-117884	Takifugu rubripes	64.52	0.00e+00	1182.00
IUUC-Tsy-119429	Tarsius syrichta	85.50	0.00e+00	1323.00
IUUC-Tni-119951	Tetraodon nigroviridis	67.04	0.00e+00	1136.00
IUUC-Tbe-127995	Tupaia belangeri	84.25	1.00e-176	613.00
IUUC-Ttr-128281	Tursiops truncatus	93.03	0.00e+00	1582.00
IUUC-Xtr-132427	Xenopus tropicalis	70.31	0.00e+00	1266.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence