iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091973

Ensembl Protein ID

ENSPANP00000019323.1

UniProt Accession

A0A096P1U8; A0A096P1U8_PAPAN

Genbank Protein ID

ENSPANP00000019323

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01061992

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000024903.1	ENSPANT00000025180.1	ENSPANP00000019323.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-22	78.8	581	619
UBD/Beta-Prp	2.60e-40	138.5	449	619

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 581  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 619
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 449  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 536
           5666688889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 537  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 619
           88888888999*********************************9.********************************997443 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMH QQQVVQAVER AKQVTMAELN AIIGQQLQAQ HLSHGHGLPV PLTPHPSGLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCGGTGAT TGTAGTCAAT CTGGCAGTAT TCTCAGGCAG GGTCGCCCGG GGCGGACTAC 60
ATCTCCCGGG ATGCTCCACG GCCCCCTCCG CTGAAGGTTG TGAATATGTA TCAGAATGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001359	Ailuropoda melanoleuca	95.00	0.00e+00	1206.00
IUUC-Aca-005279	Anolis carolinensis	92.63	0.00e+00	1252.00
IUUC-Bta-012646	Bos taurus	92.64	0.00e+00	1282.00
IUUC-Cel-018361	Caenorhabditis elegans	58.99	2.00e-122	432.00
IUUC-Cja-019079	Callithrix jacchus	93.27	0.00e+00	1327.00
IUUC-Cfa-020987	Canis familiaris	92.80	0.00e+00	1271.00
IUUC-Cpo-021606	Cavia porcellus	90.99	0.00e+00	1244.00
IUUC-Csa-023445	Chlorocebus sabaeus	93.66	0.00e+00	1299.00
IUUC-Cho-024590	Choloepus hoffmanni	81.47	0.00e+00	1165.00
IUUC-Csv-026174	Ciona savignyi	58.16	6.00e-163	568.00
IUUC-Dno-028979	Dasypus novemcinctus	93.10	0.00e+00	1256.00
IUUC-Dor-030533	Dipodomys ordii	92.54	0.00e+00	1092.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	665.00
IUUC-Ete-032887	Echinops telfairi	82.49	0.00e+00	1139.00
IUUC-Eca-034397	Equus caballus	92.56	0.00e+00	1189.00
IUUC-Eeu-035237	Erinaceus europaeus	82.54	0.00e+00	1078.00
IUUC-Fca-036030	Felis catus	93.02	0.00e+00	1288.00
IUUC-Fal-037460	Ficedula albicollis	92.88	0.00e+00	1264.00
IUUC-Gga-040416	Gallus gallus	93.27	0.00e+00	1293.00
IUUC-Ggo-045633	Gorilla gorilla	89.62	0.00e+00	1265.00
IUUC-Hsa-046461	Homo sapiens	89.81	0.00e+00	1298.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	93.54	0.00e+00	1295.00
IUUC-Lch-049943	Latimeria chalumnae	89.41	0.00e+00	1157.00
IUUC-Loc-052835	Lepisosteus oculatus	89.30	0.00e+00	1191.00
IUUC-Laf-053425	Loxodonta africana	93.40	0.00e+00	1295.00
IUUC-Mcc-055766	Macaca mulatta	89.94	0.00e+00	1300.00
IUUC-Mmr-061317	Microcebus murinus	90.39	0.00e+00	1301.00
IUUC-Mdo-062956	Monodelphis domestica	92.64	0.00e+00	1281.00
IUUC-Mmu-063576	Mus musculus	93.40	0.00e+00	1290.00
IUUC-Mpu-066410	Mustela putorius furo	99.69	0.00e+00	1195.00
IUUC-Mlu-067456	Myotis lucifugus	91.25	0.00e+00	1212.00
IUUC-Nle-069495	Nomascus leucogenys	93.54	0.00e+00	1268.00
IUUC-Ont-071419	Oreochromis niloticus	79.67	0.00e+00	1104.00
IUUC-Oan-072842	Ornithorhynchus anatinus	89.80	0.00e+00	1271.00
IUUC-Ocu-074453	Oryctolagus cuniculus	92.24	0.00e+00	1276.00
IUUC-Ola-087090	Oryzias latipes	79.25	0.00e+00	1112.00
IUUC-Oga-087939	Otolemur garnettii	93.41	0.00e+00	1293.00
IUUC-Oar-090347	Ovis aries	99.08	0.00e+00	1165.00
IUUC-Ptr-091048	Pan troglodytes	93.66	0.00e+00	1299.00
IUUC-Psi-093586	Pelodiscus sinensis	98.80	0.00e+00	1177.00
IUUC-Pab-097539	Pongo abelii	95.33	0.00e+00	1169.00
IUUC-Pca-101137	Procavia capensis	90.67	0.00e+00	1117.00
IUUC-Pva-103037	Pteropus vampyrus	88.06	0.00e+00	1276.00
IUUC-Rno-105314	Rattus norvegicus	93.09	0.00e+00	1220.00
IUUC-Ssc-116408	Sus scrofa	92.92	0.00e+00	1318.00
IUUC-Tgu-117068	Taeniopygia guttata	92.01	0.00e+00	1257.00
IUUC-Tru-118782	Takifugu rubripes	76.54	0.00e+00	1055.00
IUUC-Tsy-118884	Tarsius syrichta	88.62	0.00e+00	1035.00
IUUC-Tni-120404	Tetraodon nigroviridis	77.92	0.00e+00	1101.00
IUUC-Tbe-128013	Tupaia belangeri	85.51	0.00e+00	1191.00
IUUC-Vpa-130577	Vicugna pacos	80.58	0.00e+00	634.00
IUUC-Xtr-132974	Xenopus tropicalis	90.23	0.00e+00	1205.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence