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Tag Content
UUCD2 ID IUUC-Mcc-055344
UUCD1 version UUC-MaM-00417
Ensembl Protein ID ENSMMUP00000001723.2
UniProt Accession F7BPC7; F7BPC7_MACMU
Genbank Protein ID AFE80744.1; AFH34518.1
Protein Name E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8
Genbank Nucleotide ID JSUE03030792; JU477714
Gene Name RNF8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000001287.3 ENSMMUT00000001827.3 ENSMMUP00000001723.2
ENSMMUG00000001287.3 ENSMMUT00000001826.3 ENSMMUP00000001722.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 3.00e-07 32.0 404 442
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       ++++ CP+Cr
   Q: 404  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKIECPICR 442
           ********99.899***************......**********8 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MGEPGFFVTG DRARGRSWCL RRVGMSAGWL LLEDGREVTV GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI HQGDYIQLGV PLENKENAEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055344|E3,RING|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGGAGTCTC GCTCTGTCAC CCAGGCTGGA GTGCGGTGGC CGGATCTCAG CTCACTGCAA 60
GCTCCGCCTC CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055344|E3,RING|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0436--Ligase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00498--FHA
SMART

SM00240--FHA
SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mcc:100424611
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002124 Ailuropoda melanoleuca 83.85 0.00e+00 658.00
IUUC-Apl-003664 Anas platyrhynchos 78.89 6.00e-39 152.00
IUUC-Aca-005036 Anolis carolinensis 56.84 3.00e-121 428.00
IUUC-Ame-011537 Astyanax mexicanus 42.23 1.00e-87 317.00
IUUC-Bta-013297 Bos taurus 83.16 0.00e+00 629.00
IUUC-Cel-018658 Caenorhabditis elegans 41.07 1.00e-07 52.40
IUUC-Cja-019201 Callithrix jacchus 89.83 0.00e+00 732.00
IUUC-Cfa-021041 Canis familiaris 84.77 0.00e+00 696.00
IUUC-Csa-024133 Chlorocebus sabaeus 99.38 0.00e+00 868.00
IUUC-Cho-024624 Choloepus hoffmanni 74.63 1.00e-133 469.00
IUUC-Dre-027918 Danio rerio 41.81 8.00e-81 294.00
IUUC-Dno-029774 Dasypus novemcinctus 83.95 0.00e+00 686.00
IUUC-Dor-030190 Dipodomys ordii 71.40 2.00e-149 522.00
IUUC-Ete-032301 Echinops telfairi 66.67 1.00e-139 489.00
IUUC-Eca-033607 Equus caballus 85.78 2.00e-173 601.00
IUUC-Eeu-034888 Erinaceus europaeus 81.91 4.00e-122 431.00
IUUC-Fca-036075 Felis catus 83.33 0.00e+00 701.00
IUUC-Fal-037569 Ficedula albicollis 60.89 3.00e-117 415.00
IUUC-Gmo-038588 Gadus morhua 41.15 1.00e-72 266.00
IUUC-Gga-040777 Gallus gallus 58.14 6.00e-120 424.00
IUUC-Gac-042463 Gasterosteus aculeatus 42.15 7.00e-63 234.00
IUUC-Ggo-045269 Gorilla gorilla 97.94 0.00e+00 857.00
IUUC-Hsa-046249 Homo sapiens 97.12 0.00e+00 832.00
IUUC-Itr-048314 Ictidomys tridecemlineatus 83.98 0.00e+00 698.00
IUUC-Lch-049805 Latimeria chalumnae 50.10 2.00e-113 402.00
IUUC-Loc-052377 Lepisosteus oculatus 48.42 9.00e-92 330.00
IUUC-Meu-055950 Macropus eugenii 63.09 2.00e-129 455.00
IUUC-Mla-059052 Melampsora laricipopulina 35.38 1.00e-09 56.20
IUUC-Mga-060049 Meleagris gallopavo 57.36 1.00e-117 416.00
IUUC-Mmr-061431 Microcebus murinus 85.30 0.00e+00 662.00
IUUC-Mdo-062016 Monodelphis domestica 67.87 4.00e-124 440.00
IUUC-Mmu-063235 Mus musculus 71.46 1.00e-178 619.00
IUUC-Mpu-066449 Mustela putorius furo 86.04 0.00e+00 731.00
IUUC-Mlu-067588 Myotis lucifugus 78.88 9.00e-178 616.00
IUUC-Nle-069192 Nomascus leucogenys 97.74 0.00e+00 853.00
IUUC-Opr-070300 Ochotona princeps 63.58 2.00e-140 492.00
IUUC-Ont-071998 Oreochromis niloticus 42.13 2.00e-66 246.00
IUUC-Oan-073610 Ornithorhynchus anatinus 66.09 6.00e-67 246.00
IUUC-Ocu-074603 Oryctolagus cuniculus 79.01 0.00e+00 637.00
IUUC-Ola-086681 Oryzias latipes 40.50 3.00e-70 259.00
IUUC-Oga-088183 Otolemur garnettii 85.57 0.00e+00 721.00
IUUC-Oar-090255 Ovis aries 83.71 1.00e-163 569.00
IUUC-Ptr-091029 Pan troglodytes 96.29 0.00e+00 777.00
IUUC-Pan-092241 Papio anubis 99.38 0.00e+00 872.00
IUUC-Psi-093506 Pelodiscus sinensis 60.86 3.00e-132 464.00
IUUC-Pma-094579 Petromyzon marinus 56.67 2.00e-26 113.00
IUUC-Pfo-097014 Poecilia formosa 43.35 2.00e-64 239.00
IUUC-Pab-098530 Pongo abelii 96.54 0.00e+00 790.00
IUUC-Pca-100939 Procavia capensis 61.93 4.00e-141 494.00
IUUC-Pva-103148 Pteropus vampyrus 78.40 0.00e+00 641.00
IUUC-Rno-105338 Rattus norvegicus 72.90 0.00e+00 641.00
IUUC-Sce-106282 Saccharomyces cerevisiae 33.71 4.00e-06 46.20
IUUC-Sha-107187 Sarcophilus harrisii 66.42 2.00e-106 379.00
IUUC-Sja-107948 Schizosaccharomyces japonicus 22.34 4.00e-09 55.80
IUUC-Sar-113356 Sorex araneus 64.85 3.00e-127 448.00
IUUC-Ssc-116290 Sus scrofa 84.06 0.00e+00 738.00
IUUC-Tru-117910 Takifugu rubripes 40.43 6.00e-61 228.00
IUUC-Tsy-119329 Tarsius syrichta 79.02 2.00e-167 582.00
IUUC-Tni-120521 Tetraodon nigroviridis 38.72 7.00e-61 228.00
IUUC-Tme-126989 Tuber melanosporum 32.20 5.00e-07 49.70
IUUC-Ttr-128997 Tursiops truncatus 78.62 1.00e-178 619.00
IUUC-Vpa-130154 Vicugna pacos 81.89 0.00e+00 689.00
IUUC-Xtr-132805 Xenopus tropicalis 51.14 3.00e-108 385.00
Created Date 25-Jun-2017

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