iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036142

Ensembl Protein ID

ENSFCAP00000022176.1

UniProt Accession

M3X6C4; M3X6C4_FELCA

Genbank Protein ID

ENSFCAP00000022176

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02061227

Gene Name

LATS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000023857.1	ENSFCAT00000027520.1	ENSFCAP00000022176.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	6.70e-08	32.5	100	137

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLl 39
           + ++l+ l++ GFd++ ++qaL+ + n ++eaA+e++ 
   Q: 100  NPQMLQDLQAAGFDEDMVIQALQKTnNRSIEAAIEFIS 137
           789*********************99*********975 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MKRSEKPEGY RQMRPKTFPA SNYSGSSRQM LQEIRESLRN LSKPSDAAKA EHNISKMSTE 60
DPRQVRNPPK FGTHHKALLE IRNSLQPFAN ETSRSTSEVN PQMLQDLQAA GFDEDMVIQA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGAGGA GTGAAAAGCC AGAAGGATAT AGACAAATGA GGCCTAAGAC CTTTCCTGCC 60
AGTAACTACT CTGGCAGTAG CCGGCAAATG TTGCAAGAAA TTCGGGAATC CCTTAGGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR028741--LATS1/Warts
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS51285--AGC_KINASE_CTER
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051220--P:cytoplasmic sequestering of protein
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0030216--P:keratinocyte differentiation
GO:0060644--P:mammary gland epithelial cell differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0030833--P:regulation of actin filament polymerization
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0046620--P:regulation of organ growth
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000819--P:sister chromatid segregation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001895	Ailuropoda melanoleuca	93.17	0.00e+00	1934.00
IUUC-Apl-003278	Anas platyrhynchos	80.23	0.00e+00	1670.00
IUUC-Aca-005319	Anolis carolinensis	83.99	0.00e+00	1275.00
IUUC-Ame-011324	Astyanax mexicanus	84.96	0.00e+00	946.00
IUUC-Bta-013438	Bos taurus	91.49	0.00e+00	1853.00
IUUC-Cel-018517	Caenorhabditis elegans	50.32	4.00e-129	455.00
IUUC-Cja-019072	Callithrix jacchus	91.93	0.00e+00	1925.00
IUUC-Cfa-021267	Canis familiaris	93.70	0.00e+00	1959.00
IUUC-Cpo-021496	Cavia porcellus	85.67	0.00e+00	1536.00
IUUC-Csa-023255	Chlorocebus sabaeus	91.95	0.00e+00	1894.00
IUUC-Cho-024461	Choloepus hoffmanni	98.40	0.00e+00	788.00
IUUC-Cin-025264	Ciona intestinalis	63.68	1.00e-140	493.00
IUUC-Dre-028034	Danio rerio	82.50	0.00e+00	933.00
IUUC-Dno-029888	Dasypus novemcinctus	89.29	0.00e+00	1896.00
IUUC-Dor-030144	Dipodomys ordii	80.50	0.00e+00	1598.00
IUUC-Dme-031656	Drosophila melanogaster	73.66	0.00e+00	659.00
IUUC-Ete-032813	Echinops telfairi	94.70	0.00e+00	1236.00
IUUC-Eca-033781	Equus caballus	92.38	0.00e+00	1889.00
IUUC-Eeu-035007	Erinaceus europaeus	89.35	0.00e+00	1858.00
IUUC-Fal-036626	Ficedula albicollis	79.44	0.00e+00	1674.00
IUUC-Gmo-038688	Gadus morhua	85.99	0.00e+00	782.00
IUUC-Gga-040553	Gallus gallus	80.30	0.00e+00	1677.00
IUUC-Gac-042031	Gasterosteus aculeatus	61.78	0.00e+00	1200.00
IUUC-Ggo-045242	Gorilla gorilla	91.87	0.00e+00	1895.00
IUUC-Hsa-046081	Homo sapiens	91.77	0.00e+00	1892.00
IUUC-Itr-048668	Ictidomys tridecemlineatus	90.91	0.00e+00	1599.00
IUUC-Lch-049425	Latimeria chalumnae	73.37	0.00e+00	1538.00
IUUC-Loc-052418	Lepisosteus oculatus	64.79	0.00e+00	1270.00
IUUC-Laf-053710	Loxodonta africana	88.96	0.00e+00	1840.00
IUUC-Mcc-055079	Macaca mulatta	91.95	0.00e+00	1890.00
IUUC-Mga-059713	Meleagris gallopavo	79.72	0.00e+00	1676.00
IUUC-Mmr-061728	Microcebus murinus	91.87	0.00e+00	1916.00
IUUC-Mdo-061942	Monodelphis domestica	83.48	0.00e+00	1713.00
IUUC-Mmu-063504	Mus musculus	88.13	0.00e+00	1799.00
IUUC-Mpu-066034	Mustela putorius furo	92.55	0.00e+00	1915.00
IUUC-Mlu-067986	Myotis lucifugus	91.13	0.00e+00	1902.00
IUUC-Nle-069202	Nomascus leucogenys	91.68	0.00e+00	1894.00
IUUC-Opr-070801	Ochotona princeps	95.50	0.00e+00	1296.00
IUUC-Ont-072487	Oreochromis niloticus	59.42	0.00e+00	1161.00
IUUC-Oan-073128	Ornithorhynchus anatinus	88.90	0.00e+00	1329.00
IUUC-Ocu-073998	Oryctolagus cuniculus	97.32	0.00e+00	1450.00
IUUC-Ola-086858	Oryzias latipes	58.84	0.00e+00	1125.00
IUUC-Oga-088874	Otolemur garnettii	89.41	0.00e+00	1826.00
IUUC-Oar-089236	Ovis aries	91.41	0.00e+00	1856.00
IUUC-Ptr-091425	Pan troglodytes	92.12	0.00e+00	1904.00
IUUC-Pan-091851	Papio anubis	92.05	0.00e+00	1894.00
IUUC-Psi-093825	Pelodiscus sinensis	79.81	0.00e+00	1373.00
IUUC-Pfo-096326	Poecilia formosa	61.27	0.00e+00	1157.00
IUUC-Pab-097815	Pongo abelii	91.86	0.00e+00	1897.00
IUUC-Pva-102836	Pteropus vampyrus	91.05	0.00e+00	1806.00
IUUC-Ptt-103762	Puccinia triticina	37.78	7.00e-93	335.00
IUUC-Rno-106053	Rattus norvegicus	88.23	0.00e+00	1825.00
IUUC-Sha-106843	Sarcophilus harrisii	83.52	0.00e+00	1761.00
IUUC-Sar-113649	Sorex araneus	93.60	0.00e+00	1437.00
IUUC-Ssc-115486	Sus scrofa	97.86	0.00e+00	864.00
IUUC-Tgu-116903	Taeniopygia guttata	79.70	0.00e+00	1657.00
IUUC-Tru-118760	Takifugu rubripes	62.00	0.00e+00	1210.00
IUUC-Tsy-119361	Tarsius syrichta	90.94	0.00e+00	1613.00
IUUC-Tni-120058	Tetraodon nigroviridis	55.63	0.00e+00	1073.00
IUUC-Tbe-127681	Tupaia belangeri	95.98	0.00e+00	1471.00
IUUC-Ttr-128652	Tursiops truncatus	91.35	0.00e+00	1575.00
IUUC-Vpa-130538	Vicugna pacos	91.31	0.00e+00	1867.00
IUUC-Xtr-132895	Xenopus tropicalis	68.81	0.00e+00	1176.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence