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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045845
Ensembl Protein ID ENSP00000365312.2
UniProt Accession Q8IZP0; A9Z1Y6; B3KX62; B4DQ58; H7BXI6; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8; ABI1_HUMAN
Genbank Protein ID AAB62569.1; AAC39757.1; BAB55675.1; AAN28379.1; AAD00897.1; CAB88006.1; CAB88006.1; CAB88006.1; CAB88006.1; CAB88006.1; CAB88006.1; CAB88006.1; CAB88006.1; CAB88006.1; CAB88006.1; AAF70309.1; BAG54374.1; BAG60820.1; BAF84512.1; CAH73112.1; CAH73112.1; CAH73113.1; CAH73113.1; CAH73114.1; CAH73114.1; CAH73115.1; CAH73115.1; CAH73116.1; CAH73116.1; CAH73117.1; CAH73117.1; CAH73118.1; CAH73118.1; CAH73119.1; CAH73119.1; CAI17272.1; CAI17272.1; CAI17273.1; CAI17273.1; CAI17274.1; CAI17274.1; CAI17275.1; CAI17275.1; CAI17276.1; CAI17276.1; CAI17
Protein Name Abl interactor 1; Abelson interactor 1; Abl-binding protein 4; Eps8 SH3 domain-binding protein; Nap1-binding protein; Spectrin SH3 domain-binding protein 1; e3B1
Genbank Nucleotide ID AF006516; U87166; AB040151; AF540955; AF001628; AJ277065; AJ277066; AJ277067; AJ277068; AJ277069; AJ277070; AJ277071; AJ277072; AJ277073; AJ277074; AF260262; AK126803; AK298646; AK291823; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; AL390961; AL139404; CH471072; CH471072; BC024254
Gene Name ABI1; SSH3BP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000136754.16 ENST00000376170.8 ENSP00000365340.4
ENSG00000136754.16 ENST00000376142.6 ENSP00000365312.2
ENSG00000136754.16 ENST00000359188.8 ENSP00000352114.4
ENSG00000136754.16 ENST00000376139.6 ENSP00000365309.2
ENSG00000136754.16 ENST00000376160.5 ENSP00000365330.1
ENSG00000136754.16 ENST00000376166.5 ENSP00000365336.1
ENSG00000136754.16 ENST00000376138.7 ENSP00000365308.3
ENSG00000136754.16 ENST00000376140.3 ENSP00000365310.3
ENSG00000136754.16 ENST00000536334.5 ENSP00000439646.2
ENSG00000136754.16 ENST00000490841.6 ENSP00000440101.1
ENSG00000136754.16 ENST00000376137.8 ENSP00000365307.5
ENSG00000136754.16 ENST00000346832.9 ENSP00000279599.8
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosSNPPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.40e-13 52.2 449 503
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ekv ++ydy+  +ddeL++ +G +++vi  +++d gW +g    +   GlfP n+ve +
   Q: 449  EKVVAIYDYTKDKDDELSFMEGAIIYVI--KKNDDGWYEG--VCNRVTGLFPGNYVESI 503
           789*************************..99********..79************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
 May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Protein Sequence
(Fasta)
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS 60
VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045845|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGAAATAAA CGCTCGCGAG AGAACGAGGT TCAGGCGGCT GCACGAAGGG GGTGGAGGGG 60
GGCTGGAGAG AGTGAGGAGG AAGGGGAGGA GGTGCCGTCC CACAATACCA GGCGGGAGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045845|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
Interpro

IPR028457--ABI
IPR028456--ABI1/ABI2
IPR012849--Abl-interactor_HHR_dom
IPR001452--SH3_domain
IPR000727--T_SNARE_dom
PROSITE

PS50002--SH3
PS50192--T_SNARE
Pfam

PF07815--Abi_HHR
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0030054--C:cell junction
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0030175--C:filopodium
GO:0030426--C:growth cone
GO:0005622--C:intracellular
GO:0030027--C:lamellipodium
GO:0005634--C:nucleus
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0031209--C:SCAR complex
GO:0045296--F:cadherin binding
GO:0008092--F:cytoskeletal protein binding
GO:0032403--F:protein complex binding
GO:0030296--F:protein tyrosine kinase activator activity
GO:0017124--F:SH3 domain binding
GO:0008154--P:actin polymerization or depolymerization
GO:0048813--P:dendrite morphogenesis
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0072673--P:lamellipodium morphogenesis
GO:0035855--P:megakaryocyte development
GO:0006928--P:movement of cell or subcellular component
GO:0008285--P:negative regulation of cell proliferation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0001756--P:somitogenesis
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016032--P:viral process
KEGG hsa:10006
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001375 Ailuropoda melanoleuca 97.64 0.00e+00 777.00
IUUC-Apl-003291 Anas platyrhynchos 95.09 0.00e+00 754.00
IUUC-Aca-004955 Anolis carolinensis 90.30 0.00e+00 665.00
IUUC-Ame-011140 Astyanax mexicanus 60.34 1.00e-141 496.00
IUUC-Bta-013104 Bos taurus 65.64 6.00e-154 537.00
IUUC-Cja-019099 Callithrix jacchus 99.80 0.00e+00 796.00
IUUC-Cfa-020201 Canis familiaris 99.21 0.00e+00 795.00
IUUC-Cpo-021955 Cavia porcellus 97.91 8.00e-129 453.00
IUUC-Csa-024155 Chlorocebus sabaeus 100.00 0.00e+00 792.00
IUUC-Cho-024588 Choloepus hoffmanni 97.08 4.00e-127 448.00
IUUC-Cin-025769 Ciona intestinalis 55.88 3.00e-66 246.00
IUUC-Csv-026114 Ciona savignyi 61.29 2.00e-66 246.00
IUUC-Dre-028665 Danio rerio 94.44 5.00e-128 451.00
IUUC-Dno-029586 Dasypus novemcinctus 94.69 0.00e+00 779.00
IUUC-Ete-032286 Echinops telfairi 96.26 0.00e+00 789.00
IUUC-Eca-033716 Equus caballus 99.15 0.00e+00 714.00
IUUC-Eeu-034628 Erinaceus europaeus 83.81 8.00e-122 430.00
IUUC-Fca-036186 Felis catus 97.44 0.00e+00 780.00
IUUC-Fal-037526 Ficedula albicollis 95.67 0.00e+00 770.00
IUUC-Gmo-039109 Gadus morhua 72.01 4.00e-177 614.00
IUUC-Gga-040990 Gallus gallus 96.46 0.00e+00 776.00
IUUC-Gac-042525 Gasterosteus aculeatus 76.89 0.00e+00 673.00
IUUC-Ggo-044789 Gorilla gorilla 99.21 0.00e+00 780.00
IUUC-Itr-048893 Ictidomys tridecemlineatus 99.57 9.00e-112 396.00
IUUC-Lch-050579 Latimeria chalumnae 86.85 2.00e-152 531.00
IUUC-Loc-052683 Lepisosteus oculatus 87.38 0.00e+00 713.00
IUUC-Laf-054032 Loxodonta africana 93.90 0.00e+00 771.00
IUUC-Mcc-055180 Macaca mulatta 100.00 0.00e+00 792.00
IUUC-Mga-059287 Meleagris gallopavo 89.17 0.00e+00 679.00
IUUC-Mmr-061282 Microcebus murinus 99.80 0.00e+00 796.00
IUUC-Mdo-062996 Monodelphis domestica 93.50 0.00e+00 762.00
IUUC-Mmu-063875 Mus musculus 92.32 0.00e+00 724.00
IUUC-Mpu-065785 Mustela putorius furo 98.23 0.00e+00 787.00
IUUC-Mlu-068146 Myotis lucifugus 91.43 0.00e+00 704.00
IUUC-Nle-070077 Nomascus leucogenys 93.50 0.00e+00 758.00
IUUC-Opr-070618 Ochotona princeps 77.26 6.00e-101 361.00
IUUC-Ont-072203 Oreochromis niloticus 77.95 0.00e+00 638.00
IUUC-Oan-073650 Ornithorhynchus anatinus 92.32 0.00e+00 761.00
IUUC-Ocu-074682 Oryctolagus cuniculus 94.29 0.00e+00 778.00
IUUC-Ola-086654 Oryzias latipes 71.29 3.00e-170 591.00
IUUC-Oga-088619 Otolemur garnettii 92.43 5.00e-170 590.00
IUUC-Oar-089983 Ovis aries 94.69 0.00e+00 779.00
IUUC-Ptr-091652 Pan troglodytes 99.61 0.00e+00 791.00
IUUC-Pan-091799 Papio anubis 94.69 0.00e+00 779.00
IUUC-Psi-093802 Pelodiscus sinensis 91.54 0.00e+00 745.00
IUUC-Pfo-097441 Poecilia formosa 79.77 0.00e+00 652.00
IUUC-Pab-098208 Pongo abelii 94.69 0.00e+00 779.00
IUUC-Pca-100439 Procavia capensis 61.70 1.00e-99 357.00
IUUC-Pva-102520 Pteropus vampyrus 98.82 0.00e+00 781.00
IUUC-Rno-106012 Rattus norvegicus 92.72 0.00e+00 726.00
IUUC-Sha-106615 Sarcophilus harrisii 88.41 0.00e+00 633.00
IUUC-Sar-113140 Sorex araneus 91.34 0.00e+00 711.00
IUUC-Ssc-115676 Sus scrofa 100.00 4.00e-77 280.00
IUUC-Tgu-117093 Taeniopygia guttata 95.33 0.00e+00 695.00
IUUC-Tru-117869 Takifugu rubripes 78.38 0.00e+00 635.00
IUUC-Tsy-119104 Tarsius syrichta 92.96 0.00e+00 640.00
IUUC-Tni-120686 Tetraodon nigroviridis 76.12 0.00e+00 654.00
IUUC-Tbe-127508 Tupaia belangeri 94.49 0.00e+00 722.00
IUUC-Ttr-129105 Tursiops truncatus 98.17 0.00e+00 744.00
IUUC-Vpa-130514 Vicugna pacos 97.87 0.00e+00 670.00
IUUC-Xtr-131805 Xenopus tropicalis 85.63 0.00e+00 723.00
Created Date 25-Jun-2017

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