iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074251

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02049881

Gene Name

WSB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000004643.3	ENSOCUT00000004643.3	ENSOCUP00000004008.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	5.20e-16	58.3	375	420
E3 adaptor/Cullin RING/DCX/DWD	3.40e-33	112.3	169	203
UBD/Beta-Prp	2.50e-48	164.8	135	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++++++SLqhLCR++Irr +++q++   ++LP+P++  ++L+y+
   Q: 375  VYFWATPRQVPSLQHLCRMSIRRVMPTQEV---QELPIPSKVLEFLSYR 420
           689************************999...**************97 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 169  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 203
           9**********8865668*************9987 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfs 103
            f +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l+gh++ v+s++fs
   Q: 135  RFGQDQLLLATGLSNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRGHQNWVYSCAFS 223
           5678999***********************************************************9799******************* PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tgght 180
           p+++ l s ++ + + +w+++t++ ++  l+gh + v    ++pdg ll+++s+D+ v +Wd  +g++l ++             g+++
   Q: 224  PDSSMLCSVGASKAVFLWNMDTYTMIR-KLEGHYHDVVACDFSPDGALLATASYDTRVYIWDPYNGEILMEFghlfppptpifaGGAND 311
           ***************************.*******************************************************9888** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           + v+s+sf+++g +++s ++d+ v++w + +   +  + +  +n ++ +fs ++  l+ g++Dgs+++W
   Q: 312  RWVRSVSFSHDGLHIASLADDKMVRFWRIDED--LPVQVAPLSNGLCCAFSTDGSVLAAGTQDGSVYFW 378
           *****************************888..79999****************************** PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MELAWNSRLF LLLVRSRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA WSQGHRTVKL 60
VPWSQCLRNF LLHGTKNVTS SSSLRLSRQN SDGGQKNKPR EHIIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCTGTCC TGCGTGTGGC TGGACTTCAT ATATGGAGCT GGCTTGGAAT TCTCGGCTCT 60
TTCTTCTCTT AGGTAAAAAA GTGGAGTGGC TGACTAGGAG GGGACTTTAA CCCCTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	96.09	0.00e+00	798.00
IUUC-Apl-003903	Anas platyrhynchos	88.73	0.00e+00	766.00
IUUC-Aca-005214	Anolis carolinensis	77.83	0.00e+00	668.00
IUUC-Ame-011740	Astyanax mexicanus	74.94	0.00e+00	645.00
IUUC-Bta-013475	Bos taurus	96.33	0.00e+00	803.00
IUUC-Cja-019053	Callithrix jacchus	96.81	0.00e+00	806.00
IUUC-Cfa-020103	Canis familiaris	97.07	0.00e+00	806.00
IUUC-Cpo-022438	Cavia porcellus	95.11	0.00e+00	801.00
IUUC-Csa-024062	Chlorocebus sabaeus	96.82	0.00e+00	813.00
IUUC-Cho-024334	Choloepus hoffmanni	83.86	0.00e+00	677.00
IUUC-Cin-025590	Ciona intestinalis	40.25	3.00e-78	285.00
IUUC-Csv-026023	Ciona savignyi	40.10	3.00e-80	292.00
IUUC-Dre-028089	Danio rerio	74.69	0.00e+00	648.00
IUUC-Dno-029436	Dasypus novemcinctus	90.63	0.00e+00	663.00
IUUC-Dor-031107	Dipodomys ordii	90.22	0.00e+00	731.00
IUUC-Ete-032326	Echinops telfairi	93.33	0.00e+00	775.00
IUUC-Eca-033401	Equus caballus	96.09	0.00e+00	799.00
IUUC-Eeu-034520	Erinaceus europaeus	94.13	0.00e+00	795.00
IUUC-Fca-036386	Felis catus	96.09	0.00e+00	800.00
IUUC-Fal-036616	Ficedula albicollis	85.50	0.00e+00	733.00
IUUC-Gmo-039335	Gadus morhua	70.94	2.00e-178	618.00
IUUC-Gga-040856	Gallus gallus	88.78	0.00e+00	759.00
IUUC-Gac-042140	Gasterosteus aculeatus	73.54	0.00e+00	635.00
IUUC-Ggo-044619	Gorilla gorilla	96.33	0.00e+00	810.00
IUUC-Hsa-046300	Homo sapiens	96.58	0.00e+00	810.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	95.60	0.00e+00	804.00
IUUC-Lch-049550	Latimeria chalumnae	79.19	6.00e-166	576.00
IUUC-Loc-051769	Lepisosteus oculatus	77.02	0.00e+00	665.00
IUUC-Laf-054576	Loxodonta africana	94.87	0.00e+00	792.00
IUUC-Mcc-054666	Macaca mulatta	96.95	3.00e-152	530.00
IUUC-Meu-055989	Macropus eugenii	88.00	0.00e+00	629.00
IUUC-Mga-059722	Meleagris gallopavo	89.68	0.00e+00	764.00
IUUC-Mmr-060970	Microcebus murinus	97.07	0.00e+00	803.00
IUUC-Mdo-062249	Monodelphis domestica	78.97	0.00e+00	629.00
IUUC-Mmu-063742	Mus musculus	90.69	0.00e+00	772.00
IUUC-Mpu-066518	Mustela putorius furo	95.60	0.00e+00	807.00
IUUC-Mlu-068063	Myotis lucifugus	94.62	0.00e+00	786.00
IUUC-Nle-069561	Nomascus leucogenys	96.33	0.00e+00	810.00
IUUC-Opr-071158	Ochotona princeps	94.12	0.00e+00	786.00
IUUC-Ont-072542	Oreochromis niloticus	73.06	0.00e+00	632.00
IUUC-Oan-073217	Ornithorhynchus anatinus	90.46	0.00e+00	766.00
IUUC-Ola-086549	Oryzias latipes	71.74	0.00e+00	634.00
IUUC-Oga-088382	Otolemur garnettii	97.07	0.00e+00	805.00
IUUC-Oar-090263	Ovis aries	94.62	0.00e+00	791.00
IUUC-Ptr-090922	Pan troglodytes	96.33	0.00e+00	810.00
IUUC-Pan-092518	Papio anubis	96.82	0.00e+00	813.00
IUUC-Psi-093512	Pelodiscus sinensis	88.54	0.00e+00	754.00
IUUC-Pma-094324	Petromyzon marinus	58.75	2.00e-133	468.00
IUUC-Pfo-096264	Poecilia formosa	72.22	0.00e+00	634.00
IUUC-Pab-098018	Pongo abelii	94.87	0.00e+00	793.00
IUUC-Pca-101034	Procavia capensis	94.10	0.00e+00	766.00
IUUC-Pva-102862	Pteropus vampyrus	93.07	0.00e+00	734.00
IUUC-Rno-106116	Rattus norvegicus	91.20	0.00e+00	775.00
IUUC-Sha-106952	Sarcophilus harrisii	89.07	0.00e+00	759.00
IUUC-Sar-113211	Sorex araneus	83.96	8.00e-149	519.00
IUUC-Ssc-116440	Sus scrofa	96.58	0.00e+00	801.00
IUUC-Tgu-116675	Taeniopygia guttata	85.78	0.00e+00	730.00
IUUC-Tru-118295	Takifugu rubripes	71.84	1.00e-176	612.00
IUUC-Tsy-118916	Tarsius syrichta	83.13	0.00e+00	672.00
IUUC-Tni-120302	Tetraodon nigroviridis	71.84	5.00e-176	610.00
IUUC-Tbe-127416	Tupaia belangeri	82.80	0.00e+00	657.00
IUUC-Ttr-128185	Tursiops truncatus	96.33	0.00e+00	801.00
IUUC-Xtr-132465	Xenopus tropicalis	83.33	0.00e+00	715.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence