iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132083

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ribosome biogenesis protein wdr12; WD repeat-containing protein 12

Genbank Nucleotide ID

BC091577

Gene Name

wdr12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000022077.3	ENSXETT00000047773.3	ENSXETP00000047773.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-43	144.7	341	376
UBD/Beta-Prp	6.40e-48	163.6	249	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  s    lvsGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWspSHeQQLVSGSLDKLVKLWDTRSCK 376
           ***********754799**************99876 PP

UBD/Beta-Prp

   S: 86   cvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk...l 171
           +++tl+gh++ v s+ +s   d + s+s+d  i++wd+etg++ + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd ++++   +
   Q: 249  PIVTLSGHSEAVSSVLWSD-VDEICSASWDHNIKIWDVETGTVKS-TLAGNK-VFNCISYSPLSQRLASGSTDRHIRLWDPRSKDgslV 334
           689***************9.9***********************9.***987.99**************************66652223 PP
   S: 172  lrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           l  lt+ ht+ v+s++++++  ++lvsgsld+ vklwd +  +  ++ l +h+d v+sv+ + +  +++sg+sD+ ++ +
   Q: 335  LCSLTS-HTGWVTSVKWSPSHeQQLVSGSLDKLVKLWDTRsCKAPLYDLAAHSDKVLSVDWT-DAGLILSGGSDNKLYSY 412
           455587.***********9888******************54566****************9.9**********998776 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQIQARFFT EEEKYKVDDV PFSIPATSEI VDLSNLINKL LETKNGDHKP VEFDFLVKSQ 60
FLRMPLIKHM EAEGISTEVV VEIEYVEKIT APQPEECMMH DDWVSSIAGT EEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGATGTGCTC GGAGTGCAGG ACTGCTCCGT GTAGACACGT GGTTGGCTTC TCGCTTGTTG 60
CGTAGCGGTG TAGCTGGAGT GTGCGTCCCT AGAATTAGAG TTCCCGGCTC CGGCTGGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

KEGG

xtr:595016

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	34.05	4.00e-60	225.00
IUUC-Aml-001997	Ailuropoda melanoleuca	81.22	0.00e+00	628.00
IUUC-Atr-002544	Amborella trichopoda	34.29	2.00e-55	209.00
IUUC-Apl-003981	Anas platyrhynchos	79.68	2.00e-169	588.00
IUUC-Aca-004370	Anolis carolinensis	80.71	0.00e+00	669.00
IUUC-Aly-006455	Arabidopsis lyrata	34.38	6.00e-60	224.00
IUUC-Ath-006669	Arabidopsis thaliana	34.62	1.00e-54	206.00
IUUC-Ago-007864	Ashbya gossypii	30.54	1.00e-39	157.00
IUUC-Acl-008177	Aspergillus clavatus	29.13	3.00e-38	152.00
IUUC-Afl-008617	Aspergillus flavus	29.20	5.00e-37	148.00
IUUC-Afu-008752	Aspergillus fumigatus	27.67	6.00e-36	145.00
IUUC-Ani-009136	Aspergillus nidulans	30.85	3.00e-38	152.00
IUUC-Ang-009701	Aspergillus niger	29.41	9.00e-35	141.00
IUUC-Aor-009884	Aspergillus oryzae	29.44	4.00e-37	149.00
IUUC-Ame-011432	Astyanax mexicanus	74.00	0.00e+00	630.00
IUUC-Bgr-012218	Blumeria graminis	28.78	7.00e-35	141.00
IUUC-Bta-012829	Bos taurus	81.80	0.00e+00	656.00
IUUC-Bci-013953	Botrytis cinerea	29.64	2.00e-37	149.00
IUUC-Bdi-014351	Brachypodium distachyon	36.02	7.00e-56	211.00
IUUC-Bol-016190	Brassica oleracea	34.37	2.00e-52	199.00
IUUC-Bra-018095	Brassica rapa	33.33	3.00e-52	198.00
IUUC-Cel-018569	Caenorhabditis elegans	34.06	7.00e-49	187.00
IUUC-Cja-019468	Callithrix jacchus	81.09	0.00e+00	638.00
IUUC-Cfa-020471	Canis familiaris	80.14	0.00e+00	643.00
IUUC-Cpo-022260	Cavia porcellus	81.09	0.00e+00	640.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	31.06	9.00e-40	157.00
IUUC-Csa-023989	Chlorocebus sabaeus	81.32	0.00e+00	640.00
IUUC-Cho-024426	Choloepus hoffmanni	79.68	7.00e-135	473.00
IUUC-Cin-025789	Ciona intestinalis	43.41	1.00e-95	343.00
IUUC-Cne-027063	Cryptococcus neoformans	24.95	4.00e-20	92.40
IUUC-Dre-027907	Danio rerio	75.65	0.00e+00	645.00
IUUC-Dno-029225	Dasypus novemcinctus	79.43	0.00e+00	644.00
IUUC-Dor-031082	Dipodomys ordii	67.38	2.00e-140	491.00
IUUC-Dse-031308	Dothistroma septosporum	28.34	6.00e-38	151.00
IUUC-Dme-032189	Drosophila melanogaster	40.81	2.00e-91	329.00
IUUC-Ete-032247	Echinops telfairi	75.65	2.00e-172	598.00
IUUC-Eca-034285	Equus caballus	80.38	0.00e+00	649.00
IUUC-Eeu-035322	Erinaceus europaeus	72.61	5.00e-157	546.00
IUUC-Fca-036114	Felis catus	80.38	0.00e+00	647.00
IUUC-Fal-036891	Ficedula albicollis	80.23	6.00e-158	549.00
IUUC-Fox-037965	Fusarium oxysporum	25.69	2.00e-33	136.00
IUUC-Fso-038244	Fusarium solani	25.68	7.00e-32	131.00
IUUC-Gmo-039040	Gadus morhua	73.52	0.00e+00	635.00
IUUC-Ggr-040093	Gaeumannomyces graminis	22.86	3.00e-15	76.60
IUUC-Gga-040610	Gallus gallus	78.01	0.00e+00	653.00
IUUC-Gac-042117	Gasterosteus aculeatus	73.05	1.00e-178	618.00
IUUC-Gma-043146	Glycine max	37.26	5.00e-66	244.00
IUUC-Ggo-045179	Gorilla gorilla	81.32	0.00e+00	632.00
IUUC-Hsa-046114	Homo sapiens	81.56	0.00e+00	635.00
IUUC-Hvu-047331	Hordeum vulgare	35.22	7.00e-55	207.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	81.09	0.00e+00	650.00
IUUC-Kpa-049304	Komagataella pastoris	30.53	7.00e-45	174.00
IUUC-Lch-050655	Latimeria chalumnae	73.08	1.00e-135	475.00
IUUC-Lpe-051675	Leersia perrieri	34.93	6.00e-59	221.00
IUUC-Loc-052868	Lepisosteus oculatus	77.78	0.00e+00	639.00
IUUC-Lma-053258	Leptosphaeria maculans	26.39	1.00e-34	142.00
IUUC-Laf-053993	Loxodonta africana	80.38	0.00e+00	649.00
IUUC-Mcc-055128	Macaca mulatta	66.19	4.00e-141	493.00
IUUC-Meu-056501	Macropus eugenii	70.51	2.00e-142	498.00
IUUC-Mor-057114	Magnaporthe oryzae	26.30	3.00e-29	122.00
IUUC-Mtr-058367	Medicago truncatula	36.93	1.00e-59	223.00
IUUC-Mla-059107	Melampsora laricipopulina	28.05	4.00e-31	129.00
IUUC-Mga-059745	Meleagris gallopavo	76.24	0.00e+00	629.00
IUUC-Mvi-060362	Microbotryum violaceum	28.79	9.00e-32	131.00
IUUC-Mdo-062257	Monodelphis domestica	77.67	0.00e+00	653.00
IUUC-Mmu-063546	Mus musculus	79.20	0.00e+00	644.00
IUUC-Mac-065540	Musa acuminata	34.45	2.00e-56	213.00
IUUC-Mpu-066284	Mustela putorius furo	80.85	0.00e+00	650.00
IUUC-Mlu-067241	Myotis lucifugus	79.91	0.00e+00	645.00
IUUC-Nfi-068260	Neosartorya fischeri	28.78	3.00e-37	149.00
IUUC-Ncr-068719	Neurospora crassa	27.43	1.00e-29	124.00
IUUC-Nle-068981	Nomascus leucogenys	81.32	0.00e+00	636.00
IUUC-Opr-071218	Ochotona princeps	74.87	1.00e-167	582.00
IUUC-Ont-071646	Oreochromis niloticus	74.58	0.00e+00	631.00
IUUC-Oan-073453	Ornithorhynchus anatinus	80.85	0.00e+00	682.00
IUUC-Ocu-074008	Oryctolagus cuniculus	80.61	0.00e+00	651.00
IUUC-Oba-075712	Oryza barthii	30.84	4.00e-43	168.00
IUUC-Obr-076721	Oryza brachyantha	35.08	3.00e-58	219.00
IUUC-Ogl-077229	Oryza glaberrima	35.17	2.00e-59	223.00
IUUC-Ogu-078977	Oryza glumaepatula	30.84	2.00e-43	169.00
IUUC-Oin-079683	Oryza indica	35.17	6.00e-60	224.00
IUUC-Olo-080291	Oryza longistaminata	30.41	4.00e-29	121.00
IUUC-Ome-081834	Oryza meridionalis	35.41	8.00e-61	227.00
IUUC-Oni-082507	Oryza nivara	34.05	3.00e-55	209.00
IUUC-Opu-083396	Oryza punctata	35.41	2.00e-59	223.00
IUUC-Oru-085220	Oryza rufipogon	34.05	8.00e-55	207.00
IUUC-Osa-085767	Oryza sativa	35.17	6.00e-60	224.00
IUUC-Ola-087420	Oryzias latipes	74.23	0.00e+00	636.00
IUUC-Olu-087740	Ostreococcus lucimarinus	28.81	6.00e-39	154.00
IUUC-Oga-088264	Otolemur garnettii	80.38	0.00e+00	647.00
IUUC-Oar-089335	Ovis aries	81.09	0.00e+00	652.00
IUUC-Ptr-091320	Pan troglodytes	81.56	0.00e+00	635.00
IUUC-Pan-092833	Papio anubis	81.09	0.00e+00	636.00
IUUC-Psi-093504	Pelodiscus sinensis	81.32	0.00e+00	665.00
IUUC-Pma-094189	Petromyzon marinus	66.27	8.00e-161	559.00
IUUC-Pno-094929	Phaeosphaeria nodorum	26.60	1.00e-34	140.00
IUUC-Ppa-095429	Physcomitrella patens	35.68	1.00e-63	236.00
IUUC-Pfo-096337	Poecilia formosa	73.29	0.00e+00	637.00
IUUC-Pab-097571	Pongo abelii	81.09	0.00e+00	634.00
IUUC-Pop-099977	Populus trichocarpa	35.82	5.00e-63	234.00
IUUC-Pca-100394	Procavia capensis	77.02	4.00e-170	590.00
IUUC-Ppe-101848	Prunus persica	36.39	5.00e-62	231.00
IUUC-Pva-102921	Pteropus vampyrus	79.76	2.00e-96	345.00
IUUC-Pgr-103637	Puccinia graminis	28.48	2.00e-37	149.00
IUUC-Ptt-103781	Puccinia triticina	28.69	8.00e-38	151.00
IUUC-Pte-104135	Pyrenophora teres	27.70	2.00e-36	148.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	27.67	6.00e-36	144.00
IUUC-Rno-105114	Rattus norvegicus	80.38	0.00e+00	652.00
IUUC-Sce-106401	Saccharomyces cerevisiae	30.70	9.00e-42	164.00
IUUC-Sha-107122	Sarcophilus harrisii	77.86	2.00e-178	618.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	31.54	3.00e-48	185.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.44	1.00e-37	150.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.81	2.00e-37	149.00
IUUC-Smo-108720	Selaginella moellendorffii	31.84	3.00e-51	195.00
IUUC-Sit-110311	Setaria italica	36.67	9.00e-58	217.00
IUUC-Sly-111178	Solanum lycopersicum	35.24	2.00e-57	216.00
IUUC-Stu-112778	Solanum tuberosum	35.32	6.00e-60	224.00
IUUC-Sar-113596	Sorex araneus	65.48	1.00e-142	499.00
IUUC-Sbi-114193	Sorghum bicolor	36.25	3.00e-56	212.00
IUUC-Sre-115002	Sporisorium reilianum	26.16	3.00e-13	69.70
IUUC-Ssc-116066	Sus scrofa	80.38	0.00e+00	645.00
IUUC-Tgu-117048	Taeniopygia guttata	78.36	2.00e-168	585.00
IUUC-Tsy-119573	Tarsius syrichta	52.39	5.00e-108	384.00
IUUC-Tni-119820	Tetraodon nigroviridis	74.76	0.00e+00	635.00
IUUC-Tca-121605	Theobroma cacao	36.06	1.00e-59	223.00
IUUC-Tre-121947	Trichoderma reesei	27.02	5.00e-34	138.00
IUUC-Tvi-122481	Trichoderma virens	27.52	2.00e-36	146.00
IUUC-Tae-125861	Triticum aestivum	34.29	2.00e-60	226.00
IUUC-Tur-126586	Triticum urartu	34.78	9.00e-57	213.00
IUUC-Tme-126900	Tuber melanosporum	31.21	3.00e-47	182.00
IUUC-Tbe-127736	Tupaia belangeri	61.81	2.00e-124	439.00
IUUC-Ttr-129041	Tursiops truncatus	69.50	7.00e-160	556.00
IUUC-Uma-129628	Ustilago maydis	26.07	2.00e-07	50.80
IUUC-Vpa-130260	Vicugna pacos	81.09	0.00e+00	654.00
IUUC-Vvi-131009	Vitis vinifera	35.48	2.00e-60	226.00
IUUC-Xma-133094	Xiphophorus maculatus	73.52	0.00e+00	635.00
IUUC-Yli-134531	Yarrowia lipolytica	25.65	1.00e-22	100.00
IUUC-Zma-135509	Zea mays	34.29	3.00e-57	215.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence