iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033446

UUCD1 version

UUC-EqC-00196

Ensembl Protein ID

ENSECAP00000015339.1

UniProt Accession

F6SQ43; F6SQ43_HORSE

Protein Name

Breast cancer type 1 susceptibility protein homolog

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000016974.1	ENSECAT00000018781.1	ENSECAP00000015339.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.80e-07	31.1	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 65
           ********99.**************9666...68899********7 PP

Organism

Equus caballus

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

MDVSADRVEE VQNVLNAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 60
CPLCKNDITK RSLQESTRFS QLVEELLRII HAFELDTGLQ FAHSYSFSKK ENDSPERVKE 120

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Nucleotide Sequence
(Fasta)

GGTGGCGGCC GGTTTCCGTG GCAACAGAAA AGCGCGGGAA TTACGGATAA GTTGAAACTG 60
CGACTGCGCG GCGTGAGCGC GCTGAGGCTT TCTGGACTGA GGACGGTCTT GGGAGGCTTT 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0035066--P:positive regulation of histone acetylation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000225	Aegilops tauschii	30.12	1.00e-15	79.00
IUUC-Aml-002388	Ailuropoda melanoleuca	78.99	0.00e+00	2877.00
IUUC-Atr-002625	Amborella trichopoda	25.79	2.00e-14	75.10
IUUC-Apl-003252	Anas platyrhynchos	35.48	2.00e-127	451.00
IUUC-Aca-004526	Anolis carolinensis	58.11	1.00e-75	277.00
IUUC-Ath-006986	Arabidopsis thaliana	27.65	8.00e-15	75.90
IUUC-Ame-011720	Astyanax mexicanus	50.74	2.00e-55	211.00
IUUC-Bgr-011969	Blumeria graminis	39.62	2.00e-08	53.10
IUUC-Bta-013433	Bos taurus	75.74	0.00e+00	2730.00
IUUC-Bdi-014760	Brachypodium distachyon	30.12	2.00e-15	78.20
IUUC-Bol-016476	Brassica oleracea	29.86	3.00e-16	80.90
IUUC-Bra-017176	Brassica rapa	29.11	1.00e-16	82.40
IUUC-Cel-018208	Caenorhabditis elegans	31.52	2.00e-10	60.80
IUUC-Cja-019149	Callithrix jacchus	74.88	0.00e+00	2650.00
IUUC-Cfa-020322	Canis familiaris	78.16	0.00e+00	2808.00
IUUC-Cpo-021583	Cavia porcellus	47.37	0.00e+00	1358.00
IUUC-Csa-024227	Chlorocebus sabaeus	75.49	9.00e-164	570.00
IUUC-Cho-024530	Choloepus hoffmanni	69.67	0.00e+00	1256.00
IUUC-Cin-025364	Ciona intestinalis	31.62	5.00e-15	75.10
IUUC-Csv-026245	Ciona savignyi	39.74	3.00e-13	68.60
IUUC-Dno-029247	Dasypus novemcinctus	73.04	0.00e+00	2159.00
IUUC-Dme-032032	Drosophila melanogaster	54.35	7.00e-11	58.50
IUUC-Ete-032472	Echinops telfairi	55.80	0.00e+00	1706.00
IUUC-Eeu-034858	Erinaceus europaeus	64.10	0.00e+00	1045.00
IUUC-Fca-035991	Felis catus	79.42	0.00e+00	2907.00
IUUC-Fal-036803	Ficedula albicollis	29.77	5.00e-100	360.00
IUUC-Gmo-038782	Gadus morhua	46.88	6.00e-47	183.00
IUUC-Gga-040969	Gallus gallus	29.11	6.00e-93	336.00
IUUC-Gac-042296	Gasterosteus aculeatus	46.70	9.00e-53	202.00
IUUC-Gma-044372	Glycine max	32.14	6.00e-11	63.90
IUUC-Ggo-044740	Gorilla gorilla	73.52	0.00e+00	2552.00
IUUC-Hsa-046086	Homo sapiens	76.62	0.00e+00	2654.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	72.92	0.00e+00	2684.00
IUUC-Lch-049789	Latimeria chalumnae	36.10	1.00e-89	325.00
IUUC-Lpe-050895	Leersia perrieri	28.64	2.00e-16	81.30
IUUC-Loc-051952	Lepisosteus oculatus	56.73	6.00e-69	256.00
IUUC-Laf-053648	Loxodonta africana	75.60	0.00e+00	2607.00
IUUC-Mcc-055210	Macaca mulatta	75.87	0.00e+00	2736.00
IUUC-Meu-056342	Macropus eugenii	39.72	9.00e-138	485.00
IUUC-Mor-057034	Magnaporthe oryzae	38.78	4.00e-08	52.40
IUUC-Mpo-057316	Magnaporthe poae	35.82	1.00e-07	51.20
IUUC-Mtr-058400	Medicago truncatula	26.75	2.00e-15	78.60
IUUC-Mga-060163	Meleagris gallopavo	63.11	1.00e-79	292.00
IUUC-Mmr-061402	Microcebus murinus	70.81	0.00e+00	844.00
IUUC-Mdo-062209	Monodelphis domestica	46.63	0.00e+00	1342.00
IUUC-Mmu-064003	Mus musculus	56.49	0.00e+00	1837.00
IUUC-Mac-065131	Musa acuminata	29.66	1.00e-12	68.90
IUUC-Mpu-065825	Mustela putorius furo	79.49	0.00e+00	837.00
IUUC-Mlu-068176	Myotis lucifugus	76.77	0.00e+00	2620.00
IUUC-Nle-069178	Nomascus leucogenys	76.73	0.00e+00	2703.00
IUUC-Opr-070574	Ochotona princeps	60.55	0.00e+00	1998.00
IUUC-Ont-072380	Oreochromis niloticus	50.97	7.00e-60	226.00
IUUC-Oan-073243	Ornithorhynchus anatinus	76.19	6.00e-35	139.00
IUUC-Ocu-074424	Oryctolagus cuniculus	70.35	0.00e+00	2458.00
IUUC-Oba-075676	Oryza barthii	31.78	1.00e-12	68.90
IUUC-Obr-076308	Oryza brachyantha	31.72	3.00e-14	74.30
IUUC-Ogl-077654	Oryza glaberrima	31.78	1.00e-12	68.90
IUUC-Ogu-078659	Oryza glumaepatula	31.78	1.00e-12	68.90
IUUC-Oin-079086	Oryza indica	31.78	1.00e-12	68.90
IUUC-Olo-080264	Oryza longistaminata	31.78	2.00e-12	68.90
IUUC-Ome-081445	Oryza meridionalis	31.01	7.00e-13	69.70
IUUC-Oni-082502	Oryza nivara	31.78	1.00e-12	68.90
IUUC-Opu-083700	Oryza punctata	32.21	3.00e-16	80.90
IUUC-Oru-085093	Oryza rufipogon	31.78	1.00e-12	68.90
IUUC-Osa-086087	Oryza sativa	31.78	1.00e-12	68.90
IUUC-Ola-086863	Oryzias latipes	50.24	4.00e-56	213.00
IUUC-Oar-089938	Ovis aries	76.03	0.00e+00	2776.00
IUUC-Ptr-090960	Pan troglodytes	77.05	0.00e+00	2693.00
IUUC-Pan-092609	Papio anubis	74.97	0.00e+00	2380.00
IUUC-Psi-093889	Pelodiscus sinensis	29.11	8.00e-50	192.00
IUUC-Pfo-096328	Poecilia formosa	52.11	7.00e-62	232.00
IUUC-Pab-097982	Pongo abelii	76.78	0.00e+00	2711.00
IUUC-Pop-099956	Populus trichocarpa	26.55	1.00e-14	75.90
IUUC-Pca-100698	Procavia capensis	66.11	0.00e+00	701.00
IUUC-Ppe-101676	Prunus persica	28.24	6.00e-13	70.10
IUUC-Pva-102631	Pteropus vampyrus	79.66	0.00e+00	1273.00
IUUC-Rno-105879	Rattus norvegicus	56.87	0.00e+00	1845.00
IUUC-Sha-106701	Sarcophilus harrisii	41.25	0.00e+00	744.00
IUUC-Spo-108335	Schizosaccharomyces pombe	33.71	1.00e-09	57.80
IUUC-Sit-110609	Setaria italica	32.41	1.00e-16	82.00
IUUC-Sly-111863	Solanum lycopersicum	30.46	2.00e-15	77.80
IUUC-Stu-112154	Solanum tuberosum	28.90	7.00e-15	76.30
IUUC-Sar-113047	Sorex araneus	65.31	0.00e+00	1592.00
IUUC-Sbi-114470	Sorghum bicolor	26.96	5.00e-15	76.60
IUUC-Ssc-115846	Sus scrofa	78.51	0.00e+00	2866.00
IUUC-Tgu-116785	Taeniopygia guttata	30.46	3.00e-97	350.00
IUUC-Tru-117895	Takifugu rubripes	45.97	1.00e-52	202.00
IUUC-Tsy-118885	Tarsius syrichta	59.38	0.00e+00	731.00
IUUC-Tni-119654	Tetraodon nigroviridis	31.16	1.00e-46	182.00
IUUC-Tca-121809	Theobroma cacao	26.70	1.00e-14	75.10
IUUC-Tae-124838	Triticum aestivum	31.94	2.00e-15	78.20
IUUC-Tur-126725	Triticum urartu	31.08	1.00e-15	78.60
IUUC-Tbe-127421	Tupaia belangeri	61.74	7.00e-158	552.00
IUUC-Ttr-128685	Tursiops truncatus	80.26	0.00e+00	2763.00
IUUC-Vpa-130216	Vicugna pacos	74.43	0.00e+00	939.00
IUUC-Xtr-132398	Xenopus tropicalis	36.88	8.00e-65	243.00
IUUC-Xma-133651	Xiphophorus maculatus	52.35	1.00e-46	182.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence