iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011581

Ensembl Protein ID

ENSAMXP00000019167.1

UniProt Accession

W5LH55; W5LH55_ASTMX

Genbank Protein ID

ENSAMXP00000019167

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01075946

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000018616.1	ENSAMXT00000019167.1	ENSAMXP00000019167.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-19	70.6	590	946

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + k+k++ e + e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 590  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKSKTDVEYYLETQELLRTEIVNPLRIHGyVCATKIMKLRRILEKVEAASGF--TSEE 676
           999***************************9***********************99877679***************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk.sqik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  +kk+k    + ++l+++++  s++k    ++c  ++  r+ + +++ 
   Q: 677  KDPEEFLNILFHHILRVD--PLLKLRSAGQKVQDCYFYQIFMDKKDKVLVPTSQQLLEWSFInSDLKfaeAPSCLIIQmPRFGKDFKMF 763
           **************9977..778889999999999*************************9843444334899****999********* PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  +e++++g  + y+c++c+++ + +   k+k+++e      +lh  R          ++   k+++p+
   Q: 764  NKIFPSLEL---DITDLLEDTPRECRICGGLAlYECRECYEDADITAG-KIKQFCEkcntQVHLHPRRK---------THRYGKLSVPK 839
           **9999988...****************99888********9986555.88888884433445555554.........33456788998 PP
   S: 258  eLdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg... 327
           eL+   + +   +    +++ eL+av++ +      HYva+vk    +  Wl fd               +V++++e    l++t    
   Q: 840  ELQEGVWRQG--SFP--HQQMELFAVLCIET----SHYVAFVKYGAADsaWLFFDSmadrdggqngfniPQVSPCPEvGAYLKMTPeel 920
           8887766655..444..89*********999....9********554455888888888888888888866666655355555554666 PP
   S: 328  ................staYvlfYkr 337
                           ++aY+++Y++
   Q: 921  haldpkniqgyarrllCDAYMCMYQS 946
           6666666677777***********85 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MSSALWSQEK PAGGFRDDWR FYIVVKECVV EKPPQKTLRI PRGSLGQACQ ERNSLGRPLP 60
PSKGKRSLRI LDQTNVVVSV DERDVLELDE KLAELLFPIT NCEERYGLLC NKPRLDRARE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTAAATAGT GGTACACTAA GTTAATTTGC CATTTGCTTC GAAGGTGAGA CACATATTTT 60
GGGCTAGTTT AAGCTTCTGC AGGGCGGGTT TTAGTCTGAT TTTGGGCTGG ATATTTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:1990108--P:protein linear deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	68.60	0.00e+00	1321.00
IUUC-Apl-003356	Anas platyrhynchos	69.09	0.00e+00	1308.00
IUUC-Aca-004402	Anolis carolinensis	64.98	0.00e+00	1182.00
IUUC-Bta-012359	Bos taurus	68.67	0.00e+00	1316.00
IUUC-Cel-018528	Caenorhabditis elegans	35.86	9.00e-57	215.00
IUUC-Cja-018797	Callithrix jacchus	68.05	0.00e+00	1306.00
IUUC-Cfa-020264	Canis familiaris	68.50	0.00e+00	1317.00
IUUC-Cpo-022057	Cavia porcellus	68.73	0.00e+00	1323.00
IUUC-Csa-023093	Chlorocebus sabaeus	68.36	0.00e+00	1312.00
IUUC-Cho-024486	Choloepus hoffmanni	75.49	1.00e-136	481.00
IUUC-Cin-025179	Ciona intestinalis	44.53	2.00e-119	422.00
IUUC-Dre-028233	Danio rerio	90.66	0.00e+00	1685.00
IUUC-Dno-029496	Dasypus novemcinctus	68.36	0.00e+00	1313.00
IUUC-Dor-030919	Dipodomys ordii	82.49	0.00e+00	832.00
IUUC-Dme-032159	Drosophila melanogaster	46.17	1.00e-122	433.00
IUUC-Ete-032734	Echinops telfairi	64.23	0.00e+00	1209.00
IUUC-Eca-033350	Equus caballus	68.67	0.00e+00	1323.00
IUUC-Eeu-034566	Erinaceus europaeus	79.03	8.00e-90	325.00
IUUC-Fca-035632	Felis catus	63.03	0.00e+00	832.00
IUUC-Fal-037313	Ficedula albicollis	73.41	0.00e+00	1035.00
IUUC-Gmo-039239	Gadus morhua	87.23	0.00e+00	1586.00
IUUC-Gga-040668	Gallus gallus	69.24	0.00e+00	1310.00
IUUC-Gac-042630	Gasterosteus aculeatus	87.51	0.00e+00	1545.00
IUUC-Ggo-044462	Gorilla gorilla	67.73	0.00e+00	1305.00
IUUC-Hsa-045846	Homo sapiens	67.73	0.00e+00	1305.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	69.48	7.00e-171	593.00
IUUC-Lch-050303	Latimeria chalumnae	65.61	0.00e+00	1177.00
IUUC-Loc-052190	Lepisosteus oculatus	81.49	0.00e+00	1517.00
IUUC-Laf-054480	Loxodonta africana	78.70	0.00e+00	645.00
IUUC-Mcc-055849	Macaca mulatta	68.15	0.00e+00	1306.00
IUUC-Meu-056755	Macropus eugenii	55.05	7.00e-156	544.00
IUUC-Mga-059561	Meleagris gallopavo	68.71	0.00e+00	1297.00
IUUC-Mmr-060942	Microcebus murinus	68.25	0.00e+00	1302.00
IUUC-Mdo-062618	Monodelphis domestica	68.05	0.00e+00	1306.00
IUUC-Mmu-063843	Mus musculus	67.18	0.00e+00	1262.00
IUUC-Mpu-066919	Mustela putorius furo	68.71	0.00e+00	1325.00
IUUC-Mlu-066983	Myotis lucifugus	68.06	0.00e+00	1290.00
IUUC-Nle-069893	Nomascus leucogenys	67.84	0.00e+00	1306.00
IUUC-Opr-071181	Ochotona princeps	61.04	0.00e+00	1053.00
IUUC-Ont-071697	Oreochromis niloticus	88.71	0.00e+00	1559.00
IUUC-Oan-073658	Ornithorhynchus anatinus	68.89	0.00e+00	1306.00
IUUC-Ocu-074954	Oryctolagus cuniculus	68.56	0.00e+00	1315.00
IUUC-Ola-086523	Oryzias latipes	85.45	0.00e+00	1504.00
IUUC-Oga-089003	Otolemur garnettii	68.36	0.00e+00	1315.00
IUUC-Oar-090376	Ovis aries	68.38	0.00e+00	1318.00
IUUC-Ptr-090520	Pan troglodytes	66.42	0.00e+00	1257.00
IUUC-Pan-092281	Papio anubis	68.36	0.00e+00	1312.00
IUUC-Psi-093047	Pelodiscus sinensis	72.26	0.00e+00	1277.00
IUUC-Pma-094575	Petromyzon marinus	55.30	8.00e-66	243.00
IUUC-Pfo-096358	Poecilia formosa	85.51	0.00e+00	1447.00
IUUC-Pab-097740	Pongo abelii	67.63	0.00e+00	1303.00
IUUC-Pca-100461	Procavia capensis	61.04	0.00e+00	1023.00
IUUC-Pva-102134	Pteropus vampyrus	62.18	0.00e+00	1161.00
IUUC-Rno-105807	Rattus norvegicus	67.98	0.00e+00	1249.00
IUUC-Sha-107236	Sarcophilus harrisii	67.62	0.00e+00	1254.00
IUUC-Sar-113366	Sorex araneus	83.11	0.00e+00	796.00
IUUC-Tgu-117201	Taeniopygia guttata	66.32	0.00e+00	1234.00
IUUC-Tru-117953	Takifugu rubripes	87.67	0.00e+00	1546.00
IUUC-Tsy-119610	Tarsius syrichta	66.18	0.00e+00	1266.00
IUUC-Tni-120743	Tetraodon nigroviridis	39.62	2.00e-159	556.00
IUUC-Tbe-128155	Tupaia belangeri	57.55	3.00e-153	536.00
IUUC-Ttr-128942	Tursiops truncatus	63.60	0.00e+00	1197.00
IUUC-Vpa-130281	Vicugna pacos	61.18	0.00e+00	1124.00
IUUC-Xtr-132627	Xenopus tropicalis	63.61	0.00e+00	1134.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence