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Tag Content
UUCD2 ID IUUC-Laf-054480
UUCD1 version UUC-LoA-01120
Ensembl Protein ID ENSLAFP00000011869.4
UniProt Accession G3TCQ9; G3TCQ9_LOXAF
Protein Name Uncharacterized protein
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLAFG00000014171.4 ENSLAFT00000014174.4 ENSLAFP00000011869.4
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.10e-22 79.2 407 767
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgye 88
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e++g l +++ + ++ +w   +  +  +   +l++l+ ++ +f+ ye
   Q: 407  GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQGLLRTEIVNPLRIVWsfLCLFNFLNLGLMLNILN-ASCMFTYYE 494
           999***************************99999999999*******************9888999999999999998.666899777 PP
   S: 89   qq..DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfl 170
           +   D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + +
   Q: 495  KTflDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDF 581
           7566***************99..88999999999999**************************9854144444799****99******* PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkve 254
           +l  ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh kR   s+         + v+
   Q: 582  KLFKKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcntQVHLHPKRL--SH-------KYNPVS 657
           *******99998...***************987655********9984433.55555553334689999999..33.......246788 PP
   S: 255  fpleL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevle 324
           +p+ L   d ++ c+        ++k eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+
   Q: 658  LPKDLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLK 735
           8866411144445555.......9**********999....9********777778*****999999**99999988888876577777 PP
   S: 325  etg...................staYvlfYkr 337
           ++                    ++aY+++Y++
   Q: 736  MSLeelhsldsrriqgcarrllCDAYMCMYQS 767
           6668888899999999999***********85 PP
   
Organism Loxodonta africana
Protein Sequence
(Fasta)
MSSSLWSQEK VTSPYWEERV FYLLLQECSV TDKQTQKLIK VPKGSIGQNI QDRPLGHSRV 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Laf-054480|DUB,USP|Loxodonta africana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGTTCAA GCTTATGGAG CCAAGAAAAA GTTACCTCAC CCTACTGGGA AGAGAGGGTT 60
TTTTATTTGC TTCTTCAAGA ATGCAGTGTT ACAGACAAGC AAACGCAAAA GCTGATTAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Laf-054480|DUB,USP|Loxodonta africana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0016021--C:integral component of membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 92.23 0.00e+00 770.00
IUUC-Apl-003356 Anas platyrhynchos 89.72 0.00e+00 753.00
IUUC-Aca-004402 Anolis carolinensis 90.23 0.00e+00 759.00
IUUC-Ame-011581 Astyanax mexicanus 78.70 0.00e+00 633.00
IUUC-Bta-012359 Bos taurus 91.73 0.00e+00 765.00
IUUC-Cel-018528 Caenorhabditis elegans 31.78 4.00e-46 180.00
IUUC-Cja-018797 Callithrix jacchus 92.23 0.00e+00 769.00
IUUC-Cfa-020264 Canis familiaris 91.73 0.00e+00 764.00
IUUC-Cpo-022057 Cavia porcellus 92.23 0.00e+00 770.00
IUUC-Csa-023093 Chlorocebus sabaeus 92.73 0.00e+00 775.00
IUUC-Cho-024486 Choloepus hoffmanni 75.14 7.00e-152 531.00
IUUC-Cin-025179 Ciona intestinalis 37.00 6.00e-94 337.00
IUUC-Dre-028233 Danio rerio 77.69 2.00e-180 625.00
IUUC-Dno-029496 Dasypus novemcinctus 91.98 0.00e+00 767.00
IUUC-Dor-030919 Dipodomys ordii 92.23 0.00e+00 769.00
IUUC-Dme-032159 Drosophila melanogaster 48.17 1.00e-96 347.00
IUUC-Ete-032734 Echinops telfairi 82.96 0.00e+00 673.00
IUUC-Eca-033350 Equus caballus 92.48 0.00e+00 773.00
IUUC-Eeu-034566 Erinaceus europaeus 97.85 7.00e-114 405.00
IUUC-Fca-035632 Felis catus 87.88 0.00e+00 657.00
IUUC-Fal-037313 Ficedula albicollis 88.97 0.00e+00 746.00
IUUC-Gmo-039239 Gadus morhua 78.20 1.00e-179 623.00
IUUC-Gga-040668 Gallus gallus 89.47 0.00e+00 753.00
IUUC-Gac-042630 Gasterosteus aculeatus 77.69 1.00e-179 623.00
IUUC-Ggo-044462 Gorilla gorilla 92.48 0.00e+00 773.00
IUUC-Hsa-045846 Homo sapiens 92.48 0.00e+00 772.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 81.38 3.00e-62 232.00
IUUC-Lch-050303 Latimeria chalumnae 73.27 1.00e-173 603.00
IUUC-Loc-052190 Lepisosteus oculatus 79.95 0.00e+00 658.00
IUUC-Mcc-055849 Macaca mulatta 92.73 0.00e+00 775.00
IUUC-Meu-056755 Macropus eugenii 86.84 2.00e-133 469.00
IUUC-Mga-059561 Meleagris gallopavo 88.81 0.00e+00 748.00
IUUC-Mmr-060942 Microcebus murinus 92.73 0.00e+00 774.00
IUUC-Mdo-062618 Monodelphis domestica 91.98 0.00e+00 770.00
IUUC-Mmu-063843 Mus musculus 90.73 0.00e+00 760.00
IUUC-Mpu-066919 Mustela putorius furo 92.23 0.00e+00 770.00
IUUC-Mlu-066983 Myotis lucifugus 88.97 0.00e+00 744.00
IUUC-Nle-069893 Nomascus leucogenys 92.48 0.00e+00 773.00
IUUC-Opr-071181 Ochotona princeps 84.15 7.00e-179 620.00
IUUC-Ont-071697 Oreochromis niloticus 77.69 4.00e-180 625.00
IUUC-Oan-073658 Ornithorhynchus anatinus 90.98 0.00e+00 765.00
IUUC-Ocu-074954 Oryctolagus cuniculus 92.73 0.00e+00 775.00
IUUC-Ola-086523 Oryzias latipes 78.20 1.00e-179 623.00
IUUC-Oga-089003 Otolemur garnettii 91.98 0.00e+00 770.00
IUUC-Oar-090376 Ovis aries 92.23 0.00e+00 772.00
IUUC-Ptr-090520 Pan troglodytes 88.22 0.00e+00 723.00
IUUC-Pan-092281 Papio anubis 92.73 0.00e+00 775.00
IUUC-Psi-093047 Pelodiscus sinensis 89.97 0.00e+00 753.00
IUUC-Pma-094575 Petromyzon marinus 59.09 3.00e-26 111.00
IUUC-Pfo-096358 Poecilia formosa 77.44 1.00e-174 607.00
IUUC-Pab-097740 Pongo abelii 92.48 0.00e+00 772.00
IUUC-Pca-100461 Procavia capensis 82.82 0.00e+00 637.00
IUUC-Pva-102134 Pteropus vampyrus 80.70 0.00e+00 664.00
IUUC-Rno-105807 Rattus norvegicus 90.98 0.00e+00 759.00
IUUC-Sha-107236 Sarcophilus harrisii 91.62 0.00e+00 731.00
IUUC-Sar-113366 Sorex araneus 91.98 0.00e+00 769.00
IUUC-Tgu-117201 Taeniopygia guttata 82.79 0.00e+00 677.00
IUUC-Tru-117953 Takifugu rubripes 77.19 5.00e-179 621.00
IUUC-Tsy-119610 Tarsius syrichta 91.23 0.00e+00 756.00
IUUC-Tni-120743 Tetraodon nigroviridis 51.49 2.00e-103 370.00
IUUC-Tbe-128155 Tupaia belangeri 89.95 2.00e-99 357.00
IUUC-Ttr-128942 Tursiops truncatus 87.70 0.00e+00 653.00
IUUC-Vpa-130281 Vicugna pacos 84.97 7.00e-180 624.00
IUUC-Xtr-132627 Xenopus tropicalis 77.78 6.00e-174 604.00
Created Date 25-Jun-2017

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