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Tag Content
UUCD2 ID IUUC-Mdo-062618
UUCD1 version UUC-MoD-01160
Ensembl Protein ID ENSMODP00000016409.3
UniProt Accession F7BMW7; F7BMW7_MONDO
Protein Name Uncharacterized protein
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMODG00000013111.3 ENSMODT00000016711.3 ENSMODP00000016409.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.40e-25 88.7 593 949
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 593  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 679
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 680  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 766
           ****************99..88999999999999**************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++++ +   k+k++++      +lh kR   s+         + v++p+
   Q: 767  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDSDISAG-KIKQFCKtcntQVHLHPKRL--SH-------KYNPVSLPK 842
           ****99998...***************987655*******99984433.55555553334689999999..33.......246788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        ++k eL+av++ +      HYva+vk  +++  Wl fd               +Vt+++e  e l+++ 
   Q: 843  DLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGRDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSV 920
           6411144445555.......9**********999....9********666667999999999999999999966666655456666554 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 921  eelhsldsrriqgcarrllCDAYMCMYQS 949
           6666788888888999***********85 PP
   
Organism Monodelphis domestica
Protein Sequence
(Fasta)
MNSGLWSQEK VTSPYLEERI FYLLLQECSV SDKQTQKIIK VPKGSIGQYV QDRSLSHARI 60
PLSKGKKNHI GLKILEQPHA VLFVDEKDVV EISEKFTELL LAITNCEERF SLFKNRSRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mdo-062618|DUB,USP|Monodelphis domestica
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAGGAGGA CTGGTTGCTC CACCCCTTCC CATCACATAG CCAATGATGG CTCGAGGTCT 60
GCTGCCAGGC AACCAACCAG GGAGCGCTAC GCCACTCTCC TCGTCCCCGC CCTTTCTTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mdo-062618|DUB,USP|Monodelphis domestica
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0070266--P:necroptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mdo:100014031
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 93.10 0.00e+00 1861.00
IUUC-Apl-003356 Anas platyrhynchos 87.46 0.00e+00 1695.00
IUUC-Aca-004402 Anolis carolinensis 80.79 0.00e+00 1507.00
IUUC-Ame-011581 Astyanax mexicanus 66.77 0.00e+00 1222.00
IUUC-Bta-012359 Bos taurus 92.26 0.00e+00 1835.00
IUUC-Cel-018528 Caenorhabditis elegans 34.64 1.00e-55 211.00
IUUC-Cja-018797 Callithrix jacchus 92.36 0.00e+00 1851.00
IUUC-Cfa-020264 Canis familiaris 92.78 0.00e+00 1846.00
IUUC-Cpo-022057 Cavia porcellus 92.78 0.00e+00 1856.00
IUUC-Csa-023093 Chlorocebus sabaeus 92.57 0.00e+00 1845.00
IUUC-Cho-024486 Choloepus hoffmanni 78.63 1.00e-169 590.00
IUUC-Cin-025179 Ciona intestinalis 43.27 6.00e-115 407.00
IUUC-Dre-028233 Danio rerio 67.56 0.00e+00 1268.00
IUUC-Dno-029496 Dasypus novemcinctus 92.78 0.00e+00 1848.00
IUUC-Dor-030919 Dipodomys ordii 86.82 0.00e+00 1701.00
IUUC-Dme-032159 Drosophila melanogaster 45.45 1.00e-123 437.00
IUUC-Ete-032734 Echinops telfairi 87.66 0.00e+00 1733.00
IUUC-Eca-033350 Equus caballus 92.78 0.00e+00 1851.00
IUUC-Eeu-034566 Erinaceus europaeus 96.24 2.00e-112 400.00
IUUC-Fca-035632 Felis catus 90.59 0.00e+00 1271.00
IUUC-Fal-037313 Ficedula albicollis 82.24 0.00e+00 1577.00
IUUC-Gmo-039239 Gadus morhua 67.46 0.00e+00 1217.00
IUUC-Gga-040668 Gallus gallus 87.77 0.00e+00 1694.00
IUUC-Gac-042630 Gasterosteus aculeatus 67.53 0.00e+00 1204.00
IUUC-Ggo-044462 Gorilla gorilla 92.89 0.00e+00 1853.00
IUUC-Hsa-045846 Homo sapiens 92.99 0.00e+00 1855.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 90.55 0.00e+00 814.00
IUUC-Lch-050303 Latimeria chalumnae 70.54 0.00e+00 1303.00
IUUC-Loc-052190 Lepisosteus oculatus 69.61 0.00e+00 1284.00
IUUC-Laf-054480 Loxodonta africana 91.98 0.00e+00 758.00
IUUC-Mcc-055849 Macaca mulatta 92.89 0.00e+00 1857.00
IUUC-Meu-056755 Macropus eugenii 86.89 0.00e+00 926.00
IUUC-Mga-059561 Meleagris gallopavo 86.88 0.00e+00 1677.00
IUUC-Mmr-060942 Microcebus murinus 93.51 0.00e+00 1856.00
IUUC-Mmu-063843 Mus musculus 91.11 0.00e+00 1769.00
IUUC-Mpu-066919 Mustela putorius furo 92.78 0.00e+00 1849.00
IUUC-Mlu-066983 Myotis lucifugus 87.45 0.00e+00 1723.00
IUUC-Nle-069893 Nomascus leucogenys 92.89 0.00e+00 1854.00
IUUC-Opr-071181 Ochotona princeps 85.36 0.00e+00 1559.00
IUUC-Ont-071697 Oreochromis niloticus 67.01 0.00e+00 1200.00
IUUC-Oan-073658 Ornithorhynchus anatinus 90.59 0.00e+00 1772.00
IUUC-Ocu-074954 Oryctolagus cuniculus 93.41 0.00e+00 1863.00
IUUC-Ola-086523 Oryzias latipes 65.82 0.00e+00 1183.00
IUUC-Oga-089003 Otolemur garnettii 92.89 0.00e+00 1858.00
IUUC-Oar-090376 Ovis aries 92.29 0.00e+00 1847.00
IUUC-Ptr-090520 Pan troglodytes 91.11 0.00e+00 1802.00
IUUC-Pan-092281 Papio anubis 92.57 0.00e+00 1845.00
IUUC-Psi-093047 Pelodiscus sinensis 88.96 0.00e+00 1625.00
IUUC-Pma-094575 Petromyzon marinus 56.81 9.00e-66 243.00
IUUC-Pfo-096358 Poecilia formosa 66.33 0.00e+00 1143.00
IUUC-Pab-097740 Pongo abelii 92.36 0.00e+00 1844.00
IUUC-Pca-100461 Procavia capensis 82.68 0.00e+00 1480.00
IUUC-Pva-102134 Pteropus vampyrus 83.37 0.00e+00 1638.00
IUUC-Rno-105807 Rattus norvegicus 89.02 0.00e+00 1722.00
IUUC-Sha-107236 Sarcophilus harrisii 96.81 0.00e+00 1848.00
IUUC-Sar-113366 Sorex araneus 97.33 0.00e+00 930.00
IUUC-Tgu-117201 Taeniopygia guttata 84.05 0.00e+00 1611.00
IUUC-Tru-117953 Takifugu rubripes 67.39 0.00e+00 1190.00
IUUC-Tsy-119610 Tarsius syrichta 91.63 0.00e+00 1826.00
IUUC-Tni-120743 Tetraodon nigroviridis 40.96 4.00e-166 578.00
IUUC-Tbe-128155 Tupaia belangeri 75.29 0.00e+00 731.00
IUUC-Ttr-128942 Tursiops truncatus 87.87 0.00e+00 1737.00
IUUC-Vpa-130281 Vicugna pacos 83.05 0.00e+00 1611.00
IUUC-Xtr-132627 Xenopus tropicalis 77.34 0.00e+00 1411.00
Created Date 25-Jun-2017

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