iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090376

Ensembl Protein ID

ENSOARP00000018805.1

UniProt Accession

W5Q7W3; W5Q7W3_SHEEP

Genbank Protein ID

ENSOARP00000018805

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01027721

Gene Name

CYLD

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000017520.1	ENSOART00000019071.1	ENSOARP00000018805.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.60e-25	88.2	597	953

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 597  GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 683
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 684  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 770
           ****************99..88999999999999**************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh kR   +       +  + v++p+
   Q: 771  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcnaQVHLHPKRL--N-------HKYNPVSLPK 846
           ****99998...***************987655********9984443.66666663335689999999..2.......3356788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        ++k eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+++ 
   Q: 847  DLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 924
           6511144444555.......9**********999....9********777788*****9999********9999999987688888777 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 925  ddlhsldsrriqgcarrllCDAYMCMYQS 953
           999999999******************85 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGLSRI 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCATTTTGAT TTGCTGTCTT TTTACAGCAT GGACACCAAA TTGCTAAAAA CATGCTTTGG 60
GACTGCCAAT GAATTTGTCT TTTGTGGTTT TACTACACAC TTAGTAATTC CCTTTTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	97.29	0.00e+00	1930.00
IUUC-Apl-003356	Anas platyrhynchos	86.89	0.00e+00	1692.00
IUUC-Aca-004402	Anolis carolinensis	80.66	0.00e+00	1523.00
IUUC-Ame-011581	Astyanax mexicanus	68.15	0.00e+00	1234.00
IUUC-Bta-012359	Bos taurus	98.96	0.00e+00	1951.00
IUUC-Cel-018528	Caenorhabditis elegans	34.64	4.00e-56	213.00
IUUC-Cja-018797	Callithrix jacchus	95.94	0.00e+00	1903.00
IUUC-Cfa-020264	Canis familiaris	96.88	0.00e+00	1920.00
IUUC-Cpo-022057	Cavia porcellus	96.56	0.00e+00	1917.00
IUUC-Csa-023093	Chlorocebus sabaeus	96.56	0.00e+00	1908.00
IUUC-Cho-024486	Choloepus hoffmanni	81.46	5.00e-176	611.00
IUUC-Cin-025179	Ciona intestinalis	43.69	6.00e-116	410.00
IUUC-Dre-028233	Danio rerio	66.97	0.00e+00	1260.00
IUUC-Dno-029496	Dasypus novemcinctus	95.83	0.00e+00	1905.00
IUUC-Dor-030919	Dipodomys ordii	89.58	0.00e+00	1752.00
IUUC-Dme-032159	Drosophila melanogaster	46.34	2.00e-124	439.00
IUUC-Ete-032734	Echinops telfairi	90.31	0.00e+00	1780.00
IUUC-Eca-033350	Equus caballus	97.50	0.00e+00	1932.00
IUUC-Eeu-034566	Erinaceus europaeus	98.39	7.00e-115	408.00
IUUC-Fca-035632	Felis catus	95.76	0.00e+00	1335.00
IUUC-Fal-037313	Ficedula albicollis	81.89	0.00e+00	1580.00
IUUC-Gmo-039239	Gadus morhua	67.18	0.00e+00	1217.00
IUUC-Gga-040668	Gallus gallus	86.89	0.00e+00	1689.00
IUUC-Gac-042630	Gasterosteus aculeatus	67.36	0.00e+00	1204.00
IUUC-Ggo-044462	Gorilla gorilla	96.67	0.00e+00	1912.00
IUUC-Hsa-045846	Homo sapiens	96.56	0.00e+00	1911.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	93.61	0.00e+00	841.00
IUUC-Lch-050303	Latimeria chalumnae	70.35	0.00e+00	1303.00
IUUC-Loc-052190	Lepisosteus oculatus	69.52	0.00e+00	1282.00
IUUC-Laf-054480	Loxodonta africana	92.23	0.00e+00	760.00
IUUC-Mcc-055849	Macaca mulatta	96.67	0.00e+00	1914.00
IUUC-Meu-056755	Macropus eugenii	83.27	0.00e+00	891.00
IUUC-Mga-059561	Meleagris gallopavo	86.51	0.00e+00	1683.00
IUUC-Mmr-060942	Microcebus murinus	96.98	0.00e+00	1910.00
IUUC-Mdo-062618	Monodelphis domestica	92.29	0.00e+00	1847.00
IUUC-Mmu-063843	Mus musculus	94.69	0.00e+00	1822.00
IUUC-Mpu-066919	Mustela putorius furo	96.77	0.00e+00	1919.00
IUUC-Mlu-066983	Myotis lucifugus	90.31	0.00e+00	1771.00
IUUC-Nle-069893	Nomascus leucogenys	96.77	0.00e+00	1912.00
IUUC-Opr-071181	Ochotona princeps	87.88	0.00e+00	1602.00
IUUC-Ont-071697	Oreochromis niloticus	68.60	0.00e+00	1197.00
IUUC-Oan-073658	Ornithorhynchus anatinus	89.90	0.00e+00	1777.00
IUUC-Ocu-074954	Oryctolagus cuniculus	96.56	0.00e+00	1919.00
IUUC-Ola-086523	Oryzias latipes	65.96	0.00e+00	1187.00
IUUC-Oga-089003	Otolemur garnettii	96.88	0.00e+00	1924.00
IUUC-Ptr-090520	Pan troglodytes	94.90	0.00e+00	1862.00
IUUC-Pan-092281	Papio anubis	96.56	0.00e+00	1908.00
IUUC-Psi-093047	Pelodiscus sinensis	88.23	0.00e+00	1617.00
IUUC-Pma-094575	Petromyzon marinus	55.50	1.00e-66	246.00
IUUC-Pfo-096358	Poecilia formosa	66.16	0.00e+00	1142.00
IUUC-Pab-097740	Pongo abelii	96.35	0.00e+00	1904.00
IUUC-Pca-100461	Procavia capensis	86.43	0.00e+00	1530.00
IUUC-Pva-102134	Pteropus vampyrus	86.25	0.00e+00	1682.00
IUUC-Rno-105807	Rattus norvegicus	92.92	0.00e+00	1783.00
IUUC-Sha-107236	Sarcophilus harrisii	92.79	0.00e+00	1789.00
IUUC-Sar-113366	Sorex araneus	98.44	0.00e+00	939.00
IUUC-Tgu-117201	Taeniopygia guttata	83.90	0.00e+00	1618.00
IUUC-Tru-117953	Takifugu rubripes	67.56	0.00e+00	1197.00
IUUC-Tsy-119610	Tarsius syrichta	94.90	0.00e+00	1873.00
IUUC-Tni-120743	Tetraodon nigroviridis	53.67	7.00e-137	481.00
IUUC-Tbe-128155	Tupaia belangeri	78.38	0.00e+00	756.00
IUUC-Ttr-128942	Tursiops truncatus	92.81	0.00e+00	1816.00
IUUC-Vpa-130281	Vicugna pacos	87.29	0.00e+00	1676.00
IUUC-Xtr-132627	Xenopus tropicalis	76.01	0.00e+00	1405.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence