iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071697

Ensembl Protein ID

ENSONIP00000003551.1

UniProt Accession

I3J3W1; I3J3W1_ORENI

Genbank Protein ID

ENSONIP00000003551

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01000132

Gene Name

cylda; cyld

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000002832.1	ENSONIT00000003552.1	ENSONIP00000003551.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.70e-22	78.0	593	949

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + ++k++ e + e+++ l +++ + ++     + +k+++ r++l+++++++    ++e+
   Q: 593  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPRSKTDVEYYRETQELLRTEIVNPLRIHGyVCATKVMKLRRILEKVEAASGF--TSEE 679
           999***************************99999999999999999999999999877679***************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk.sqik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  +kk+k +  +i++l+++++  s++k    ++c  ++  r+ + +++ 
   Q: 680  KDPEEFLNILFHHILRVD--PLLKLRSAGQKVQDCYFYQIFMDKKDKVGVPTIQQLLEWSFInSDLKfaeAPSCLIIQmPRFGKDFKMF 766
           **************9977..778889999999999*************************9843444334899****999********* PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  +e++++g  + y+c+ c+++ + +   k+k+++e      +lh  R           + + k+++p+
   Q: 767  NKIFPSLEL---DITDLLEDTPRECRICGGLAlYECRDCYEDGDITAG-KIKQFCEkcntQVHLHPRRK---------AHRHGKLSVPK 842
           **9999988...****************998889******99986555.88888874423444554444.........34467889998 PP
   S: 258  eLdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg... 327
           eL+ s  + ++ +    +++ eL+av++ +      HYva+vk  + +  Wl fd               +V++++e e+ l++t    
   Q: 843  ELQES--TGRQGSFP--RQRMELFAVLCIET----SHYVAFVKYGSADsaWLFFDSmadrdggqngfniPQVSPCPEvETYLKMTPeel 923
           88877..44434444..99*********999....9********666667**9999999999999999999999976688888777899 PP
   S: 328  ................staYvlfYkr 337
                           ++aY+++Y++
   Q: 924  htldpksiqgqarrllCDAYMCMYQS 949
           9999999999999***********95 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSSALWSQEK PSGGFREDWR FYMVVKECTV EKPPQKTLRI PRGSLGQACQ ERNSLGRTLP 60
PCKGKKSLRI LDQTNVVLSL DERDVLELDE KLAELLFPIT NCEERYALLC NKSRLERVRD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTGCCTTG GAAGCCGCAC TCCAACCTAA CTACGCTTTC TGCCGTCCGT GGGAAAACCC 60
CAGAAAGTGG GACTTGGTTA TTGACAAAAC AAACAGCGAA TCAGCGTTTT AGAAAGAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:1990108--P:protein linear deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	69.09	0.00e+00	1300.00
IUUC-Apl-003356	Anas platyrhynchos	69.11	0.00e+00	1277.00
IUUC-Aca-004402	Anolis carolinensis	64.16	0.00e+00	1138.00
IUUC-Ame-011581	Astyanax mexicanus	88.71	0.00e+00	1574.00
IUUC-Bta-012359	Bos taurus	69.09	0.00e+00	1297.00
IUUC-Cel-018528	Caenorhabditis elegans	31.71	1.00e-57	219.00
IUUC-Cja-018797	Callithrix jacchus	68.88	0.00e+00	1290.00
IUUC-Cfa-020264	Canis familiaris	68.99	0.00e+00	1298.00
IUUC-Cpo-022057	Cavia porcellus	69.50	0.00e+00	1305.00
IUUC-Csa-023093	Chlorocebus sabaeus	69.20	0.00e+00	1295.00
IUUC-Cho-024486	Choloepus hoffmanni	74.84	1.00e-134	474.00
IUUC-Cin-025179	Ciona intestinalis	45.76	2.00e-120	426.00
IUUC-Dre-028233	Danio rerio	86.94	0.00e+00	1579.00
IUUC-Dno-029496	Dasypus novemcinctus	69.13	0.00e+00	1295.00
IUUC-Dor-030919	Dipodomys ordii	81.86	0.00e+00	825.00
IUUC-Dme-032159	Drosophila melanogaster	47.16	1.00e-125	444.00
IUUC-Ete-032734	Echinops telfairi	65.28	0.00e+00	1189.00
IUUC-Eca-033350	Equus caballus	69.09	0.00e+00	1301.00
IUUC-Eeu-034566	Erinaceus europaeus	76.88	1.00e-85	311.00
IUUC-Fca-035632	Felis catus	63.21	0.00e+00	820.00
IUUC-Fal-037313	Ficedula albicollis	73.30	0.00e+00	1005.00
IUUC-Gmo-039239	Gadus morhua	91.66	0.00e+00	1619.00
IUUC-Gga-040668	Gallus gallus	69.21	0.00e+00	1276.00
IUUC-Gac-042630	Gasterosteus aculeatus	96.13	0.00e+00	1691.00
IUUC-Ggo-044462	Gorilla gorilla	68.78	0.00e+00	1285.00
IUUC-Hsa-045846	Homo sapiens	68.78	0.00e+00	1285.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	70.80	9.00e-163	566.00
IUUC-Lch-050303	Latimeria chalumnae	66.33	0.00e+00	1155.00
IUUC-Loc-052190	Lepisosteus oculatus	81.77	0.00e+00	1494.00
IUUC-Laf-054480	Loxodonta africana	77.19	0.00e+00	637.00
IUUC-Mcc-055849	Macaca mulatta	68.98	0.00e+00	1290.00
IUUC-Meu-056755	Macropus eugenii	58.30	2.00e-155	543.00
IUUC-Mga-059561	Meleagris gallopavo	69.05	0.00e+00	1266.00
IUUC-Mmr-060942	Microcebus murinus	68.98	0.00e+00	1285.00
IUUC-Mdo-062618	Monodelphis domestica	69.19	0.00e+00	1297.00
IUUC-Mmu-063843	Mus musculus	68.88	0.00e+00	1258.00
IUUC-Mpu-066919	Mustela putorius furo	69.20	0.00e+00	1305.00
IUUC-Mlu-066983	Myotis lucifugus	67.85	0.00e+00	1281.00
IUUC-Nle-069893	Nomascus leucogenys	68.88	0.00e+00	1287.00
IUUC-Opr-071181	Ochotona princeps	62.39	0.00e+00	1038.00
IUUC-Oan-073658	Ornithorhynchus anatinus	68.92	0.00e+00	1284.00
IUUC-Ocu-074954	Oryctolagus cuniculus	69.50	0.00e+00	1296.00
IUUC-Ola-086523	Oryzias latipes	92.16	0.00e+00	1600.00
IUUC-Oga-089003	Otolemur garnettii	69.09	0.00e+00	1299.00
IUUC-Oar-090376	Ovis aries	68.80	0.00e+00	1298.00
IUUC-Ptr-090520	Pan troglodytes	67.22	0.00e+00	1236.00
IUUC-Pan-092281	Papio anubis	69.20	0.00e+00	1295.00
IUUC-Psi-093047	Pelodiscus sinensis	71.54	0.00e+00	1246.00
IUUC-Pma-094575	Petromyzon marinus	55.76	3.00e-66	244.00
IUUC-Pfo-096358	Poecilia formosa	92.47	0.00e+00	1535.00
IUUC-Pab-097740	Pongo abelii	68.67	0.00e+00	1284.00
IUUC-Pca-100461	Procavia capensis	61.17	0.00e+00	1010.00
IUUC-Pva-102134	Pteropus vampyrus	71.48	0.00e+00	816.00
IUUC-Rno-105807	Rattus norvegicus	68.68	0.00e+00	1245.00
IUUC-Sha-107236	Sarcophilus harrisii	69.21	0.00e+00	1261.00
IUUC-Sar-113366	Sorex araneus	82.00	0.00e+00	785.00
IUUC-Tgu-117201	Taeniopygia guttata	65.88	0.00e+00	1201.00
IUUC-Tru-117953	Takifugu rubripes	95.19	0.00e+00	1653.00
IUUC-Tsy-119610	Tarsius syrichta	67.22	0.00e+00	1254.00
IUUC-Tbe-128155	Tupaia belangeri	58.30	2.00e-149	523.00
IUUC-Ttr-128942	Tursiops truncatus	64.32	0.00e+00	1182.00
IUUC-Vpa-130281	Vicugna pacos	61.27	0.00e+00	1098.00
IUUC-Xtr-132627	Xenopus tropicalis	62.72	0.00e+00	1097.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence