iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000003079.1	ENSSHAT00000003541.1	ENSSHAP00000003505.1
ENSSHAG00000003079.1	ENSSHAT00000003542.1	ENSSHAP00000003506.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.30e-23	83.1	590	887

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 590  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 676
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 677  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 763
           ****************99..88999999999999**************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++++ +   k+k++++      +lh kR   +       +  + v++p+
   Q: 764  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDSDISAG-KIKQFCKtcntQVHLHPKRL--N-------HKYNPVSLPK 839
           ****99998...***************987655*******99984433.55555553334688999999..2.......3356788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD 311
            L   d ++ c+        ++k eL+av++ +      HYva+vk  +++  Wl fd 
   Q: 840  DLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGRDDsaWLFFDS 887
           6511144444554.......9**********999....9********666677****96 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MSSGLWSQEK VTSPYLEERI FYLLLQECSV SDKQTQKILK VPKGSIGQYI QDRSLGHTRI 60
PLSKGKKNHI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERY SLFKNRNRLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCACAATG AGTTCAGGCT TATGGAGCCA AGAAAAAGTT ACTTCACCCT ATTTGGAAGA 60
ACGGATTTTT TACTTGCTTC TTCAAGAATG CAGTGTTTCA GACAAACAAA CACAAAAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	93.40	0.00e+00	1829.00
IUUC-Apl-003356	Anas platyrhynchos	87.73	0.00e+00	1663.00
IUUC-Aca-004402	Anolis carolinensis	80.38	0.00e+00	1470.00
IUUC-Ame-011581	Astyanax mexicanus	67.27	0.00e+00	1187.00
IUUC-Bta-012359	Bos taurus	93.16	0.00e+00	1812.00
IUUC-Cel-018528	Caenorhabditis elegans	36.58	1.00e-54	208.00
IUUC-Cja-018797	Callithrix jacchus	92.55	0.00e+00	1809.00
IUUC-Cfa-020264	Canis familiaris	93.59	0.00e+00	1828.00
IUUC-Cpo-022057	Cavia porcellus	93.08	0.00e+00	1818.00
IUUC-Csa-023093	Chlorocebus sabaeus	93.48	0.00e+00	1818.00
IUUC-Cho-024486	Choloepus hoffmanni	78.63	4.00e-168	585.00
IUUC-Cin-025179	Ciona intestinalis	42.61	3.00e-108	385.00
IUUC-Dre-028233	Danio rerio	67.43	0.00e+00	1233.00
IUUC-Dno-029496	Dasypus novemcinctus	93.59	0.00e+00	1826.00
IUUC-Dor-030919	Dipodomys ordii	87.01	0.00e+00	1662.00
IUUC-Dme-032159	Drosophila melanogaster	46.62	2.00e-117	416.00
IUUC-Ete-032734	Echinops telfairi	87.65	0.00e+00	1693.00
IUUC-Eca-033350	Equus caballus	93.80	0.00e+00	1833.00
IUUC-Eeu-034566	Erinaceus europaeus	73.81	6.00e-105	375.00
IUUC-Fca-035632	Felis catus	91.43	0.00e+00	1285.00
IUUC-Fal-037313	Ficedula albicollis	82.71	0.00e+00	1548.00
IUUC-Gmo-039239	Gadus morhua	67.23	0.00e+00	1180.00
IUUC-Gga-040668	Gallus gallus	88.05	0.00e+00	1662.00
IUUC-Gac-042630	Gasterosteus aculeatus	67.51	0.00e+00	1174.00
IUUC-Ggo-044462	Gorilla gorilla	93.50	0.00e+00	1820.00
IUUC-Hsa-045846	Homo sapiens	93.50	0.00e+00	1820.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	91.18	0.00e+00	818.00
IUUC-Lch-050303	Latimeria chalumnae	70.22	0.00e+00	1261.00
IUUC-Loc-052190	Lepisosteus oculatus	69.70	0.00e+00	1257.00
IUUC-Laf-054480	Loxodonta africana	91.62	0.00e+00	718.00
IUUC-Mcc-055849	Macaca mulatta	93.18	0.00e+00	1815.00
IUUC-Meu-056755	Macropus eugenii	87.27	0.00e+00	926.00
IUUC-Mga-059561	Meleagris gallopavo	87.23	0.00e+00	1648.00
IUUC-Mmr-060942	Microcebus murinus	93.61	0.00e+00	1811.00
IUUC-Mdo-062618	Monodelphis domestica	96.81	0.00e+00	1877.00
IUUC-Mmu-063843	Mus musculus	91.37	0.00e+00	1734.00
IUUC-Mpu-066919	Mustela putorius furo	93.59	0.00e+00	1831.00
IUUC-Mlu-066983	Myotis lucifugus	88.14	0.00e+00	1703.00
IUUC-Nle-069893	Nomascus leucogenys	93.40	0.00e+00	1819.00
IUUC-Opr-071181	Ochotona princeps	85.59	0.00e+00	1559.00
IUUC-Ont-071697	Oreochromis niloticus	66.98	0.00e+00	1168.00
IUUC-Oan-073658	Ornithorhynchus anatinus	91.03	0.00e+00	1744.00
IUUC-Ocu-074954	Oryctolagus cuniculus	93.72	0.00e+00	1826.00
IUUC-Ola-086523	Oryzias latipes	65.87	0.00e+00	1151.00
IUUC-Oga-089003	Otolemur garnettii	93.50	0.00e+00	1826.00
IUUC-Oar-090376	Ovis aries	92.79	0.00e+00	1815.00
IUUC-Ptr-090520	Pan troglodytes	91.69	0.00e+00	1769.00
IUUC-Pan-092281	Papio anubis	93.48	0.00e+00	1818.00
IUUC-Psi-093047	Pelodiscus sinensis	89.17	0.00e+00	1590.00
IUUC-Pma-094575	Petromyzon marinus	56.81	3.00e-66	244.00
IUUC-Pfo-096358	Poecilia formosa	66.28	0.00e+00	1112.00
IUUC-Pab-097740	Pongo abelii	93.08	0.00e+00	1813.00
IUUC-Pca-100461	Procavia capensis	83.35	0.00e+00	1481.00
IUUC-Pva-102134	Pteropus vampyrus	82.96	0.00e+00	1596.00
IUUC-Rno-105807	Rattus norvegicus	89.96	0.00e+00	1702.00
IUUC-Sar-113366	Sorex araneus	97.92	0.00e+00	897.00
IUUC-Tgu-117201	Taeniopygia guttata	84.45	0.00e+00	1583.00
IUUC-Tru-117953	Takifugu rubripes	67.37	0.00e+00	1159.00
IUUC-Tsy-119610	Tarsius syrichta	91.37	0.00e+00	1776.00
IUUC-Tni-120743	Tetraodon nigroviridis	40.30	3.00e-155	542.00
IUUC-Tbe-128155	Tupaia belangeri	75.49	0.00e+00	728.00
IUUC-Ttr-128942	Tursiops truncatus	87.97	0.00e+00	1698.00
IUUC-Vpa-130281	Vicugna pacos	82.64	0.00e+00	1563.00
IUUC-Xtr-132627	Xenopus tropicalis	76.87	0.00e+00	1377.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence