iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059289

UUCD1 version

UUC-MeG-00557

Ensembl Protein ID

ENSMGAP00000012963.2

UniProt Accession

G1NI87; G1NI87_MELGA

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000012296.2	ENSMGAT00000013864.2	ENSMGAP00000012963.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-79	266.7	1891	2213

Active Site

Position(s)	Description	Evidence
2183	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 1891 ENRKRHGSSRSVVDMELDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 1973
           556777999999999999999988777888234444777777777765....89********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+++G nipVt +N +eYv++++e+r+  
   Q: 1974 LGRKVNWHDFAFFDPVMYESlRQLILASQstDADAVFAAMDLAFAIDLCKEEGGGQVELISNGVNIPVTPQNVYEYVRKYAEHRMLV 2060
           ********************5555666655566889999************************************************ PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2061 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2147
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2148 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2213
           *********999******..799999.99**********************************9.99875 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

SNDFHSRPES KQEPVKTEMG PPPSPASTCS DASSIASSAS MPYKRRRSTP APKEEEKVNE 60
EQWSLREVVF VEDVKNVPVG KVLKVDGAYV AVKFPGTSSN ANCQSSSNSD PDPSSLLQDC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTAATGATT TTCATTCTAG GCCTGAAAGT AAACAGGAAC CAGTGAAAAC AGAGATGGGT 60
CCTCCACCTT CCCCAGCTTC CACTTGCAGT GATGCATCTT CAATAGCAAG CAGCGCATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	97.61	0.00e+00	3587.00
IUUC-Apl-004165	Anas platyrhynchos	98.06	0.00e+00	3599.00
IUUC-Aca-004577	Anolis carolinensis	97.02	0.00e+00	3487.00
IUUC-Ame-010702	Astyanax mexicanus	84.64	0.00e+00	2486.00
IUUC-Bta-012313	Bos taurus	97.24	0.00e+00	3590.00
IUUC-Cel-018165	Caenorhabditis elegans	35.10	1.00e-68	256.00
IUUC-Cja-019858	Callithrix jacchus	97.02	0.00e+00	3602.00
IUUC-Cfa-020973	Canis familiaris	97.43	0.00e+00	3598.00
IUUC-Cpo-022108	Cavia porcellus	96.63	0.00e+00	1692.00
IUUC-Csa-023985	Chlorocebus sabaeus	97.20	0.00e+00	3608.00
IUUC-Cho-025034	Choloepus hoffmanni	88.59	0.00e+00	983.00
IUUC-Cin-025715	Ciona intestinalis	43.96	0.00e+00	800.00
IUUC-Csv-026131	Ciona savignyi	47.56	0.00e+00	687.00
IUUC-Dre-027730	Danio rerio	88.88	0.00e+00	3157.00
IUUC-Dno-029123	Dasypus novemcinctus	94.53	0.00e+00	3439.00
IUUC-Dor-030757	Dipodomys ordii	91.74	0.00e+00	1910.00
IUUC-Dme-032192	Drosophila melanogaster	51.67	2.00e-173	604.00
IUUC-Ete-032292	Echinops telfairi	93.74	0.00e+00	2144.00
IUUC-Eca-034347	Equus caballus	97.20	0.00e+00	3547.00
IUUC-Eeu-034873	Erinaceus europaeus	91.73	0.00e+00	3367.00
IUUC-Fca-036485	Felis catus	95.89	0.00e+00	3495.00
IUUC-Fal-037071	Ficedula albicollis	98.55	0.00e+00	3596.00
IUUC-Gmo-039589	Gadus morhua	88.64	0.00e+00	3150.00
IUUC-Gga-041195	Gallus gallus	97.47	0.00e+00	3513.00
IUUC-Gac-042538	Gasterosteus aculeatus	88.50	0.00e+00	3176.00
IUUC-Ggo-045351	Gorilla gorilla	96.17	0.00e+00	3644.00
IUUC-Hsa-045941	Homo sapiens	97.07	0.00e+00	3628.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	97.02	0.00e+00	3586.00
IUUC-Lch-050480	Latimeria chalumnae	95.11	0.00e+00	3491.00
IUUC-Loc-052664	Lepisosteus oculatus	90.17	0.00e+00	3290.00
IUUC-Laf-053960	Loxodonta africana	95.94	0.00e+00	1546.00
IUUC-Mcc-054703	Macaca mulatta	97.24	0.00e+00	3612.00
IUUC-Meu-056431	Macropus eugenii	87.02	0.00e+00	794.00
IUUC-Mmr-061737	Microcebus murinus	96.70	0.00e+00	3516.00
IUUC-Mdo-062499	Monodelphis domestica	97.43	0.00e+00	3557.00
IUUC-Mmu-063273	Mus musculus	96.16	0.00e+00	3542.00
IUUC-Mpu-066907	Mustela putorius furo	97.65	0.00e+00	3574.00
IUUC-Mlu-067942	Myotis lucifugus	97.34	0.00e+00	3611.00
IUUC-Nle-069527	Nomascus leucogenys	97.11	0.00e+00	3635.00
IUUC-Opr-070626	Ochotona princeps	90.54	0.00e+00	1258.00
IUUC-Ont-071951	Oreochromis niloticus	88.57	0.00e+00	3140.00
IUUC-Oan-072958	Ornithorhynchus anatinus	98.01	0.00e+00	3561.00
IUUC-Ocu-074503	Oryctolagus cuniculus	95.08	0.00e+00	3497.00
IUUC-Ola-086757	Oryzias latipes	88.45	0.00e+00	3193.00
IUUC-Oga-088781	Otolemur garnettii	97.20	0.00e+00	3581.00
IUUC-Oar-089274	Ovis aries	97.24	0.00e+00	3571.00
IUUC-Ptr-090669	Pan troglodytes	97.02	0.00e+00	3628.00
IUUC-Pan-092226	Papio anubis	97.07	0.00e+00	3596.00
IUUC-Psi-093502	Pelodiscus sinensis	98.29	0.00e+00	3591.00
IUUC-Pma-094454	Petromyzon marinus	83.00	0.00e+00	734.00
IUUC-Pfo-096173	Poecilia formosa	88.33	0.00e+00	3193.00
IUUC-Pab-098355	Pongo abelii	97.08	0.00e+00	2413.00
IUUC-Pca-100570	Procavia capensis	96.87	0.00e+00	1156.00
IUUC-Pva-102572	Pteropus vampyrus	92.39	0.00e+00	1333.00
IUUC-Rno-104916	Rattus norvegicus	95.17	0.00e+00	3505.00
IUUC-Sha-106653	Sarcophilus harrisii	97.88	0.00e+00	3588.00
IUUC-Sar-113517	Sorex araneus	96.41	0.00e+00	1114.00
IUUC-Ssc-115470	Sus scrofa	98.16	0.00e+00	2515.00
IUUC-Tgu-116932	Taeniopygia guttata	98.42	0.00e+00	3585.00
IUUC-Tru-117682	Takifugu rubripes	88.18	0.00e+00	2582.00
IUUC-Tsy-119417	Tarsius syrichta	93.27	0.00e+00	2454.00
IUUC-Tni-120442	Tetraodon nigroviridis	84.08	0.00e+00	2880.00
IUUC-Tbe-127456	Tupaia belangeri	85.00	0.00e+00	1702.00
IUUC-Ttr-128606	Tursiops truncatus	98.87	0.00e+00	1029.00
IUUC-Vpa-130112	Vicugna pacos	94.33	0.00e+00	3390.00
IUUC-Xtr-131929	Xenopus tropicalis	94.12	0.00e+00	3493.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence