iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132219

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase arih1; Protein ariadne-1 homolog; RING-type E3 ubiquitin transferase arih1

Genbank Nucleotide ID

BC160576

Gene Name

arih1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000032729.1	ENSXETT00000063196.1	ENSXETP00000058410.1

Status

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	9.40e-55	186.2	158	347

Active Site

Position(s)	Description	Evidence
329	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelk.ikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalk 89
           C++C+l+++++ +t  leC h+fC++C+++yl++k i+eg+ ++iscpa+ c   ++++++++l+++++++ +y++l ++++ve+++ lk
   Q: 158  CQICYLNYPNSYFTG-LECGHKFCMQCWSEYLTTKiIEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLK 246
           **********99985.5**************66652799999************************************************ PP
   S: 90   wcpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnh 179
           wcpapdC++vv ++   +++ v+c kcg++fC++C e+wH++++Ck+lk++ +k++   +++e++++++an+k+CpkC+v+iek++gCnh
   Q: 247  WCPAPDCHHVVKVQYP-DAKPVRC-KCGRQFCFNCGENWHDPVKCKWLKKWIKKCD---DDSETSNWIAANTKECPKCHVTIEKDGGCNH 331
           ***************7.9999999.9******************************...99***************************** PP
   S: 180  mtC..akCkaefCwlC 193
           m C  ++CkaefCw+C
   Q: 332  MVCrnQNCKAEFCWVC 347
           ***9999********* PP

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes.

Protein Sequence
(Fasta)

MDSDEGYNYE FDDEEECSED SGADEHEDDL ELGEVELVEA GLSGSERAGI CGEGGGSALG 60
PGPGGEEEED YRYEVLTAEQ ILQHMVECIR EVNEVIQNPA TITRILLSHF NWDKEKLMER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCCCAGTA CCGGAACCGG GGGAGGGGGG GTCGTCCGGG AGCTGAACAC CAAGAACACT 60
TGGAACAGTG CAGCGTGTGC GTGAGGAGGA GGAGCGGTCA CTTGACCCAC GGGGGCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0097413--C:Lewy body
GO:0016604--C:nuclear body
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

xtr:100144731

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000970	Aegilops tauschii	29.54	3.00e-55	209.00
IUUC-Aml-001385	Ailuropoda melanoleuca	99.13	0.00e+00	921.00
IUUC-Atr-002480	Amborella trichopoda	31.85	4.00e-65	242.00
IUUC-Apl-004184	Anas platyrhynchos	97.51	0.00e+00	871.00
IUUC-Aca-004976	Anolis carolinensis	98.62	0.00e+00	872.00
IUUC-Aly-005807	Arabidopsis lyrata	32.74	6.00e-65	241.00
IUUC-Ath-007166	Arabidopsis thaliana	33.04	4.00e-65	242.00
IUUC-Ago-007926	Ashbya gossypii	29.65	1.00e-55	211.00
IUUC-Acl-008252	Aspergillus clavatus	42.30	3.00e-104	372.00
IUUC-Afl-008468	Aspergillus flavus	42.95	1.00e-105	376.00
IUUC-Afu-009062	Aspergillus fumigatus	44.52	3.00e-106	379.00
IUUC-Ani-009219	Aspergillus nidulans	42.73	3.00e-106	378.00
IUUC-Ang-009538	Aspergillus niger	43.29	3.00e-98	352.00
IUUC-Aor-010009	Aspergillus oryzae	42.95	7.00e-105	374.00
IUUC-Ate-010497	Aspergillus terreus	44.25	2.00e-98	353.00
IUUC-Ame-011264	Astyanax mexicanus	93.80	0.00e+00	976.00
IUUC-Bgr-012016	Blumeria graminis	41.34	3.00e-102	365.00
IUUC-Bta-013518	Bos taurus	99.13	0.00e+00	924.00
IUUC-Bci-013819	Botrytis cinerea	42.46	4.00e-107	381.00
IUUC-Bdi-014685	Brachypodium distachyon	32.81	1.00e-67	250.00
IUUC-Bol-016087	Brassica oleracea	31.94	5.00e-61	228.00
IUUC-Bra-017944	Brassica rapa	33.10	4.00e-56	212.00
IUUC-Cel-018521	Caenorhabditis elegans	55.04	7.00e-138	483.00
IUUC-Cja-019869	Callithrix jacchus	91.58	0.00e+00	830.00
IUUC-Cfa-020812	Canis familiaris	98.91	0.00e+00	918.00
IUUC-Cpo-021627	Cavia porcellus	99.13	0.00e+00	924.00
IUUC-Cre-022815	Chlamydomonas reinhardtii	30.73	5.00e-52	198.00
IUUC-Csa-023034	Chlorocebus sabaeus	99.07	0.00e+00	868.00
IUUC-Cho-024444	Choloepus hoffmanni	96.52	0.00e+00	892.00
IUUC-Cin-025135	Ciona intestinalis	68.91	0.00e+00	681.00
IUUC-Csv-026243	Ciona savignyi	62.78	0.00e+00	665.00
IUUC-Cgl-026434	Colletotrichum gloeosporioides	42.40	9.00e-107	380.00
IUUC-Cne-026861	Cryptococcus neoformans	41.98	2.00e-101	362.00
IUUC-Dre-027785	Danio rerio	94.23	0.00e+00	980.00
IUUC-Dno-029205	Dasypus novemcinctus	99.13	0.00e+00	924.00
IUUC-Dor-030769	Dipodomys ordii	81.25	0.00e+00	717.00
IUUC-Dse-031171	Dothistroma septosporum	42.46	1.00e-104	373.00
IUUC-Dme-031903	Drosophila melanogaster	70.65	0.00e+00	698.00
IUUC-Ete-032929	Echinops telfairi	83.33	2.00e-132	464.00
IUUC-Eca-033431	Equus caballus	98.88	0.00e+00	890.00
IUUC-Eeu-034838	Erinaceus europaeus	85.42	0.00e+00	748.00
IUUC-Fca-035882	Felis catus	95.16	0.00e+00	784.00
IUUC-Fal-037068	Ficedula albicollis	98.65	0.00e+00	889.00
IUUC-Fox-037790	Fusarium oxysporum	50.73	3.00e-77	281.00
IUUC-Fso-038125	Fusarium solani	42.25	2.00e-105	375.00
IUUC-Gmo-038703	Gadus morhua	93.41	0.00e+00	961.00
IUUC-Ggr-039722	Gaeumannomyces graminis	41.76	1.00e-104	373.00
IUUC-Gga-040319	Gallus gallus	99.14	0.00e+00	692.00
IUUC-Gac-041708	Gasterosteus aculeatus	93.40	0.00e+00	949.00
IUUC-Gma-043188	Glycine max	32.81	2.00e-59	223.00
IUUC-Ggo-045178	Gorilla gorilla	99.13	0.00e+00	924.00
IUUC-Hsa-045718	Homo sapiens	99.13	0.00e+00	924.00
IUUC-Hvu-047322	Hordeum vulgare	31.99	3.00e-58	219.00
IUUC-Itr-048934	Ictidomys tridecemlineatus	99.36	5.00e-177	613.00
IUUC-Kpa-049350	Komagataella pastoris	31.73	8.00e-64	237.00
IUUC-Lpe-051110	Leersia perrieri	33.41	2.00e-68	253.00
IUUC-Loc-052442	Lepisosteus oculatus	95.60	0.00e+00	987.00
IUUC-Lma-053253	Leptosphaeria maculans	43.16	4.00e-111	395.00
IUUC-Laf-054351	Loxodonta africana	99.07	0.00e+00	868.00
IUUC-Mcc-054670	Macaca mulatta	95.65	0.00e+00	913.00
IUUC-Meu-056335	Macropus eugenii	91.40	9.00e-142	496.00
IUUC-Mor-057179	Magnaporthe oryzae	42.22	3.00e-105	375.00
IUUC-Mpo-057553	Magnaporthe poae	41.54	1.00e-103	370.00
IUUC-Mtr-058263	Medicago truncatula	31.88	4.00e-58	218.00
IUUC-Mla-058889	Melampsora laricipopulina	36.76	6.00e-78	284.00
IUUC-Mga-059385	Meleagris gallopavo	97.31	0.00e+00	877.00
IUUC-Mvi-060517	Microbotryum violaceum	40.52	2.00e-104	372.00
IUUC-Mmr-061439	Microcebus murinus	92.44	0.00e+00	839.00
IUUC-Mdo-062890	Monodelphis domestica	98.91	0.00e+00	923.00
IUUC-Mmu-063433	Mus musculus	99.13	0.00e+00	924.00
IUUC-Mac-065341	Musa acuminata	33.96	2.00e-64	239.00
IUUC-Mpu-066288	Mustela putorius furo	99.13	0.00e+00	924.00
IUUC-Mlu-067187	Myotis lucifugus	99.13	0.00e+00	919.00
IUUC-Nfi-068339	Neosartorya fischeri	44.30	1.00e-105	377.00
IUUC-Ncr-068947	Neurospora crassa	43.32	2.00e-102	365.00
IUUC-Nle-069263	Nomascus leucogenys	99.13	0.00e+00	924.00
IUUC-Opr-071000	Ochotona princeps	98.83	1.00e-96	346.00
IUUC-Ont-072309	Oreochromis niloticus	93.41	0.00e+00	947.00
IUUC-Oan-073731	Ornithorhynchus anatinus	99.03	0.00e+00	827.00
IUUC-Ocu-074000	Oryctolagus cuniculus	97.29	0.00e+00	871.00
IUUC-Oba-075628	Oryza barthii	32.06	3.00e-62	232.00
IUUC-Obr-076492	Oryza brachyantha	32.96	8.00e-69	254.00
IUUC-Ogl-077447	Oryza glaberrima	33.41	3.00e-69	256.00
IUUC-Ogu-078881	Oryza glumaepatula	33.41	3.00e-69	256.00
IUUC-Oin-079573	Oryza indica	33.41	3.00e-67	249.00
IUUC-Olo-080774	Oryza longistaminata	33.41	7.00e-70	258.00
IUUC-Ome-081275	Oryza meridionalis	32.05	9.00e-62	231.00
IUUC-Oni-082267	Oryza nivara	32.05	9.00e-62	231.00
IUUC-Opu-084135	Oryza punctata	33.41	3.00e-69	256.00
IUUC-Oru-084849	Oryza rufipogon	33.41	4.00e-69	255.00
IUUC-Osa-085435	Oryza sativa	33.41	5.00e-69	255.00
IUUC-Ola-086792	Oryzias latipes	96.96	0.00e+00	942.00
IUUC-Olu-087826	Ostreococcus lucimarinus	32.90	3.00e-50	192.00
IUUC-Oga-088706	Otolemur garnettii	99.13	0.00e+00	924.00
IUUC-Oar-089354	Ovis aries	98.91	0.00e+00	924.00
IUUC-Ptr-091287	Pan troglodytes	99.13	0.00e+00	924.00
IUUC-Pan-091701	Papio anubis	99.07	0.00e+00	867.00
IUUC-Psi-093814	Pelodiscus sinensis	99.07	0.00e+00	868.00
IUUC-Pno-095124	Phaeosphaeria nodorum	35.71	2.00e-78	286.00
IUUC-Ppa-095545	Physcomitrella patens	32.21	3.00e-61	229.00
IUUC-Pfo-096449	Poecilia formosa	92.70	0.00e+00	947.00
IUUC-Pab-098132	Pongo abelii	99.13	0.00e+00	924.00
IUUC-Pop-099139	Populus trichocarpa	32.48	3.00e-64	239.00
IUUC-Pca-100303	Procavia capensis	99.09	0.00e+00	649.00
IUUC-Ppe-101740	Prunus persica	32.74	1.00e-59	224.00
IUUC-Pva-102457	Pteropus vampyrus	99.13	0.00e+00	924.00
IUUC-Pgr-103443	Puccinia graminis	42.53	1.00e-103	370.00
IUUC-Ptt-103795	Puccinia triticina	39.88	1.00e-92	333.00
IUUC-Pte-104022	Pyrenophora teres	41.18	1.00e-101	363.00
IUUC-Pyt-104643	Pyrenophora triticirepentis	42.80	2.00e-109	389.00
IUUC-Rno-106083	Rattus norvegicus	99.13	0.00e+00	924.00
IUUC-Sce-106154	Saccharomyces cerevisiae	29.82	1.00e-64	240.00
IUUC-Sha-106765	Sarcophilus harrisii	96.85	0.00e+00	877.00
IUUC-Sja-107977	Schizosaccharomyces japonicus	43.68	2.00e-98	353.00
IUUC-Spo-108222	Schizosaccharomyces pombe	44.73	1.00e-110	393.00
IUUC-Smo-108845	Selaginella moellendorffii	32.48	4.00e-59	222.00
IUUC-Sit-110348	Setaria italica	32.37	3.00e-65	243.00
IUUC-Sly-111454	Solanum lycopersicum	32.79	2.00e-61	229.00
IUUC-Stu-112533	Solanum tuberosum	32.08	2.00e-59	223.00
IUUC-Sar-113023	Sorex araneus	98.84	0.00e+00	862.00
IUUC-Sbi-114262	Sorghum bicolor	33.04	1.00e-66	247.00
IUUC-Sre-115120	Sporisorium reilianum	43.83	7.00e-110	390.00
IUUC-Ssc-115667	Sus scrofa	88.92	1.00e-180	625.00
IUUC-Tgu-117273	Taeniopygia guttata	98.62	0.00e+00	868.00
IUUC-Tru-118338	Takifugu rubripes	91.39	0.00e+00	950.00
IUUC-Tsy-119096	Tarsius syrichta	90.74	0.00e+00	773.00
IUUC-Tni-120238	Tetraodon nigroviridis	91.90	0.00e+00	946.00
IUUC-Tca-121037	Theobroma cacao	33.11	3.00e-66	245.00
IUUC-Tre-121902	Trichoderma reesei	42.11	6.00e-103	367.00
IUUC-Tvi-122474	Trichoderma virens	41.19	2.00e-103	369.00
IUUC-Tae-124132	Triticum aestivum	33.33	4.00e-68	252.00
IUUC-Tur-126320	Triticum urartu	30.99	1.00e-55	210.00
IUUC-Tme-127089	Tuber melanosporum	42.92	1.00e-103	370.00
IUUC-Tbe-127409	Tupaia belangeri	92.17	4.00e-121	427.00
IUUC-Ttr-128909	Tursiops truncatus	89.98	0.00e+00	809.00
IUUC-Uma-129487	Ustilago maydis	42.49	2.00e-110	392.00
IUUC-Vda-129939	Verticillium dahliae	41.97	7.00e-105	374.00
IUUC-Vpa-130259	Vicugna pacos	95.87	0.00e+00	882.00
IUUC-Vvi-131463	Vitis vinifera	32.29	2.00e-58	220.00
IUUC-Xma-133423	Xiphophorus maculatus	92.70	0.00e+00	947.00
IUUC-Yli-134622	Yarrowia lipolytica	35.65	3.00e-73	268.00
IUUC-Zma-135131	Zea mays	33.33	3.00e-67	249.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence