iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020554

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03015346

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000016252.3	ENSCAFT00000025792.3	ENSCAFP00000023954.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-59	200.9	22	336

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q L++   +++ l++    ++++   +e+  ++  +l  l+e +++s++kav+p el  +l+k+++    + q
   Q: 22   VGLHNIGQTCCLNSLIQILIMNVGFTKILKR---ITVPRGT-EEQRRSVPFQLLLLLERMQDSRQKAVQPMELAYCLQKYNVP--MFVQ 104
           6******************************...4444432.466789*********************************98..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   + + +++++                          ++    + ++ l+ +++k++++clec  + sr++++l+l+lp+ +
   Q: 105  HDAAQLYLTVWNLIKDQI--------------------------TDVDLVERLKALYTIRVKESLVCLECTVERSRNSSMLTLPLPLFD 167
           ******************..........................667788999***********************************9 PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +++ +++l+d+L+ f+++ el ++ k++cekc kk+  ++ lkl++lP++L++hL Rfs +  +++ eki  +++fp++Ldls+++  
   Q: 168  MDSKPLKTLEDALRCFFQPRELSDKSKCFCEKCGKKTCGKQVLKLTHLPQTLTIHLLRFSIR--NSRTEKICHSLYFPQSLDLSQVLLM 254
           99999******************************************************665..57999***************96555 PP
   S: 268  .peekqke...kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkr 337
            ++  ++e    ++YeL+avv H G ++ GHY+ay++n  +gkW++f+Ds+V+ v++e+++ + g       +taY+l+Y++
   Q: 255  eEDLYDAEeqlGRQYELFAVVAHVGAADFGHYCAYIQNsVDGKWFCFNDSNVSWVSWEDIQCTYGnhnyrwrETAYLLVYMK 336
           2333332255599*************************45677*******************888***************97 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MKRKKEQRRE CLSAWDCPHG PVGLHNIGQT CCLNSLIQIL IMNVGFTKIL KRITVPRGTE 60
EQRRSVPFQL LLLLERMQDS RQKAVQPMEL AYCLQKYNVP MFVQHDAAQL YLTVWNLIKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTCCCACC AAAGCTGACT CAGGTGAACT CTTCCTGGAA GTGTGCAGTC CTGAAGACAA 60
GCCGGGCAGC CAGTAGCCTG GGGATTTTGG AGTGATCACT AATGGGTCAG GTGTTGGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cfa:486763

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	95.30	0.00e+00	635.00
IUUC-Apl-004006	Anas platyrhynchos	56.88	1.00e-106	379.00
IUUC-Aca-005088	Anolis carolinensis	55.28	1.00e-91	329.00
IUUC-Ame-010606	Astyanax mexicanus	32.49	6.00e-40	157.00
IUUC-Bta-013036	Bos taurus	80.62	2.00e-157	548.00
IUUC-Cja-019052	Callithrix jacchus	75.16	4.00e-141	493.00
IUUC-Cpo-022421	Cavia porcellus	75.15	7.00e-150	523.00
IUUC-Csa-023737	Chlorocebus sabaeus	79.70	7.00e-96	342.00
IUUC-Cho-024807	Choloepus hoffmanni	69.04	3.00e-69	255.00
IUUC-Dre-027408	Danio rerio	33.13	5.00e-46	178.00
IUUC-Dno-029813	Dasypus novemcinctus	72.81	4.00e-123	434.00
IUUC-Dor-030532	Dipodomys ordii	77.88	5.00e-157	546.00
IUUC-Ete-032254	Echinops telfairi	72.39	8.00e-146	509.00
IUUC-Eca-033482	Equus caballus	87.19	5.00e-169	586.00
IUUC-Eeu-034451	Erinaceus europaeus	77.36	6.00e-99	353.00
IUUC-Fca-036313	Felis catus	95.11	0.00e+00	651.00
IUUC-Fal-037216	Ficedula albicollis	54.30	7.00e-104	370.00
IUUC-Gmo-038649	Gadus morhua	33.02	3.00e-39	155.00
IUUC-Gga-041082	Gallus gallus	55.21	2.00e-94	338.00
IUUC-Gac-042439	Gasterosteus aculeatus	36.28	4.00e-49	188.00
IUUC-Ggo-044957	Gorilla gorilla	81.62	6.00e-134	469.00
IUUC-Hsa-046381	Homo sapiens	81.19	2.00e-165	575.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	80.53	6.00e-162	563.00
IUUC-Loc-052688	Lepisosteus oculatus	33.33	1.00e-46	180.00
IUUC-Laf-054109	Loxodonta africana	80.53	8.00e-166	576.00
IUUC-Mcc-054814	Macaca mulatta	80.77	4.00e-166	577.00
IUUC-Meu-056253	Macropus eugenii	69.10	1.00e-110	392.00
IUUC-Mmr-061613	Microcebus murinus	79.94	1.00e-162	565.00
IUUC-Mdo-061890	Monodelphis domestica	66.18	5.00e-130	457.00
IUUC-Mmu-064329	Mus musculus	74.34	4.00e-145	507.00
IUUC-Mpu-066342	Mustela putorius furo	94.29	0.00e+00	658.00
IUUC-Mlu-067010	Myotis lucifugus	83.09	6.00e-171	593.00
IUUC-Nle-069148	Nomascus leucogenys	80.00	1.00e-162	565.00
IUUC-Opr-070988	Ochotona princeps	68.79	2.00e-63	235.00
IUUC-Ont-072039	Oreochromis niloticus	34.80	3.00e-46	178.00
IUUC-Oan-073740	Ornithorhynchus anatinus	58.42	1.00e-77	282.00
IUUC-Ocu-074498	Oryctolagus cuniculus	81.79	3.00e-151	527.00
IUUC-Ola-086753	Oryzias latipes	36.08	2.00e-49	189.00
IUUC-Oga-088497	Otolemur garnettii	81.54	2.00e-160	558.00
IUUC-Oar-089505	Ovis aries	79.38	9.00e-155	539.00
IUUC-Ptr-091656	Pan troglodytes	80.60	2.00e-164	571.00
IUUC-Pan-092498	Papio anubis	80.47	2.00e-165	575.00
IUUC-Psi-093409	Pelodiscus sinensis	54.62	1.00e-107	383.00
IUUC-Pfo-096507	Poecilia formosa	35.99	2.00e-48	186.00
IUUC-Pab-097828	Pongo abelii	79.81	4.00e-155	540.00
IUUC-Pca-100299	Procavia capensis	77.40	1.00e-92	333.00
IUUC-Pva-102972	Pteropus vampyrus	83.48	1.00e-169	588.00
IUUC-Rno-105738	Rattus norvegicus	72.27	1.00e-147	515.00
IUUC-Sha-107309	Sarcophilus harrisii	64.60	1.00e-120	426.00
IUUC-Sar-112983	Sorex araneus	77.35	4.00e-126	444.00
IUUC-Ssc-116049	Sus scrofa	82.81	2.00e-162	565.00
IUUC-Tgu-117115	Taeniopygia guttata	55.70	1.00e-102	366.00
IUUC-Tru-118022	Takifugu rubripes	32.40	5.00e-40	158.00
IUUC-Tsy-118986	Tarsius syrichta	63.64	3.00e-60	225.00
IUUC-Tni-120306	Tetraodon nigroviridis	32.80	1.00e-39	157.00
IUUC-Tbe-127768	Tupaia belangeri	73.11	6.00e-106	377.00
IUUC-Ttr-128686	Tursiops truncatus	77.81	1.00e-156	545.00
IUUC-Xtr-132032	Xenopus tropicalis	44.65	3.00e-72	265.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence