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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031879
Ensembl Protein ID FBpp0078689
UniProt Accession O02195; Q540Y6; Q9VMX5; EIF3I_DROME
Genbank Protein ID AAB53431.1; AAF52183.1; AAM49896.1
Protein Name Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; TRIP-1 homolog; eIF-3-beta
Genbank Nucleotide ID U90930; AE014134; AY118527
Gene Name Trip1; DmTRIP; eif3-S2; CG8882
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0015834 FBtr0079053 FBpp0078689
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.50e-25 87.1 50 86
UBD/Beta-Prp 3.10e-41 141.5 148 313
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtcl..af.sdtllvsGsdDgtikvWDlrtgvl 35
           gH++ v+cl  ++ s + l++G++D t k+WD+  g++
   Q: 50   GHQGAVWCLdvDWeS-RKLITGAGDMTAKIWDVEYGTV 86
           8*******6337755.99**************988766 PP
   

   UBD/Beta-Prp
   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkllrsl.sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
           s it++ + p ++ ++tg ++g i +wd+++g+++     +h+a+++++++s+dg ++vt+s+D t+k++d ++  c+ t+k  e+ v s ++sp  d
   Q: 148  SKITSMLWGPLDETIITGHDNGNIAIWDIRKGQKVVDSgTDHSAGINDMQLSKDGTMFVTASKDTTAKLFDSESLMCLKTYK-TERPVNSAAISPIMD 244
           679999999**********************98855555*******************************************.*************** PP
   S: 108  klvsGshdrtirv..............wdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrl 163
           ++v G+  +  +v              ++l  ++++   l+gh g +n++++hpdg+ ++sG+ D++vr+
   Q: 245  HVVLGGGQDAMEVtttstkagkfdsrfFHLIYEEEFA-RLKGHFGPINSLAFHPDGKSYASGGEDGFVRV 313
           *************888888888777766666666666.*******************************8 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Protein Sequence
(Fasta)
MRPLMLQGHE RSITQIKYNR EGDLLFSCSK DQKPNVWYSL NGERLGTYDG HQGAVWCLDV 60
DWESRKLITG AGDMTAKIWD VEYGTVIASI PTKSSVRTSN FSFSGNQAAY STDKAMGQSC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031879|E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGCTCTTTT GGCGTGTAGT GCTGCGTGGA TGTTGTTGCA AAAATATTCG TTTTCTCGCA 60
ACAAATAACA ATATAATACA AAATGGTGCG TGCCTGGTCA ATGACTACAC AGTTTGCATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031879|E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR027525--eIF3i
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0005875--C:microtubule associated complex
GO:0003743--F:translation initiation factor activity
GO:0006413--P:translational initiation
KEGG dme:Dmel_CG8882
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000115 Aegilops tauschii 55.93 2.00e-35 142.00
IUUC-Aml-001321 Ailuropoda melanoleuca 60.62 2.00e-119 421.00
IUUC-Atr-002468 Amborella trichopoda 49.49 3.00e-53 200.00
IUUC-Apl-003841 Anas platyrhynchos 60.00 3.00e-120 423.00
IUUC-Aca-005123 Anolis carolinensis 61.04 4.00e-122 429.00
IUUC-Aly-006532 Arabidopsis lyrata 47.53 1.00e-87 315.00
IUUC-Ath-007094 Arabidopsis thaliana 46.91 3.00e-89 321.00
IUUC-Ago-008000 Ashbya gossypii 41.69 1.00e-77 282.00
IUUC-Acl-008098 Aspergillus clavatus 46.71 1.00e-87 315.00
IUUC-Afl-008494 Aspergillus flavus 46.79 5.00e-90 323.00
IUUC-Afu-009080 Aspergillus fumigatus 47.01 2.00e-88 317.00
IUUC-Ani-009230 Aspergillus nidulans 47.13 4.00e-88 317.00
IUUC-Aor-010114 Aspergillus oryzae 46.79 5.00e-90 323.00
IUUC-Ate-010285 Aspergillus terreus 46.97 2.00e-88 317.00
IUUC-Ame-011534 Astyanax mexicanus 60.37 2.00e-120 424.00
IUUC-Bgr-012121 Blumeria graminis 44.51 8.00e-81 292.00
IUUC-Bta-013143 Bos taurus 61.04 2.00e-120 424.00
IUUC-Bci-013950 Botrytis cinerea 44.95 3.00e-86 311.00
IUUC-Bdi-015019 Brachypodium distachyon 47.69 2.00e-88 317.00
IUUC-Bol-015709 Brassica oleracea 46.01 4.00e-86 311.00
IUUC-Bra-017760 Brassica rapa 46.32 8.00e-87 313.00
IUUC-Cel-018226 Caenorhabditis elegans 45.34 2.00e-89 321.00
IUUC-Cja-019741 Callithrix jacchus 60.74 3.00e-120 423.00
IUUC-Cfa-021204 Canis familiaris 60.62 2.00e-119 421.00
IUUC-Cpo-021661 Cavia porcellus 60.92 8.00e-120 422.00
IUUC-Cre-022952 Chlamydomonas reinhardtii 45.57 3.00e-85 307.00
IUUC-Csa-024038 Chlorocebus sabaeus 60.74 3.00e-120 423.00
IUUC-Cin-025597 Ciona intestinalis 61.09 4.00e-121 426.00
IUUC-Cgl-026583 Colletotrichum gloeosporioides 44.34 2.00e-82 298.00
IUUC-Cne-026838 Cryptococcus neoformans 48.02 1.00e-91 328.00
IUUC-Cme-027304 Cyanidioschyzon merolae 44.92 3.00e-77 280.00
IUUC-Dre-028567 Danio rerio 60.56 3.00e-120 423.00
IUUC-Dno-029171 Dasypus novemcinctus 60.62 4.00e-119 421.00
IUUC-Dor-030257 Dipodomys ordii 50.29 3.00e-46 177.00
IUUC-Dse-031191 Dothistroma septosporum 44.68 1.00e-82 298.00
IUUC-Ete-032336 Echinops telfairi 58.41 4.00e-71 259.00
IUUC-Eca-033259 Equus caballus 60.62 2.00e-119 421.00
IUUC-Eeu-035153 Erinaceus europaeus 53.96 5.00e-35 140.00
IUUC-Fca-036489 Felis catus 60.62 2.00e-119 421.00
IUUC-Fal-037485 Ficedula albicollis 60.62 3.00e-121 426.00
IUUC-Fox-037860 Fusarium oxysporum 44.51 1.00e-81 295.00
IUUC-Fso-038188 Fusarium solani 44.82 5.00e-80 290.00
IUUC-Gmo-039311 Gadus morhua 59.50 2.00e-117 414.00
IUUC-Ggr-040045 Gaeumannomyces graminis 45.26 2.00e-86 311.00
IUUC-Gga-040645 Gallus gallus 58.68 8.00e-119 419.00
IUUC-Gac-042086 Gasterosteus aculeatus 59.94 2.00e-117 414.00
IUUC-Gma-043246 Glycine max 47.99 3.00e-90 324.00
IUUC-Ggo-045578 Gorilla gorilla 60.74 3.00e-120 423.00
IUUC-Hsa-046734 Homo sapiens 60.74 3.00e-120 423.00
IUUC-Hvu-047553 Hordeum vulgare 48.31 2.00e-88 317.00
IUUC-Itr-048467 Ictidomys tridecemlineatus 60.62 3.00e-119 420.00
IUUC-Kpa-049325 Komagataella pastoris 43.56 4.00e-78 283.00
IUUC-Lch-049620 Latimeria chalumnae 60.33 1.00e-110 391.00
IUUC-Lpe-051338 Leersia perrieri 47.12 1.00e-84 305.00
IUUC-Loc-052094 Lepisosteus oculatus 56.00 2.00e-106 377.00
IUUC-Lma-053047 Leptosphaeria maculans 46.04 4.00e-86 310.00
IUUC-Laf-053801 Loxodonta africana 60.82 1.00e-116 411.00
IUUC-Mcc-055498 Macaca mulatta 54.91 6.00e-98 349.00
IUUC-Meu-056729 Macropus eugenii 58.10 9.00e-110 389.00
IUUC-Mor-057025 Magnaporthe oryzae 46.04 3.00e-85 307.00
IUUC-Mpo-057511 Magnaporthe poae 46.34 2.00e-86 311.00
IUUC-Mtr-058051 Medicago truncatula 48.92 3.00e-90 324.00
IUUC-Mla-059061 Melampsora laricipopulina 45.68 7.00e-86 309.00
IUUC-Mga-059229 Meleagris gallopavo 59.33 1.00e-117 415.00
IUUC-Mvi-060399 Microbotryum violaceum 45.32 6.00e-82 296.00
IUUC-Mmr-060764 Microcebus murinus 61.04 7.00e-121 426.00
IUUC-Mdo-062088 Monodelphis domestica 60.43 6.00e-119 419.00
IUUC-Mmu-064304 Mus musculus 60.43 5.00e-120 422.00
IUUC-Mac-065520 Musa acuminata 49.06 1.00e-90 325.00
IUUC-Mpu-066340 Mustela putorius furo 60.62 2.00e-119 421.00
IUUC-Mlu-067111 Myotis lucifugus 60.62 1.00e-119 421.00
IUUC-Nfi-068478 Neosartorya fischeri 47.01 1.00e-88 318.00
IUUC-Ncr-068820 Neurospora crassa 45.57 2.00e-84 305.00
IUUC-Nle-069903 Nomascus leucogenys 60.62 2.00e-119 421.00
IUUC-Opr-070221 Ochotona princeps 59.20 9.00e-117 412.00
IUUC-Ont-071765 Oreochromis niloticus 60.56 2.00e-120 424.00
IUUC-Oan-073660 Ornithorhynchus anatinus 59.04 4.00e-103 366.00
IUUC-Ocu-074039 Oryctolagus cuniculus 60.62 1.00e-119 421.00
IUUC-Oba-075395 Oryza barthii 42.11 5.00e-73 266.00
IUUC-Obr-076334 Oryza brachyantha 45.20 7.00e-81 293.00
IUUC-Ogl-077751 Oryza glaberrima 48.30 6.00e-90 323.00
IUUC-Ogu-078207 Oryza glumaepatula 48.30 3.00e-90 324.00
IUUC-Oin-079878 Oryza indica 48.30 7.00e-90 322.00
IUUC-Olo-080677 Oryza longistaminata 41.38 5.00e-81 293.00
IUUC-Ome-081228 Oryza meridionalis 34.58 1.00e-45 175.00
IUUC-Oni-082411 Oryza nivara 41.85 4.00e-73 266.00
IUUC-Opu-083136 Oryza punctata 47.99 2.00e-89 321.00
IUUC-Oru-084916 Oryza rufipogon 46.39 3.00e-88 317.00
IUUC-Osa-085776 Oryza sativa 48.30 6.00e-90 323.00
IUUC-Ola-087053 Oryzias latipes 59.63 4.00e-118 416.00
IUUC-Olu-087602 Ostreococcus lucimarinus 51.24 2.00e-100 358.00
IUUC-Oga-088154 Otolemur garnettii 60.92 4.00e-120 423.00
IUUC-Oar-089915 Ovis aries 60.92 9.00e-120 422.00
IUUC-Ptr-091124 Pan troglodytes 50.16 1.00e-87 315.00
IUUC-Pan-092035 Papio anubis 60.74 3.00e-120 423.00
IUUC-Psi-094096 Pelodiscus sinensis 59.91 1.00e-75 274.00
IUUC-Pno-094988 Phaeosphaeria nodorum 42.02 7.00e-75 273.00
IUUC-Ppa-095536 Physcomitrella patens 50.62 5.00e-98 349.00
IUUC-Pfo-096101 Poecilia formosa 59.63 9.00e-119 418.00
IUUC-Pab-097726 Pongo abelii 60.74 3.00e-120 423.00
IUUC-Pop-099617 Populus trichocarpa 47.68 2.00e-89 321.00
IUUC-Pca-101014 Procavia capensis 60.74 3.00e-120 423.00
IUUC-Ppe-101320 Prunus persica 48.61 1.00e-89 322.00
IUUC-Pva-102789 Pteropus vampyrus 55.21 1.00e-102 365.00
IUUC-Pgr-103479 Puccinia graminis 45.03 1.00e-85 308.00
IUUC-Ptt-103981 Puccinia triticina 45.03 2.00e-86 311.00
IUUC-Pte-104278 Pyrenophora teres 45.43 1.00e-82 298.00
IUUC-Pyt-104492 Pyrenophora triticirepentis 45.43 1.00e-82 298.00
IUUC-Rno-105867 Rattus norvegicus 52.29 2.00e-94 337.00
IUUC-Sce-106251 Saccharomyces cerevisiae 45.12 3.00e-83 300.00
IUUC-Sha-107039 Sarcophilus harrisii 60.12 1.00e-118 418.00
IUUC-Sja-107758 Schizosaccharomyces japonicus 45.68 6.00e-85 306.00
IUUC-Spo-108314 Schizosaccharomyces pombe 45.68 4.00e-86 310.00
IUUC-Ssl-108478 Sclerotinia sclerotiorum 44.65 1.00e-85 308.00
IUUC-Smo-108728 Selaginella moellendorffii 49.07 1.00e-93 335.00
IUUC-Sit-110801 Setaria italica 48.62 1.00e-88 318.00
IUUC-Sly-111326 Solanum lycopersicum 49.85 2.00e-92 331.00
IUUC-Stu-112458 Solanum tuberosum 49.54 1.00e-91 328.00
IUUC-Sbi-114063 Sorghum bicolor 47.69 7.00e-87 312.00
IUUC-Sre-115096 Sporisorium reilianum 45.62 6.00e-80 290.00
IUUC-Ssc-116080 Sus scrofa 60.74 5.00e-120 422.00
IUUC-Tgu-116988 Taeniopygia guttata 60.62 3.00e-121 426.00
IUUC-Tru-118766 Takifugu rubripes 60.56 9.00e-120 422.00
IUUC-Tni-120197 Tetraodon nigroviridis 60.87 3.00e-120 424.00
IUUC-Tca-121316 Theobroma cacao 48.62 1.00e-89 321.00
IUUC-Tre-122097 Trichoderma reesei 45.43 3.00e-83 300.00
IUUC-Tvi-122442 Trichoderma virens 45.12 5.00e-83 300.00
IUUC-Tae-125800 Triticum aestivum 48.31 3.00e-88 318.00
IUUC-Tur-126334 Triticum urartu 41.23 3.00e-68 251.00
IUUC-Tme-127038 Tuber melanosporum 46.18 2.00e-86 311.00
IUUC-Ttr-128659 Tursiops truncatus 56.75 1.00e-97 348.00
IUUC-Uma-129464 Ustilago maydis 46.22 3.00e-80 291.00
IUUC-Vda-129841 Verticillium dahliae 45.87 2.00e-85 308.00
IUUC-Vvi-131076 Vitis vinifera 48.30 1.00e-89 322.00
IUUC-Xtr-132395 Xenopus tropicalis 61.96 3.00e-123 433.00
IUUC-Xma-133383 Xiphophorus maculatus 59.63 1.00e-118 418.00
IUUC-Yli-134586 Yarrowia lipolytica 44.07 1.00e-71 262.00
IUUC-Zma-135904 Zea mays 48.00 6.00e-88 316.00
Created Date 25-Jun-2017

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