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Tag Content
iUUCD ID IUUC-Kpa-049157
Ensembl Protein ID CAY69014
UniProt Accession C4R0J0; C4R0J0_KOMPG
Genbank Protein ID CAY69014.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID FN392320
Gene Name URM1; PAS_chr2-1_0393
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
PAS_chr2-1_0393 CAY69014 CAY69014
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 56.57 6.00e-27 113.00 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Komagataella pastoris
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MLTINVEFLG GLDAIFGHVR EHTVQVEDGS NFRELTQHLV EHLLKDRKDE DVFIEDGSIR 60
PGILVLINDT DWELEGEDEY ELQDKDLITF TSTLHGG 97
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Protein Fasta Sequence


>IUUC-Kpa-049157|ULD,UBQ_Other|Komagataella pastoris
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Nucleotide Sequence
(Fasta)
ATGTTGACCA TCAACGTAGA ATTTCTGTAA GCCTGACAAA CAAGACTCTA CGAGAGTTTT 60
TTGAGCATAC GCTAACAAAT AGGGGCGGAC TTGATGCTAT ATTTGGCCAT GTGCGAGAGC 120
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Nucleotide Fasta Sequence


>IUUC-Kpa-049157|ULD,UBQ_Other|Komagataella pastoris
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0031386--F:protein tag
GO:0016783--F:sulfurtransferase activity
GO:0007114--P:cell budding
GO:0034599--P:cellular response to oxidative stress
GO:0001403--P:invasive growth in response to glucose limitation
GO:0032447--P:protein urmylation
GO:0002143--P:tRNA wobble position uridine thiolation
KEGG ppa:PAS_chr2-1_0393
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 46.46 3.00e-20 87.80
IUUC-Atr-003089 Amborella trichopoda 43.56 1.00e-17 79.00
IUUC-Apl-003382 Anas platyrhynchos 46.24 3.00e-18 80.50
IUUC-Aca-004981 Anolis carolinensis 44.44 6.00e-20 86.70
IUUC-Aly-005517 Arabidopsis lyrata 38.71 3.00e-15 70.50
IUUC-Ath-006718 Arabidopsis thaliana 40.48 6.00e-14 66.60
IUUC-Ago-007917 Ashbya gossypii 56.44 4.00e-28 113.00
IUUC-Acl-008054 Aspergillus clavatus 62.96 2.00e-15 71.20
IUUC-Afl-008704 Aspergillus flavus 49.44 8.00e-19 82.40
IUUC-Aor-009890 Aspergillus oryzae 50.00 6.00e-23 97.10
IUUC-Bta-012448 Bos taurus 47.47 2.00e-20 88.20
IUUC-Bci-013865 Botrytis cinerea 47.06 2.00e-20 88.60
IUUC-Bdi-014980 Brachypodium distachyon 48.53 2.00e-14 68.60
IUUC-Bol-016055 Brassica oleracea 43.21 5.00e-14 67.00
IUUC-Bra-016845 Brassica rapa 43.21 5.00e-14 67.00
IUUC-Cel-018485 Caenorhabditis elegans 29.59 6.00e-08 47.00
IUUC-Cja-019587 Callithrix jacchus 48.48 1.00e-20 88.60
IUUC-Cfa-020653 Canis familiaris 48.48 1.00e-20 89.00
IUUC-Cpo-021622 Cavia porcellus 48.48 1.00e-20 88.60
IUUC-Cre-023015 Chlamydomonas reinhardtii 39.60 6.00e-18 80.10
IUUC-Csa-023756 Chlorocebus sabaeus 43.42 4.00e-12 61.60
IUUC-Cgl-026518 Colletotrichum gloeosporioides 47.06 7.00e-21 90.10
IUUC-Cne-026953 Cryptococcus neoformans 44.76 2.00e-18 82.40
IUUC-Cme-027314 Cyanidioschyzon merolae 44.90 1.00e-16 75.10
IUUC-Dre-027884 Danio rerio 47.47 4.00e-20 87.40
IUUC-Dno-029262 Dasypus novemcinctus 43.59 1.00e-11 60.50
IUUC-Dor-030601 Dipodomys ordii 44.78 4.00e-08 47.40
IUUC-Dme-031893 Drosophila melanogaster 40.82 1.00e-16 75.50
IUUC-Ete-032773 Echinops telfairi 46.94 7.00e-19 82.80
IUUC-Eca-034187 Equus caballus 49.49 9.00e-21 89.40
IUUC-Eeu-034808 Erinaceus europaeus 47.47 4.00e-20 87.00
IUUC-Fca-036107 Felis catus 47.47 3.00e-20 87.40
IUUC-Fal-036607 Ficedula albicollis 45.16 4.00e-18 80.10
IUUC-Fox-037698 Fusarium oxysporum 48.04 6.00e-22 93.60
IUUC-Gmo-039492 Gadus morhua 46.46 5.00e-20 87.00
IUUC-Ggr-039965 Gaeumannomyces graminis 47.06 3.00e-20 88.60
IUUC-Gga-041268 Gallus gallus 45.45 6.00e-20 86.70
IUUC-Gac-042111 Gasterosteus aculeatus 46.46 1.00e-19 85.90
IUUC-Gma-043240 Glycine max 43.66 8.00e-14 66.20
IUUC-Ggo-045176 Gorilla gorilla 43.42 3.00e-09 52.00
IUUC-Hsa-046077 Homo sapiens 47.47 2.00e-17 78.20
IUUC-Itr-048111 Ictidomys tridecemlineatus 47.25 6.00e-15 69.70
IUUC-Lch-049889 Latimeria chalumnae 42.42 2.00e-19 84.70
IUUC-Lpe-050783 Leersia perrieri 42.17 5.00e-13 63.50
IUUC-Loc-052400 Lepisosteus oculatus 44.44 2.00e-18 82.00
IUUC-Lma-053259 Leptosphaeria maculans 50.98 1.00e-23 99.00
IUUC-Laf-053596 Loxodonta africana 47.52 7.00e-20 86.30
IUUC-Mcc-054845 Macaca mulatta 45.45 3.00e-18 80.90
IUUC-Meu-055968 Macropus eugenii 48.48 8.00e-21 89.70
IUUC-Mor-057126 Magnaporthe oryzae 47.06 5.00e-20 87.80
IUUC-Mpo-057311 Magnaporthe poae 49.02 3.00e-22 95.10
IUUC-Mtr-058266 Medicago truncatula 42.25 3.00e-13 64.70
IUUC-Mla-058847 Melampsora laricipopulina 34.65 2.00e-10 55.50
IUUC-Mga-059468 Meleagris gallopavo 46.24 1.00e-18 81.60
IUUC-Mvi-060235 Microbotryum violaceum 51.47 9.00e-14 67.40
IUUC-Mdo-061948 Monodelphis domestica 47.47 2.00e-20 88.20
IUUC-Mmu-063946 Mus musculus 49.49 6.00e-21 90.10
IUUC-Mac-064812 Musa acuminata 45.68 5.00e-14 67.00
IUUC-Mpu-066763 Mustela putorius furo 49.49 2.00e-20 88.60
IUUC-Mlu-066970 Myotis lucifugus 44.74 1.00e-12 61.60
IUUC-Ncr-068824 Neurospora crassa 44.66 4.00e-19 84.30
IUUC-Nle-069849 Nomascus leucogenys 43.42 4.00e-12 61.60
IUUC-Opr-070227 Ochotona princeps 48.48 1.00e-20 88.60
IUUC-Ont-072530 Oreochromis niloticus 47.47 1.00e-20 89.40
IUUC-Oan-073191 Ornithorhynchus anatinus 44.44 5.00e-18 80.10
IUUC-Ocu-074460 Oryctolagus cuniculus 48.48 3.00e-20 87.80
IUUC-Oba-075499 Oryza barthii 44.16 4.00e-13 65.10
IUUC-Obr-076896 Oryza brachyantha 46.97 8.00e-14 68.20
IUUC-Ogl-077834 Oryza glaberrima 46.97 2.00e-13 65.10
IUUC-Ogu-078622 Oryza glumaepatula 46.97 2.00e-13 65.10
IUUC-Oin-079358 Oryza indica 44.16 6.00e-13 65.10
IUUC-Olo-081035 Oryza longistaminata 45.45 1.00e-13 67.00
IUUC-Oni-082425 Oryza nivara 46.97 2.00e-13 65.10
IUUC-Opu-083461 Oryza punctata 44.74 7.00e-13 64.30
IUUC-Oru-084875 Oryza rufipogon 44.29 4.00e-12 60.10
IUUC-Oga-089128 Otolemur garnettii 49.49 8.00e-21 89.40
IUUC-Oar-089896 Ovis aries 47.47 2.00e-20 88.20
IUUC-Ptr-091618 Pan troglodytes 43.42 3.00e-09 52.00
IUUC-Pan-092238 Papio anubis 43.42 4.00e-12 61.60
IUUC-Psi-093879 Pelodiscus sinensis 43.43 2.00e-19 84.70
IUUC-Pma-094484 Petromyzon marinus 52.05 4.00e-16 73.90
IUUC-Ppa-095801 Physcomitrella patens 40.74 2.00e-14 68.20
IUUC-Pfo-097192 Poecilia formosa 46.46 4.00e-19 84.00
IUUC-Pab-098203 Pongo abelii 47.47 2.00e-17 78.60
IUUC-Pop-099614 Populus trichocarpa 41.67 1.00e-14 68.90
IUUC-Pca-100507 Procavia capensis 43.42 2.00e-12 60.80
IUUC-Ppe-101174 Prunus persica 39.60 4.00e-17 77.00
IUUC-Pva-102735 Pteropus vampyrus 48.48 1.00e-17 78.60
IUUC-Pgr-103510 Puccinia graminis 34.31 1.00e-10 56.60
IUUC-Ptt-103918 Puccinia triticina 33.98 4.00e-09 51.20
IUUC-Pte-104173 Pyrenophora teres 42.16 7.00e-21 89.70
IUUC-Pyt-104806 Pyrenophora triticirepentis 42.16 7.00e-21 89.70
IUUC-Rno-105820 Rattus norvegicus 49.49 2.00e-20 87.80
IUUC-Sce-106366 Saccharomyces cerevisiae 56.57 5.00e-28 113.00
IUUC-Sja-107727 Schizosaccharomyces japonicus 41.24 1.00e-17 79.30
IUUC-Spo-108074 Schizosaccharomyces pombe 37.76 6.00e-13 63.20
IUUC-Smo-108944 Selaginella moellendorffii 46.07 1.00e-17 78.60
IUUC-Sit-110277 Setaria italica 44.16 1.00e-13 65.90
IUUC-Sly-111505 Solanum lycopersicum 40.48 7.00e-14 66.20
IUUC-Stu-112076 Solanum tuberosum 41.67 9.00e-14 66.20
IUUC-Sbi-114274 Sorghum bicolor 43.66 5.00e-14 67.40
IUUC-Sre-114953 Sporisorium reilianum 43.14 1.00e-17 79.00
IUUC-Ssc-115418 Sus scrofa 48.48 3.00e-20 87.40
IUUC-Tgu-117311 Taeniopygia guttata 45.16 4.00e-18 80.10
IUUC-Tru-118598 Takifugu rubripes 49.45 3.00e-19 84.30
IUUC-Tni-120109 Tetraodon nigroviridis 47.00 3.00e-18 81.30
IUUC-Tca-120942 Theobroma cacao 40.48 1.00e-13 65.50
IUUC-Tre-122099 Trichoderma reesei 51.06 7.00e-14 66.20
IUUC-Tvi-122285 Trichoderma virens 50.00 1.00e-15 72.40
IUUC-Tae-125193 Triticum aestivum 50.70 5.00e-16 73.60
IUUC-Tur-126677 Triticum urartu 43.37 3.00e-13 64.70
IUUC-Tme-127120 Tuber melanosporum 49.02 4.00e-24 100.00
IUUC-Tbe-128050 Tupaia belangeri 39.18 9.00e-13 62.80
IUUC-Ttr-129019 Tursiops truncatus 47.96 9.00e-20 85.90
IUUC-Uma-129483 Ustilago maydis 44.12 2.00e-17 78.20
IUUC-Vda-129690 Verticillium dahliae 40.18 5.00e-14 67.40
IUUC-Vvi-131174 Vitis vinifera 41.67 2.00e-14 68.20
IUUC-Xma-133862 Xiphophorus maculatus 46.46 4.00e-19 84.00
IUUC-Yli-134398 Yarrowia lipolytica 52.53 9.00e-26 105.00
IUUC-Zma-134964 Zea mays 44.05 8.00e-14 66.20
Created Date 25-Jun-2017

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