iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tme-127120

Ensembl Protein ID

CAZ81414

UniProt Accession

D5GA60; D5GA60_TUBMM

Genbank Protein ID

CAZ81414.1

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

FN430075

Gene Name

URM1; GSTUM_00005147001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GSTUM_00005147001	CAZ81414	CAZ81414

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	46.08	5.00e-23	100.00	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Tuber melanosporum

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MGEQQDPSPN GIYSKPVSLN IEFSGGLEML FSNQRSHHIQ MPAKGPSKQP VNIGFLVRHL 60
CENLMKDKRK DLFVLEDRIR PGILVLINDA DWELEGEEEY LIQDGDTILF VSTLHGG 117

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Nucleotide Sequence
(Fasta)

ATCGATAACT GCGATTCCTG CGACAGGTGA CAATCACATA CACGCCGCAC ACACACACGA 60
CAAACGAGTA TGGGCGAACA ACAAGACCCC TCCCCAAACG GGATTTATTC TAAACCTGTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

KEGG

tml:GSTUM_00005147001

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	47.12	2.00e-24	101.00
IUUC-Atr-003089	Amborella trichopoda	43.56	1.00e-20	89.00
IUUC-Apl-003382	Anas platyrhynchos	48.42	2.00e-21	91.70
IUUC-Aca-004981	Anolis carolinensis	49.04	1.00e-24	102.00
IUUC-Aly-005517	Arabidopsis lyrata	39.36	1.00e-15	72.00
IUUC-Ath-006718	Arabidopsis thaliana	52.73	2.00e-13	65.50
IUUC-Ago-007917	Ashbya gossypii	47.57	3.00e-24	101.00
IUUC-Acl-008054	Aspergillus clavatus	73.58	1.00e-20	88.20
IUUC-Afl-008704	Aspergillus flavus	61.80	9.00e-30	119.00
IUUC-Aor-009890	Aspergillus oryzae	61.39	1.00e-34	135.00
IUUC-Bta-012448	Bos taurus	47.12	1.00e-24	102.00
IUUC-Bci-013865	Botrytis cinerea	60.58	1.00e-36	142.00
IUUC-Bdi-014980	Brachypodium distachyon	52.73	5.00e-13	63.90
IUUC-Bol-016055	Brassica oleracea	54.55	3.00e-14	67.80
IUUC-Bra-016845	Brassica rapa	54.55	3.00e-14	67.80
IUUC-Cel-018485	Caenorhabditis elegans	33.96	9.00e-12	59.70
IUUC-Cja-019587	Callithrix jacchus	48.08	1.00e-24	102.00
IUUC-Cfa-020653	Canis familiaris	48.08	8.00e-25	103.00
IUUC-Cpo-021622	Cavia porcellus	48.08	1.00e-24	102.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	47.52	3.00e-23	97.80
IUUC-Csa-023756	Chlorocebus sabaeus	44.44	7.00e-16	74.30
IUUC-Cgl-026518	Colletotrichum gloeosporioides	65.05	6.00e-38	146.00
IUUC-Cne-026953	Cryptococcus neoformans	46.22	2.00e-23	99.80
IUUC-Cme-027314	Cyanidioschyzon merolae	40.78	3.00e-17	77.40
IUUC-Dre-027884	Danio rerio	46.15	2.00e-23	98.60
IUUC-Dno-029262	Dasypus novemcinctus	41.94	4.00e-16	75.50
IUUC-Dor-030601	Dipodomys ordii	50.00	1.00e-09	52.40
IUUC-Dme-031893	Drosophila melanogaster	45.36	5.00e-19	84.00
IUUC-Ete-032773	Echinops telfairi	48.48	1.00e-22	95.50
IUUC-Eca-034187	Equus caballus	49.04	8.00e-25	103.00
IUUC-Eeu-034808	Erinaceus europaeus	48.08	2.00e-24	101.00
IUUC-Fca-036107	Felis catus	48.08	2.00e-24	101.00
IUUC-Fal-036607	Ficedula albicollis	47.37	4.00e-21	90.50
IUUC-Fox-037698	Fusarium oxysporum	66.34	1.00e-38	149.00
IUUC-Gmo-039492	Gadus morhua	47.12	8.00e-25	102.00
IUUC-Ggr-039965	Gaeumannomyces graminis	60.00	4.00e-34	135.00
IUUC-Gga-041268	Gallus gallus	49.04	4.00e-25	104.00
IUUC-Gac-042111	Gasterosteus aculeatus	46.15	9.00e-25	102.00
IUUC-Gma-043240	Glycine max	50.91	4.00e-13	63.90
IUUC-Ggo-045176	Gorilla gorilla	39.51	9.00e-13	63.90
IUUC-Hsa-046077	Homo sapiens	48.08	2.00e-21	91.70
IUUC-Itr-048111	Ictidomys tridecemlineatus	49.46	6.00e-18	79.70
IUUC-Kpa-049157	Komagataella pastoris	49.02	3.00e-24	100.00
IUUC-Lch-049889	Latimeria chalumnae	45.19	1.00e-22	95.90
IUUC-Lpe-050783	Leersia perrieri	50.00	2.00e-11	58.50
IUUC-Loc-052400	Lepisosteus oculatus	48.08	7.00e-25	103.00
IUUC-Lma-053259	Leptosphaeria maculans	64.36	6.00e-37	143.00
IUUC-Laf-053596	Loxodonta africana	47.17	8.00e-24	99.80
IUUC-Mcc-054845	Macaca mulatta	49.02	1.00e-22	95.50
IUUC-Meu-055968	Macropus eugenii	50.00	1.00e-25	105.00
IUUC-Mor-057126	Magnaporthe oryzae	56.14	8.00e-33	130.00
IUUC-Mpo-057311	Magnaporthe poae	64.42	8.00e-37	143.00
IUUC-Mtr-058266	Medicago truncatula	34.88	6.00e-13	63.50
IUUC-Mla-058847	Melampsora laricipopulina	36.13	4.00e-15	71.20
IUUC-Mga-059468	Meleagris gallopavo	48.42	9.00e-22	92.40
IUUC-Mvi-060235	Microbotryum violaceum	30.46	2.00e-17	79.30
IUUC-Mdo-061948	Monodelphis domestica	49.04	1.00e-25	105.00
IUUC-Mmu-063946	Mus musculus	48.08	2.00e-24	101.00
IUUC-Mac-064812	Musa acuminata	37.65	2.00e-12	62.00
IUUC-Mpu-066763	Mustela putorius furo	49.04	2.00e-24	101.00
IUUC-Mlu-066970	Myotis lucifugus	44.44	5.00e-16	73.20
IUUC-Ncr-068824	Neurospora crassa	57.43	4.00e-34	134.00
IUUC-Nle-069849	Nomascus leucogenys	44.44	7.00e-16	74.30
IUUC-Opr-070227	Ochotona princeps	48.08	1.00e-24	102.00
IUUC-Ont-072530	Oreochromis niloticus	45.19	7.00e-23	96.70
IUUC-Oan-073191	Ornithorhynchus anatinus	48.39	2.00e-20	88.20
IUUC-Ocu-074460	Oryctolagus cuniculus	49.02	4.00e-24	100.00
IUUC-Oba-075499	Oryza barthii	50.00	8.00e-12	60.80
IUUC-Obr-076896	Oryza brachyantha	49.09	3.00e-11	59.70
IUUC-Ogl-077834	Oryza glaberrima	50.91	5.00e-12	60.50
IUUC-Ogu-078622	Oryza glumaepatula	50.91	5.00e-12	60.50
IUUC-Oin-079358	Oryza indica	46.77	8.00e-12	61.20
IUUC-Olo-081035	Oryza longistaminata	39.00	2.00e-13	66.60
IUUC-Oni-082425	Oryza nivara	50.91	5.00e-12	60.50
IUUC-Opu-083461	Oryza punctata	50.00	3.00e-11	58.90
IUUC-Oru-084875	Oryza rufipogon	48.00	5.00e-10	53.10
IUUC-Oga-089128	Otolemur garnettii	50.00	3.00e-25	104.00
IUUC-Oar-089896	Ovis aries	47.12	1.00e-24	102.00
IUUC-Ptr-091618	Pan troglodytes	39.51	8.00e-13	63.90
IUUC-Pan-092238	Papio anubis	44.44	7.00e-16	74.30
IUUC-Psi-093879	Pelodiscus sinensis	47.12	4.00e-24	100.00
IUUC-Pma-094484	Petromyzon marinus	47.12	6.00e-18	80.10
IUUC-Ppa-095801	Physcomitrella patens	41.18	1.00e-15	72.80
IUUC-Pfo-097192	Poecilia formosa	48.08	4.00e-24	100.00
IUUC-Pab-098203	Pongo abelii	48.08	1.00e-21	92.00
IUUC-Pop-099614	Populus trichocarpa	49.09	4.00e-13	63.90
IUUC-Pca-100507	Procavia capensis	43.21	7.00e-16	72.80
IUUC-Ppe-101174	Prunus persica	35.64	3.00e-17	77.80
IUUC-Pva-102735	Pteropus vampyrus	48.08	1.00e-21	92.00
IUUC-Pgr-103510	Puccinia graminis	43.40	3.00e-16	75.10
IUUC-Ptt-103918	Puccinia triticina	43.40	3.00e-16	75.10
IUUC-Pte-104173	Pyrenophora teres	59.41	7.00e-36	140.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	60.40	3.00e-36	140.00
IUUC-Rno-105820	Rattus norvegicus	48.08	4.00e-24	100.00
IUUC-Sce-106366	Saccharomyces cerevisiae	46.08	4.00e-24	100.00
IUUC-Sja-107727	Schizosaccharomyces japonicus	36.36	7.00e-19	83.60
IUUC-Spo-108074	Schizosaccharomyces pombe	41.58	5.00e-16	73.60
IUUC-Smo-108944	Selaginella moellendorffii	41.94	4.00e-17	77.00
IUUC-Sit-110277	Setaria italica	38.37	9.00e-13	63.20
IUUC-Sly-111505	Solanum lycopersicum	39.76	1.00e-14	68.90
IUUC-Stu-112076	Solanum tuberosum	38.55	4.00e-14	67.40
IUUC-Sbi-114274	Sorghum bicolor	38.46	7.00e-14	67.00
IUUC-Sre-114953	Sporisorium reilianum	46.23	5.00e-27	110.00
IUUC-Ssc-115418	Sus scrofa	48.08	1.00e-24	102.00
IUUC-Tgu-117311	Taeniopygia guttata	47.37	4.00e-21	90.50
IUUC-Tru-118598	Takifugu rubripes	47.87	2.00e-20	87.80
IUUC-Tni-120109	Tetraodon nigroviridis	46.67	5.00e-22	94.00
IUUC-Tca-120942	Theobroma cacao	38.75	1.00e-12	62.80
IUUC-Tre-122099	Trichoderma reesei	69.15	1.00e-30	122.00
IUUC-Tvi-122285	Trichoderma virens	69.31	3.00e-34	134.00
IUUC-Tae-125193	Triticum aestivum	52.73	3.00e-13	64.30
IUUC-Tur-126677	Triticum urartu	43.28	2.00e-10	55.80
IUUC-Tbe-128050	Tupaia belangeri	39.42	7.00e-17	76.60
IUUC-Ttr-129019	Tursiops truncatus	48.08	6.00e-23	96.70
IUUC-Uma-129483	Ustilago maydis	46.60	5.00e-25	103.00
IUUC-Vda-129690	Verticillium dahliae	51.79	2.00e-28	115.00
IUUC-Vvi-131174	Vitis vinifera	50.91	4.00e-13	64.30
IUUC-Xma-133862	Xiphophorus maculatus	48.08	4.00e-24	100.00
IUUC-Yli-134398	Yarrowia lipolytica	44.76	9.00e-23	96.30
IUUC-Zma-134964	Zea mays	38.37	3.00e-15	71.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence