iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105484

Ensembl Protein ID

ENSRNOP00000015318.5

UniProt Accession

P36876; A1A5M9; O35512; P36878; 2ABA_RAT

Genbank Protein ID

AAA41910.1; AAA41909.1; AAI28732.1; BAA21904.1

Protein Name

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform BRA; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha

Genbank Nucleotide ID

M83298; M83297; BC128731; D14419

Gene Name

Ppp2r2a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000011158.6	ENSRNOT00000015318.6	ENSRNOP00000015318.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.40e-12	45.3	227	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           + +t+ +f  ++ +++v +s  gti+++D+r
   Q: 227  EVITAAEFhpNScNTFVYSSSKGTIRLCDMR 257
           5689999**744799999999********87 PP

Organism

Rattus norvegicus

Functional Description
(View)

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity).

Protein Sequence
(Fasta)

MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 60
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGCCTGCC CCTGCCGCCG GGGCCGCCGT CGCTGTCCTA GCCGCCGCCG CTGCCGCCGC 60
CGCCGCTGCC GTCTTCACCG CGGGAGAAGG AGCACGAGAC AGGACGCCCC TGAGTGAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS01024--PR55_1
PS01025--PR55_2

PRINTS

PR00600--PP2APR55

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0000159--C:protein phosphatase type 2A complex
GO:0032403--F:protein complex binding
GO:0051721--F:protein phosphatase 2A binding
GO:0019888--F:protein phosphatase regulator activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0048156--F:tau protein binding
GO:0032502--P:developmental process
GO:0000278--P:mitotic cell cycle
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0043278--P:response to morphine

KEGG

rno:117104

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001197	Ailuropoda melanoleuca	99.78	0.00e+00	887.00
IUUC-Atr-002517	Amborella trichopoda	50.00	3.00e-127	448.00
IUUC-Apl-004226	Anas platyrhynchos	98.66	0.00e+00	881.00
IUUC-Aca-005147	Anolis carolinensis	98.88	0.00e+00	880.00
IUUC-Ame-011776	Astyanax mexicanus	92.41	0.00e+00	825.00
IUUC-Bta-012702	Bos taurus	99.78	0.00e+00	884.00
IUUC-Bdi-014767	Brachypodium distachyon	50.52	9.00e-126	443.00
IUUC-Bol-015921	Brassica oleracea	50.71	1.00e-135	476.00
IUUC-Bra-017400	Brassica rapa	50.71	3.00e-135	474.00
IUUC-Cel-018618	Caenorhabditis elegans	65.56	2.00e-173	602.00
IUUC-Cja-019036	Callithrix jacchus	99.78	0.00e+00	883.00
IUUC-Cfa-021248	Canis familiaris	99.78	0.00e+00	884.00
IUUC-Cpo-022172	Cavia porcellus	99.78	0.00e+00	883.00
IUUC-Csa-023864	Chlorocebus sabaeus	99.78	0.00e+00	889.00
IUUC-Cin-025380	Ciona intestinalis	77.53	0.00e+00	706.00
IUUC-Dre-027406	Danio rerio	91.78	0.00e+00	817.00
IUUC-Dme-032131	Drosophila melanogaster	80.41	0.00e+00	725.00
IUUC-Eca-033584	Equus caballus	99.76	0.00e+00	852.00
IUUC-Fca-035565	Felis catus	95.51	0.00e+00	835.00
IUUC-Fal-036821	Ficedula albicollis	98.20	0.00e+00	873.00
IUUC-Gmo-038834	Gadus morhua	91.95	0.00e+00	811.00
IUUC-Gga-041009	Gallus gallus	99.10	0.00e+00	878.00
IUUC-Gma-044088	Glycine max	50.59	1.00e-129	456.00
IUUC-Ggo-044599	Gorilla gorilla	99.78	0.00e+00	883.00
IUUC-Hsa-046718	Homo sapiens	99.78	0.00e+00	883.00
IUUC-Hvu-047813	Hordeum vulgare	51.24	4.00e-129	454.00
IUUC-Itr-048651	Ictidomys tridecemlineatus	99.78	0.00e+00	889.00
IUUC-Lch-050528	Latimeria chalumnae	95.98	0.00e+00	827.00
IUUC-Lpe-050866	Leersia perrieri	52.73	2.00e-131	462.00
IUUC-Loc-052663	Lepisosteus oculatus	88.54	0.00e+00	827.00
IUUC-Laf-053403	Loxodonta africana	99.55	0.00e+00	887.00
IUUC-Mcc-055776	Macaca mulatta	99.77	0.00e+00	880.00
IUUC-Mtr-058561	Medicago truncatula	49.50	1.00e-125	443.00
IUUC-Mga-059946	Meleagris gallopavo	98.66	0.00e+00	881.00
IUUC-Mdo-062340	Monodelphis domestica	98.88	0.00e+00	882.00
IUUC-Mmu-064151	Mus musculus	99.78	0.00e+00	889.00
IUUC-Mpu-066190	Mustela putorius furo	99.78	0.00e+00	888.00
IUUC-Mlu-068197	Myotis lucifugus	99.52	0.00e+00	849.00
IUUC-Nle-069966	Nomascus leucogenys	97.75	0.00e+00	853.00
IUUC-Ont-071603	Oreochromis niloticus	91.07	0.00e+00	809.00
IUUC-Oan-073540	Ornithorhynchus anatinus	97.32	2.00e-168	584.00
IUUC-Ocu-074222	Oryctolagus cuniculus	99.78	0.00e+00	889.00
IUUC-Oba-075019	Oryza barthii	52.08	8.00e-131	460.00
IUUC-Obr-076686	Oryza brachyantha	51.87	1.00e-134	473.00
IUUC-Ogl-077077	Oryza glaberrima	51.11	3.00e-130	458.00
IUUC-Ogu-078671	Oryza glumaepatula	52.08	4.00e-131	461.00
IUUC-Ome-081334	Oryza meridionalis	52.08	4.00e-131	461.00
IUUC-Osa-085954	Oryza sativa	51.88	7.00e-131	460.00
IUUC-Ola-087128	Oryzias latipes	89.59	0.00e+00	790.00
IUUC-Oga-089168	Otolemur garnettii	99.55	0.00e+00	887.00
IUUC-Oar-089815	Ovis aries	99.33	0.00e+00	885.00
IUUC-Ptr-091110	Pan troglodytes	99.78	0.00e+00	884.00
IUUC-Pan-092884	Papio anubis	99.78	0.00e+00	889.00
IUUC-Ppa-095378	Physcomitrella patens	50.30	8.00e-132	464.00
IUUC-Pfo-097312	Poecilia formosa	90.34	0.00e+00	832.00
IUUC-Pab-098146	Pongo abelii	99.78	0.00e+00	889.00
IUUC-Pca-100882	Procavia capensis	99.19	2.00e-140	492.00
IUUC-Pva-102176	Pteropus vampyrus	92.17	0.00e+00	828.00
IUUC-Sha-107382	Sarcophilus harrisii	99.29	0.00e+00	849.00
IUUC-Sit-110793	Setaria italica	51.04	3.00e-131	462.00
IUUC-Sly-111422	Solanum lycopersicum	51.51	1.00e-129	456.00
IUUC-Sbi-114402	Sorghum bicolor	50.90	1.00e-131	463.00
IUUC-Ssc-115355	Sus scrofa	99.78	0.00e+00	889.00
IUUC-Tgu-116737	Taeniopygia guttata	98.43	0.00e+00	879.00
IUUC-Tru-118130	Takifugu rubripes	90.99	0.00e+00	804.00
IUUC-Tsy-119206	Tarsius syrichta	96.63	0.00e+00	838.00
IUUC-Tni-120009	Tetraodon nigroviridis	90.99	0.00e+00	805.00
IUUC-Tca-121708	Theobroma cacao	50.00	4.00e-129	454.00
IUUC-Tae-125564	Triticum aestivum	50.83	9.00e-127	447.00
IUUC-Ttr-128725	Tursiops truncatus	99.55	0.00e+00	880.00
IUUC-Vpa-130425	Vicugna pacos	95.72	0.00e+00	861.00
IUUC-Vvi-130930	Vitis vinifera	51.51	2.00e-128	452.00
IUUC-Xtr-131852	Xenopus tropicalis	93.81	0.00e+00	867.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence