iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074791

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Genbank Nucleotide ID

AAGW02007417

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000001498.2	ENSOCUT00000001498.2	ENSOCUP00000001289.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-44	148.2	192	222
UBD/Beta-Prp	4.90e-62	209.8	11	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvh 88
           +++h++s++  +++ p ++lla+ + d++i++w ++  +    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv 
   Q: 11   VSAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWATEGDSWvcKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVT 99
           57899999999************************9866543666789******************************99999****** PP
   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llr 173
           tl+ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ + ++  +  
   Q: 100  TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDwvCCA 188
           ***********************************9987776566*********************************9977754499* PP
   S: 174  tltgghtdsvyslsfdsngkelvsgsldgtvklw 207
           tl+g h++ v sl+fd++g++l+s+s+d+tv++w
   Q: 189  TLEG-HESTVWSLAFDPSGQRLASCSDDRTVRIW 221
           ***9.***************************** PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLSR VSAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWATEGDSW VCKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGGATT CTCTGGTGCT GCTGAGCCGT GTCTCGGCGC ACCCGGACTC CCGCTGCTGG 60
TTCCTGGCCT GGAACCCTGC AGGGACTCTG CTGGCCTCGT GCGGTGGCGA CCGTAGAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

KEGG

ocu:100350981

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	42.37	2.00e-66	247.00
IUUC-Aml-001317	Ailuropoda melanoleuca	94.99	2.00e-180	624.00
IUUC-Atr-003029	Amborella trichopoda	51.32	1.00e-93	336.00
IUUC-Apl-004042	Anas platyrhynchos	75.76	1.00e-55	207.00
IUUC-Aly-006458	Arabidopsis lyrata	47.97	4.00e-85	307.00
IUUC-Ath-006671	Arabidopsis thaliana	48.26	2.00e-85	309.00
IUUC-Ago-007820	Ashbya gossypii	40.94	2.00e-60	225.00
IUUC-Acl-008042	Aspergillus clavatus	32.33	4.00e-50	191.00
IUUC-Afl-008639	Aspergillus flavus	33.89	1.00e-52	200.00
IUUC-Afu-008899	Aspergillus fumigatus	31.89	7.00e-49	187.00
IUUC-Ani-009453	Aspergillus nidulans	31.49	2.00e-50	193.00
IUUC-Ang-009758	Aspergillus niger	35.09	1.00e-52	200.00
IUUC-Aor-010212	Aspergillus oryzae	33.89	1.00e-52	200.00
IUUC-Ate-010314	Aspergillus terreus	32.85	2.00e-53	203.00
IUUC-Ame-010676	Astyanax mexicanus	76.95	6.00e-158	549.00
IUUC-Bgr-012095	Blumeria graminis	30.63	5.00e-40	158.00
IUUC-Bta-012884	Bos taurus	93.22	5.00e-177	613.00
IUUC-Bci-013622	Botrytis cinerea	32.85	2.00e-38	153.00
IUUC-Bdi-014614	Brachypodium distachyon	48.52	1.00e-84	306.00
IUUC-Bol-016439	Brassica oleracea	47.94	2.00e-84	305.00
IUUC-Bra-016830	Brassica rapa	46.61	1.00e-82	299.00
IUUC-Cel-018709	Caenorhabditis elegans	39.76	8.00e-64	236.00
IUUC-Cja-019822	Callithrix jacchus	95.58	1.00e-180	625.00
IUUC-Cfa-020823	Canis familiaris	94.99	0.00e+00	625.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	47.41	5.00e-80	291.00
IUUC-Csa-023754	Chlorocebus sabaeus	95.87	0.00e+00	629.00
IUUC-Cin-025395	Ciona intestinalis	57.31	1.00e-115	409.00
IUUC-Csv-025943	Ciona savignyi	55.26	1.00e-110	392.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	30.87	1.00e-36	147.00
IUUC-Cne-026939	Cryptococcus neoformans	32.06	9.00e-48	184.00
IUUC-Cme-027239	Cyanidioschyzon merolae	40.93	2.00e-44	173.00
IUUC-Dre-028172	Danio rerio	76.05	1.00e-154	538.00
IUUC-Dno-029472	Dasypus novemcinctus	94.54	4.00e-151	526.00
IUUC-Dor-031134	Dipodomys ordii	83.19	4.00e-150	523.00
IUUC-Dse-031535	Dothistroma septosporum	30.57	1.00e-48	186.00
IUUC-Dme-032020	Drosophila melanogaster	58.56	2.00e-118	418.00
IUUC-Eca-033700	Equus caballus	95.28	0.00e+00	625.00
IUUC-Eeu-035010	Erinaceus europaeus	92.92	3.00e-173	600.00
IUUC-Fca-036309	Felis catus	87.06	2.00e-169	587.00
IUUC-Fal-037243	Ficedula albicollis	73.95	6.00e-86	309.00
IUUC-Fox-038058	Fusarium oxysporum	32.24	1.00e-43	171.00
IUUC-Fso-038459	Fusarium solani	32.30	2.00e-39	156.00
IUUC-Gmo-039375	Gadus morhua	75.22	4.00e-140	490.00
IUUC-Ggr-040002	Gaeumannomyces graminis	35.11	4.00e-40	159.00
IUUC-Gga-040294	Gallus gallus	82.21	4.00e-128	450.00
IUUC-Gac-042499	Gasterosteus aculeatus	73.59	2.00e-137	481.00
IUUC-Gma-043543	Glycine max	49.26	4.00e-88	317.00
IUUC-Ggo-045181	Gorilla gorilla	95.87	0.00e+00	629.00
IUUC-Hsa-046528	Homo sapiens	95.87	0.00e+00	629.00
IUUC-Hvu-047341	Hordeum vulgare	57.45	3.00e-56	211.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	95.87	0.00e+00	630.00
IUUC-Kpa-049353	Komagataella pastoris	37.25	4.00e-57	214.00
IUUC-Lch-049763	Latimeria chalumnae	80.54	2.00e-160	558.00
IUUC-Lpe-051500	Leersia perrieri	44.53	2.00e-80	292.00
IUUC-Loc-052021	Lepisosteus oculatus	80.54	2.00e-153	535.00
IUUC-Lma-053331	Leptosphaeria maculans	35.50	2.00e-56	214.00
IUUC-Laf-054558	Loxodonta africana	93.81	9.00e-177	612.00
IUUC-Mcc-055374	Macaca mulatta	95.58	0.00e+00	627.00
IUUC-Meu-056042	Macropus eugenii	76.90	1.00e-111	395.00
IUUC-Mor-057187	Magnaporthe oryzae	31.58	2.00e-41	163.00
IUUC-Mtr-058072	Medicago truncatula	48.82	2.00e-87	315.00
IUUC-Mla-059108	Melampsora laricipopulina	31.52	6.00e-53	201.00
IUUC-Mga-059370	Meleagris gallopavo	63.74	8.00e-100	356.00
IUUC-Mvi-060495	Microbotryum violaceum	37.10	1.00e-56	213.00
IUUC-Mmr-060902	Microcebus murinus	95.87	0.00e+00	630.00
IUUC-Mdo-062510	Monodelphis domestica	91.74	2.00e-167	581.00
IUUC-Mmu-063575	Mus musculus	93.51	4.00e-178	617.00
IUUC-Mac-065322	Musa acuminata	49.70	2.00e-89	322.00
IUUC-Mpu-065925	Mustela putorius furo	94.69	5.00e-180	623.00
IUUC-Mlu-067755	Myotis lucifugus	94.40	1.00e-179	621.00
IUUC-Nfi-068327	Neosartorya fischeri	32.05	2.00e-49	189.00
IUUC-Ncr-068845	Neurospora crassa	32.92	2.00e-32	133.00
IUUC-Nle-069406	Nomascus leucogenys	93.51	1.00e-175	608.00
IUUC-Opr-070416	Ochotona princeps	97.55	6.00e-79	287.00
IUUC-Ont-071936	Oreochromis niloticus	75.07	9.00e-142	496.00
IUUC-Oan-073452	Ornithorhynchus anatinus	89.70	2.00e-74	270.00
IUUC-Oba-075636	Oryza barthii	49.26	9.00e-88	316.00
IUUC-Obr-076742	Oryza brachyantha	48.25	8.00e-76	276.00
IUUC-Ogl-077766	Oryza glaberrima	49.26	9.00e-88	316.00
IUUC-Ogu-079039	Oryza glumaepatula	49.26	3.00e-88	318.00
IUUC-Oin-079315	Oryza indica	48.97	9.00e-77	280.00
IUUC-Olo-080669	Oryza longistaminata	43.75	6.00e-80	291.00
IUUC-Ome-081490	Oryza meridionalis	49.26	6.00e-88	317.00
IUUC-Oni-082572	Oryza nivara	49.26	9.00e-88	316.00
IUUC-Opu-083732	Oryza punctata	49.40	5.00e-88	317.00
IUUC-Oru-084763	Oryza rufipogon	49.26	9.00e-88	316.00
IUUC-Osa-085372	Oryza sativa	49.26	9.00e-88	316.00
IUUC-Ola-087379	Oryzias latipes	73.90	4.00e-138	483.00
IUUC-Olu-087801	Ostreococcus lucimarinus	36.61	2.00e-45	175.00
IUUC-Oga-089076	Otolemur garnettii	95.87	0.00e+00	631.00
IUUC-Oar-090022	Ovis aries	93.22	4.00e-176	610.00
IUUC-Ptr-090809	Pan troglodytes	95.87	0.00e+00	629.00
IUUC-Pan-091685	Papio anubis	95.87	0.00e+00	636.00
IUUC-Psi-093046	Pelodiscus sinensis	86.94	1.00e-165	575.00
IUUC-Pma-094181	Petromyzon marinus	64.09	8.00e-132	462.00
IUUC-Pno-094882	Phaeosphaeria nodorum	35.02	9.00e-56	210.00
IUUC-Ppa-095172	Physcomitrella patens	47.09	8.00e-85	306.00
IUUC-Pfo-096396	Poecilia formosa	72.40	7.00e-140	489.00
IUUC-Pab-098427	Pongo abelii	95.28	2.00e-179	621.00
IUUC-Pop-100016	Populus trichocarpa	50.44	1.00e-90	326.00
IUUC-Pca-101048	Procavia capensis	93.81	5.00e-178	616.00
IUUC-Ppe-102050	Prunus persica	47.43	1.00e-86	312.00
IUUC-Pva-103117	Pteropus vampyrus	94.69	4.00e-180	623.00
IUUC-Pgr-103307	Puccinia graminis	33.79	1.00e-57	217.00
IUUC-Ptt-103938	Puccinia triticina	38.41	2.00e-49	189.00
IUUC-Pte-104315	Pyrenophora teres	34.05	4.00e-57	215.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	33.57	1.00e-56	213.00
IUUC-Rno-105523	Rattus norvegicus	93.81	1.00e-178	619.00
IUUC-Sce-106297	Saccharomyces cerevisiae	42.27	3.00e-65	241.00
IUUC-Sha-106981	Sarcophilus harrisii	92.15	1.00e-141	495.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	39.59	4.00e-57	216.00
IUUC-Spo-108214	Schizosaccharomyces pombe	40.78	5.00e-58	218.00
IUUC-Smo-109034	Selaginella moellendorffii	46.48	3.00e-82	298.00
IUUC-Sit-110663	Setaria italica	50.15	4.00e-89	321.00
IUUC-Sly-110898	Solanum lycopersicum	47.97	5.00e-83	301.00
IUUC-Stu-112647	Solanum tuberosum	51.50	2.00e-70	258.00
IUUC-Sbi-114288	Sorghum bicolor	47.80	7.00e-85	307.00
IUUC-Sre-115065	Sporisorium reilianum	43.18	3.00e-76	278.00
IUUC-Ssc-115960	Sus scrofa	87.24	5.00e-176	609.00
IUUC-Tru-118382	Takifugu rubripes	70.92	1.00e-146	512.00
IUUC-Tsy-119585	Tarsius syrichta	86.73	2.00e-159	555.00
IUUC-Tni-120133	Tetraodon nigroviridis	74.85	4.00e-143	500.00
IUUC-Tca-121167	Theobroma cacao	48.97	2.00e-82	298.00
IUUC-Tre-122119	Trichoderma reesei	29.48	5.00e-41	161.00
IUUC-Tvi-122407	Trichoderma virens	32.18	4.00e-41	162.00
IUUC-Tae-124500	Triticum aestivum	47.77	5.00e-81	294.00
IUUC-Tur-126682	Triticum urartu	48.52	3.00e-67	248.00
IUUC-Tme-127095	Tuber melanosporum	36.55	2.00e-62	232.00
IUUC-Tbe-128004	Tupaia belangeri	95.28	0.00e+00	630.00
IUUC-Ttr-129284	Tursiops truncatus	89.77	2.00e-168	585.00
IUUC-Uma-129527	Ustilago maydis	43.58	8.00e-76	277.00
IUUC-Vda-129854	Verticillium dahliae	32.08	3.00e-37	149.00
IUUC-Vpa-130681	Vicugna pacos	96.55	7.00e-50	190.00
IUUC-Vvi-131004	Vitis vinifera	53.45	3.00e-88	318.00
IUUC-Xtr-131928	Xenopus tropicalis	81.60	2.00e-154	537.00
IUUC-Xma-134290	Xiphophorus maculatus	70.62	4.00e-135	474.00
IUUC-Yli-134364	Yarrowia lipolytica	43.73	7.00e-68	250.00
IUUC-Zma-135658	Zea mays	48.39	3.00e-85	308.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence