iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096293

Ensembl Protein ID

ENSPFOP00000001978.1

UniProt Accession

A0A087X875; A0A087X875_POEFO

Genbank Protein ID

ENSPFOP00000001978

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AYCK01016038

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000001958.1	ENSPFOT00000001982.1	ENSPFOP00000001978.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	69.21	0.00e+00	1202.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
815	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Poecilia formosa

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MNSHSRQVDV STAALPSQVP SAASAILPMD LRVVDHPHHH HQQPPFGLVS QPHPTPAPST 60
ACPASSELGN GPVAGRQDQH LQQELVALKH KQELQRQLLI AEFHRQHEQL SRQHEVQLQE 120

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Nucleotide Sequence
(Fasta)

CTCAAATAAC ACATCCTAGA TCTGAATGAA TGAAATATTC TCATTGAATA CTTTGTTCTG 60
TACAAAGTTG AATGTACTGA CAACAAAATC ACACAAAAAT CATCAATGGA AATCAAATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	71.63	0.00e+00	1240.00
IUUC-Apl-003250	Anas platyrhynchos	81.71	0.00e+00	850.00
IUUC-Aca-004668	Anolis carolinensis	77.97	0.00e+00	843.00
IUUC-Bta-013215	Bos taurus	71.71	0.00e+00	1236.00
IUUC-Cja-019816	Callithrix jacchus	69.98	0.00e+00	1236.00
IUUC-Cfa-020861	Canis familiaris	71.21	0.00e+00	1224.00
IUUC-Cpo-021562	Cavia porcellus	69.18	0.00e+00	1231.00
IUUC-Csa-023612	Chlorocebus sabaeus	69.14	0.00e+00	1210.00
IUUC-Csv-026359	Ciona savignyi	53.04	7.00e-91	327.00
IUUC-Dre-028284	Danio rerio	87.74	0.00e+00	873.00
IUUC-Dno-029951	Dasypus novemcinctus	66.93	0.00e+00	1132.00
IUUC-Dor-030362	Dipodomys ordii	60.14	0.00e+00	984.00
IUUC-Dme-031766	Drosophila melanogaster	58.75	5.00e-156	545.00
IUUC-Fca-036187	Felis catus	71.71	0.00e+00	1269.00
IUUC-Gmo-038473	Gadus morhua	77.23	0.00e+00	782.00
IUUC-Gga-040501	Gallus gallus	81.91	0.00e+00	850.00
IUUC-Gac-042335	Gasterosteus aculeatus	81.13	0.00e+00	1492.00
IUUC-Ggo-045380	Gorilla gorilla	69.28	0.00e+00	1204.00
IUUC-Hsa-046925	Homo sapiens	69.68	0.00e+00	1227.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	69.58	0.00e+00	1209.00
IUUC-Lch-050325	Latimeria chalumnae	77.63	0.00e+00	816.00
IUUC-Loc-052231	Lepisosteus oculatus	72.46	0.00e+00	1285.00
IUUC-Laf-054490	Loxodonta africana	67.30	0.00e+00	1194.00
IUUC-Mcc-055265	Macaca mulatta	68.90	0.00e+00	1214.00
IUUC-Meu-056676	Macropus eugenii	75.57	1.00e-178	620.00
IUUC-Mmr-061633	Microcebus murinus	64.61	0.00e+00	1082.00
IUUC-Mmu-063089	Mus musculus	82.44	0.00e+00	847.00
IUUC-Mpu-065887	Mustela putorius furo	72.11	0.00e+00	1249.00
IUUC-Mlu-067470	Myotis lucifugus	69.95	0.00e+00	1250.00
IUUC-Nle-069099	Nomascus leucogenys	61.28	0.00e+00	679.00
IUUC-Ont-071613	Oreochromis niloticus	85.49	0.00e+00	1558.00
IUUC-Oan-073275	Ornithorhynchus anatinus	70.67	0.00e+00	1236.00
IUUC-Ola-087031	Oryzias latipes	81.08	0.00e+00	1489.00
IUUC-Oga-088201	Otolemur garnettii	80.90	0.00e+00	795.00
IUUC-Oar-089997	Ovis aries	66.24	0.00e+00	1056.00
IUUC-Ptr-091116	Pan troglodytes	69.68	0.00e+00	1241.00
IUUC-Pan-092132	Papio anubis	68.91	0.00e+00	862.00
IUUC-Psi-093734	Pelodiscus sinensis	80.89	0.00e+00	815.00
IUUC-Pma-094347	Petromyzon marinus	68.41	0.00e+00	684.00
IUUC-Pab-098491	Pongo abelii	66.30	0.00e+00	1137.00
IUUC-Pca-101004	Procavia capensis	67.92	6.00e-92	332.00
IUUC-Pva-102961	Pteropus vampyrus	54.96	8.00e-121	428.00
IUUC-Rno-105005	Rattus norvegicus	81.82	0.00e+00	840.00
IUUC-Sha-107646	Sarcophilus harrisii	71.46	8.00e-165	574.00
IUUC-Ssc-115428	Sus scrofa	69.42	0.00e+00	1217.00
IUUC-Tgu-116776	Taeniopygia guttata	82.14	0.00e+00	848.00
IUUC-Tru-118180	Takifugu rubripes	80.86	0.00e+00	1475.00
IUUC-Tsy-119468	Tarsius syrichta	58.37	6.00e-145	508.00
IUUC-Tni-120196	Tetraodon nigroviridis	84.09	0.00e+00	893.00
IUUC-Ttr-128360	Tursiops truncatus	71.29	0.00e+00	752.00
IUUC-Xtr-132956	Xenopus tropicalis	75.00	0.00e+00	800.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence