iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133179

Ensembl Protein ID

ENSXMAP00000002854.1

UniProt Accession

M3ZKW2; M3ZKW2_XIPMA

Genbank Protein ID

ENSXMAP00000002854

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01010415

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000002803.1	ENSXMAT00000002859.1	ENSXMAP00000002854.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-22	78.6	615	653
UBD/Beta-Prp	2.50e-40	138.5	483	652

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 615  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 653
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl t +   +  
   Q: 483  SHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKTPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLATPTPRIKaE 570
           4555788899999985.555555579*******999888888888889*********************************99877658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv 215
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ +
   Q: 571  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL 652
           888888888999********************************9.********************************99754 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MIRDLSKMYP PARHPVPHQP GQPFKFTVTE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCCGGGA AGTTGTAGTT CTTCACGGCA CATTCACATC TGTAGGGCTT ATTATCGACT 60
AATATGAATT AAACTACACG TCCCGACGTC ACGGTGTGCG TGCTCCAGTA AATGTTGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0006355--P:regulation of transcription, DNA-templated

KEGG

xma:102227775

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005279	Anolis carolinensis	89.56	0.00e+00	1216.00
IUUC-Bta-012646	Bos taurus	88.16	0.00e+00	1224.00
IUUC-Cel-018361	Caenorhabditis elegans	58.43	6.00e-121	427.00
IUUC-Cja-019079	Callithrix jacchus	89.30	0.00e+00	1265.00
IUUC-Cfa-020987	Canis familiaris	89.38	0.00e+00	1222.00
IUUC-Cpo-021606	Cavia porcellus	87.61	0.00e+00	1192.00
IUUC-Csa-023445	Chlorocebus sabaeus	89.30	0.00e+00	1243.00
IUUC-Cho-024590	Choloepus hoffmanni	76.70	0.00e+00	1075.00
IUUC-Cin-025767	Ciona intestinalis	58.18	5.00e-174	604.00
IUUC-Csv-026174	Ciona savignyi	57.97	3.00e-165	575.00
IUUC-Dno-028979	Dasypus novemcinctus	88.81	0.00e+00	1188.00
IUUC-Dor-030533	Dipodomys ordii	84.12	0.00e+00	1045.00
IUUC-Dme-031576	Drosophila melanogaster	86.59	0.00e+00	668.00
IUUC-Ete-032887	Echinops telfairi	77.37	0.00e+00	1095.00
IUUC-Eeu-035237	Erinaceus europaeus	75.76	0.00e+00	1023.00
IUUC-Fca-036030	Felis catus	88.85	0.00e+00	1227.00
IUUC-Fal-037460	Ficedula albicollis	89.36	0.00e+00	1220.00
IUUC-Gga-040416	Gallus gallus	89.56	0.00e+00	1246.00
IUUC-Gac-041739	Gasterosteus aculeatus	82.69	0.00e+00	1136.00
IUUC-Ggo-045633	Gorilla gorilla	85.62	0.00e+00	1211.00
IUUC-Hsa-046461	Homo sapiens	85.77	0.00e+00	1241.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	89.19	0.00e+00	1238.00
IUUC-Lch-049943	Latimeria chalumnae	87.81	0.00e+00	1157.00
IUUC-Loc-052835	Lepisosteus oculatus	89.83	0.00e+00	1201.00
IUUC-Laf-053425	Loxodonta africana	89.22	0.00e+00	1234.00
IUUC-Mcc-055766	Macaca mulatta	85.77	0.00e+00	1240.00
IUUC-Meu-056209	Macropus eugenii	84.49	0.00e+00	1228.00
IUUC-Mmr-061317	Microcebus murinus	86.19	0.00e+00	1242.00
IUUC-Mdo-062956	Monodelphis domestica	88.80	0.00e+00	1233.00
IUUC-Mmu-063576	Mus musculus	89.18	0.00e+00	1236.00
IUUC-Mlu-067456	Myotis lucifugus	85.77	0.00e+00	1162.00
IUUC-Nle-069495	Nomascus leucogenys	89.36	0.00e+00	1216.00
IUUC-Ont-071419	Oreochromis niloticus	96.89	0.00e+00	1276.00
IUUC-Oan-072842	Ornithorhynchus anatinus	86.57	0.00e+00	1221.00
IUUC-Ocu-074453	Oryctolagus cuniculus	88.40	0.00e+00	1226.00
IUUC-Ola-087090	Oryzias latipes	96.11	0.00e+00	1281.00
IUUC-Oga-087939	Otolemur garnettii	89.32	0.00e+00	1239.00
IUUC-Ptr-091048	Pan troglodytes	89.30	0.00e+00	1243.00
IUUC-Pan-091973	Papio anubis	84.66	0.00e+00	1188.00
IUUC-Pfo-097518	Poecilia formosa	97.80	0.00e+00	1249.00
IUUC-Pva-103037	Pteropus vampyrus	81.91	0.00e+00	1224.00
IUUC-Rno-105314	Rattus norvegicus	88.80	0.00e+00	1167.00
IUUC-Sar-113585	Sorex araneus	78.80	0.00e+00	659.00
IUUC-Ssc-116408	Sus scrofa	88.59	0.00e+00	1247.00
IUUC-Tgu-117068	Taeniopygia guttata	88.99	0.00e+00	1212.00
IUUC-Tru-118782	Takifugu rubripes	91.13	0.00e+00	1191.00
IUUC-Tsy-118884	Tarsius syrichta	77.34	0.00e+00	988.00
IUUC-Tni-120404	Tetraodon nigroviridis	89.69	0.00e+00	1223.00
IUUC-Tbe-128013	Tupaia belangeri	81.77	0.00e+00	1137.00
IUUC-Ttr-129285	Tursiops truncatus	84.36	0.00e+00	1222.00
IUUC-Vpa-130577	Vicugna pacos	75.10	1.00e-164	573.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence