iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096464

Ensembl Protein ID

ENSPFOP00000006890.1

UniProt Accession

A0A087XM87; A0A087XM87_POEFO

Genbank Protein ID

ENSPFOP00000006890

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01007580

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000006327.1	ENSPFOT00000006902.1	ENSPFOP00000006890.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-10	40.3	3406	3438
E3 activity/HECT	1.40e-82	278.4	4491	4828

Active Site

Position(s)	Description	Evidence
4797	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH ++v ++++ sd +ll+++s D+++++W + 
   Q: 3406 GHYNKVASCSWsSDqGLLATCSQDKVVQLWKVN 3438
           78899*******999***************986 PP

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallsk.elqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdg 85
            +r++ v++vgE + d+gGv+ ++++++++ elq+  + l+ +++n+ + +  n d++l np     +h+  F+flG+l+++a++++
   Q: 4491 PSRAWkVKLVGEGADDAGGVFDDTITEMCQqELQSGVVDLLIHTPNSFSDVGCNTDRFLLNPgahseDHMVQFRFLGILMAVAIRTK 4577
           556666**********************963788899************************9************************* PP
   S: 86   rlldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNk 170
           ++ldl++++ ++k+l+  +ls  dleevd  +y++l+ i+++++s i++ ++++++  ++    +++ +    +p+G+ni+ t +N+
   Q: 4578 KPLDLHMAPWVWKQLCCMPLSGADLEEVDLLTYRTLQGILHLENSGITADNFHVMIPLDSFMAHSADGRLvpVVPRGQNISLTFSNR 4664
           ********************************************************9999887776666555899************ PP
   S: 171  eeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefs 257
            eYv++ ++yrl+e +++qv+a+reG++++ip  llsl+t+++le+l+cG +e++ve+l+k  +y++ +te+++ i+wFw+ l+ef+
   Q: 4665 TEYVERALDYRLHE-MDSQVDAVREGMSTIIPVPLLSLLTAQQLEQLVCGLPEVSVEMLRKLVRYRD-ITESHQLIRWFWQSLKEFT 4749
           **************.**************************************************88.******************* PP
   S: 258  seerkafLqFvTgssrlPlgGfaelkprlfvirk..dasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +eer  fL+Fv+g+srlP  + a+++ ++f+i k   +++ + lP+++TCf++L+LP+Y+s+ il e+L+y i++++++++
   Q: 4750 NEERVLFLRFVSGRSRLP-SNPADIS-QKFQIIKvdRRQPiNGLPTAQTCFFLLRLPPYTSQAILAERLRYSIHNCTSIDM 4828
           ******************.699****.55666666745557***********************************99987 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MVPCQTHVLL KWQEHFNSSW AAEDSVQTAR RHGAAGLYNK LLYNKEVVTL AQPVQELASP 60
RLPDFECESN TSAEKDEYLS SLLHSQRWLA HRMLTQTSYT LGLHQRLVVL QRIYYALHSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGCCTT GTCAAACTCA TGTGTTGCTG AAGTGGCAGG AGCATTTCAA CAGTTCCTGG 60
GCCGCAGAAG ACAGCGTGCA GACGGCCAGG AGGCACGGGG CGGCCGGGCT CTACAATAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006545	Arabidopsis lyrata	35.76	1.00e-49	192.00
IUUC-Ame-011268	Astyanax mexicanus	66.15	0.00e+00	2662.00
IUUC-Gac-042444	Gasterosteus aculeatus	77.89	0.00e+00	7197.00
IUUC-Hvu-047529	Hordeum vulgare	35.36	1.00e-49	192.00
IUUC-Loc-052805	Lepisosteus oculatus	63.85	0.00e+00	5506.00
IUUC-Mtr-058277	Medicago truncatula	33.33	7.00e-52	197.00
IUUC-Ola-086308	Oryzias latipes	77.16	0.00e+00	6856.00
IUUC-Pop-099121	Populus trichocarpa	35.05	5.00e-54	206.00
IUUC-Stu-112166	Solanum tuberosum	32.12	5.00e-49	190.00
IUUC-Tru-118723	Takifugu rubripes	75.93	0.00e+00	6907.00
IUUC-Tur-126300	Triticum urartu	35.36	5.00e-50	193.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence