iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133003

Ensembl Protein ID

ENSXMAP00000005900.1

UniProt Accession

M3ZUK7; M3ZUK7_XIPMA

Genbank Protein ID

ENSXMAP00000005900

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGAJ01006489

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000005842.1	ENSXMAT00000005906.1	ENSXMAP00000005900.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.40e-111	370.4	149	691

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++l+     ++   ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 149  TGMKNIGNSCYMNAALQALSNCPPLTQFFLD-----CSGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 232
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde................................................ 129
           qqD+qEfl++l+dql+eelk+  ++  ++ e++d  e+ d                                                 
   Q: 233  QQDTQEFLRCLMDQLHEELKEPLTECSMSGEGSDGDERRDGdrspsedeflscdsgsssdrgeggglgegelllqdecdgfrspsagvg 321
           *******************99666666666555555555446777777899999999999***************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 322  sgmvisekerlkerrvsgsplrggsqemdedadvdtaaedgapergeeeppaptanpdvqednpdneasmtqpqstpcspvrtlqelhp 410
           ***************************************************************************************** PP
   S: 130  .............................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.... 185
                                        +++kk+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+    
   Q: 411  klssspprssplrsagpaysfkkaqllltSRKKKQSHYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhssi 499
           *****************************99*************************************************99888**** PP
   S: 186  .............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPev 229
                                                        +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ klPe+
   Q: 500  hqnlpvktgvcpdtygsqgwisyimdsirrfvvsciptwfwgpmvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLKLPEI 588
           ***************************************************************************************** PP
   S: 230  LilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVte 316
           L++hLkRf  ++e + + ki+++v+fple Ld++pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vte
   Q: 589  LCIHLKRF--RHEVMYSFKISSHVSFPLEgLDMQPFLAKESPSQ--VTTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTE 673
           ********..9999*************************88887..9**************************78999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+e+ v++   ++aYvlfY++
   Q: 674  VHETVVQN---AEAYVLFYRK 691
           ********...********98 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MAEPDVCPHL DSIGEVTKED LLQKSKGTCQ SCGAGGPNLW ACLQSDCSYV GCGESYADHS 60
TLHAQAKKHN LTVNLTTFRI WCYVCEREVF LDQRPALVPV PAASRHCKAA EQEAAAQSAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGAGC CAGACGTTTG TCCTCACCTG GACTCAATAG GAGAGGTCAC CAAAGAGGAC 60
CTACTCCAGA AATCCAAGGT GGGTGTAAAT TAATTTATTG GTGCAAGTCA TTGGCTGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	74.13	0.00e+00	1329.00
IUUC-Apl-003351	Anas platyrhynchos	75.08	0.00e+00	1371.00
IUUC-Aca-005077	Anolis carolinensis	70.07	0.00e+00	1021.00
IUUC-Ame-011777	Astyanax mexicanus	81.84	0.00e+00	1458.00
IUUC-Bta-013063	Bos taurus	75.41	0.00e+00	1355.00
IUUC-Cja-019868	Callithrix jacchus	75.05	0.00e+00	1362.00
IUUC-Cfa-020761	Canis familiaris	74.70	0.00e+00	1345.00
IUUC-Cpo-022267	Cavia porcellus	73.55	0.00e+00	1329.00
IUUC-Csa-024251	Chlorocebus sabaeus	75.81	0.00e+00	1368.00
IUUC-Cho-024483	Choloepus hoffmanni	90.09	1.00e-117	417.00
IUUC-Csv-025889	Ciona savignyi	41.57	3.00e-35	140.00
IUUC-Dre-028061	Danio rerio	72.02	0.00e+00	1297.00
IUUC-Dno-029423	Dasypus novemcinctus	75.38	0.00e+00	1360.00
IUUC-Dor-030877	Dipodomys ordii	76.00	0.00e+00	901.00
IUUC-Dme-031837	Drosophila melanogaster	50.00	9.00e-136	478.00
IUUC-Ete-032802	Echinops telfairi	62.09	8.00e-107	381.00
IUUC-Eca-034283	Equus caballus	73.62	0.00e+00	1321.00
IUUC-Fca-036357	Felis catus	76.05	0.00e+00	1353.00
IUUC-Fal-037411	Ficedula albicollis	76.11	0.00e+00	1369.00
IUUC-Gmo-038563	Gadus morhua	81.31	0.00e+00	926.00
IUUC-Gga-041101	Gallus gallus	75.19	0.00e+00	1356.00
IUUC-Gac-041315	Gasterosteus aculeatus	90.67	0.00e+00	1566.00
IUUC-Ggo-045600	Gorilla gorilla	75.03	0.00e+00	1332.00
IUUC-Hsa-045825	Homo sapiens	75.11	0.00e+00	1347.00
IUUC-Lch-050002	Latimeria chalumnae	73.76	0.00e+00	1281.00
IUUC-Loc-052574	Lepisosteus oculatus	83.21	0.00e+00	1470.00
IUUC-Laf-054428	Loxodonta africana	73.76	0.00e+00	1350.00
IUUC-Mcc-055736	Macaca mulatta	75.70	0.00e+00	1368.00
IUUC-Mga-059781	Meleagris gallopavo	74.79	0.00e+00	1363.00
IUUC-Mmr-061328	Microcebus murinus	83.44	0.00e+00	822.00
IUUC-Mdo-063048	Monodelphis domestica	76.36	0.00e+00	1340.00
IUUC-Mmu-064079	Mus musculus	75.22	0.00e+00	1329.00
IUUC-Mpu-066616	Mustela putorius furo	74.65	0.00e+00	1365.00
IUUC-Mlu-067294	Myotis lucifugus	75.22	0.00e+00	1316.00
IUUC-Nle-070015	Nomascus leucogenys	75.54	0.00e+00	1347.00
IUUC-Opr-070328	Ochotona princeps	74.27	0.00e+00	1343.00
IUUC-Ont-071464	Oreochromis niloticus	92.27	0.00e+00	1538.00
IUUC-Oan-073259	Ornithorhynchus anatinus	70.24	0.00e+00	1176.00
IUUC-Ocu-074630	Oryctolagus cuniculus	72.46	0.00e+00	1293.00
IUUC-Ola-087240	Oryzias latipes	90.04	0.00e+00	1516.00
IUUC-Oga-088761	Otolemur garnettii	74.89	0.00e+00	1368.00
IUUC-Oar-089490	Ovis aries	72.30	0.00e+00	1249.00
IUUC-Ptr-091662	Pan troglodytes	75.22	0.00e+00	1347.00
IUUC-Pan-092199	Papio anubis	75.75	0.00e+00	1357.00
IUUC-Psi-093726	Pelodiscus sinensis	76.47	0.00e+00	1366.00
IUUC-Pma-094389	Petromyzon marinus	63.73	2.00e-100	358.00
IUUC-Pfo-096522	Poecilia formosa	95.75	0.00e+00	1220.00
IUUC-Pab-098632	Pongo abelii	75.11	0.00e+00	1344.00
IUUC-Pca-100614	Procavia capensis	69.72	0.00e+00	1075.00
IUUC-Rno-105215	Rattus norvegicus	75.43	0.00e+00	1322.00
IUUC-Sha-106601	Sarcophilus harrisii	75.22	0.00e+00	1327.00
IUUC-Ssc-115533	Sus scrofa	75.00	0.00e+00	1338.00
IUUC-Tgu-117364	Taeniopygia guttata	75.84	0.00e+00	1364.00
IUUC-Tru-117770	Takifugu rubripes	90.09	0.00e+00	1560.00
IUUC-Tni-120001	Tetraodon nigroviridis	90.23	0.00e+00	1519.00
IUUC-Ttr-128732	Tursiops truncatus	75.57	0.00e+00	1357.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence