iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028626

UUCD1 version

UUC-DaR-00129

Ensembl Protein ID

ENSDARP00000131139.1

UniProt Accession

A0A0R4IDL4; A0A0R4IDL4_DANRE

Genbank Protein ID

ENSDARP00000131139

Protein Name

Cbl proto-oncogene C, E3 ubiquitin protein ligase

Genbank Nucleotide ID

CR391937

Gene Name

cblc

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000078217.4	ENSDART00000166759.1	ENSDARP00000131139.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.30e-06	28.1	363	402

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ ++ Cl  w     ++s   +CP+Cr
   Q: 363  CKICTERDKD-TRIQPCGHLLCQPCLTGW-----QKSDGHTCPYCR 402
           99****9999.******************.....5677778****8 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MMAMARRPGT AGRSQISDTS ETPSQPPTSA DRKLLEKVLK RLDKLHKLSV DPRLALKNSP 60
PYLPELLSET AIHLTEVWAP YRGSAMAVPR WDEGDYMRIH IRHLLDKTDR AVLLFKEGKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCACTTGTT CTCGTTTCCT TTTTGTTGTT GCTAAAATGA CATTAATCGC AGACTTGACA 60
CTGATTATCA GTTGTTGCAT GTAAATAAGC CCACTTCTAC ATTGACTTCA CCTTAATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0023051--P:regulation of signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011768	Astyanax mexicanus	68.79	0.00e+00	741.00
IUUC-Ont-071754	Oreochromis niloticus	70.34	0.00e+00	659.00
IUUC-Pfo-096070	Poecilia formosa	76.88	9.00e-166	576.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence